WITHDRAWAL:Zhang,J.J.,Guo,Y.Q.,Qin,Z.Y.,Wei,C.T.,Hu,Q.H.,Vandeginste,V.,Miao,H.Y.,Yao,P.,and Zhang,P.F.,“Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphol...WITHDRAWAL:Zhang,J.J.,Guo,Y.Q.,Qin,Z.Y.,Wei,C.T.,Hu,Q.H.,Vandeginste,V.,Miao,H.Y.,Yao,P.,and Zhang,P.F.,“Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphological Division and Fractal Models”,Acta Geologica Sinica-English Edition(Accepted Article):https://doi.org/10.1111/1755-6724.15094.展开更多
AIM:Regulatory T cells(Tregs)are a specialized subset of CD4^(+)T cells primarily involved in im⁃munosuppressive functions.AMP-activated protein kinase(AMPK)serves as a metabolic sensor that governs the differen⁃tiati...AIM:Regulatory T cells(Tregs)are a specialized subset of CD4^(+)T cells primarily involved in im⁃munosuppressive functions.AMP-activated protein kinase(AMPK)serves as a metabolic sensor that governs the differen⁃tiation,maturation,and immune functions of Tregs through metabolic reprogramming.However,the impact of AMPKα1(the catalytic subunit of AMPK)knockout specifically in Tregs on the host's immune microenvironment remains largely un⁃explored.METHODS:Histological changes in immune organs were assessed using HE staining.The types of immune cells and their relative population percentages in immune organs and blood were quantified through flow cytometry in both AMPKα1flox/flox(AMPKα1^(fl/fl))mice and Treg-specific AMPKα1 knockout mice(AMPKα1^(fl/fl)Foxp3^(cre)mice).RESULTS:Compared to AMPKα1^(fl/fl)mice,the percentage of eosinophils in the bone marrow of AMPKα1^(fl/fl)Foxp3^(cre)mice was significant⁃ly reduced.Additionally,while the thymus of AMPKα1^(fl/fl)Foxp3^(cre)mice exhibited normal structure,both its size and the ratio of thymus weight to body weight were significantly decreased.The knockout of AMPKα1 in Tregs led to a notable reduction in the total percentage of immature double-negative(DN)cells.Consequently,the percentage of CD4^(+)T cells derived from these DN cells also decreased,even though the percentages of DN1 and DN4 cells were higher in the thymus of AMPKα1^(fl/fl)Foxp3^(cre)mice compared to AMPKα1^(fl/fl)mice.Importantly,the proportion of Siglec-F+CD11b^(+)eosinophils in the thymus was significantly lower in AMPKα1^(fl/fl)Foxp3^(cre)mice.Knockout of AMPKα1 in Tregs resulted in a marked increase in the percentage of CD4^(+)T cells in peripheral blood,alongside a decrease in the proportion of mature CD8^(+)T cells.Similarly,the proportion of CD4^(+)T cells in the spleen of AMPKα1^(fl/fl)Foxp3^(cre)mice was elevated compared to AMPKα1^(fl/fl)mice.In contrast,the proportion of neutrophils significantly decreased,while mononuclear cell proportions increased in the spleen of AMPKα1^(fl/fl)Foxp3^(cre)mice.In lymph nodes,the medullary boundaries in AMPKα1^(fl/fl)Foxp3^(cre)mice were blurred,and the lymphoid follicles were missing,a feature not observed in AMPKα1^(fl/fl)mice.Furthermore,the knockout of AMPKα1 in Tregs reduced the CD3^(+)T cell population,particularly the CD8^(+)T cell population,in lymph nodes.Although the mature Treg cell population was significantly lower in AMPKα1^(fl/fl)Foxp3^(cre)mice,the percentage of CD4^(+)T cells was markedly in⁃creased.In contrast,there was no statistically significant difference in granulocyte populations between AMPKα1^(fl/fl)Foxp3^(cre)and AMPKα1^(fl/fl)mice.CONCLUSION:The populations of mature Tregs,CD8^(+)T cells and eosinophils in various im⁃mune organs were significantly altered in mice with Treg-specific AMPKα1 knockout,suggesting a potential remodeling of the host immune microenvironment in response to inflammatory stimuli.展开更多
Starting from cheap inorganic salts , ultrafine P L Z T po w ders were synthesized by a co pre cipitation m ethod . The results show that the precursor precipitate obtained by the co precipita tion method transf...Starting from cheap inorganic salts , ultrafine P L Z T po w ders were synthesized by a co pre cipitation m ethod . The results show that the precursor precipitate obtained by the co precipita tion method transfor ms co m pletely to P L Z T phase by calcining at 420 ℃ for 4 hours , about300 ℃low er than the nor m al transform ation te m perature of P L Z T obtained by m ixed oxidemethod . The effect of residual N H4 N O3 in the precursor precipitate on transfor m ation te m perature of the P L Z Tpow der w as investigated . The residual N H4 N O3 in the precursor po w der can reduce further the P L Z Ttransfor m ation tem perature to about 300 ℃, but a sm alla mount of Zr O2 and Pb Ti O3 re m ained . By a proper control of the synthesizing route , a P L Z T po w der with a pri m ary particle size of 10 n m and an agglom eration size of 0 3 μm hasbeen produced .展开更多
The Mn-Ce-Nb-O_x/P84 catalytic filter for removal of particulates and NO simultaneous was prepared by a novel method(foam coating method). The process parameters including the concentrations of PTFE emulsion, particle...The Mn-Ce-Nb-O_x/P84 catalytic filter for removal of particulates and NO simultaneous was prepared by a novel method(foam coating method). The process parameters including the concentrations of PTFE emulsion, particle size of catalyst and calcination temperature for preparation of catalytic filters were analyzed. In addition, the physical properties and performance for removal of NO(NH_3-SCR) and particulates of Mn-Ce-Nb-O_x/P84 catalytic filter prepared under the optimized parameters, were also systematic studied. Results show that the process parameters had significant influences on stability and performance of catalytic filter, The Mn-Ce-Nb-O_x/P84 catalytic filter prepared by foam coating method under the optimized parameters, has satisfactory physical properties and catalytic performance for removal of NO and particulates at 140-220 ℃. The NO removal efficiency of catalytic filter can reach95.3% at 200 ℃ as the catalyst loading amount is 450 g/m^2, Moreover,the dust removal efficiency of MnGe-Nb-O_x/P84 catalytic filter reaches as high as 99.98%, and the PM2.5 removal efficiency also reaches99.98%. The anti-sulfur performance of Mn-Ce-Nb-O_x catalytic filter is also attractive, after injecting150 ppm SO_2, the NO removal efficiency still retains up to 85%. It is indicated that the foam coating method can not only make a bond of high strength between catalyst and filter, but also make the catalytic filter possessing an excellent and stable performance for removal of NO and particulates.展开更多
Complex phase transitions occur in P2-type materials during charging and discharging.A high-entropy structure can effectively inhibit the structural phase transition of a P2-type layered material.In this study,a hight...Complex phase transitions occur in P2-type materials during charging and discharging.A high-entropy structure can effectively inhibit the structural phase transition of a P2-type layered material.In this study,a hightemperature solid-phase method is used to synthesize the P2-type high-entropy fluorine oxide(HEFO)Na_(0.7)Li_(0.08)Mn(Ⅳ)_(0.21)Mn(Ⅲ)_(0.43)Mg_(0.11)Ni_(0.11)W_(0.04)Nb_(0.02)O_(1.9)F_(0.1)[■-NLM(Ⅳ)0.21M(Ⅲ)0.43F(■=NMNWO)],with a superlattice structure and Na_(2)WO_(4)coating.Na_(2)WO_(4)can effectively inhibit the complex phase transition to improve the structural stability of the material and overcome the limitations of P2-type Na_(x)TMO_(2)(TM=transition metal)via additional charge compensation.Adjusting the Mn^(3+)/Mn^(4+)ratio to increase the average valence state of Mn and introducing F^(-)and Li^(+)to inhibit the Jahn-Teller effect suppress the complex phase transition during charging and discharging.The material exhibits a good multiplicative performance(discharge specific capacity of 88.4 mAh g^(-1)at a multiplicative rate of 10C)and capacity retention(99.22%after 200 cycles at 1C in the potential window of 1.5-4.3 V).The structural stabilities of HEFO are effectively demonstrated using electrochemical in situ X-ray diffraction and ex situ X-ray photoelectron spectroscopy.Theoretical calculations reveal that the high-entropy structure effectively improves the electronic structure and charge distribution of the layered oxide material.This study provides new concepts for use in developing novel energy batteries.展开更多
The in-plane optical anisotropy(IPOA) of c-plane In Ga N/Ga N quantum disks(Qdisks) in nanowires grown on MoS_(2)/Mo and Ti/Mo substrates is investigated using reflectance difference spectroscopy(RDS) at room temperat...The in-plane optical anisotropy(IPOA) of c-plane In Ga N/Ga N quantum disks(Qdisks) in nanowires grown on MoS_(2)/Mo and Ti/Mo substrates is investigated using reflectance difference spectroscopy(RDS) at room temperature. A large IPOA related to defect or impurity states is observed. The IPOA of samples grown on MoS_(2)/Mo is approximately one order of magnitude larger than that of samples grown on Ti/Mo substrates. Numerical calculations based on the envelope function approximation have been performed to analyze the origin of the IPOA. It is found that the IPOA primarily results from the segregation of indium atoms in the In Ga N/Ga N Qdisks. This work highlights the significant influence of substrate materials on the IPOA of semiconductor heterostructures.展开更多
文摘WITHDRAWAL:Zhang,J.J.,Guo,Y.Q.,Qin,Z.Y.,Wei,C.T.,Hu,Q.H.,Vandeginste,V.,Miao,H.Y.,Yao,P.,and Zhang,P.F.,“Predicting Irreducible Water Saturation of Unconventional Reservoirs by Using NMR T2 Spectra:Methods of Morphological Division and Fractal Models”,Acta Geologica Sinica-English Edition(Accepted Article):https://doi.org/10.1111/1755-6724.15094.
基金Supported by the National Natural Science Foundation of China(No.81800423)the Guangdong Medical Science and Technology Research project(No.B2022102)。
文摘AIM:Regulatory T cells(Tregs)are a specialized subset of CD4^(+)T cells primarily involved in im⁃munosuppressive functions.AMP-activated protein kinase(AMPK)serves as a metabolic sensor that governs the differen⁃tiation,maturation,and immune functions of Tregs through metabolic reprogramming.However,the impact of AMPKα1(the catalytic subunit of AMPK)knockout specifically in Tregs on the host's immune microenvironment remains largely un⁃explored.METHODS:Histological changes in immune organs were assessed using HE staining.The types of immune cells and their relative population percentages in immune organs and blood were quantified through flow cytometry in both AMPKα1flox/flox(AMPKα1^(fl/fl))mice and Treg-specific AMPKα1 knockout mice(AMPKα1^(fl/fl)Foxp3^(cre)mice).RESULTS:Compared to AMPKα1^(fl/fl)mice,the percentage of eosinophils in the bone marrow of AMPKα1^(fl/fl)Foxp3^(cre)mice was significant⁃ly reduced.Additionally,while the thymus of AMPKα1^(fl/fl)Foxp3^(cre)mice exhibited normal structure,both its size and the ratio of thymus weight to body weight were significantly decreased.The knockout of AMPKα1 in Tregs led to a notable reduction in the total percentage of immature double-negative(DN)cells.Consequently,the percentage of CD4^(+)T cells derived from these DN cells also decreased,even though the percentages of DN1 and DN4 cells were higher in the thymus of AMPKα1^(fl/fl)Foxp3^(cre)mice compared to AMPKα1^(fl/fl)mice.Importantly,the proportion of Siglec-F+CD11b^(+)eosinophils in the thymus was significantly lower in AMPKα1^(fl/fl)Foxp3^(cre)mice.Knockout of AMPKα1 in Tregs resulted in a marked increase in the percentage of CD4^(+)T cells in peripheral blood,alongside a decrease in the proportion of mature CD8^(+)T cells.Similarly,the proportion of CD4^(+)T cells in the spleen of AMPKα1^(fl/fl)Foxp3^(cre)mice was elevated compared to AMPKα1^(fl/fl)mice.In contrast,the proportion of neutrophils significantly decreased,while mononuclear cell proportions increased in the spleen of AMPKα1^(fl/fl)Foxp3^(cre)mice.In lymph nodes,the medullary boundaries in AMPKα1^(fl/fl)Foxp3^(cre)mice were blurred,and the lymphoid follicles were missing,a feature not observed in AMPKα1^(fl/fl)mice.Furthermore,the knockout of AMPKα1 in Tregs reduced the CD3^(+)T cell population,particularly the CD8^(+)T cell population,in lymph nodes.Although the mature Treg cell population was significantly lower in AMPKα1^(fl/fl)Foxp3^(cre)mice,the percentage of CD4^(+)T cells was markedly in⁃creased.In contrast,there was no statistically significant difference in granulocyte populations between AMPKα1^(fl/fl)Foxp3^(cre)and AMPKα1^(fl/fl)mice.CONCLUSION:The populations of mature Tregs,CD8^(+)T cells and eosinophils in various im⁃mune organs were significantly altered in mice with Treg-specific AMPKα1 knockout,suggesting a potential remodeling of the host immune microenvironment in response to inflammatory stimuli.
文摘Starting from cheap inorganic salts , ultrafine P L Z T po w ders were synthesized by a co pre cipitation m ethod . The results show that the precursor precipitate obtained by the co precipita tion method transfor ms co m pletely to P L Z T phase by calcining at 420 ℃ for 4 hours , about300 ℃low er than the nor m al transform ation te m perature of P L Z T obtained by m ixed oxidemethod . The effect of residual N H4 N O3 in the precursor precipitate on transfor m ation te m perature of the P L Z Tpow der w as investigated . The residual N H4 N O3 in the precursor po w der can reduce further the P L Z Ttransfor m ation tem perature to about 300 ℃, but a sm alla mount of Zr O2 and Pb Ti O3 re m ained . By a proper control of the synthesizing route , a P L Z T po w der with a pri m ary particle size of 10 n m and an agglom eration size of 0 3 μm hasbeen produced .
基金Project supported by the National Natural Science Foundation of China(21501097,21272118,21577065)the Natural Science Foundation of Jiangsu Province(BK20170954)+2 种基金the Startup Foundation for Introducing Talent of NUIST(2017r073)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China,China(18KJB430019)University Science Research Project of Jiangsu Province(18KJB430019)
文摘The Mn-Ce-Nb-O_x/P84 catalytic filter for removal of particulates and NO simultaneous was prepared by a novel method(foam coating method). The process parameters including the concentrations of PTFE emulsion, particle size of catalyst and calcination temperature for preparation of catalytic filters were analyzed. In addition, the physical properties and performance for removal of NO(NH_3-SCR) and particulates of Mn-Ce-Nb-O_x/P84 catalytic filter prepared under the optimized parameters, were also systematic studied. Results show that the process parameters had significant influences on stability and performance of catalytic filter, The Mn-Ce-Nb-O_x/P84 catalytic filter prepared by foam coating method under the optimized parameters, has satisfactory physical properties and catalytic performance for removal of NO and particulates at 140-220 ℃. The NO removal efficiency of catalytic filter can reach95.3% at 200 ℃ as the catalyst loading amount is 450 g/m^2, Moreover,the dust removal efficiency of MnGe-Nb-O_x/P84 catalytic filter reaches as high as 99.98%, and the PM2.5 removal efficiency also reaches99.98%. The anti-sulfur performance of Mn-Ce-Nb-O_x catalytic filter is also attractive, after injecting150 ppm SO_2, the NO removal efficiency still retains up to 85%. It is indicated that the foam coating method can not only make a bond of high strength between catalyst and filter, but also make the catalytic filter possessing an excellent and stable performance for removal of NO and particulates.
基金financially supported by the Guizhou Provincial Basic Research Program(Natural Science)(No.QKHJC-ZK[2023]YB051)the Natural Science Special Foundation of Guizhou University(No.GDTGH[2022]33)+2 种基金the Natural Science Research project of the Education Department of Guizhou Province(No.QJJ[2022]001)the National Natural Science Foundation of China(No.52161029)the Science and Technology Innovation Team of Education Agency in Guizhou Province(No.Qian Jiao Ji[2023]056)
文摘Complex phase transitions occur in P2-type materials during charging and discharging.A high-entropy structure can effectively inhibit the structural phase transition of a P2-type layered material.In this study,a hightemperature solid-phase method is used to synthesize the P2-type high-entropy fluorine oxide(HEFO)Na_(0.7)Li_(0.08)Mn(Ⅳ)_(0.21)Mn(Ⅲ)_(0.43)Mg_(0.11)Ni_(0.11)W_(0.04)Nb_(0.02)O_(1.9)F_(0.1)[■-NLM(Ⅳ)0.21M(Ⅲ)0.43F(■=NMNWO)],with a superlattice structure and Na_(2)WO_(4)coating.Na_(2)WO_(4)can effectively inhibit the complex phase transition to improve the structural stability of the material and overcome the limitations of P2-type Na_(x)TMO_(2)(TM=transition metal)via additional charge compensation.Adjusting the Mn^(3+)/Mn^(4+)ratio to increase the average valence state of Mn and introducing F^(-)and Li^(+)to inhibit the Jahn-Teller effect suppress the complex phase transition during charging and discharging.The material exhibits a good multiplicative performance(discharge specific capacity of 88.4 mAh g^(-1)at a multiplicative rate of 10C)and capacity retention(99.22%after 200 cycles at 1C in the potential window of 1.5-4.3 V).The structural stabilities of HEFO are effectively demonstrated using electrochemical in situ X-ray diffraction and ex situ X-ray photoelectron spectroscopy.Theoretical calculations reveal that the high-entropy structure effectively improves the electronic structure and charge distribution of the layered oxide material.This study provides new concepts for use in developing novel energy batteries.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 62074036, 61674038, and 11574302)Foreign Cooperation Project of Fujian Province (Grant No. 2023I0005)+2 种基金Open Research Fund Program of the State Key Laboratory of Low-Dimensional Quantum Physics (Grant No. KF202108)the National Key Research and Development Program (Grant No. 2016YFB0402303)the Foundation of Fujian Provincial Department of Industry and Information Technology of China (Grant No. 82318075)。
文摘The in-plane optical anisotropy(IPOA) of c-plane In Ga N/Ga N quantum disks(Qdisks) in nanowires grown on MoS_(2)/Mo and Ti/Mo substrates is investigated using reflectance difference spectroscopy(RDS) at room temperature. A large IPOA related to defect or impurity states is observed. The IPOA of samples grown on MoS_(2)/Mo is approximately one order of magnitude larger than that of samples grown on Ti/Mo substrates. Numerical calculations based on the envelope function approximation have been performed to analyze the origin of the IPOA. It is found that the IPOA primarily results from the segregation of indium atoms in the In Ga N/Ga N Qdisks. This work highlights the significant influence of substrate materials on the IPOA of semiconductor heterostructures.
