An efficient and practical methods for the synthesis of carbamoyl quinoline-2,4-diones via the reaction of ortho-cyanoarylacrylamides with oxamic acids was described.This cyclic reaction could be performed efficiently...An efficient and practical methods for the synthesis of carbamoyl quinoline-2,4-diones via the reaction of ortho-cyanoarylacrylamides with oxamic acids was described.This cyclic reaction could be performed efficiently under metal free conditions.Various products with functional groups could be obtained with moderate to high yields via radical mechanism.展开更多
Aqueous Zn metal batteries(AZMBs)are plagued by hydrogen evolution and interfacial alkalization induced by water and its decomposition products(H^(+)and OH^(-)),which critically undermine the reversibility and cycling...Aqueous Zn metal batteries(AZMBs)are plagued by hydrogen evolution and interfacial alkalization induced by water and its decomposition products(H^(+)and OH^(-)),which critically undermine the reversibility and cycling stability of zinc plating and stripping.To address this challenge,oxamic acid(OA),a small bipolar molecule containing both carboxyl and amide groups,is proposed as a multifunctional electrolyte additive.OA forms hydrogen bonds with water molecules,thereby reconstructing the hydrogen-bond network and effectively suppressing both proton transport and hydrogen evolution.Meanwhile,OA dynamically scavenges OH-generated from water decomposition,thus mitigating the generation of alkaline byproducts.Additionally,OA is adsorbed onto the zinc surface,promoting the formation of a water-depleted inner Helmholtz layer and limiting the interfacial reactivity of water.Combined ex situ/in situ characterizations,molecular dynamics simulations,and density functional theory(DFT)calculations collectively verify that OA significantly mitigates parasitic reactions and enhances the stability of the Zn/electrolyte interface.As a result,Zn||Zn cells exhibit over 4000 h of stable cycling at 2 mA cm^(-2)and a cumulative plating capacity of 6.875 Ah cm^(-2)at 5 mA cm^(-2).Zn||Cu cells maintain a high Coulombic efficiency of 99.5%over 4500 cycles,Zn||a-MnO_(2)full cells retain 80.1%of their capacity after2000 cycles,and pouch cells retain 81.5%of their capacity after 600 cycles,highlighting the practical feasibility of this interfacial regulation strategy.展开更多
The development of innovative and sustainable catalytic strategies for organic synthesis is a pivotal aspect of advancing material science and chemical engineering.This research presents a new catalytic method for the...The development of innovative and sustainable catalytic strategies for organic synthesis is a pivotal aspect of advancing material science and chemical engineering.This research presents a new catalytic method for the aminoacylation of N-sulfonyl ketimines by utilizing a potassium-doped graphite-like carbon nitride(g-C_(3)N_(4))framework.This method not only enhances the catalytic efficiency and broadens the light absorption spectrum of g-C_(3)N_(4)but also significantly reduces the recombination rate of electronhole pairs,thereby increasing the reaction yield and selectivity.Importantly,our approach facilitates the synthesis of aminoacylated N-heterocycles,expanding the applicability of potassium-modified g-C_(3)N_(4)in photocatalytic organic synthesis.A notable accomplishment of this study is the unprecedented generation of carbamoyl radicals via heterogeneous photocatalysis,which can be easily recycled after reaction.This advancement highlights the capability of potassium-doped g-C_(3)N_(4)(namely K-CN)as an advanced heterogeneous photocatalyst for the formation of complex organic compounds.展开更多
Hydrazones of poorly studied fluorine-containing oxamic acid thiohydrazides were synthesized by the reaction with salicylaldehydes. Tests showed that the newly synthesized compounds were effective low-toxic inhibitors...Hydrazones of poorly studied fluorine-containing oxamic acid thiohydrazides were synthesized by the reaction with salicylaldehydes. Tests showed that the newly synthesized compounds were effective low-toxic inhibitors of type III secretion system in Chlamydia trachomatis.展开更多
Background:T-cell acute lymphoblastic leukemia(T-ALL)is an uncommon and aggressive subtype of acute lymphoblastic leukemia(ALL).In the serum of T-ALL patients,the activity of lactate dehydrogenase A(LDHA)is increased....Background:T-cell acute lymphoblastic leukemia(T-ALL)is an uncommon and aggressive subtype of acute lymphoblastic leukemia(ALL).In the serum of T-ALL patients,the activity of lactate dehydrogenase A(LDHA)is increased.We proposed that targeting LDHA may be a potential strategy to improve T-ALL outcomes.The current study was conducted to investigate the antileukemic effect of LDHA gene-targeting treatment on T-ALL and the underlying molecular mechanism.Methods:Primary T-ALL cell lines Jurkat and DU528 were treated with the LDH inhibitor oxamate.MTT,colony formation,apoptosis,and cell cycle assays were performed to investigate the effects of oxamate on T-ALL cells.Quantitative real-time PCR(qPCR)and Western blotting analyses were applied to determine the related signaling pathways.A mitochondrial reactive oxygen species(ROS)assay was performed to evaluate ROS production after T-ALL cells were treated with oxamate.A T-ALL transgenic zebrafish model with LDHA gene knockdown was established using CRISPR/Cas9 gene-editing technology,and then TUNEL,Western blotting,and T-ALL tumor progression analyses were conducted to investigate the effects of LDHA gene knockdown on T-ALL transgenic zebrafish.Results:Oxamate significantly inhibited proliferation and induced apoptosis of Jurkat and DU528 cells.It also arrested Jurkat and DU528 cells in G0/G1 phase and stimulated ROS production(all P<0.001).Blocking LDHA significantly decreased the gene and protein expression of c-Myc,as well as the levels of phosphorylated serine/threonine kinase(AKT)and glycogen synthase kinase 3 beta(GSK-3β)in the phosphatidylinositol 3′-kinase(PI3K)signaling pathway.LDHA gene knockdown delayed disease progression and down-regulated c-Myc mRNA and protein expression in T-ALL transgenic zebrafish.Conclusion:Targeting LDHA exerted an antileukemic effect on T-ALL,representing a potential strategy for T-ALL treatment.展开更多
Presented here are two isostructural uranyl coordination polymers [UOe（EDO）（H2O）]· H2O （1） and [UO2（BDO）（H2O）]-2H2O （2） （EDO2---ethylene-1,2-dioxamate; BDO2 =butylene-1,2-dioxamate） with identical s...Presented here are two isostructural uranyl coordination polymers [UOe（EDO）（H2O）]· H2O （1） and [UO2（BDO）（H2O）]-2H2O （2） （EDO2---ethylene-1,2-dioxamate; BDO2 =butylene-1,2-dioxamate） with identical stepwise zigzag chain structure and distinct interchain hydrogen bonding interaction, prepared from hydrothermal reaction of DEEDO or DEBDO （DEEDO- diethyl ethylene-1,2-dioxamate; DEBDO--diethyl butylene-l,2-dioxamate） with uranyl ions. The monomeric uranyl-based fluorescence emissions of compounds 1 and 2 are red-shifted by about 6 and 5 nm respectively, compared to that of uranyl nitrate hexahydrate. Compound 1 has stronger emission than compound 2, but both their emissions exhibit triple-exponential decay. The photophysics of uranyl oxalate trihydrate was also investigated for comparison. The selective crystallization of compound 1 in alkaline solution was applied to the sequestration of uranyl ions, showing a kinetic preference.展开更多
基金supported by the National Natural Science Foundation of China(No.21772107)Shandong Province Key Research and Development Plan(No.2019GSF108017)。
文摘An efficient and practical methods for the synthesis of carbamoyl quinoline-2,4-diones via the reaction of ortho-cyanoarylacrylamides with oxamic acids was described.This cyclic reaction could be performed efficiently under metal free conditions.Various products with functional groups could be obtained with moderate to high yields via radical mechanism.
基金supported by the National Nature Science Foundation(52333009 and 52372125)the Shaanxi Provincial Science Foundation(2021GXLH-01-11)+4 种基金the Yulin Project(2022-19-11)the High-Quality Patent Cultivation Project(XGD2021-04)the Fundamental Research Funds for the Central Universities(D5000230071)the 111 Program of MOE of China(B08040)the Analytical&Testing Center of Northwestern Polytechnical University and the fund(2024T008)。
文摘Aqueous Zn metal batteries(AZMBs)are plagued by hydrogen evolution and interfacial alkalization induced by water and its decomposition products(H^(+)and OH^(-)),which critically undermine the reversibility and cycling stability of zinc plating and stripping.To address this challenge,oxamic acid(OA),a small bipolar molecule containing both carboxyl and amide groups,is proposed as a multifunctional electrolyte additive.OA forms hydrogen bonds with water molecules,thereby reconstructing the hydrogen-bond network and effectively suppressing both proton transport and hydrogen evolution.Meanwhile,OA dynamically scavenges OH-generated from water decomposition,thus mitigating the generation of alkaline byproducts.Additionally,OA is adsorbed onto the zinc surface,promoting the formation of a water-depleted inner Helmholtz layer and limiting the interfacial reactivity of water.Combined ex situ/in situ characterizations,molecular dynamics simulations,and density functional theory(DFT)calculations collectively verify that OA significantly mitigates parasitic reactions and enhances the stability of the Zn/electrolyte interface.As a result,Zn||Zn cells exhibit over 4000 h of stable cycling at 2 mA cm^(-2)and a cumulative plating capacity of 6.875 Ah cm^(-2)at 5 mA cm^(-2).Zn||Cu cells maintain a high Coulombic efficiency of 99.5%over 4500 cycles,Zn||a-MnO_(2)full cells retain 80.1%of their capacity after2000 cycles,and pouch cells retain 81.5%of their capacity after 600 cycles,highlighting the practical feasibility of this interfacial regulation strategy.
基金financial support from the National Natural Science Foundation of China(No.22171249)the Science&Technology Innovation Talents in Universities of Henan Province(No.23HASTIT003)。
文摘The development of innovative and sustainable catalytic strategies for organic synthesis is a pivotal aspect of advancing material science and chemical engineering.This research presents a new catalytic method for the aminoacylation of N-sulfonyl ketimines by utilizing a potassium-doped graphite-like carbon nitride(g-C_(3)N_(4))framework.This method not only enhances the catalytic efficiency and broadens the light absorption spectrum of g-C_(3)N_(4)but also significantly reduces the recombination rate of electronhole pairs,thereby increasing the reaction yield and selectivity.Importantly,our approach facilitates the synthesis of aminoacylated N-heterocycles,expanding the applicability of potassium-modified g-C_(3)N_(4)in photocatalytic organic synthesis.A notable accomplishment of this study is the unprecedented generation of carbamoyl radicals via heterogeneous photocatalysis,which can be easily recycled after reaction.This advancement highlights the capability of potassium-doped g-C_(3)N_(4)(namely K-CN)as an advanced heterogeneous photocatalyst for the formation of complex organic compounds.
文摘Hydrazones of poorly studied fluorine-containing oxamic acid thiohydrazides were synthesized by the reaction with salicylaldehydes. Tests showed that the newly synthesized compounds were effective low-toxic inhibitors of type III secretion system in Chlamydia trachomatis.
基金This work was supported by the National Natural Science Foundation of China(81200368,81670160)the Hunan Natural Science Foundation(2017JJ2355).
文摘Background:T-cell acute lymphoblastic leukemia(T-ALL)is an uncommon and aggressive subtype of acute lymphoblastic leukemia(ALL).In the serum of T-ALL patients,the activity of lactate dehydrogenase A(LDHA)is increased.We proposed that targeting LDHA may be a potential strategy to improve T-ALL outcomes.The current study was conducted to investigate the antileukemic effect of LDHA gene-targeting treatment on T-ALL and the underlying molecular mechanism.Methods:Primary T-ALL cell lines Jurkat and DU528 were treated with the LDH inhibitor oxamate.MTT,colony formation,apoptosis,and cell cycle assays were performed to investigate the effects of oxamate on T-ALL cells.Quantitative real-time PCR(qPCR)and Western blotting analyses were applied to determine the related signaling pathways.A mitochondrial reactive oxygen species(ROS)assay was performed to evaluate ROS production after T-ALL cells were treated with oxamate.A T-ALL transgenic zebrafish model with LDHA gene knockdown was established using CRISPR/Cas9 gene-editing technology,and then TUNEL,Western blotting,and T-ALL tumor progression analyses were conducted to investigate the effects of LDHA gene knockdown on T-ALL transgenic zebrafish.Results:Oxamate significantly inhibited proliferation and induced apoptosis of Jurkat and DU528 cells.It also arrested Jurkat and DU528 cells in G0/G1 phase and stimulated ROS production(all P<0.001).Blocking LDHA significantly decreased the gene and protein expression of c-Myc,as well as the levels of phosphorylated serine/threonine kinase(AKT)and glycogen synthase kinase 3 beta(GSK-3β)in the phosphatidylinositol 3′-kinase(PI3K)signaling pathway.LDHA gene knockdown delayed disease progression and down-regulated c-Myc mRNA and protein expression in T-ALL transgenic zebrafish.Conclusion:Targeting LDHA exerted an antileukemic effect on T-ALL,representing a potential strategy for T-ALL treatment.
基金supported by the National Natural Science Foundation of China (21431002)the Specialized Research Fund for the Doctoral Program of Higher Education (20110211130002)
文摘Presented here are two isostructural uranyl coordination polymers [UOe（EDO）（H2O）]· H2O （1） and [UO2（BDO）（H2O）]-2H2O （2） （EDO2---ethylene-1,2-dioxamate; BDO2 =butylene-1,2-dioxamate） with identical stepwise zigzag chain structure and distinct interchain hydrogen bonding interaction, prepared from hydrothermal reaction of DEEDO or DEBDO （DEEDO- diethyl ethylene-1,2-dioxamate; DEBDO--diethyl butylene-l,2-dioxamate） with uranyl ions. The monomeric uranyl-based fluorescence emissions of compounds 1 and 2 are red-shifted by about 6 and 5 nm respectively, compared to that of uranyl nitrate hexahydrate. Compound 1 has stronger emission than compound 2, but both their emissions exhibit triple-exponential decay. The photophysics of uranyl oxalate trihydrate was also investigated for comparison. The selective crystallization of compound 1 in alkaline solution was applied to the sequestration of uranyl ions, showing a kinetic preference.
