目的:优化以普朗尼克P123为载体材料的多西他赛胶束处方工艺。方法:采用薄膜水化法制备多西他赛普朗尼克P123胶束。采用星点设计-效应面法优化胶束处方工艺,以包封率作为评价指标,考察投药量、有机溶剂体积、水化体积、水化温度。采用...目的:优化以普朗尼克P123为载体材料的多西他赛胶束处方工艺。方法:采用薄膜水化法制备多西他赛普朗尼克P123胶束。采用星点设计-效应面法优化胶束处方工艺,以包封率作为评价指标,考察投药量、有机溶剂体积、水化体积、水化温度。采用透射电镜观察胶束形态,并测定胶束的粒径和Zeta电位,以透析法进行胶束体外释放特性考察。结果:以多元线性回归和二次、三次多项式拟合指标与因素之间的数学关系,结果表明三次多项式拟合度较好,制备出的胶束形态圆整,平均粒径和Zeta电位分别为108.3 nm和-3.99 m V,多分散指数为0.265,平均包封率和载药率分别为(97.91%±0.28%)和(3.72%±0.12%),多西他赛胶束120 h的累积释放率达95.03%,具有一定的缓释能力。结论:采用薄膜水化法制备的多西他赛胶束工艺简单可行,具有较高的包封率,在体外具有较好的缓释效果。展开更多
Mesoporous silicas with different morphologies have attracted great interest in the fields of catalysis,separation and so on. In this study, silica hollow tubes with ordered mesopores were synthesized via a novel sol-...Mesoporous silicas with different morphologies have attracted great interest in the fields of catalysis,separation and so on. In this study, silica hollow tubes with ordered mesopores were synthesized via a novel sol-gel method with an ionic liquid 1-decyl-3-methylimidazolium chloride（[Dmim]Cl） and a nonionic surfactant P123（PEO_（20）PPO_（70）PEO_（20）） as the co-template. Comparatively, silica hollow spheres with disordered mesopores were synthesized with only [Dmim]Cl as the template. The template dosage is the key factor in controlling the morphology. The micelles assembly mechanism based on hydrogen bonding interactions is proposed to be responsible for the formation of the final silica morphology and mesostructure.展开更多
文摘目的:优化以普朗尼克P123为载体材料的多西他赛胶束处方工艺。方法:采用薄膜水化法制备多西他赛普朗尼克P123胶束。采用星点设计-效应面法优化胶束处方工艺,以包封率作为评价指标,考察投药量、有机溶剂体积、水化体积、水化温度。采用透射电镜观察胶束形态,并测定胶束的粒径和Zeta电位,以透析法进行胶束体外释放特性考察。结果:以多元线性回归和二次、三次多项式拟合指标与因素之间的数学关系,结果表明三次多项式拟合度较好,制备出的胶束形态圆整,平均粒径和Zeta电位分别为108.3 nm和-3.99 m V,多分散指数为0.265,平均包封率和载药率分别为(97.91%±0.28%)和(3.72%±0.12%),多西他赛胶束120 h的累积释放率达95.03%,具有一定的缓释能力。结论:采用薄膜水化法制备的多西他赛胶束工艺简单可行,具有较高的包封率,在体外具有较好的缓释效果。
基金financially supported by the National Natural Science Foundation of China (Nos. 21206118, 21328601)
文摘Mesoporous silicas with different morphologies have attracted great interest in the fields of catalysis,separation and so on. In this study, silica hollow tubes with ordered mesopores were synthesized via a novel sol-gel method with an ionic liquid 1-decyl-3-methylimidazolium chloride（[Dmim]Cl） and a nonionic surfactant P123（PEO_（20）PPO_（70）PEO_（20）） as the co-template. Comparatively, silica hollow spheres with disordered mesopores were synthesized with only [Dmim]Cl as the template. The template dosage is the key factor in controlling the morphology. The micelles assembly mechanism based on hydrogen bonding interactions is proposed to be responsible for the formation of the final silica morphology and mesostructure.
