Background Research data regarding the correlation between elevated oxidised low-density lipoprotein(oxLDL)cholesterol concentrations and unfavourable clinical outcomes in individuals experiencing minor acute ischaemi...Background Research data regarding the correlation between elevated oxidised low-density lipoprotein(oxLDL)cholesterol concentrations and unfavourable clinical outcomes in individuals experiencing minor acute ischaemic cerebrovascular events or transient ischaemic attack(TIA)with presumed atherosclerotic aetiology are still limited.Methods This investigation incorporated a cohort of 5814 participants derived from the Intensive Statin and Antiplatelet Therapy for Acute High-Risk Intracranial or Extracranial Atherosclerosis clinical trial.The core laboratory conducted blinded measurements of baseline plasma oxLDL concentrations.Multivariable Cox regression analyses were employed to assess the correlations between oxLDL levels and adverse clinical events.The principal endpoint for efficacy assessment was defined as the occurrence of stroke within a 90-day follow-up period.Additional secondary endpoints encompassed composite vascular events during the same observation window.The main safety endpoint assessed was the occurrence of bleeding events of moderate to severe intensity.Results The final analytical cohort comprised 5814 patients included in the final analysis.The mean age was 63.7±9.6 years,and 36.0%were female.The average concentration of circulating oxLDL was 36.62μg/dL.Elevated oxLDL concentrations demonstrated a potential correlation with heightened stroke risk(T3 vs T1:HR 1.39,95%CI 1.04 to 1.85),ischaemic stroke(T3 vs T1:HR 1.31,95%CI 0.98 to 1.76)and composite vascular events(T3 vs T1:HR 1.36,95%CI 1.02 to 1.81)within 90 days.An increased concentration of oxLDL demonstrated a significant association with elevated susceptibility to moderate and severe haemorrhagic events(T3 vs T1:HR 3.61,95%CI 1.26 to 10.34)within 90 days.Conclusion Increased concentrations of oxLDL demonstrated an independent correlation with both stroke recurrence and the occurrence of moderate-to severe haemorrhagic events in individuals presenting with acute minor ischaemic stroke or TIA at elevated risk,accompanied by intracranial or extracranial atherosclerotic lesions.展开更多
Highly concentrated hydrogen peroxide has been widely used as a rocket mono-propellant and oxidiser since 1940＇s. Although the relevant specialist literature concerning HTP is relatively extensive, one can still find...Highly concentrated hydrogen peroxide has been widely used as a rocket mono-propellant and oxidiser since 1940＇s. Although the relevant specialist literature concerning HTP is relatively extensive, one can still find many myths about highly concentrated hydrogen peroxide, especially concerning safety aspects about its preparation by different techniques, handling or further utilisation. Such ambiguities can result in rather apprehensive approach towards preparing, utilising or even handling of HTP in relevant industry or research fields. The paper contains modern approach to laboratory preparation of highly concentrated solutions of hydrogen peroxide of HTP class （concentration 98%＋） that is intended for propulsive （rocket） applications. Authors, who have gained extensive experience in the field of HTP preparation, handling and utilisation, concisely explain facts and disprove some common myths concerning HTP. Additionally, advantages and possible application of 98%＋ solutions of HTP in various propulsive systems such as small satellites are described. The attention is also paid to the possibility of replacing currently used toxic and corrosive rocket propellants, such as hydrazine and its derivatives, RFNA （red fuming nitric acid）, MON （mixed oxides of nitrogen） or NTO （dinitrogen tetroxide）, by 98%＋ HTP. The potential of the medium as green and easy to handle propellant that can act both, as monopropellant or strong liquid oxidiser with hypergolic capability, is outlined briefly as well.展开更多
基金supported by the Capital’s Funds for Health Improvement and Research(2024-1-2043)National Natural Science Foundation of China(No.82425101,No.82101358)+3 种基金Beijing Nova Program(20230484336)Capital's Funds for Health Improvement and Research(2022-2-2045)the National Key R&D Program of China(No.2022YFF1501500,2022YFF1501501,2022YFF1501502,2022YFF1501503,2022YFF1501504,2022YFF1501505,2017YFC1307900,2017YFC1307905)Beijing Laboratory of Oral Health(PXM2021_014226_000041).
文摘Background Research data regarding the correlation between elevated oxidised low-density lipoprotein(oxLDL)cholesterol concentrations and unfavourable clinical outcomes in individuals experiencing minor acute ischaemic cerebrovascular events or transient ischaemic attack(TIA)with presumed atherosclerotic aetiology are still limited.Methods This investigation incorporated a cohort of 5814 participants derived from the Intensive Statin and Antiplatelet Therapy for Acute High-Risk Intracranial or Extracranial Atherosclerosis clinical trial.The core laboratory conducted blinded measurements of baseline plasma oxLDL concentrations.Multivariable Cox regression analyses were employed to assess the correlations between oxLDL levels and adverse clinical events.The principal endpoint for efficacy assessment was defined as the occurrence of stroke within a 90-day follow-up period.Additional secondary endpoints encompassed composite vascular events during the same observation window.The main safety endpoint assessed was the occurrence of bleeding events of moderate to severe intensity.Results The final analytical cohort comprised 5814 patients included in the final analysis.The mean age was 63.7±9.6 years,and 36.0%were female.The average concentration of circulating oxLDL was 36.62μg/dL.Elevated oxLDL concentrations demonstrated a potential correlation with heightened stroke risk(T3 vs T1:HR 1.39,95%CI 1.04 to 1.85),ischaemic stroke(T3 vs T1:HR 1.31,95%CI 0.98 to 1.76)and composite vascular events(T3 vs T1:HR 1.36,95%CI 1.02 to 1.81)within 90 days.An increased concentration of oxLDL demonstrated a significant association with elevated susceptibility to moderate and severe haemorrhagic events(T3 vs T1:HR 3.61,95%CI 1.26 to 10.34)within 90 days.Conclusion Increased concentrations of oxLDL demonstrated an independent correlation with both stroke recurrence and the occurrence of moderate-to severe haemorrhagic events in individuals presenting with acute minor ischaemic stroke or TIA at elevated risk,accompanied by intracranial or extracranial atherosclerotic lesions.
文摘Highly concentrated hydrogen peroxide has been widely used as a rocket mono-propellant and oxidiser since 1940＇s. Although the relevant specialist literature concerning HTP is relatively extensive, one can still find many myths about highly concentrated hydrogen peroxide, especially concerning safety aspects about its preparation by different techniques, handling or further utilisation. Such ambiguities can result in rather apprehensive approach towards preparing, utilising or even handling of HTP in relevant industry or research fields. The paper contains modern approach to laboratory preparation of highly concentrated solutions of hydrogen peroxide of HTP class （concentration 98%＋） that is intended for propulsive （rocket） applications. Authors, who have gained extensive experience in the field of HTP preparation, handling and utilisation, concisely explain facts and disprove some common myths concerning HTP. Additionally, advantages and possible application of 98%＋ solutions of HTP in various propulsive systems such as small satellites are described. The attention is also paid to the possibility of replacing currently used toxic and corrosive rocket propellants, such as hydrazine and its derivatives, RFNA （red fuming nitric acid）, MON （mixed oxides of nitrogen） or NTO （dinitrogen tetroxide）, by 98%＋ HTP. The potential of the medium as green and easy to handle propellant that can act both, as monopropellant or strong liquid oxidiser with hypergolic capability, is outlined briefly as well.
