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The work hardening and softening behavior of spherical Ti_(p)/Mg-5Zn-0.3Ca composite 被引量:1
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作者 Cui-ju Wang Jin-Kai Zhang +2 位作者 Kai-bo Nie Chao Xu Kun-kun Deng 《Journal of Magnesium and Alloys》 2025年第6期2752-2768,共17页
To obtain the Ti_(p)with different aspect ratios,the Ti_(p)/Mg-5Zn-0.3Ca composite prepared by semi-solid stir casting was subjected to extrusion at 220℃,180℃,and 140℃,respectively.Then,the effect of the Ti_(p)’s ... To obtain the Ti_(p)with different aspect ratios,the Ti_(p)/Mg-5Zn-0.3Ca composite prepared by semi-solid stir casting was subjected to extrusion at 220℃,180℃,and 140℃,respectively.Then,the effect of the Ti_(p)’s aspect ratio on the microstructure,mechanical properties,work hardening and softening behaviors of Ti_(p)/Mg-5Zn-0.3Ca composites was investigated.The results indicated that the Ti_(p)could be elongated obviously after low-temperature extrusion,and the aspect ratio of which would reach to 13.7:1 as the extrusion temperature deceased to 140℃.Then the“Ti/Mg”layer-like structure was formed in the Ti_(p)/Mg-5Zn-0.3Ca composite.Accompanied with the elongation of Ti_(p),the dynamic recrystallized grains and dynamic precipitates were both refined significantly,however,the dynamic recrystallization rate changed a little.The elongated Ti_(p)endowed the Ti_(p)/Mg-5Zn-0.3Ca composites with better matching of strength and toughness without the sacrifice of elongation and bending strain.Both the work hardening rate and softening rate of Ti_(p)/Mg-5Zn-0.3Ca composites increased with the increasing aspect ratio of Ti_(p).The formation of“Ti/Mg”layer-like structure contributed to the redistribution of strain from large aggregations to a network-like distribution,which effectively suppresses the initiation and propagation of micro-cracks,thus enhancing the plasticity of the Ti_(p)/Mg-5Zn-0.3Ca composites. 展开更多
关键词 Ti_(p) particle reinforced magnesium matrix composites Work hardening and softening behavior Laminar-like configuration
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Mechanical Properties and Work Hardening Behavior of Ti_(p)/Mg‑Gd‑Y‑Zn Composites
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作者 Fang‑Fang Cao Cui‑Ju Wang +3 位作者 Kai‑Bo Nie Quan‑Xin Shi Yi‑Jia Li Kun‑Kun Deng 《Acta Metallurgica Sinica(English Letters)》 2025年第10期1777-1793,共17页
In this work,Ti_(p)/Mg-7Gd-2Y-3Zn(Ti_(p)/GWZ723)composites with various Ti_(p) sizes(~10μm,~20μm and~35μm)were fabricated using semi-solid stirring casting method,the composites were subjected to hot extrusion,and ... In this work,Ti_(p)/Mg-7Gd-2Y-3Zn(Ti_(p)/GWZ723)composites with various Ti_(p) sizes(~10μm,~20μm and~35μm)were fabricated using semi-solid stirring casting method,the composites were subjected to hot extrusion,and the infuence of Ti_(p) size on long-period stacking ordered(LPSO)phase,dynamic recrystallization(DRX),mechanical properties,and work hardening behavior of the Ti_(p)/GWZ723 composites was investigated.The results indicate that with the increase in Ti_(p) size,the grain size of the as-cast Ti_(p)/GWZ723 composites increases,and the lamellar 14H LPSO phase precipitates within the matrix after homogenization treatment.With the increase in Ti_(p) size,the reduction in the Ti_(p) surface area leads to a decrease in surface energy.Consequently,the enrichment of RE element is reduced,which facilitates the formation of the 14H LPSO phase.Moreover,the layer spacing of the 14H LPSO phase decreases.Particle deformation zone(PDZ)is formed around the Ti_(p) after extrusion,promoting the nucleation of DRX.The PDZ size increases with the increase in the Ti_(p) size.Nevertheless,the elongation of the Ti_(p) releases stress and reduces the PDZ size.Simultaneously,the 14H LPSO phase with a small interlayer spacing inhibits the non-basal slip,and the volume fraction of DRX(VDRX)decreases with the increase in the Ti_(p) size.With the increase in Ti_(p) size,the refned grain size and the 14H LPSO phase with smaller interlayer spacing contribute to enhancing the work hardening rate and dynamic recovery rate of the Ti_(p)/GWZ723 composites.The Ti_(p)/Mg laminar-like interface formed in the Ti_(p)/GWZ723 composites can alleviate local stress concentration and inhibit the initiation and propagation of cracks. 展开更多
关键词 Ti_(p)reinforced magnesium matrix composites Ti_(p)/Mg laminar-like interface Dynamic recrystallization(DRX)behavior Work hardening
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血清sP-selectin、sE-selectin对原发性高血压伴2型糖尿病的诊断价值及其与胰岛素抵抗的关系 被引量:3
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作者 谷君 张志英 +5 位作者 宁改君 邓文娟 胡利梅 刘慧颖 蔡裕 任卫东 《检验医学与临床》 2025年第6期805-809,共5页
目的探讨血清可溶性P-选择素(sP-selectin)、可溶性E-选择素(sE-selectin)对原发性高血压(EH)伴2型糖尿病(T2DM)的诊断价值及其与胰岛素抵抗的关系。方法选取2019年9月至2021年9月该院收治的124例EH患者作为研究对象,根据是否伴有T2DM... 目的探讨血清可溶性P-选择素(sP-selectin)、可溶性E-选择素(sE-selectin)对原发性高血压(EH)伴2型糖尿病(T2DM)的诊断价值及其与胰岛素抵抗的关系。方法选取2019年9月至2021年9月该院收治的124例EH患者作为研究对象,根据是否伴有T2DM将其分为非T2DM组66例和T2DM组58例;另选取同期在该院体检的50例健康志愿者作为对照组。收集研究对象的收缩压、舒张压、脉压及甘油三酯、胆固醇、空腹血糖水平等临床资料;采用酶联免疫吸附试验检测血清sP-selectin、sE-selectin水平;采用电化学发光法测定空腹胰岛素水平,并计算胰岛素抵抗指数。采用Pearson相关分析T2DM患者血清sP-selectin、sE-selectin水平与空腹胰岛素水平、胰岛素抵抗指数的相关性;绘制受试者工作特征(ROC)曲线分析血清sP-selectin、sE-selectin对EH伴T2DM的诊断价值。结果与对照组比较,非T2DM组、T2DM组收缩压、舒张压、脉压及甘油三酯、胆固醇、空腹血糖水平均明显升高(P<0.05);与非T2DM组比较,T2DM组甘油三酯、胆固醇、空腹血糖水平均明显升高(P<0.05)。血清sP-selectin、sE-selectin水平及空腹胰岛素水平、胰岛素抵抗指数在对照组<非T2DM组<T2DM组,且两两比较,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,T2DM患者血清sP-selectin、sE-selectin水平与空腹胰岛素水平、胰岛素抵抗指数均呈正相关(P<0.05)。ROC曲线分析结果显示,血清sP-selectin、sE-selectin联合诊断EH伴T2DM的曲线下面积优于各指标单独诊断(Z二者联合-sP-selectin=2.099、P=0.036;Z二者联合-sE-selectin=2.998、P=0.003)。结论EH伴T2DM患者血清sP-selectin、sE-selectin水平升高,且与空腹胰岛素水平、胰岛素抵抗指数呈正相关,二者联合检测对EH伴T2DM具有较高的诊断价值。 展开更多
关键词 原发性高血压 2型糖尿病 可溶性p-选择素 可溶性e-选择素 空腹胰岛素 胰岛素抵抗指数
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Foraging behavior of parasitoid chalcid to the essential oil from bark of Populus pseudo-simonii P. nigra and Quadraspidiotus gigas 被引量:2
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作者 迟德富 Rafael Ocete Rubio +2 位作者 严善春 张丹丹 温振宏 《Journal of Forestry Research》 SCIE CAS CSCD 2002年第4期255-259,共5页
采用四臂式嗅觉仪测定了长棒四节蚜小蜂(Pteroptrix longgiclava(Girault)(Hymenoptera:Aphelinidae))和黄胸扑虱蚜小蜂(Encarsia gigas(Tshumakova)(Hymenoptera:Aphelinidae)),对健康的小青×黑杨(Populus pseudo-simonii×... 采用四臂式嗅觉仪测定了长棒四节蚜小蜂(Pteroptrix longgiclava(Girault)(Hymenoptera:Aphelinidae))和黄胸扑虱蚜小蜂(Encarsia gigas(Tshumakova)(Hymenoptera:Aphelinidae)),对健康的小青×黑杨(Populus pseudo-simonii×P.nigra)树皮、被杨圆蚧(Quadraspidiotus gigas(Thiem & Gerneck))危害的杨树皮、杨圆蚧1齿固定若虫的虫体和介壳的挥发油的趋性反应。测定结果表明:被杨圆蚧危害后的小青×黑杨树皮和杨圆蚧1龄因定若虫的介壳对长棒四节蚜小蜂和黄胸扑虱蚜小蜂成虫具有较大的吸引力。3-7μL介壳挥发油和5-9μL受害杨树皮挥发油对长棒四节蚜小蜂的寄主搜寻行为具有较强的引导作用。虫体的挥发油对小蜂的寄生定位也起到了一定的引诱作用。两种小蜂对健康树皮的挥发油几乎没有反应。图4表1参20。 展开更多
关键词 populus pseudo-simonii ×p. nigra Quadraspidiotus gigas (Thiem & Gerneck) pteroptrix longgiclava (Girault) encarsia gigas (Tshumakova) essential Oil pARASITOID Foraging behavior
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miR-24-3p BHLHE22在子宫内膜癌中的表达及其与术后复发转移的关系
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作者 王佳 索青霞 +2 位作者 王纪元 成丽 王磊 《安徽医学》 2025年第7期847-852,共6页
目的探究微小RNA-24-3p(miR-24-3p)、基本螺旋-环-螺旋家族成员e22(BHLHE22)在子宫内膜癌(EC)中的表达及其与术后复发、转移的关系。方法选取2018年6月至2022年12月保定市妇幼保健院收治的134例EC患者为EC组,另选取同期134例良性子宫内... 目的探究微小RNA-24-3p(miR-24-3p)、基本螺旋-环-螺旋家族成员e22(BHLHE22)在子宫内膜癌(EC)中的表达及其与术后复发、转移的关系。方法选取2018年6月至2022年12月保定市妇幼保健院收治的134例EC患者为EC组,另选取同期134例良性子宫内膜增生患者为对照组。采用实时荧光定量-聚合酶链式反应(qRT-PCR)测定血清miR-24-3p、BHLHE22表达水平;采用Pearson法分析血清miR-24-3p与BHLHE22的关系;EC患者术后复发转移的影响因素采用Cox回归分析;血清miR-24-3p、BHLHE22对EC患者术后复发转移的预测价值绘制受试者工作特征(ROC)曲线分析。结果与对照组相比,EC组中血清miR-24-3p表达水平升高(P<0.05),BHLHE22表达水平降低(P<0.05)。TargetScanHuman网址预测miR-24-3p与BHLHE22间存在结合位点。EC患者血清中miR-24-3p与BHLHE22表达水平呈负相关(r=-0.491,P<0.001)。与未复发转移组相比,复发转移组EC患者血清中miR-24-3p表达水平升高(P<0.05),BHLHE22表达水平降低(P<0.05)。未复发转移组和复发转移组淋巴结转移、远处转移差异有统计学意义(P<0.05)。BHLHE22是EC患者术后复发转移的保护因素(P<0.05),miR-24-3p、淋巴结转移、远处转移是其危险因素(P<0.05)。血清miR-24-3p、BHLHE22二者联合预测EC患者术后复发转移的曲线下面积最高,优于血清miR-24-3p、BHLHE22各自单独预测(Z_(二者联合-miR-24-3p)=3.434,P=0.001;Z_(二者联合-BHLHE22)=2.281,P=0.023)。结论EC患者血清miR-24-3p水平升高,BHLHE22水平降低,与术后复发转移有关,二者联合预测EC患者术后复发转移价值较高。 展开更多
关键词 微小RNA-24-3p 基本螺旋-环-螺旋家族成员e22 子宫内膜癌 复发 转移
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miR-204-5p通过靶向结合转录因子E2F1下调RRM2的表达以抑制乳腺癌细胞增殖并影响细胞周期分布
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作者 褚旭 李翔 +1 位作者 赵浩 邹燕 《四川医学》 2025年第7期773-780,共8页
目的探讨miR-204-5p调控乳腺癌细胞恶性表型的具体机制,为乳腺癌靶向药物的开发以及新治疗靶标的挖掘提供新思路。方法qRT-PCR检测乳腺癌细胞中miR-204-5p、E2F1和RRM2的表达水平。CCK-8和克隆形成实验检测乳腺癌细胞增殖能力,流式细胞... 目的探讨miR-204-5p调控乳腺癌细胞恶性表型的具体机制,为乳腺癌靶向药物的开发以及新治疗靶标的挖掘提供新思路。方法qRT-PCR检测乳腺癌细胞中miR-204-5p、E2F1和RRM2的表达水平。CCK-8和克隆形成实验检测乳腺癌细胞增殖能力,流式细胞术检测细胞周期变化,生信预测和双荧光素酶活性检测miR-204-5p和E2F1,E2F1和RRM2的结合关系。结果双荧光素酶活性检测结果表明miR-204-5p靶向结合E2F1抑制E2F1的表达,转录因子E2F1能够通过靶向结合关系促进RRM2的表达。回复实验结果表明miR-204-5p可以通过结合转录因子E2F1抑制乳腺癌细胞的增殖并诱导细胞G1期阻滞,E2F1可以通过结合RRM2促进乳腺癌细胞增殖抑制细胞G1期阻滞。结论miR-204-5p可以通过结合转录因子E2F1抑制RRM2的表达,从而诱导乳腺癌细胞停滞于G1期,抑制乳腺癌细胞的增殖,这为乳腺癌靶向药物的开发以及新治疗靶标的挖掘提供了新的思路。 展开更多
关键词 miR-204-5p 乳腺癌 e2F1 RRM2 增殖 G1期阻滞
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CYP2E1-RsaⅠ基因多态性在胰腺炎中的表达及与肠道菌群的关系分析
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作者 高晓 《新疆医学》 2025年第4期468-472,共5页
目的探究CYP2E1-RsaⅠ基因多态性在胰腺炎中的表达及与肠道菌群的关系分析。方法选取2022年1月-2023年5月本院收治的胰腺炎患者85例作为研究对象,其中51例轻度胰腺炎患者作为轻度胰腺炎组,34例重度胰腺炎患者作为重点胰腺炎组;同一时间... 目的探究CYP2E1-RsaⅠ基因多态性在胰腺炎中的表达及与肠道菌群的关系分析。方法选取2022年1月-2023年5月本院收治的胰腺炎患者85例作为研究对象,其中51例轻度胰腺炎患者作为轻度胰腺炎组,34例重度胰腺炎患者作为重点胰腺炎组;同一时间选取50例健康体检者作为对照组。三组研究对象均采用Gene Amp9700型PCR扩增仪进行CYP2E1-RsaⅠ扩增,比较基因型C2/C2、C1/C2及C1/C1的占比;另收集各组研究对象粪便,采用16S rDNA测序法进行肠道菌群丰度分析。结果三组研究对象的CYP2E1基因-RsaⅠ基因型在C2/C2及C1/C2比较差异无统计学意义(P>0.05);在C1/C1基因型中与对照组相比,轻度胰腺炎组占比升高,与轻度胰腺炎组相比,重度胰腺炎组占比升高(P<0.05);与对照组相比,轻度胰腺炎组患者乳酸杆菌、双歧杆菌丰度降低,葡萄球菌及大肠埃希菌丰度升高(P<0.05);与轻度胰腺炎组患者相比,重度胰腺炎组患者乳酸杆菌、双歧杆菌丰度降低,葡萄球菌及大肠埃希菌丰度升高(P<0.05);与CYP2E1基因-RsaⅠ基因型C2/C2相比,C1/C2基因型患者乳酸杆菌、双歧杆菌丰度降低,葡萄球菌及大肠埃希菌丰度升高(P<0.05);与C1/C2基因型相比,C1/C1基因型患者乳酸杆菌、双歧杆菌降低,葡萄球菌及大肠埃希菌升高(P<0.05)。结论胰腺炎患者中CYP2E1-RsaⅠ基因C1/C1基因型占比较高且随着疾病加重而占比升高,且C1/C1基因型的胰腺炎患者葡萄球菌及大肠埃希菌丰度增多,认为CYP2E1-RsaⅠ基因多态性与胰腺炎患者病情严重程度及肠道菌群失衡相关。 展开更多
关键词 胰腺炎 细胞色素p4502e1 肠道菌群 基因多态性
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右美托咪定预处理通过调控p62/Keap1/Nrf2途径减轻脂多糖诱导的大鼠肝脏氧化应激、炎症和铁死亡 被引量:4
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作者 沈耘 吴佳艺 +2 位作者 韩艳艳 钱淑雯 郭旋 《安徽医药》 2025年第3期472-481,I0001,共11页
目的研究右美托咪定(Dex)对脂多糖(LPS)诱导的肝脏氧化应激、炎症及铁死亡的影响及其可能的机制。方法2022年8月至2023年6月,腹腔注射LPS制备大鼠肝损伤模型。50只雄性Wistar大鼠按随机数字表法分为五组:对照组、Dex组、LPS组、LPS+Dex... 目的研究右美托咪定(Dex)对脂多糖(LPS)诱导的肝脏氧化应激、炎症及铁死亡的影响及其可能的机制。方法2022年8月至2023年6月,腹腔注射LPS制备大鼠肝损伤模型。50只雄性Wistar大鼠按随机数字表法分为五组:对照组、Dex组、LPS组、LPS+Dex组和LPS+Dex+p62活化抑制剂(XRK3F2)组,每组各10只。Kaplan‒Meier法进行生存分析;酶联免疫吸附测定(ELISA)大鼠血清中天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、肿瘤坏死因子α(TNF-α)、白细胞介素(IL)-1β和IL-6含量;苏木素-伊红(HE)染色观察大鼠肝组织的形态学变化;流式细胞术检测肝脏组织中活性氧簇含量;丙二醛、谷胱甘肽和总谷胱甘肽(T-GSH)含量,超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)活性及谷胱甘肽/氧化型谷胱甘肽(GSH/GSSG)比值采用试剂盒进行检测;实时荧光定量PCR(RT-qPCR)检测炎症因子、铁死亡及信号通路相关分子mRNA的表达;大鼠肝组织中Fe^(2+)含量用组织铁测定试剂盒检测;透射电镜观察大鼠肝组织细胞中线粒体形态;蛋白质印迹法检测铁死亡及信号通路相关分子蛋白的表达。结果与对照组相比,LPS组大鼠生存率和体质量明显降低,肝组织湿/干比及AST和ALT酶活力显著增加,肝组织形态发生损坏、炎症和坏死细胞增加;相较于LPS组,LPS+Dex组大鼠生存率和体质量明显增加,肝水肿、肝功能受损及肝组织病理学损伤明显减轻。与对照组相比,LPS可导致大鼠肝组织中活性氧簇和丙二醛含量增加,SOD、CAT和GSH-Px酶活性降低,谷胱甘肽和T-GSH含量和GSH/GSSG比值减少;Dex预处理则减弱了LPS诱导的氧化应激参数的改变。与对照组相比,LPS组大鼠血清中TNF-α、IL-1β和IL-6含量和肝组织中TNF-α、IL-1β和IL-6 mRNA表达升高;Dex则降低了LPS诱导的炎症因子的表达和释放。与对照组相比,LPS组大鼠肝组织细胞线粒体皱缩、嵴减少、膜密度增加,Fe^(2+)含量增加,谷胱甘肽过氧化物酶4(GPX4)、溶质载体家族7成员11(SLC7A11)和铁蛋白重链(l FTH1)的mRNA和蛋白表达明显降低,乙酰辅酶A合成酶长链家族成员4(ACSL4)和转铁蛋白受体1(TfR1)的mRNA和蛋白表达水平显著升高;Dex预处理显著改善线粒体受损并抑制铁死亡。与对照组相比,LPS组大鼠肝组织中p62表达(0.44±0.02比1.00±0.05)减少,Kelch样ECH2相关蛋白1(Keap1)(2.98±0.01比1.00±0.04)和核因子E2相关因子2(Nrf2)(2.50±0.06比1.00±0.03)表达升高;Dex预处理则增加了p62和核内Nrf2的表达,减少了Keap1和胞质内Nrf2表达。在用Dex预处理的基础上使用p62抑制剂(XRK3F2)后,与LPS+Dex组相比,Dex的抗氧化应激、抗炎症反应及抗铁死亡作用均明显降低。结论Dex对LPS诱导的大鼠肝损伤的保护作用与其抗氧化应激、抗炎症反应及抗铁死亡效应有关,其作用机制可能是通过调控p62/Keap1/Nrf2途径来实现的。 展开更多
关键词 肝损伤 右美托咪定 氧化应激 炎症 铁死亡 p62蛋白/Kelch样eCH2相关蛋白1/核因子e2相关因子2通路
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STUDIES ON MICROYIELD BEHAVIOR OF A SiCp/2024Al COMPOSITE 被引量:4
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作者 Zhang, Fan Li, Xiaocui +1 位作者 Jin, Chen Hu, Zhengjun 《中国有色金属学会会刊:英文版》 EI CSCD 1998年第3期94-99,共6页
1INTRODUCTIONDuetotheexcelentcomprehensivepropertiessuchashighspecificstrengthandYoung’smodulus,lowerthermal... 1INTRODUCTIONDuetotheexcelentcomprehensivepropertiessuchashighspecificstrengthandYoung’smodulus,lowerthermalconductivityandt... 展开更多
关键词 microyield behavior STRAIN ReLAXATION SIC p/2024Al COMpOSITe
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CYP2E1在三氯乙烯致敏豚鼠皮肤和肝损伤中的作用
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作者 吴丽娟 宋向荣 +4 位作者 陆丰荣 李宏玲 何嘉恒 张骁 王海兰 《中国职业医学》 2025年第3期249-256,共8页
目的 在豚鼠三氯乙烯致敏试验中同时给予细胞色素P450 2E1(CYP2E1)抑制剂二烯丙基硫醚(DAS),探讨CYP2E1在三氯乙烯致敏豚鼠皮肤和肝损伤中的作用。方法 将无特定病原体级雌性豚鼠随机分为空白对照组、溶剂对照组、阳性对照(2,4-二硝基氯... 目的 在豚鼠三氯乙烯致敏试验中同时给予细胞色素P450 2E1(CYP2E1)抑制剂二烯丙基硫醚(DAS),探讨CYP2E1在三氯乙烯致敏豚鼠皮肤和肝损伤中的作用。方法 将无特定病原体级雌性豚鼠随机分为空白对照组、溶剂对照组、阳性对照(2,4-二硝基氯苯)组、三氯乙烯组和DAS干预组,采用豚鼠最大剂量试验进行皮肤致敏实验。在三氯乙烯诱导和激发后检测豚鼠尿中三氯乙酸水平。终末激发48 h后,检测豚鼠血清肝功能指标和炎症因子水平,进行皮肤和肝组织病理学检查,并检测肝组织中CYP2E1蛋白相对表达水平和氧化应激指标。结果 阳性对照组、三氯乙烯组和DAS干预组豚鼠致敏率分别为100.0%、75.0%和33.3%;空白对照组和溶剂对照组豚鼠致敏率均为0.0%。DAS干预组豚鼠在皮内诱导、局部诱导、首次激发和终末激发后24 h时间点即可观察到尿中三氯乙酸水平低于三氯乙烯组(P值均<0.05)。三氯乙烯组豚鼠皮肤可见真皮内炎性细胞浸润,表皮基底层细胞变性坏死;DAS干预组豚鼠仅可见真皮内有少量炎细胞。三氯乙烯组豚鼠肝脏可见肝细胞弥漫性坏死;DAS干预组豚鼠肝脏损伤较三氯乙烯组减轻,肝组织仅可见轻微肝细胞脂肪变性和中央静脉周围肝细胞肿胀。与空白对照组和溶剂对照组比较,三氯乙烯组豚鼠皮肤致敏率升高(P值均<0.01),血清丙氨酸氨基转移酶(ALT)活力和白细胞介素(IL)-2、IL-17、肿瘤坏死因子-α(TNF-α)水平均升高(P值均<0.05),肝组织中CYP2E1蛋白相对表达水平、超氧化物歧化酶(SOD)活力和丙二醛水平均升高(P值均<0.05),过氧化氢酶活力下降(P<0.05)。与三氯乙烯组比较,DAS干预组豚鼠血清ALT活力和IL-2、IL-17、TNF-α水平均下降(P值均<0.05),肝组织中CYP2E1蛋白表达水平、SOD活力和丙二醛水平均下降(P值均<0.05)。结论 三氯乙烯可诱导肝脏CYP2E1的表达,促进氧化应激和炎症反应,导致皮肤致敏和肝损伤。DAS通过抑制CYP2E1表达可减轻三氯乙烯致敏反应中对皮肤和肝脏的毒性作用。 展开更多
关键词 三氯乙烯 致敏 皮肤 肝脏 细胞色素p4502e1 二烯丙基硫醚 氧化应激 炎症反应
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针灸联合卡马西平对枕神经痛患者脑电图及血清PGE2、P物质水平的影响
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作者 王雪静 张国贤 +3 位作者 李彦瑶 赵泽华 张艳云 张志国 《临床和实验医学杂志》 2025年第21期2259-2263,共5页
目的分析针灸联合卡马西平对枕神经痛患者脑电图及血清前列腺素E2(PGE2)、P物质水平的影响。方法前瞻性纳入2023年2月至2024年6月河北省沧州中西医结合医院收治的100例枕神经痛患者,按随机数字表法将其分为观察组、对照组,每组各50例。... 目的分析针灸联合卡马西平对枕神经痛患者脑电图及血清前列腺素E2(PGE2)、P物质水平的影响。方法前瞻性纳入2023年2月至2024年6月河北省沧州中西医结合医院收治的100例枕神经痛患者,按随机数字表法将其分为观察组、对照组,每组各50例。对照组口服卡马西平片进行治疗,观察组在对照组基础上加以针灸治疗。观察两组疗效,统计两组治疗2个疗程后的视觉模拟评分法(VAS)评分、头痛持续时间评分、头痛频率评分、颈椎功能障碍指数(NDI)评分、脑电图指标及血清PGE2、P物质水平。结果在疗效方面,观察组总有效率为92.00%,明显高于对照组(76.00%),差异有统计学意义(P<0.05)。治疗2个疗程后,观察组VAS评分、头痛持续时间评分和头痛频率评分分别为(1.91±0.58)、(0.52±0.51)、(1.26±0.27)分,均显著低于对照组[(3.06±0.72)、(0.88±0.67)、(2.06±0.44)分],差异均有统计学意义(P<0.05)。治疗2个疗程后,观察组NDI评分为(15.76±3.54)分,显著低于对照组[(19.81±4.02)分],差异有统计学意义(P<0.05)。治疗2个疗程后,观察组α波(额叶)、α波(中央叶)、θ波(顶叶)功率分别为(16.25±3.49)、(17.50±5.02)、(24.08±6.48)uv^(2),均显著高于对照组[(13.38±3.02)、(14.15±4.36)、(15.47±5.21)uv^(2)],差异均有统计学意义(P<0.05)。治疗2个疗程后,观察组血清PGE2、P物质水平分别为(140.41±22.05)ng/L、(7.43±1.56)mg/L,均显著低于对照组[(172.85±30.47)ng/L、(8.84±1.97)mg/L],差异均有统计学意义(P<0.05)。结论针灸联合卡马西平能有效改善枕神经痛患者头痛程度、持续时间和头痛频率,调节颈椎功能和脑电图功率,降低疼痛性炎症介质水平,提升疗效。 展开更多
关键词 卡马西平 前列腺素e p物质 枕神经痛 针灸 脑电图
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血清NT-proBNP联合T_(p)-T_(e)间期对慢性心力衰竭患者发生恶性心律失常的预测价值分析
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作者 徐秀珍 《反射疗法与康复医学》 2025年第6期75-78,共4页
目的分析血清N末端B型利钠肽原(NT-proBNP)联合T波峰末间期(T_(p)-T_(e))对慢性心力衰竭患者发生恶性心律失常的预测价值。方法选取2023年2-11月潍坊市人民医院收治的101例慢性心力衰竭患者的临床资料,根据患者住院期间是否发生恶性心... 目的分析血清N末端B型利钠肽原(NT-proBNP)联合T波峰末间期(T_(p)-T_(e))对慢性心力衰竭患者发生恶性心律失常的预测价值。方法选取2023年2-11月潍坊市人民医院收治的101例慢性心力衰竭患者的临床资料,根据患者住院期间是否发生恶性心律失常将其分为发生组(n=26)和未发生组(n=75)。收集两组患者的一般资料、血清NT-proBNP、T_(p)-T_(e)间期,并进行单因素分析与多因素Logistic回归分析,以明确慢性心力衰竭患者发生恶性心律失常的影响因素,并绘制受试者工作特征(ROC)曲线,探讨血清NT-proBNP、T_(p)-T_(e)间期及其联合预测对慢性心力衰竭患者发生恶性心律失常的价值。结果101例慢性心力衰竭患者中,26例发生恶性心律失常,发生率为25.74%(26/101)。单因素分析结果显示,两组的血清胱抑素C(Cys-C)、QRS波群时限比较,组间差异有统计学意义(P<0.05)。发生组的血清NT-proBNP、T_(p)-T_(e)间期均高于未发生组,组间差异有统计学意义(P<0.05)。多因素分析结果显示,血清Cys-C、QRS波群时限、血清NT-proBNP、T_(p)-T_(e)间期是慢性心力衰竭患者发生恶性心律失常的危险因素(P<0.05)。ROC曲线结果显示,血清NT-proBNP、T_(p)-T_(e)间期及两者联合预测在慢性心力衰竭发生恶性心律失常的的曲线下面积分别为0.846、0.843、0.908,敏感度分别为76.90、84.60、76.90,特异度分别为85.30、76.00、94.70。血清NT-proBNP、T_(p)-T_(e)间期联合预测慢性心力衰竭患者发生恶性心律失常的曲线下面积高于两者单独预测。结论血清NT-proBNP、T_(p)-T_(e)间期是评估慢性心力衰竭患者发生恶性心律失常的有效指标,且两者联合能够有效增强预测效能。 展开更多
关键词 慢性心力衰竭 恶性心律失常 血清NT-pROBNp T_(p)-T_(e)间期 预测价值
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SEM in-situ investigation on fatigue cracking behavior of P/M Rene95 alloy with surface inclusions 被引量:3
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作者 Xishu Wang Lina Zhang +1 位作者 Yanping Zeng Xishan Xie 《Journal of University of Science and Technology Beijing》 CSCD 2006年第3期244-249,共6页
The low-cycle fatigue behavior of powder metallurgy Rene95 alloy containing surface inclusions was investigated by in-situ observation with scanning electron microscopy (SEM). The process of fatigue crack initiation... The low-cycle fatigue behavior of powder metallurgy Rene95 alloy containing surface inclusions was investigated by in-situ observation with scanning electron microscopy (SEM). The process of fatigue crack initiation and early stage of propagation behavior indicates that fatigue crack mainly occurs at the interface between the inclusion and the matrix. The effect of inclusion on the fatigue crack initiation and the early stage of crack growth was very obvious. The fatigue crack growth path in the matrix is similar to the shape of inclusion made on the basis of fatigue fracture image analysis. The empiric relation between the surface and inside crack growth length, near a surface inclusion, can be expressed. Therefore, the fatigue crack growth rate or life of P/M Rene95 alloy including the inclusions can be evaluated on the basis of the measurable surface crack length parameter. In addition, the effect of two inclusions on the fatigue crack initiation behavior was investigated by the in-situ observation with SEM. 展开更多
关键词 p/M Rene95 alloy fatigue behavior INCLUSION powder metallurgy in-situ observation SeM
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Corrosion Behaviors of P110 Steel and Chromium Coating in CO_2-saturated Simulated Oilfield Brine 被引量:6
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作者 林乃明 谢发勤 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2011年第2期191-197,共7页
The protective chromium coating was prepared on P110 steel by employing pack cementation.The corrosion behaviors of P110 steel and the obtained coating in CO2-saturated simulated oilfield brine were studied by static ... The protective chromium coating was prepared on P110 steel by employing pack cementation.The corrosion behaviors of P110 steel and the obtained coating in CO2-saturated simulated oilfield brine were studied by static complete immersion tests and electrochemical measurements.The corrosion attacks of the samples were determined by mass loss,corroded surface morphologies,corrosion products,and results of electrochemical measurements.The experimental results showed that the coating was uniform,continuous and compact.The chromium coating was slightly corroded,and the mass loss and corrosion rate of the coating were far lower than those of P110 steel.Chromium coating has higher self-corroding potential and lower corrosion current density than P110 steel in accordance with the electrochemical tests results.Taken as a whole,chromizing treatment has significantly improved the corrosion resistance of P110 steel. 展开更多
关键词 corrosion behavior p110 steel chromium coating simulated oilfield brine
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P300 change and cognitive behavioral therapy in subjects with Internet addiction disorder A 3-month follow-up study 被引量:7
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作者 Ling Ge Xiuchun Ge +3 位作者 Yong Xu Kerang Zhang Jing Zhao Xin Kong 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第26期2037-2041,共5页
Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Intern... Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Internet addiction disorder. We found that individuals with Internet addiction disorder exhibited significantly longer P300 latencies than controls (N2: P = 0.035; P3a: P = 0.031 P3b: P = 0.043) and similar P300 amplitudes compared to control participants. After 3 months of cognitive behavioral therapy, P300 latencies decreased significantly in the P3a and P3b (P3a: P = 0.045; P3b: P = 0.062). These results suggest that deficits in cognitive function may be involved in Internet addiction disorder, and that clinical psychological treatment may be effective. 展开更多
关键词 Internet addiction disorder follow-up study college students event-related potential p300 cognitive behavioral therapy
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Effect of hot extrusion on microstructure and tribological behavior of Al_(2)O_(3p) reinforced 7075 aluminum-matrix composites 被引量:4
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作者 LEI Yu-shun YAN Hong +4 位作者 WEI Zhi-fan XIONG Jun-jie ZHANG Peng-xiang WAN Jian-ping WANG Zhi-lu 《Journal of Central South University》 SCIE EI CAS CSCD 2021年第8期2269-2284,共16页
The effects of hot extrusion and addition of Al_(2)O_(3p) on both microstructure and tribological behavior of 7075 composites were investigated via optical microscopy(OM),scanning electron microscopy(SEM),energy dispe... The effects of hot extrusion and addition of Al_(2)O_(3p) on both microstructure and tribological behavior of 7075 composites were investigated via optical microscopy(OM),scanning electron microscopy(SEM),energy dispersive spectrometry(EDS),and transmission electron microscopy(TEM).The experimental consequences reveal that the optimal addition of Al_(2)O_(3p) was 2 wt%.After hot extrusion,the Mg(Zn,Cu,Al)2 phases partially dissolve into the matrix and generate many uniformly distributed aging precipitation particles,the Al_(7)Cu_(2)Fe phases are squeezed and broken,and the Al_(2)O_(3p) become uniform distribution.The microhardness of as-extruded 2 wt%Al_(2)O_(3p)/7075 composites reaches HV 170.34,increased by 41.5%than as-cast composites.The wear rate of as-extruded 2 wt%Al_(2)O_(3p)/7075 composites is further lower than that of as-cast composites under the same condition.SEM-EDS analyses reveal that the reinforced wear resistance of composites can put down to the protective effect of the Al_(2)O_(3p) reinforced transition layer.After hot extrusion,the transition layer becomes stable,which determines the reinforced wear resistance of the as-extruded composites. 展开更多
关键词 7075 alloy AL2O3p COMpOSITeS hot extrusion MICROSTRUCTURe tribological behavior
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Critical Behavior in Nuclear Structure from Spherical to γ-Soft Deformed Shape in IBM 被引量:3
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作者 ZHANG Jin-Fu LU Li-Jun BAI Hong-Bo 《Communications in Theoretical Physics》 SCIE CAS CSCD 2007年第4期705-710,共6页
Comparing with the predictions of the transitional dynamical symmetry E(5) proposed by Iachello [Phys. Rev. Lett. 85 (2000) 3580], the critical behaviors from U(5)-0(6) are studied in the space of two control ... Comparing with the predictions of the transitional dynamical symmetry E(5) proposed by Iachello [Phys. Rev. Lett. 85 (2000) 3580], the critical behaviors from U(5)-0(6) are studied in the space of two control parameters in the interacting boson model. A simple shape phase diagram has been presented. It is found that E(5) predictions cannot be exactly reproduced by our calculations and that the best agreement is close to the calculations with boson number N = 9. By comparing with experimental data on E(5)-like nuclei, we find that E(5) predictions and IBM calculations can reproduce the energy ratios and E2 transition ones. 展开更多
关键词 nuclear structure critical behavior e(5) nuclei IBM
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Microstructure and mechanical behavior of Mg-5Zn matrix influenced by particle deformation zone 被引量:5
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作者 Quan-xin Shi Cui-ju Wang +4 位作者 Kun-kun Deng Kai-bo Nie Yucheng Wu Wei-min Gan Wei Liang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第1期8-20,共13页
The effect of particle deformation zone(PDZ) on the microstructure and mechanical properties of SiC_(p)/Mg-5Zn composites was studied.Meanwhile,the work hardening and so ftening behavior of SiC_(p)/Mg-5Zn composites i... The effect of particle deformation zone(PDZ) on the microstructure and mechanical properties of SiC_(p)/Mg-5Zn composites was studied.Meanwhile,the work hardening and so ftening behavior of SiC_(p)/Mg-5Zn composites influenced by PDZ size were analyzed and discussed using neutron diffraction under in-situ tensile deformation.The evolution of FWHM(full width at half maximum) extracted from the diffraction pattern of SiC_(p)/Mg-5Zn composites was used to interpret the modification of dislocation density during in-situ tension,which discovered the effect of dislocation on the work hardening behavior of SiC_(p)/Mg-5Zn composites.In addition,the tensile stress reduction(△P_i) values during in-situ tension test were calculated to analyze the effect of PDZ size on the softening behavior of SiC_(p)/Mg-5Zn composites.The results show that the work hardening rate of SiC_(p)/Mg-5Zn composites increased with the enlargement of PDZ size,which was attributed to the grain size of SiC_(p)/Mg-5Zn composites increased with the enlargement of PDZ size.Moreover,the stress reduction(△P_i) values increased continuously during in-situ tensile for SiC_(p)/Mg-5Zn composites due to the increased stored energy produced during plastic deformation,which provided a driving force for the softening effect.However,the effect of grain size on the softening behavior is greater than that of the stored energy,which led to the tensile stress reduction(△P_i) values of P30(d_(PDZ)=30 μm)-SiC_(p)/Mg-5Zn composite were higher than that of P60(d_(PDZ)=60 μm)-SiC_(p)/Mg-5Zn composite when the ε_(ri) were 0.25,0.5,0.75 and 1,respectively. 展开更多
关键词 pDZ size SiC_(p)/Mg-5Zn composites Work hardening behavior SOFTeNING In-situ tensile Neutron diffraction
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Electrochemical behavior of electroplated Zn-P alloy 被引量:1
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作者 张昭 《中国有色金属学会会刊:英文版》 CSCD 2001年第4期603-605,共3页
The electroplating behavior of Zn P alloy on copper from light acid chloride solutions (LACS) was investigated using cyclic voltammetry and linear potential sweep method. It is found that, under the experimental condi... The electroplating behavior of Zn P alloy on copper from light acid chloride solutions (LACS) was investigated using cyclic voltammetry and linear potential sweep method. It is found that, under the experimental conditions, the concentrations of H 3PO 3 and ascorbic acid in LACS change the codeposition mechanism of Zn P alloy, the addition of H 3PO 3 into LACS promotes the three dimentional (3 D) instantaneous nucleation/growth, while the addition of ascorbic acid promotes the two dimentional (2 D) instantaneous nucleation and layer by layer growth. H 3PO 3 and zinc ions inhibit the deposition each other. The experimental results also show that H 3PO 3 in the LACS can be reduced on the cathode individually, and low pH value of the LACS promotes the reduction of H 3PO 3. 展开更多
关键词 Zn p alloy codeposition electrochemical behavior
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Nanoindentation Characterization of Creep-fatigue Interaction on Local Creep Behavior of P92 Steel Welded Joint 被引量:2
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作者 Yuxuan Song Yi Ma +3 位作者 Zhouxin Pan Yuebing Li Taihua Zhang Zengliang Gao 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2021年第6期85-97,共13页
In modern fossil and nuclear power plants,the components are subjected to creep,fatigue,and creep-fatigue(CF)due to frequent start-up and shut-down operations at high temperatures.The CF interaction on the in-service ... In modern fossil and nuclear power plants,the components are subjected to creep,fatigue,and creep-fatigue(CF)due to frequent start-up and shut-down operations at high temperatures.The CF interaction on the in-service P92 steel welded joint was investigated by strain-controlled CF tests with different dwell times of 30,120,300,600 and 900 s at 650℃.Based on the observations of the fracture surface by scanning electron microscope(SEM),the character-istic microstructure of fatigue-induced damage was found for the CF specimens with short dwell times(30 and 120 s).The hardness,elastic modulus and creep deformation near the fracture edges of four typical CF specimens with 30,120,600 and 900 s dwell times were measured by nanoindentation.Compared to specimens with post-weld heat treatment(PWHT),lower hardness and creep strength were found for all CF specimens.In addition,significant reduc-tions in hardness,elastic modulus,and creep strength were measured near the fracture edges for the CF specimens with short dwell times compared to the PWHT specimens.Compared to PWHT specimens(0.007),the increased strain rate sensitivities(SRS)of 0.010 to 0.17 were estimated from secondary creep.The increased values of SRS indicate that the room temperature creeps behavior is strongly affected by the decrease in dislocation density after the CF tests. 展开更多
关键词 p92 steel Welded joint Creep-fatigue interaction NANOINDeNTATION Creep behavior
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