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Peer-to-peer transaction with voltage management strategy in distribution network considering trading risk
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作者 Lei Dong Kuang Zhang +3 位作者 Shiming Zhang Tao Zhang Ye Li Ji Qiao 《Global Energy Interconnection》 2025年第4期685-699,共15页
P2P trading is driving the decentralization of the electricity market,the autonomy and privacy requirements of prosumers may intro-duce safety risks such as voltage violations.Existing security management methods base... P2P trading is driving the decentralization of the electricity market,the autonomy and privacy requirements of prosumers may intro-duce safety risks such as voltage violations.Existing security management methods based on price guidance may face unsolvable situa-tions in trading scenarios and have difficulty assessing the impact of P2P transactions on voltage security.To this end,this paper proposes a novel distribution system operator(DSO)-prosumers bi-level optimization framework incorporating the dynamic operating envelope(DOE)and risk coefficient-based network usage charge(RC-NUC).In the upper-level,the DOE is employed for dynamic voltage man-agement to prevent violations while the RC-NUC further guides prosumers to engage in grid-friendly transactions.The lower-level decen-tralized market enables prosumers to optimize trading decisions autonomously.Only price signals and energy quantities are exchanged between the two levels,ensuring the privacy of both parties.Additionally,an alternating direction method of multipliers(ADMM)with adaptive penalty factor is introduced to improve computational efficiency.Case studies on a modified IEEE 33-bus system demonstrate that the proposed method reduces voltage violation risks by 18.31%and enhances trading efficiency by 32.3%.These results highlight the feasibility and effectiveness of the approach in advancing secure and efficient distributed energy transactions. 展开更多
关键词 p2p transaction DOE RC-NUC Distribution network Distributed algorithm
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Actuator Fault Diagnosis of 3-PR(P)S Parallel Robot Based on Dung Beetle Optimization-Back Propagation Neural Network
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作者 Junjie Huang Chenhao Huangfu +3 位作者 Qinlei Zhang Shikai Li Yonggang Yan Jiangkun Cai 《Journal of Dynamics, Monitoring and Diagnostics》 2025年第2期91-100,共10页
Any malfunctions of the actuators of the robots have the potential to destroy the robot’s normal motion,and most of the current actuator fault diagnosis methods are difficult to meet the requirements of simplifying t... Any malfunctions of the actuators of the robots have the potential to destroy the robot’s normal motion,and most of the current actuator fault diagnosis methods are difficult to meet the requirements of simplifying the actuator modeling and solving the difficulty of fault data collection.To solve the problem of real-time diagnosis of actuator faults in the 3-PR(P)S parallel robot,the model of 3-PR(P)S parallel robot and data-driven-based method for the fault diagnosis are presented.Firstly,only the input-output relationship of the actuator is considered for modeling actuator faults,reducing the complexity of fault modeling and reducing the time consumption of parameter identification,thereby meeting the requirements of real-time diagnosis.A Simulink model of the electromechanical actuator(EMA)was constructed to analyze actuator faults.Then the short-term analysis method was employed for collecting the sample data of the slider position on the test platform of the EMA system and feature extraction.Training samples for neural networks are obtained.Furthermore,we optimized the Back Propagation(BP)neural network using the Dung Beetle Optimization Algorithm(DBO),which effectively resolved the weights and thresholds of the BP neural network.Compared to BP and Particle Swarm Optimization(PSO)-BP,the DBO-BP has better convergence,convergence rate,and the best-classifying quality.So,the classification for the different actuator faults is obviously improved.Finally,a fault diagnosis system was designed for the actuator of the 3-PR(P)S parallel robot,and the experimental results demonstrate that this system can detect actuator faults within 0.1 seconds.This work also provides the technical support for the fault-tolerant control of the 3-PR(P)S Parallel robot. 展开更多
关键词 ACtUAtOR Back propagation neural network Dung Beetle Algorithm fault diagnosis 3-pR(p)S parallel robot
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融合组织P系统的自适应t分布蜣螂算法 被引量:2
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作者 许家昌 江琳 苏树智 《计算机工程与应用》 北大核心 2025年第4期99-113,共15页
针对原始蜣螂算法(dung beetle optimizer,DBO)易受自身影响,导致局部搜索和全局搜索不平衡,容易陷入局部最优的问题,提出一种结合组织膜的自适应t分布蜣螂算法(adaptive t-distribution DBO with tissue-like membrane,MC-TDBO)。设计... 针对原始蜣螂算法(dung beetle optimizer,DBO)易受自身影响,导致局部搜索和全局搜索不平衡,容易陷入局部最优的问题,提出一种结合组织膜的自适应t分布蜣螂算法(adaptive t-distribution DBO with tissue-like membrane,MC-TDBO)。设计自适应惯性因子改变繁育蜣螂和小偷蜣螂的步长,动态调节蜣螂个体的探索幅度,协调并优化算法的全局搜索和局部开发能力;引入鲸鱼算法改进觅食行为,促使种群向最优位置靠近,提高算法的计算精度;结合成功率和自适应t分布,提升算法跳出局部最优的能力;引入组织P系统与改进后的DBO算法结合,增强算法收敛效率。采用14个基准函数进行仿真测试,实验结果表明,MC-TDBO算法和原始DBO算法等四种算法相比,寻优速度、求解精度和稳定性均得到了显著提升。将MC-TDBO算法在阈值分割中进行应用测试,进一步验证其有效性。 展开更多
关键词 组织p系统 蜣螂算法 自适应t分布 动态惯性权重
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系统性红斑狼疮患者血清miR-125b-5p水平与Th1/Th2细胞、Th17/Treg细胞失衡的相关性 被引量:1
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作者 冯彦飞 杨小杰 +2 位作者 强建红 高彩霞 汤喜红 《检验医学与临床》 2025年第2期227-231,共5页
目的探讨系统性红斑狼疮(SLE)患者血清微小核糖核酸-125b-5p(miR-125b-5p)水平与辅助性T细胞(Th)1/Th2、Th17/调节性T细胞(Treg)失衡的相关性。方法选取2021年1月至2023年1月该院收治的88例SLE患者作为SLE组,另选取同期在该院体检的29... 目的探讨系统性红斑狼疮(SLE)患者血清微小核糖核酸-125b-5p(miR-125b-5p)水平与辅助性T细胞(Th)1/Th2、Th17/调节性T细胞(Treg)失衡的相关性。方法选取2021年1月至2023年1月该院收治的88例SLE患者作为SLE组,另选取同期在该院体检的29例体检健康者作为对照组。SLE组根据疾病活动程度分为轻度组、中度组和重度组。检测所有研究对象血清miR-125b-5p水平和外周血Th1、Th2、Th17、Treg细胞比例。采用Spearman相关分析SLE患者血清miR-125b-5p水平与SLE疾病活动程度之间的相关性,外周血Th1、Th2、Th17、Treg细胞比例及Th1/Th2细胞、Th17/Treg细胞比值与SLE疾病活动程度之间的相关性。采用Pearson相关分析SLE患者血清miR-125b-5p水平与外周血Th1、Th2、Th17、Treg细胞比例及Th1/Th2细胞比值、Th17/Treg细胞比值之间的相关性。结果SLE组血清miR-125b-5p水平及外周血Th2、Treg细胞比例均低于对照组(P<0.05),外周血Th1、Th17细胞比例和Th1/Th2细胞、Th17/Treg细胞比值均高于对照组(P<0.05)。SLE患者轻度组35例、中度组30例、重度组23例。血清miR-125b-5p和外周血Th2、Treg细胞比例表现为轻度组>中度组>重度组,外周血Th1、Th17细胞比例和Th1/Th2细胞、Th17/Tre细胞比值表现为轻度组<中度组<重度组,且任意两组间比较,差异均有统计学意义(P<0.05)。Spearman相关分析结果显示,SLE患者血清miR-125b-5p水平与SLE疾病活动程度呈负相关(r=-0.811,P<0.001),外周血Th1、Th17细胞比例及Th1/Th2细胞、Th17/Treg细胞比值与SLE疾病活动程度呈正相关(r=0.728、0.786、0.812、0.808,P<0.001),外周血Th2、Treg细胞比例与SLE疾病活动程度呈负相关(r=-0.811、-0.723,P<0.001)。Pearson相关分析结果显示,SLE患者血清miR-125b-5p水平与外周血Th1、Th17细胞比例及Th1/Th2细胞、Th17/Treg细胞比值呈负相关(r=-0.801、-0.781、-0.816、-0.819,P<0.001),与外周血Th2、Treg细胞比例呈正相关(r=0.845、0.812,P<0.001)。结论SLE患者血清miR-125b-5p水平降低,能通过调节Th1/Th2细胞、Th17/Treg细胞平衡参与SLE的发生、发展。 展开更多
关键词 系统性红斑狼疮 微小核糖核酸-125b-5p 辅助性t细胞1 辅助性t细胞2 辅助性t细胞17 调节性t细胞 炎症反应
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低分子肝素钠调控miR-33a-3p、S1PR1表达促进不明原因反复妊娠丢失大鼠Treg细胞分化
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作者 耿旭景 毛跟红 +4 位作者 项云改 万利静 王梦 朱颖 谭丽 《中国药学杂志》 北大核心 2025年第1期47-54,共8页
目的探究低分子肝素钠可否调控miR-33a-3p、1-磷酸鞘氨醇受体1(S1PR1)表达影响不明原因反复妊娠丢失(URPL)大鼠调节性T细胞(Treg)分化。方法60只雌性大鼠随机分为空白对照组(Control)、阴性对照组(NC)、URPL组、低分子肝素钠组(LMWH)和... 目的探究低分子肝素钠可否调控miR-33a-3p、1-磷酸鞘氨醇受体1(S1PR1)表达影响不明原因反复妊娠丢失(URPL)大鼠调节性T细胞(Treg)分化。方法60只雌性大鼠随机分为空白对照组(Control)、阴性对照组(NC)、URPL组、低分子肝素钠组(LMWH)和芬戈莫德(FTY720)组,每组12只。妊娠第8天、第12天时,采用背部多部位皮下注射抗心磷脂抗体(ACA)-IgG诱导大鼠URPL模型;LMWH组、FTY720组在URPL组基础上给药。妊娠第0天至第15天,LMWH组大鼠皮下注射低分子肝素钠(420 IU·kg-1),FTY720组尾静脉注射FTY720(100μg·kg-1),Control组、NC组、URPL组大鼠尾静脉注射等量生理盐水。治疗结束后,胚胎称重并计算胚胎吸收率;苏木精-伊红(HE)染色观察胎盘组织病理学;酶联免疫吸附试验(ELISA)检测血清白介素(IL)-10、转化生长因子-β1(TGF-β1)水平;实时荧光定量聚合酶链式反应(RT-qPCR)和蛋白印迹(Western blot)检测胎盘组织中miR-33a-3p、S1PR1、叉头框蛋白P3(FOXP3)、细胞毒性T淋巴细胞相关蛋白4(CTLA-4)、糖皮质激素诱导肿瘤坏死因子受体(GITR)mRNA和蛋白水平;流式细胞术检测胎盘组织中Treg细胞数量。结果Control组、NC组大鼠胎盘细胞排列整齐、结构清晰;与Control组相比,URPL组胚胎质量减轻,胚胎吸收率升高,胎盘组织存在大量炎症细胞浸润、细胞增生和水肿,血清IL-10、TGF-β1水平降低,胎盘组织miR-33a-3p、FOXP3、CTLA-4、GITR mRNA和蛋白水平降低,S1PR1 mRNA和蛋白水平升高,Treg细胞数量减少(P<0.05);与URPL组相比,LMWH组、FTY720组胚胎质量增加,胚胎吸收率降低,胎盘组织病理损伤明显减轻,可见少量炎症细胞浸润和水肿,血清IL-10、TGF-β1水平升高,胎盘组织miR-33a-3p、FOXP3、CTLA-4、GITR mRNA和蛋白水平升高,S1PR1 mRNA和蛋白水平降低,Treg细胞数量增多(P<0.05);LMWH组、FTY720组上述指标差异无统计学意义(P>0.05)。结论低分子肝素钠可能通过调控miR-33a-3p、S1PR1表达促进URPL大鼠Treg细胞分化。 展开更多
关键词 低分子肝素钠 miR-33a-3p 1-磷酸鞘氨醇受体1 不明原因反复妊娠丢失 调节性t细胞
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结直肠癌组织P53、TIGIT、PD-L1表达及其意义分析 被引量:1
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作者 买春阳 张建 闫振宇 《四川生理科学杂志》 2025年第2期328-331,378,共5页
目的:探讨结直肠癌患者癌组织中P53、T细胞免疫球蛋白和ITIM结构域(T-cell immunoreceptor with immunoglobulin and ITIM domains,TIGIT)、细胞程序性死亡-配体1(Programmed cell death-ligand 1,PD-L1)的表达。方法:回顾性纳入2022年1... 目的:探讨结直肠癌患者癌组织中P53、T细胞免疫球蛋白和ITIM结构域(T-cell immunoreceptor with immunoglobulin and ITIM domains,TIGIT)、细胞程序性死亡-配体1(Programmed cell death-ligand 1,PD-L1)的表达。方法:回顾性纳入2022年12月至2023年12月到我院就诊的120例结直肠癌患者,收集研究对象的癌组织及其癌旁组织,检测并比较癌组织、癌旁组织中P53、TIGIT、PD-L1表达情况。结果:相较于癌旁组织,癌组织中P53、TIGIT、PD-L1阳性表达率较高(P<0.05)。相较于中高分化、肿瘤-结节-转移分期(Tumor,nodes,metastasis classification,TNM)分期为Ⅰ~Ⅱ期、淋巴结未转移、肿瘤直径≤5 cm的结直肠癌患者,低分化、TNM分期为Ⅲ~Ⅳ期、淋巴结转移、肿瘤直径>5 cm的结直肠癌患者组织P53、TIGIT、PD-L1阳性表达率均较高(P<0.05)。结直肠癌组织P53与TIGIT、PD-L1呈正相关,TIGIT与PD-L1呈正相关(P<0.05)。结论:在结直肠癌组织中P53、TIGIT、PD-L1呈高表达,且与疾病分期、分化程度等存在关系。 展开更多
关键词 结直肠癌 细胞程序性死亡-配体1 t细胞免疫球蛋白和ItIM结构域 免疫组织化学染色法 p53
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Prediction of SO_2 Concentration in Urban Atmosphere Based on B-P Neural Network 被引量:1
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作者 姚建 王丽梅 袁野 《Meteorological and Environmental Research》 CAS 2010年第11期9-11,14,共4页
Base on the principle and method of B-P neural network,the prediction model of SO2 concentration in urban atmosphere was established by using the statistical data of a city in southwest China from 1991 to 2009,so as t... Base on the principle and method of B-P neural network,the prediction model of SO2 concentration in urban atmosphere was established by using the statistical data of a city in southwest China from 1991 to 2009,so as to forecast atmospheric SO2 concentration in a city of southwest China.The results showed that B-P neural network applied in the prediction of SO2 concentration in urban atmosphere was reasonable and efficient with high accuracy and wide adaptability,so it was worthy to be popularized. 展开更多
关键词 B-p neural network SO2 concentration in urban atmospheric prediction model China
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lncRNA MCM3AP-AS1调节miR-424-5p/TCP1轴对卵巢癌细胞恶性生物学行为的影响
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作者 齐丽宁 王琪 +4 位作者 朱继红 耿艳红 葛新苗 魏旭静 刘彩辉 《中国优生与遗传杂志》 2025年第2期260-267,共8页
目的探究长链非编码RNA(lncRNA)MCM3AP-AS1调节微小RNA-424-5p(miR-424-5p)/T复合物蛋白1(TCP1)轴对卵巢癌细胞恶性生物学行为的影响。方法将Skov-3细胞分为对照组、si-NC组、si-MCM3AP-AS1组、miR-NC组、miR-424-5p mimics组、si-MCM3A... 目的探究长链非编码RNA(lncRNA)MCM3AP-AS1调节微小RNA-424-5p(miR-424-5p)/T复合物蛋白1(TCP1)轴对卵巢癌细胞恶性生物学行为的影响。方法将Skov-3细胞分为对照组、si-NC组、si-MCM3AP-AS1组、miR-NC组、miR-424-5p mimics组、si-MCM3AP-AS1+miR inhibitor-NC组、si-MCM3AP-AS1+miR-424-5p inhibitor组,MTT和集落形成测定细胞增殖,Transwell小室检测细胞的侵袭和迁移,流式细胞术检测细胞凋亡,qRT-PCR检测细胞MCM3AP-AS1、miR-424-5p和TCP1 mRNA表达,BALB/c雌性裸鼠皮下种植Skov-3细胞并观察移植瘤生长情况,Westernblot检测细胞和肿瘤组织中TCP1蛋白表达。结果与IOSE80细胞相比,Caov-3、A2780和Skov-3细胞MCM3AP-AS1和TCP1 mRNA高表达,miR-424-5p低表达(P<0.05)。在Skov-3细胞中,与si-NC组/miR-NC组相比,si-MCM3AP-AS1组/miR-424-5pmimics组细胞MCM3AP-AS1和TCP1mRNA表达、细胞A490和集落形成率、侵袭和迁移细胞数、Skov-3细胞和肿瘤中TCP1蛋白表达降低,移植瘤质量和体积减小,miR-424-5p表达和细胞凋亡率升高(P<0.05);与si-MCM3AP-AS1+miR inhibitor-NC组相比,si-MCM3AP-AS1+miR-424-5p inhibitor组细胞TCP1 mRNA表达、细胞A490值和集落形成率、侵袭和迁移细胞数、Skov-3细胞和肿瘤中TCP1蛋白表达升高,移植瘤质量和体积减小,miR-424-5p表达和细胞凋亡率降低(P<0.05);双荧光素酶基因检测报告显示MCM3AP-AS1、TCP1与miR-424-5p间均存在靶向关系(P<0.05)。结论沉默MCM3AP-AS1能够上调miR-424-5p抑制TCP1表达,从而抑制卵巢癌细胞的增殖、侵袭和迁移。 展开更多
关键词 长链非编码RNA MCM3Ap-AS1 卵巢癌 微小RNA-424-5p t复合物蛋白1 恶性生物学行为
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Approximation to NLAR(p) with Wavelet Neural Networks
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作者 朱石焕 吴曦 《Chinese Quarterly Journal of Mathematics》 CSCD 2002年第4期94-98,共5页
Recently, wavelet neural networks have become a popular tool for non-linear functional approximation. Wavelet neural networks, which basis functions are orthonormal scalling functions, are more suitable in approximati... Recently, wavelet neural networks have become a popular tool for non-linear functional approximation. Wavelet neural networks, which basis functions are orthonormal scalling functions, are more suitable in approximating to function. Based on it, approximating to NLAR(p) with wavelet neural networks is studied. 展开更多
关键词 wavelet neural networks orthonormal scaling functions NLAR(p)
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脓毒症病人外周血IL-2R、FOXP3及调节性T细胞水平与病人病情严重程度和预后的相关性分析
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作者 赵志涛 杜蕊 +1 位作者 郝丽娜 李栋梁 《蚌埠医科大学学报》 2025年第7期913-916,921,共5页
目的:探究脓毒症病人外周血白细胞介素-2受体(IL-2R)、叉头/翼状螺旋转录因子p3(FOXP3)及调节性T(Treg)细胞水平与脓毒症病人的病情严重程度和预后的相关性。方法:选取80例脓毒症病人作为观察组,根据病人28 d预后结果分为死亡组和生存组... 目的:探究脓毒症病人外周血白细胞介素-2受体(IL-2R)、叉头/翼状螺旋转录因子p3(FOXP3)及调节性T(Treg)细胞水平与脓毒症病人的病情严重程度和预后的相关性。方法:选取80例脓毒症病人作为观察组,根据病人28 d预后结果分为死亡组和生存组;选取同期健康体检者75名作为对照组。采用ELISA法检测血清IL-2R水平,RT-qPCR检测FOXP3水平,流式细胞术测定外周血Treg细胞水平,Pearson法分析外周血IL-2R、FOXP3、Treg细胞水平与急性生理与慢性健康评分(APACHEⅡ)、序贯器官衰竭评分(SOFA)的相关性,Cox回归分析脓毒症预后的影响因素,ROC曲线评价外周血IL-2R、FOXP3、Treg细胞水平单独及其联合对脓毒症病人28 d预后的预测效能。结果:观察组病人外周血IL-2R、FOXP3及Treg细胞水平均明显高于对照组(P<0.01)。死亡组病人外周血中IL-2R、FOXP3、Treg细胞水平均高于生存组(P<0.05~P<0.01)。与生存组相比,死亡组病人APACHEⅡ评分、SOFA评分明显增加(P<0.01)。脓毒症病人外周血IL-2R水平与FOXP3水平、Treg细胞水平、APACHEⅡ评分、SOFA评分均呈正相关关系(r=0.611、0.583、0.579、0.558,P<0.05);FOXP3水平与Treg细胞水平、APACHEⅡ评分、SOFA评分均呈正相关关系(r=0.594、0.585、0.622,P<0.05);Treg细胞水平与APACHEⅡ评分、SOFA评分均呈正相关关系(r=0.572、0.554,P<0.05)。COX回归分析显示,IL-2R、FOXP3、Treg细胞均是影响脓毒症病人预后的独立危险因素(P<0.01)。ROC曲线分析显示,外周血IL-2R、FOXP3、Treg细胞水平及三者联合预测脓毒症病人不良预后结局的AUC分别为0.717、0.712、0.790、0.829,其中联合预测AUC高于三者单独预测AUC(P<0.05)。结论:脓毒症病人外周血IL-2、Foxp3、Treg细胞水平显著升高,与病情严重程度和预后关系密切,可能用于脓毒症病人的预后评估。 展开更多
关键词 脓毒症 白细胞介素-2受体 叉头/翼状螺旋转录因子p3 调节性t细胞 病情严重程度 预后
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CircACTR2调节miR-101-3p/NFAT5轴对高糖诱导的肾小管上皮细胞增殖、凋亡和上皮间质转化的影响
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作者 王晶 黄斌芳 周光全 《蚌埠医科大学学报》 2025年第3期281-287,共7页
目的:探讨环状非编码RNA(circRNA)ACTR2调节微小RNA-101-3p(miR-101-3p)/活化T细胞核因子5(NFAT5)轴对高糖诱导的肾小管上皮细胞增殖、凋亡和上皮间质转化的影响。方法:体外培养人肾小管上皮细胞HK-2,分为对照组、高糖组(30 mmol/L葡萄... 目的:探讨环状非编码RNA(circRNA)ACTR2调节微小RNA-101-3p(miR-101-3p)/活化T细胞核因子5(NFAT5)轴对高糖诱导的肾小管上皮细胞增殖、凋亡和上皮间质转化的影响。方法:体外培养人肾小管上皮细胞HK-2,分为对照组、高糖组(30 mmol/L葡萄糖),同时在高糖组的基础上对HK-2细胞进行转染,设置为小干扰RNA阴性对照(si NC)组、circACTR2特异性小干扰RNA(si circACTR2)组、si circACTR2+抑制物阴性对照(inhibitor NC)组、si circACTR2+miR-101-3p抑制物(miR-101-3p inhibitor)组。流式细胞术、CCK-8分别检测细胞凋亡和增殖;qRT-PCR检测细胞中circACTR2、miR-101-3p及NFAT5 mRNA表达;Western blotting检测各组细胞中增殖蛋白Ki-67、抗凋亡蛋白Bcl-2、E-钙黏附蛋白(E-cadherin)、α-平滑肌肌动蛋白(α-SMA)、NFAT5表达水平;ELISA检测细胞中白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)水平;双荧光素酶实验验证circACTR2、NFAT5分别与miR-101-3p的靶向关系。结果:miR-101-3p分别与circACTR2、NFAT5存在靶向关系。与对照组相比,高糖组细胞凋亡率、TNF-α、IL-6、circACTR2、NFAT5、α-SMA水平增加(P<0.05),细胞光密度(OD_(450))值(24、48 h)、miR-101-3p、Bcl-2、Ki-67、E-cadherin水平降低(P<0.05);与si NC组相比,si circACTR2组细胞凋亡率、TNF-α、IL-6、circACTR2、NFAT5、α-SMA水平下降(P<0.05),细胞OD_(450)值(24、48 h)、miR-101-3p、Bcl-2、Ki-67、E-cadherin水平增加(P<0.05);与si circACTR2+inhibitor NC组相比,si circACTR2+miR-101-3p inhibitor组细胞凋亡率、TNF-α、IL-6、circACTR2、NFAT5、α-SMA水平增加(P<0.05),细胞OD_(450)值(24、48 h)、miR-101-3p、Bcl-2、Ki-67、E-cadherin水平降低(P<0.05)。结论:干扰circACTR2表达可以促进高糖诱导HK-2细胞增殖、抑制其凋亡及上皮间质转化,可能与调控miR-101-3p/NFAT5轴有关。 展开更多
关键词 糖尿病肾病 环状非编码RNA ACtR2 微小RNA-101-3p/活化t细胞核因子5轴 肾小管上皮细胞
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互联网赋能下C+T+P教学模式在“审计学”课程中的应用研究
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作者 郑怡婷 《互联网周刊》 2025年第19期76-78,共3页
在互联网技术迅猛发展的背景下,教育领域正经历深刻变革。本文阐述互联网赋能教育的理论支撑与C+T+P教学模式内涵,构建互联网赋能的C+T+P教学模式理论框架,包括核心逻辑与技术支撑体系,聚焦“审计学”课程,详细剖析互联网+C+T+P模式在... 在互联网技术迅猛发展的背景下,教育领域正经历深刻变革。本文阐述互联网赋能教育的理论支撑与C+T+P教学模式内涵,构建互联网赋能的C+T+P教学模式理论框架,包括核心逻辑与技术支撑体系,聚焦“审计学”课程,详细剖析互联网+C+T+P模式在学科竞赛、混合式教学、校内外实训三个维度的具体应用。本文旨在探索互联网赋能下该教学模式在“审计学”课程中的有效应用路径,提升教学质量与学生实践能力。 展开更多
关键词 互联网赋能 C%pLUS%t%pLUS%p教学模式 “审计学”课程 应用路径
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STOP信号灯交接模式联合舒适化管理对发热门诊患者满意度的影响
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作者 刘莹 《江苏卫生事业管理》 2025年第1期63-65,87,共4页
目的:探讨S.T.O.P.信号灯交接模式联合舒适化管理对门诊发热患者满意度的影响。方法:2023年4月-2023年12月期间在本院发热门诊就诊的患者127例,用随机数字表法将其分为干预组(65例)和对照组(62例)。采用Spearman进行相关分析,探讨干预... 目的:探讨S.T.O.P.信号灯交接模式联合舒适化管理对门诊发热患者满意度的影响。方法:2023年4月-2023年12月期间在本院发热门诊就诊的患者127例,用随机数字表法将其分为干预组(65例)和对照组(62例)。采用Spearman进行相关分析,探讨干预后自我管理意识在满意度和依从性中的中介效应。结果:干预后,两组患者发热时间、依从性、自我管理意识和门诊护理服务满意度存在组间差异(P<0.001);自我管理意识的中介效应成立。结论:基于S.T.O.P.信号灯交接模式联合舒适化管理的临床成效显著,值得推广。 展开更多
关键词 S.t.O.p.信号灯交接 舒适化管理 护理服务满意度 中介分析
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基于Space P和K-means的货运航司航线网络特征分析研究
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作者 罗凤娥 卫昌波 +1 位作者 韩晓彤 郭玲玉 《现代电子技术》 北大核心 2026年第1期102-107,共6页
针对航空货运行业的迅速扩张,航空货运网络结构变得更加复杂,文中通过Space P建模方法构建了货运航空公司航线网络模型,并运用K-means聚类算法对网络进行了深入分析。选取度、平均路径长度、聚类系数和中间度等关键网络特性指标对航线... 针对航空货运行业的迅速扩张,航空货运网络结构变得更加复杂,文中通过Space P建模方法构建了货运航空公司航线网络模型,并运用K-means聚类算法对网络进行了深入分析。选取度、平均路径长度、聚类系数和中间度等关键网络特性指标对航线网络进行层次化分类,揭示了网络的复杂特征和层次结构。通过仿真实验评估了网络的小世界特性,并利用轮廓系数得到不同K值下的聚类结果,进而确定最优聚类结果。同时,模拟了航线网络在遭受攻击时的鲁棒性,实验结果表明:在航线网络较为脆弱的情况下,该方法为货运航司航线网络的优化和抗风险能力的提升提供了重要参考。 展开更多
关键词 航空货运 Space p 航线网络 复杂网络 聚类算法 网络特征
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Deadline-aware network coding for video on demand service over P2P networks 被引量:13
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作者 CHI Hui-cheng ZHANG Qian 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2006年第5期755-763,共9页
We are interested in providing Video-on-Demand (VoD) streaming service to a large population of clients using peer-to-peer (P2P) approach. Given the asynchronous demands from multiple clients, continuously changing of... We are interested in providing Video-on-Demand (VoD) streaming service to a large population of clients using peer-to-peer (P2P) approach. Given the asynchronous demands from multiple clients, continuously changing of the buffered contents, and the continuous video display requirement, how to collaborate with potential partners to get expected data for future content delivery are very important and challenging. In this paper, we develop a novel scheduling algorithm based on deadline- aware network coding (DNC) to fully exploit the network resource for efficient VoD service. DNC generalizes the existing net- work coding (NC) paradigm, an elegant solution for ubiquitous data distribution. Yet, with deadline awareness, DNC improves the network throughput and meanwhile avoid missing the play deadline in high probability, which is a major deficiency of the con- ventional NC. Extensive simulation results demonstrated that DNC achieves high streaming continuity even in tight network conditions. 展开更多
关键词 Video on Demand (VoD) peer-to-peer (p2p) network CODING (NC) Deadline-aware network CODING (DNC)
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Soft Computing of Biochemical Oxygen Demand Using an Improved T–S Fuzzy Neural Network 被引量:5
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作者 乔俊飞 李微 韩红桂 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2014年第Z1期1254-1259,共6页
It is difficult to measure the online values of biochemical oxygen demand(BOD) due to the characteristics of nonlinear dynamics, large lag and uncertainty in wastewater treatment process. In this paper, based on the k... It is difficult to measure the online values of biochemical oxygen demand(BOD) due to the characteristics of nonlinear dynamics, large lag and uncertainty in wastewater treatment process. In this paper, based on the knowledge representation ability and learning capability, an improved T–S fuzzy neural network(TSFNN) is introduced to predict BOD values by the soft computing method. In this improved TSFNN, a K-means clustering is used to initialize the structure of TSFNN, including the number of fuzzy rules and parameters of membership function. For training TSFNN, a gradient descent method with the momentum item is used to adjust antecedent parameters and consequent parameters. This improved TSFNN is applied to predict the BOD values in effluent of the wastewater treatment process. The simulation results show that the TSFNN with K-means clustering algorithm can measure the BOD values accurately. The algorithm presents better approximation performance than some other methods. 展开更多
关键词 BIOCHEMICAL oxygen DEMAND WAStEWAtER treatment t–S fuzzy NEURAL network K-MEANS clustering
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A Methodology for Reliability of WSN Based on Software Defined Network in Adaptive Industrial Environment 被引量:7
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作者 Ying Duan Wenfeng Li +2 位作者 Xiuwen Fu Yun Luo Lin Yang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2018年第1期74-82,共9页
As communication technology and smart manufacturing have developed, the industrial internet of things(IIo T)has gained considerable attention from academia and industry.Wireless sensor networks(WSNs) have many advanta... As communication technology and smart manufacturing have developed, the industrial internet of things(IIo T)has gained considerable attention from academia and industry.Wireless sensor networks(WSNs) have many advantages with broad applications in many areas including environmental monitoring, which makes it a very important part of IIo T. However,energy depletion and hardware malfunctions can lead to node failures in WSNs. The industrial environment can also impact the wireless channel transmission, leading to network reliability problems, even with tightly coupled control and data planes in traditional networks, which obviously also enhances network management cost and complexity. In this paper, we introduce a new software defined network(SDN), and modify this network to propose a framework called the improved software defined wireless sensor network(improved SD-WSN). This proposed framework can address the following issues. 1) For a large scale heterogeneous network, it solves the problem of network management and smooth merging of a WSN into IIo T. 2) The network coverage problem is solved which improves the network reliability. 3) The framework addresses node failure due to various problems, particularly related to energy consumption.Therefore, it is necessary to improve the reliability of wireless sensor networks, by developing certain schemes to reduce energy consumption and the delay time of network nodes under IIo T conditions. Experiments have shown that the improved approach significantly reduces the energy consumption of nodes and the delay time, thus improving the reliability of WSN. 展开更多
关键词 Industrial internet of things(IIo t) RELIABILItY software defined network(SDN) wireless sensor network(WSN)
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低碳Q-P-T钢中残余奥氏体对高温拉伸性能的影响 被引量:1
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作者 田起辉 秦盛伟 +1 位作者 邸黎寅 卢金生 《中南大学学报(自然科学版)》 北大核心 2025年第4期1320-1330,共11页
研究不同温度下残余奥氏体对Q-P-T钢力学性能的影响,以Q-T钢为对照,在不同温度(25、100、200和300℃)下对Q-T钢和Q-P-T钢进行轴向拉伸试验。研究结果表明:Q-T钢的抗拉强度与温度成负相关,而Q-P-T钢的抗拉强度随拉伸温度升高显示出先减... 研究不同温度下残余奥氏体对Q-P-T钢力学性能的影响,以Q-T钢为对照,在不同温度(25、100、200和300℃)下对Q-T钢和Q-P-T钢进行轴向拉伸试验。研究结果表明:Q-T钢的抗拉强度与温度成负相关,而Q-P-T钢的抗拉强度随拉伸温度升高显示出先减小后增大的趋势,其原因在于,随着温度的升高,残余奥氏体热稳定性增加,在热力耦合作用下,在300℃时,Q-P-T钢中残余奥氏体在高应力下发生持续相变而非过早相变,TRIP效应更加显著,使Q-P-T钢的抗拉强度出现与Q-T钢的抗拉强度不同的变化趋势。高温下残余奥氏体的TRIP效应能加强组织间的协调变形,推迟颈缩的发生,抑制裂纹和孔洞的萌生,从而在保证Q-P-T强度的同时提高了塑性。 展开更多
关键词 Q-t Q-p-t tRIp效应 残余奥氏体 高温拉伸性能
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miR-125a-5p对实验性自身免疫性重症肌无力小鼠胸腺Treg细胞的影响
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作者 谭舒婷 黎入荧 +2 位作者 陈柳伶 刘竞丽 李劲频 《医学研究杂志》 2025年第8期34-41,共8页
目的探讨miR-125a-5p对实验性自身免疫性重症肌无力(experimental autoimmune myasthenia gravis,EAMG)小鼠胸腺调节性T细胞(regulatory T cell,Treg)的影响。方法使用鼠源性乙酰胆碱受体α亚基97~116多肽免疫诱导建立EAMG模型,随机分... 目的探讨miR-125a-5p对实验性自身免疫性重症肌无力(experimental autoimmune myasthenia gravis,EAMG)小鼠胸腺调节性T细胞(regulatory T cell,Treg)的影响。方法使用鼠源性乙酰胆碱受体α亚基97~116多肽免疫诱导建立EAMG模型,随机分为对照组和EAMG组,对小鼠进行Lennon评分和低频重复电刺激实验评估模型。为进一步探讨miR-125a-5p对Treg细胞的影响,分别给予EAMG小鼠尾静脉注射阴性对照腺病毒和miR-125a-5p抑制腺病毒,实验分组为阴性对照组和miR-125a-5p抑制组。采用实时荧光定量聚合酶链反应(real-time fluorescence quantitative polymerase chain reaction,RT-qPCR)法检测miR-125a-5p和叉状头转录因子P3(forkhead box P3,Foxp3)mRNA表达水平,Western blot法检测Foxp3蛋白表达水平,流式细胞术检测Treg细胞数量百分比,酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)法检测血清白细胞介素-10(interleukin 10,IL-10)、转化生长因子-β1(transforming growth factor-β1,TGF-β1)表达水平。结果成功构建EAMG小鼠模型,与对照组比较,EAMG组Lennon评分升高,5Hz低频重复电刺激阳性,miR-125a-5p表达升高,Foxp3mRNA和蛋白表达均下降,Treg细胞数量百分比减少,IL-10、TGF-β1表达降低;抑制EAMG小鼠miR-125a-5p表达后,与阴性对照组比较,miR-125a-5p抑制组miR-125a-5p表达降低,Lennon评分降低,Foxp3mRNA和蛋白表达均升高,Treg细胞数量百分比增加,IL-10、TGF-β1表达升高,差异均有统计学意义(P<0.05)。结论miR-125a-5p在EAMG中表达上调,抑制miR-125a-5p表达能够上调Foxp3的表达,促进Treg细胞数量增加和升高IL-10、TGF-β1水平,减轻EAMG小鼠肌无力症状,表明miR-125a-5p可能通过影响Foxp3导致Treg细胞数量减少和功能异常参与重症肌无力疾病的发生。 展开更多
关键词 重症肌无力 miR-125a-5p 调节性t细胞
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t/k-fault diagnosis algorithm of n-dimensional hypercube network based on the MM*model 被引量:4
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作者 LIANG Jiarong ZHOU Ning YUN Long 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2018年第1期216-222,共7页
Compared with accurate diagnosis, the system’s selfdiagnosing capability can be greatly increased through the t/kdiagnosis strategy at most k vertexes to be mistakenly identified as faulty under the comparison model,... Compared with accurate diagnosis, the system’s selfdiagnosing capability can be greatly increased through the t/kdiagnosis strategy at most k vertexes to be mistakenly identified as faulty under the comparison model, where k is typically a small number. Based on the Preparata, Metze, and Chien(PMC)model, the n-dimensional hypercube network is proved to be t/kdiagnosable. In this paper, based on the Maeng and Malek(MM)*model, a novel t/k-fault diagnosis(1≤k≤4) algorithm of ndimensional hypercube, called t/k-MM*-DIAG, is proposed to isolate all faulty processors within the set of nodes, among which the number of fault-free nodes identified wrongly as faulty is at most k. The time complexity in our algorithm is only O(2~n n~2). 展开更多
关键词 hypercube network t/k-diagnosis algorithm multiprocessor systems the Maeng and Malek(MM)* model preparata Metze and Chien(pMC)
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