Epidermal growth factor receptor(EGFR)-positive nonsmall cell lung cancer is a dynamic entity,with tumor progression and resistance to tyrosine kinase inhibitors(TKls)stemming from the accumulation of mutations over t...Epidermal growth factor receptor(EGFR)-positive nonsmall cell lung cancer is a dynamic entity,with tumor progression and resistance to tyrosine kinase inhibitors(TKls)stemming from the accumulation of mutations over time and across different disease sites,leading to temporal and spatial heterogeneity.展开更多
Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental p...Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental protection and resource recycling in bismuth smelting.It’s learned that the company recovers up to100,000 tons of bismuth-containing lead-展开更多
The superresolution microscopy that broadens the detection range in the spatial frequency domain through the spatialfrequency-shift(SFS)effect[1-5]shows intriguing advantages including a large field of view,high speed...The superresolution microscopy that broadens the detection range in the spatial frequency domain through the spatialfrequency-shift(SFS)effect[1-5]shows intriguing advantages including a large field of view,high speed,and good modularity.Significantly,it captures pictures in the wide-field mode and allows a universal implementation without using special fluorophores labeling.To enable the sub-diffraction resolution in the SFS microscopy,it is essential to use the evanescent wave illumination with a large wave vector,which can be built on the integrated photonic configuration,paving the way for a compact nanoscopy on a thin chip[6-8].However,the lack of an approach to actively tune the SFS value in a large range hampers the progress to achieve deep-subwavelength resolution through evanescent illumination with ultra-large wave vectors.When the wave vector of the illumination surpasses twice the cutoff frequency of the objective,a missing band exists between the shifted components and the zeroth component in the spatial frequency domain,which causes severe artifacts and a distortion in the image.As a result,the resolution of current linear SFS microscopy has been restricted less than thrice the Abbe diffraction limit of the detection system.展开更多
The key pathogenesis of chronic myeloid leukemia(CML)is the formation of BCR-ABL fusion gene,encoding a 210 kDa Bcr-Abl tyrosine kinase,which is crucial for the occurrence and development of CML.Imatinib(IM)is the fir...The key pathogenesis of chronic myeloid leukemia(CML)is the formation of BCR-ABL fusion gene,encoding a 210 kDa Bcr-Abl tyrosine kinase,which is crucial for the occurrence and development of CML.Imatinib(IM)is the first targeted anticancer drug approved by FDA for the treatment of CML;however,some patients,especially those in accelerated phase and blastic phase,develop primary or secondary drug resistance to IM.Particularly,the most challenging resistance is caused by T315I mutation of Bcr-Abl,which represents approximately 15%–20%of all acquired mutations and renders cell resistant to a variety of tyrosine kinase inhibitors.1,2 Thus,there is an urgent need to develop novel strategies to overcome Bcr-Abl T315I-meidated IM resistance.展开更多
We regret that an error was made in“A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance”(Genes Dis 2019 Dec;694:419e430).In Fig.1C of the original manuscrip...We regret that an error was made in“A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance”(Genes Dis 2019 Dec;694:419e430).In Fig.1C of the original manuscript,the right panel(showing the migration ability of the MHCCLM3 cells)was erroneously duplicated with the left panel(showing the migration ability of the Huh7 cells)when the figures were assembled.We have now checked the original data and request to replace the right panel with the correct data for MHCCLM3 cells.The corrected Fig.展开更多
Propylene is an important feedstock for polymer production.The greater abundance of propane in shale gas has led to a switch in the industrial feedstocks for propylene from naphtha to propane[1].Catalytic dehydrogenat...Propylene is an important feedstock for polymer production.The greater abundance of propane in shale gas has led to a switch in the industrial feedstocks for propylene from naphtha to propane[1].Catalytic dehydrogenation of propane can convert propane directly into propylene in a distributed fashion and fills the so-called propylene supply gap in steam cracking process of ethane.展开更多
Apical microsurgery is accurate and minimally invasive,produces few complications,and has a success rate of more than 90%.However,due to the lack of awareness and understanding of apical microsurgery by dental general...Apical microsurgery is accurate and minimally invasive,produces few complications,and has a success rate of more than 90%.However,due to the lack of awareness and understanding of apical microsurgery by dental general practitioners and even endodontists,many clinical problems remain to be overcome.The consensus has gathered well-known domestic experts to hold a series of special discussions and reached the consensus.This document specifies the indications,contraindications,preoperative preparations,operational procedures,complication prevention measures,and efficacy evaluation of apical microsurgery and is applicable to dentists who perform apical microsurgery after systematic training.展开更多
A group of 16 humanoid robots,developed by Chinese startup Unitree Robotics,wore folkloric jackets and performed the traditional yangge dance with fluid handkerchief movements and precise formations at CCTV’s popular...A group of 16 humanoid robots,developed by Chinese startup Unitree Robotics,wore folkloric jackets and performed the traditional yangge dance with fluid handkerchief movements and precise formations at CCTV’s popular Spring Festival Gala.While showcasing a fusion of cutting-edge technology and traditional culture,the performance also brought China’s humanoid development into the spotlight.展开更多
Brain-inspired intelligence is considered to be a computational model with the most promising potential to overcome the shortcomings of the von Neumann architecture,making it a current research hotspot.Due to advantag...Brain-inspired intelligence is considered to be a computational model with the most promising potential to overcome the shortcomings of the von Neumann architecture,making it a current research hotspot.Due to advantages such as nonvolatility,high density,low power consumption,and high response ratio,memristors are regarded as devices with promising applications in brain-inspired intelligence.This paper proposes a physical Ag/HfO_(x)/FeO_(x)/Pt memristor model.The Ag/HfO_(x)/FeO_(x)/Pt memristor is first fabricated using magnetron sputtering,and its internal principles and characteristics are then thoroughly analyzed.Furthermore,we construct a corresponding physical memristor model which achieves a simulation accuracy of up to 99.72%for the physical memristor.We design a fully functional Pavlovian associative memory circuit,realizing functions including generalization,primary differentiation,secondary differentiation,and forgetting.Finally,the circuit is validated through PSPICE simulation and analysis.展开更多
With the booming of Industrial Internet of Things(IIoT)and Artificial Intelligence(AI),the objective of the work in Cai et al.(2022)is to explore the utilizing of data-driven methodology for the prediction of the burs...With the booming of Industrial Internet of Things(IIoT)and Artificial Intelligence(AI),the objective of the work in Cai et al.(2022)is to explore the utilizing of data-driven methodology for the prediction of the burst strength of cor‐roded pipelines,which can hopefully overcome the com‐mon drawbacks of widely-used traditional Finite Element Method(FEM)and the needs of sufficient domain knowl‐edge.The authors in Cai et al.(2022)are not aiming to overthrow the functionality and beneficence introduced by physical-based methods and widely-used empirical/semi-emprical engineering expressions,such as the DNV standars(DNVGL,2017)in offshore engineering.展开更多
Last year marked the golden jubilee of Malaysia-China diplomatic relations—a milestone that underscored the enduring friendship and collaboration between the two nations.Over the past five decades,Malaysia and China ...Last year marked the golden jubilee of Malaysia-China diplomatic relations—a milestone that underscored the enduring friendship and collaboration between the two nations.Over the past five decades,Malaysia and China have overcome many challenges together,fostering strong bilateral ties built on mutual respect,economic cooperation,cultural exchange,and shared aspirations for regional peace and prosperity.展开更多
On July 10,2025,General Secretary of the Communist Party of China(CPC)Central Committee Xi Jinping,also the President of the People’s Republic of China,sent a congratulatory letter to the Global Civilizations Dialogu...On July 10,2025,General Secretary of the Communist Party of China(CPC)Central Committee Xi Jinping,also the President of the People’s Republic of China,sent a congratulatory letter to the Global Civilizations Dialogue Ministerial Meeting.Xi pointed out that amidst intertwined global transformations and uncertainties,humanity stands at a new crossroads,urgently requiring transcending civilizational estrangement through exchanges and overcoming civilizational clashes through mutual learning.展开更多
The year 2024 marks the tenth anniversary of General Secretary Xi Jinping’s proposal for a new energy security strategy and the start of the second decade of the Belt and Road Initiative.During this year,the internat...The year 2024 marks the tenth anniversary of General Secretary Xi Jinping’s proposal for a new energy security strategy and the start of the second decade of the Belt and Road Initiative.During this year,the international situation grew increasingly complex,with intensifying rivalries among major powers and sporadic occurrences of geopolitical conflicts and localized disturbances.CNPC’s international operations focus on maintaining stability while making progress,successfully overcoming various intertwined risks and achieving new milestones in international business development.For six consecutive years,the overseas equity production has maintained an equivalent of 100 million tons.International trade has achieved stable progress,and engineering services have made new breakthroughs in market expansion,contributing new momentum to CNPC’s establishment as a world-class enterprise.展开更多
Developing chemically complex intermetallic alloys(CCIMAs)is considered an effective strategy for overcoming the serious brittleness of conventional intermetallic alloys,especially under a high stress level.However,mo...Developing chemically complex intermetallic alloys(CCIMAs)is considered an effective strategy for overcoming the serious brittleness of conventional intermetallic alloys,especially under a high stress level.However,most CCIMAs still struggle to achieve yield strengths exceeding gigapascals,limiting their use as reliable structural materials in many engineering fields.展开更多
This paper will firstly provide a review of the content of Gloria' article,then,the article will be critical analyzed.Finally,the implication of the article with reference to a Chinese adult EFL context will be ev...This paper will firstly provide a review of the content of Gloria' article,then,the article will be critical analyzed.Finally,the implication of the article with reference to a Chinese adult EFL context will be evaluated.展开更多
Lithium-ion battery has reached its capacity and energy density limits.In the past decade,significant efforts have been taken to explore new electrode materials that have the potential to enable high-energy-density ba...Lithium-ion battery has reached its capacity and energy density limits.In the past decade,significant efforts have been taken to explore new electrode materials that have the potential to enable high-energy-density battery systems.Among them,elemental sulfur is one of the high-capacity cathode candidates and has been studied intensively over the past decade.The formation of lithium polysulfides in ethereal liquid electrolyte upon cycling results in several challenges such as active material dissolution,shuttle effect,and limited cycle life.Although some approaches have been developed to overcome these issues,the attainable energy densities of lithium–sulfur(Li-S)batteries seem to be low.The main reason is largely due to the high electrolyte/sulfur(E/S)ratios used in the sulfur cathode.This perspective provides new insights on the energy density analysis of sulfur cathode.The“average mass density”of sulfur cathode is found to be a useful parameter for this purpose.Some emerging alternative sulfur-based cathode materials such as organopolysulfides and metal polysulfides which possess unique properties and performances are presented.They are promising to overcome the intrinsic issues associated with elemental sulfur cathode and enable truly high-energy-density Li-S battery systems.展开更多
Designing highly efficient and stable photocatalysts is of vital importance for solar-to-fuel conversion,as a potential strategy to address the concerns of global energy crisis and environmental deterioration.The deve...Designing highly efficient and stable photocatalysts is of vital importance for solar-to-fuel conversion,as a potential strategy to address the concerns of global energy crisis and environmental deterioration.The development of novel photocatalytic materials is desirable to overcome those shortcomings of traditional semiconductor photocatalysts.展开更多
The convertion of solar energy into hydrogen energy with high energy density by photocatalysis is a green and eco-friendly avenue to solve the energy crisis and environmental pollution issues 1,2.Unfortunately,most ph...The convertion of solar energy into hydrogen energy with high energy density by photocatalysis is a green and eco-friendly avenue to solve the energy crisis and environmental pollution issues 1,2.Unfortunately,most photocatalysts usually suffer from the rapid quenching of photogenerated carriers and depressed interfacial H_(2)-generation dynamics 3,4.To overcome the above shortcomings,cocatalysts are widely employed to promote the separation of photocarriers and to create active sites for surface catalytic reactions 5.For a superb cocatalyst,its active sites usually play a key role in the overall performance of photocatalytic H_(2) evolution because the active sites can not only provide a large number of adsorption centers to enrich H+,but also present an outstanding catalytic efficiency to convert H+into H_(2) by reducing its reaction overpotential 6.Thus,the active-site number and efficiency of cocatalysts should be maximized as much as possible to greatly boost the cocatalytic H2-evolution activity by photocatalysis.展开更多
基金supported by the Natural Scientific Foundation of Zhejiang Province,China (No.LTGY23H160007).
文摘Epidermal growth factor receptor(EGFR)-positive nonsmall cell lung cancer is a dynamic entity,with tumor progression and resistance to tyrosine kinase inhibitors(TKls)stemming from the accumulation of mutations over time and across different disease sites,leading to temporal and spatial heterogeneity.
文摘Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental protection and resource recycling in bismuth smelting.It’s learned that the company recovers up to100,000 tons of bismuth-containing lead-
文摘The superresolution microscopy that broadens the detection range in the spatial frequency domain through the spatialfrequency-shift(SFS)effect[1-5]shows intriguing advantages including a large field of view,high speed,and good modularity.Significantly,it captures pictures in the wide-field mode and allows a universal implementation without using special fluorophores labeling.To enable the sub-diffraction resolution in the SFS microscopy,it is essential to use the evanescent wave illumination with a large wave vector,which can be built on the integrated photonic configuration,paving the way for a compact nanoscopy on a thin chip[6-8].However,the lack of an approach to actively tune the SFS value in a large range hampers the progress to achieve deep-subwavelength resolution through evanescent illumination with ultra-large wave vectors.When the wave vector of the illumination surpasses twice the cutoff frequency of the objective,a missing band exists between the shifted components and the zeroth component in the spatial frequency domain,which causes severe artifacts and a distortion in the image.As a result,the resolution of current linear SFS microscopy has been restricted less than thrice the Abbe diffraction limit of the detection system.
基金This work was supported by NSFC,China(No.82170177/H0809,and 81670154/H0812)Projects(No.2020KTSCX10,and 2021A1515011334)from the Foundation of Innovation Projects of General Colleges and Universities in Guangdong Province and GD-NSF,China,KeyDiscipline of Guangzhou Education Bureau(Basic Medicine)(No.201851839),Chinathe project(No.202201010811)from the Foundation of Guangzhou Science and Technology Innovation Committee,China to XS.
文摘The key pathogenesis of chronic myeloid leukemia(CML)is the formation of BCR-ABL fusion gene,encoding a 210 kDa Bcr-Abl tyrosine kinase,which is crucial for the occurrence and development of CML.Imatinib(IM)is the first targeted anticancer drug approved by FDA for the treatment of CML;however,some patients,especially those in accelerated phase and blastic phase,develop primary or secondary drug resistance to IM.Particularly,the most challenging resistance is caused by T315I mutation of Bcr-Abl,which represents approximately 15%–20%of all acquired mutations and renders cell resistant to a variety of tyrosine kinase inhibitors.1,2 Thus,there is an urgent need to develop novel strategies to overcome Bcr-Abl T315I-meidated IM resistance.
文摘We regret that an error was made in“A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance”(Genes Dis 2019 Dec;694:419e430).In Fig.1C of the original manuscript,the right panel(showing the migration ability of the MHCCLM3 cells)was erroneously duplicated with the left panel(showing the migration ability of the Huh7 cells)when the figures were assembled.We have now checked the original data and request to replace the right panel with the correct data for MHCCLM3 cells.The corrected Fig.
基金supported by National Natural Science Foundation of China(22175193,22261132517,22108286),QIBEBT(S202306)Shandong Provincial Natural Science Foundation(ZR2021MB058).
文摘Propylene is an important feedstock for polymer production.The greater abundance of propane in shale gas has led to a switch in the industrial feedstocks for propylene from naphtha to propane[1].Catalytic dehydrogenation of propane can convert propane directly into propylene in a distributed fashion and fills the so-called propylene supply gap in steam cracking process of ethane.
文摘Apical microsurgery is accurate and minimally invasive,produces few complications,and has a success rate of more than 90%.However,due to the lack of awareness and understanding of apical microsurgery by dental general practitioners and even endodontists,many clinical problems remain to be overcome.The consensus has gathered well-known domestic experts to hold a series of special discussions and reached the consensus.This document specifies the indications,contraindications,preoperative preparations,operational procedures,complication prevention measures,and efficacy evaluation of apical microsurgery and is applicable to dentists who perform apical microsurgery after systematic training.
文摘A group of 16 humanoid robots,developed by Chinese startup Unitree Robotics,wore folkloric jackets and performed the traditional yangge dance with fluid handkerchief movements and precise formations at CCTV’s popular Spring Festival Gala.While showcasing a fusion of cutting-edge technology and traditional culture,the performance also brought China’s humanoid development into the spotlight.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62476230 and 61976246)the Natural Science Foundation of Chongqing(Grant No.CSTB2023NSCQ-MSX0018)Fundamental Research Funds for the Central Universities(Grant No.SWUKR22046)。
文摘Brain-inspired intelligence is considered to be a computational model with the most promising potential to overcome the shortcomings of the von Neumann architecture,making it a current research hotspot.Due to advantages such as nonvolatility,high density,low power consumption,and high response ratio,memristors are regarded as devices with promising applications in brain-inspired intelligence.This paper proposes a physical Ag/HfO_(x)/FeO_(x)/Pt memristor model.The Ag/HfO_(x)/FeO_(x)/Pt memristor is first fabricated using magnetron sputtering,and its internal principles and characteristics are then thoroughly analyzed.Furthermore,we construct a corresponding physical memristor model which achieves a simulation accuracy of up to 99.72%for the physical memristor.We design a fully functional Pavlovian associative memory circuit,realizing functions including generalization,primary differentiation,secondary differentiation,and forgetting.Finally,the circuit is validated through PSPICE simulation and analysis.
文摘With the booming of Industrial Internet of Things(IIoT)and Artificial Intelligence(AI),the objective of the work in Cai et al.(2022)is to explore the utilizing of data-driven methodology for the prediction of the burst strength of cor‐roded pipelines,which can hopefully overcome the com‐mon drawbacks of widely-used traditional Finite Element Method(FEM)and the needs of sufficient domain knowl‐edge.The authors in Cai et al.(2022)are not aiming to overthrow the functionality and beneficence introduced by physical-based methods and widely-used empirical/semi-emprical engineering expressions,such as the DNV standars(DNVGL,2017)in offshore engineering.
文摘Last year marked the golden jubilee of Malaysia-China diplomatic relations—a milestone that underscored the enduring friendship and collaboration between the two nations.Over the past five decades,Malaysia and China have overcome many challenges together,fostering strong bilateral ties built on mutual respect,economic cooperation,cultural exchange,and shared aspirations for regional peace and prosperity.
文摘On July 10,2025,General Secretary of the Communist Party of China(CPC)Central Committee Xi Jinping,also the President of the People’s Republic of China,sent a congratulatory letter to the Global Civilizations Dialogue Ministerial Meeting.Xi pointed out that amidst intertwined global transformations and uncertainties,humanity stands at a new crossroads,urgently requiring transcending civilizational estrangement through exchanges and overcoming civilizational clashes through mutual learning.
文摘The year 2024 marks the tenth anniversary of General Secretary Xi Jinping’s proposal for a new energy security strategy and the start of the second decade of the Belt and Road Initiative.During this year,the international situation grew increasingly complex,with intensifying rivalries among major powers and sporadic occurrences of geopolitical conflicts and localized disturbances.CNPC’s international operations focus on maintaining stability while making progress,successfully overcoming various intertwined risks and achieving new milestones in international business development.For six consecutive years,the overseas equity production has maintained an equivalent of 100 million tons.International trade has achieved stable progress,and engineering services have made new breakthroughs in market expansion,contributing new momentum to CNPC’s establishment as a world-class enterprise.
基金financially supported by the National Natural Science Foundation of China(Nos.52222112,52101151 and 52101135)Hong Kong Research Grant Council(RGC)(No.C1020-21G)+1 种基金Shenzhen Science and Technology Program(No.RCBS20210609103202012)APT research was conducted at the Inter-University 3D APT Unit of City University of Hong Kong(CityU),which is supported by the CityU grant 9360161
文摘Developing chemically complex intermetallic alloys(CCIMAs)is considered an effective strategy for overcoming the serious brittleness of conventional intermetallic alloys,especially under a high stress level.However,most CCIMAs still struggle to achieve yield strengths exceeding gigapascals,limiting their use as reliable structural materials in many engineering fields.
文摘This paper will firstly provide a review of the content of Gloria' article,then,the article will be critical analyzed.Finally,the implication of the article with reference to a Chinese adult EFL context will be evaluated.
文摘Lithium-ion battery has reached its capacity and energy density limits.In the past decade,significant efforts have been taken to explore new electrode materials that have the potential to enable high-energy-density battery systems.Among them,elemental sulfur is one of the high-capacity cathode candidates and has been studied intensively over the past decade.The formation of lithium polysulfides in ethereal liquid electrolyte upon cycling results in several challenges such as active material dissolution,shuttle effect,and limited cycle life.Although some approaches have been developed to overcome these issues,the attainable energy densities of lithium–sulfur(Li-S)batteries seem to be low.The main reason is largely due to the high electrolyte/sulfur(E/S)ratios used in the sulfur cathode.This perspective provides new insights on the energy density analysis of sulfur cathode.The“average mass density”of sulfur cathode is found to be a useful parameter for this purpose.Some emerging alternative sulfur-based cathode materials such as organopolysulfides and metal polysulfides which possess unique properties and performances are presented.They are promising to overcome the intrinsic issues associated with elemental sulfur cathode and enable truly high-energy-density Li-S battery systems.
文摘Designing highly efficient and stable photocatalysts is of vital importance for solar-to-fuel conversion,as a potential strategy to address the concerns of global energy crisis and environmental deterioration.The development of novel photocatalytic materials is desirable to overcome those shortcomings of traditional semiconductor photocatalysts.
基金funded by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,under grant No.RG-72-130-42.
文摘The convertion of solar energy into hydrogen energy with high energy density by photocatalysis is a green and eco-friendly avenue to solve the energy crisis and environmental pollution issues 1,2.Unfortunately,most photocatalysts usually suffer from the rapid quenching of photogenerated carriers and depressed interfacial H_(2)-generation dynamics 3,4.To overcome the above shortcomings,cocatalysts are widely employed to promote the separation of photocarriers and to create active sites for surface catalytic reactions 5.For a superb cocatalyst,its active sites usually play a key role in the overall performance of photocatalytic H_(2) evolution because the active sites can not only provide a large number of adsorption centers to enrich H+,but also present an outstanding catalytic efficiency to convert H+into H_(2) by reducing its reaction overpotential 6.Thus,the active-site number and efficiency of cocatalysts should be maximized as much as possible to greatly boost the cocatalytic H2-evolution activity by photocatalysis.
