Epidermal growth factor receptor(EGFR)-positive nonsmall cell lung cancer is a dynamic entity,with tumor progression and resistance to tyrosine kinase inhibitors(TKls)stemming from the accumulation of mutations over t...Epidermal growth factor receptor(EGFR)-positive nonsmall cell lung cancer is a dynamic entity,with tumor progression and resistance to tyrosine kinase inhibitors(TKls)stemming from the accumulation of mutations over time and across different disease sites,leading to temporal and spatial heterogeneity.展开更多
Propylene is an important feedstock for polymer production.The greater abundance of propane in shale gas has led to a switch in the industrial feedstocks for propylene from naphtha to propane[1].Catalytic dehydrogenat...Propylene is an important feedstock for polymer production.The greater abundance of propane in shale gas has led to a switch in the industrial feedstocks for propylene from naphtha to propane[1].Catalytic dehydrogenation of propane can convert propane directly into propylene in a distributed fashion and fills the so-called propylene supply gap in steam cracking process of ethane.展开更多
Apical microsurgery is accurate and minimally invasive,produces few complications,and has a success rate of more than 90%.However,due to the lack of awareness and understanding of apical microsurgery by dental general...Apical microsurgery is accurate and minimally invasive,produces few complications,and has a success rate of more than 90%.However,due to the lack of awareness and understanding of apical microsurgery by dental general practitioners and even endodontists,many clinical problems remain to be overcome.The consensus has gathered well-known domestic experts to hold a series of special discussions and reached the consensus.This document specifies the indications,contraindications,preoperative preparations,operational procedures,complication prevention measures,and efficacy evaluation of apical microsurgery and is applicable to dentists who perform apical microsurgery after systematic training.展开更多
A group of 16 humanoid robots,developed by Chinese startup Unitree Robotics,wore folkloric jackets and performed the traditional yangge dance with fluid handkerchief movements and precise formations at CCTV’s popular...A group of 16 humanoid robots,developed by Chinese startup Unitree Robotics,wore folkloric jackets and performed the traditional yangge dance with fluid handkerchief movements and precise formations at CCTV’s popular Spring Festival Gala.While showcasing a fusion of cutting-edge technology and traditional culture,the performance also brought China’s humanoid development into the spotlight.展开更多
Brain-inspired intelligence is considered to be a computational model with the most promising potential to overcome the shortcomings of the von Neumann architecture,making it a current research hotspot.Due to advantag...Brain-inspired intelligence is considered to be a computational model with the most promising potential to overcome the shortcomings of the von Neumann architecture,making it a current research hotspot.Due to advantages such as nonvolatility,high density,low power consumption,and high response ratio,memristors are regarded as devices with promising applications in brain-inspired intelligence.This paper proposes a physical Ag/HfO_(x)/FeO_(x)/Pt memristor model.The Ag/HfO_(x)/FeO_(x)/Pt memristor is first fabricated using magnetron sputtering,and its internal principles and characteristics are then thoroughly analyzed.Furthermore,we construct a corresponding physical memristor model which achieves a simulation accuracy of up to 99.72%for the physical memristor.We design a fully functional Pavlovian associative memory circuit,realizing functions including generalization,primary differentiation,secondary differentiation,and forgetting.Finally,the circuit is validated through PSPICE simulation and analysis.展开更多
With the booming of Industrial Internet of Things(IIoT)and Artificial Intelligence(AI),the objective of the work in Cai et al.(2022)is to explore the utilizing of data-driven methodology for the prediction of the burs...With the booming of Industrial Internet of Things(IIoT)and Artificial Intelligence(AI),the objective of the work in Cai et al.(2022)is to explore the utilizing of data-driven methodology for the prediction of the burst strength of cor‐roded pipelines,which can hopefully overcome the com‐mon drawbacks of widely-used traditional Finite Element Method(FEM)and the needs of sufficient domain knowl‐edge.The authors in Cai et al.(2022)are not aiming to overthrow the functionality and beneficence introduced by physical-based methods and widely-used empirical/semi-emprical engineering expressions,such as the DNV standars(DNVGL,2017)in offshore engineering.展开更多
Last year marked the golden jubilee of Malaysia-China diplomatic relations—a milestone that underscored the enduring friendship and collaboration between the two nations.Over the past five decades,Malaysia and China ...Last year marked the golden jubilee of Malaysia-China diplomatic relations—a milestone that underscored the enduring friendship and collaboration between the two nations.Over the past five decades,Malaysia and China have overcome many challenges together,fostering strong bilateral ties built on mutual respect,economic cooperation,cultural exchange,and shared aspirations for regional peace and prosperity.展开更多
On July 10,2025,General Secretary of the Communist Party of China(CPC)Central Committee Xi Jinping,also the President of the People’s Republic of China,sent a congratulatory letter to the Global Civilizations Dialogu...On July 10,2025,General Secretary of the Communist Party of China(CPC)Central Committee Xi Jinping,also the President of the People’s Republic of China,sent a congratulatory letter to the Global Civilizations Dialogue Ministerial Meeting.Xi pointed out that amidst intertwined global transformations and uncertainties,humanity stands at a new crossroads,urgently requiring transcending civilizational estrangement through exchanges and overcoming civilizational clashes through mutual learning.展开更多
The year 2024 marks the tenth anniversary of General Secretary Xi Jinping’s proposal for a new energy security strategy and the start of the second decade of the Belt and Road Initiative.During this year,the internat...The year 2024 marks the tenth anniversary of General Secretary Xi Jinping’s proposal for a new energy security strategy and the start of the second decade of the Belt and Road Initiative.During this year,the international situation grew increasingly complex,with intensifying rivalries among major powers and sporadic occurrences of geopolitical conflicts and localized disturbances.CNPC’s international operations focus on maintaining stability while making progress,successfully overcoming various intertwined risks and achieving new milestones in international business development.For six consecutive years,the overseas equity production has maintained an equivalent of 100 million tons.International trade has achieved stable progress,and engineering services have made new breakthroughs in market expansion,contributing new momentum to CNPC’s establishment as a world-class enterprise.展开更多
Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental p...Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental protection and resource recycling in bismuth smelting.It’s learned that the company recovers up to100,000 tons of bismuth-containing lead-展开更多
The superresolution microscopy that broadens the detection range in the spatial frequency domain through the spatialfrequency-shift(SFS)effect[1-5]shows intriguing advantages including a large field of view,high speed...The superresolution microscopy that broadens the detection range in the spatial frequency domain through the spatialfrequency-shift(SFS)effect[1-5]shows intriguing advantages including a large field of view,high speed,and good modularity.Significantly,it captures pictures in the wide-field mode and allows a universal implementation without using special fluorophores labeling.To enable the sub-diffraction resolution in the SFS microscopy,it is essential to use the evanescent wave illumination with a large wave vector,which can be built on the integrated photonic configuration,paving the way for a compact nanoscopy on a thin chip[6-8].However,the lack of an approach to actively tune the SFS value in a large range hampers the progress to achieve deep-subwavelength resolution through evanescent illumination with ultra-large wave vectors.When the wave vector of the illumination surpasses twice the cutoff frequency of the objective,a missing band exists between the shifted components and the zeroth component in the spatial frequency domain,which causes severe artifacts and a distortion in the image.As a result,the resolution of current linear SFS microscopy has been restricted less than thrice the Abbe diffraction limit of the detection system.展开更多
The key pathogenesis of chronic myeloid leukemia(CML)is the formation of BCR-ABL fusion gene,encoding a 210 kDa Bcr-Abl tyrosine kinase,which is crucial for the occurrence and development of CML.Imatinib(IM)is the fir...The key pathogenesis of chronic myeloid leukemia(CML)is the formation of BCR-ABL fusion gene,encoding a 210 kDa Bcr-Abl tyrosine kinase,which is crucial for the occurrence and development of CML.Imatinib(IM)is the first targeted anticancer drug approved by FDA for the treatment of CML;however,some patients,especially those in accelerated phase and blastic phase,develop primary or secondary drug resistance to IM.Particularly,the most challenging resistance is caused by T315I mutation of Bcr-Abl,which represents approximately 15%–20%of all acquired mutations and renders cell resistant to a variety of tyrosine kinase inhibitors.1,2 Thus,there is an urgent need to develop novel strategies to overcome Bcr-Abl T315I-meidated IM resistance.展开更多
We regret that an error was made in“A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance”(Genes Dis 2019 Dec;694:419e430).In Fig.1C of the original manuscrip...We regret that an error was made in“A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance”(Genes Dis 2019 Dec;694:419e430).In Fig.1C of the original manuscript,the right panel(showing the migration ability of the MHCCLM3 cells)was erroneously duplicated with the left panel(showing the migration ability of the Huh7 cells)when the figures were assembled.We have now checked the original data and request to replace the right panel with the correct data for MHCCLM3 cells.The corrected Fig.展开更多
Osteoporosis,a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture,has led to a high risk of fatal osteoporotic fractures worldwide.Accumulating evidence has re...Osteoporosis,a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture,has led to a high risk of fatal osteoporotic fractures worldwide.Accumulating evidence has revealed that sexual dimorphism is a notable feature of osteoporosis,with sex-specific differences in epidemiology and pathogenesis.Specifically,females are more susceptible than males to osteoporosis,while males are more prone to disability or death from the disease.To date,sex chromosome abnormalities and steroid hormones have been proven to contribute greatly to sexual dimorphism in osteoporosis by regulating the functions of bone cells.Understanding the sex-specific differences in osteoporosis and its related complications is essential for improving treatment strategies tailored to women and men.This literature review focuses on the mechanisms underlying sexual dimorphism in osteoporosis,mainly in a population of aging patients,chronic glucocorticoid administration,and diabetes.Moreover,we highlight the implications of sexual dimorphism for developing therapeutics and preventive strategies and screening approaches tailored to women and men.Additionally,the challenges in translating bench research to bedside treatments and future directions to overcome these obstacles will be discussed.展开更多
Dear Editor, This letter is concerned with the evolution strategy for addressing multi-objective feature selection problems in classification. Previous methods suffer from limitations such as being trapped in local op...Dear Editor, This letter is concerned with the evolution strategy for addressing multi-objective feature selection problems in classification. Previous methods suffer from limitations such as being trapped in local optima and lacking stability. To overcome them, we propose a novel eliteguided mechanism based on information theory. Firstly, an elite solution is generated through a dimension reduction strategy and incorporated to the initialization population.展开更多
Intelligent and connected vehicles(ICVs)are confronted with critically complex traffic scenarios and safety challenges that have attracted increasing attention from academia and industry.The intelligent safety of ICVs...Intelligent and connected vehicles(ICVs)are confronted with critically complex traffic scenarios and safety challenges that have attracted increasing attention from academia and industry.The intelligent safety of ICVs involves several technologies and requires the common efforts of researchers and engineers,including the safety of the intended functionality(SOTIF),the safety of artificial intelligence,the intricacies of cybersecurity,and ethical dilemmas.Ensuring the intelligent safety of ICVs presents substantial chal-lenges in both research and commercialization,particularly SOTIF,which refers to the absence of unreasonable risk owing to hazards resulting from functional insufficiencies of the intended functiona-lity or reasonably foreseeable misuse by person.Because of the limited scene coverage ability of training samples and the practical application conditions without boundary restrictions,it is very dif-ficult to find the functional insufficiency of the intended function-ality and overcome it under dynamic unknown scenarios,which is also the source of SOTIF.展开更多
Precision medicine is a growing field worldwide.Despite its potential benefit to many patients,several major obstacles must be overcome before precision medicine can be more widely used in clinical practice.The main o...Precision medicine is a growing field worldwide.Despite its potential benefit to many patients,several major obstacles must be overcome before precision medicine can be more widely used in clinical practice.The main obstacles are associated with the quality of samples used for genomic analysis。展开更多
The obligate biotrophic basidiomycete fungus Puccinia striformis f.sp.tritici(Pst)is the causative agent of wheat stripe(yellow)rust,a disease that results in severe damage to global wheat production(Chen and Kang,201...The obligate biotrophic basidiomycete fungus Puccinia striformis f.sp.tritici(Pst)is the causative agent of wheat stripe(yellow)rust,a disease that results in severe damage to global wheat production(Chen and Kang,2017).This pathogen has a mixed reproductive mode encompassing both asexual and sexual reproduction.The asexual stage is accomplished by reinfecting wheat with urediniospores,while the sexual cycle involves five different spore types and two phylogenetically unrelated plant hosts wheat,which is the primary host,and barberry,which is the alternate host(Zhao et al.,2016).This extremely complex lifecycle facilitates large genetic variation among Pst populations,which is conducive to the emergence of new virulent races that can overcome wheat resistance genes,resulting in epidemics(Chen and Kang,2017).Secreted effector proteins,the key virulence factors in fungal pathogens,can not only suppress plant immune systems but also trigger host immune responses following recognition by plant receptors(Toruno et al.,2016).展开更多
The detection and localization of bone joint regions in medical X-ray images are essential for contemporary medical diagnostics.Traditional methods rely on subjective interpretation by physicians,leading to variabilit...The detection and localization of bone joint regions in medical X-ray images are essential for contemporary medical diagnostics.Traditional methods rely on subjective interpretation by physicians,leading to variability and potential errors.Automated bone joint detection techniques have become feasible with advancements in general-purpose object detection.However,applying these algorithms to X-ray images faces challenges due to the domain gap.To overcome these challenges,a novel framework called effective and efficient network(EAE-Net)is proposed.It incorporates a context augment module(CAM)to leverage global structural information and a ghost bottleneck module(GBM)to reduce redundant features.The EAE-Net model achieves exceptional detection performance,striking a balance between accuracy and speed.This advancement improves efficiency,enabling clinicians to focus on critical aspects of diagnosis and treatment.展开更多
This paper proposes a method for learning background restoration for infrared small target detection,employing a local sparse dictionary alongside an equalized structural texture representation.The method is specifica...This paper proposes a method for learning background restoration for infrared small target detection,employing a local sparse dictionary alongside an equalized structural texture representation.The method is specifically designed for the detection of small infrared targets,accommodating various levels of brightness,spatial size,and intensity.Our proposed model intelligently combines global low-rankness and local sparsity to estimate the rank of the background tensor,leveraging spatial and structural information to overcome the limitations posed by insufficient detailed texture knowledge.Subsequently,a structural texture representation,combining local gradient maps and local intensity maps,is applied to emphasize small objects.By comparing our method with nine advanced and representative approaches and quantifying the comparison using various metrics,the experimental results indicate that our proposed method has achieved favorable outcomes in both quantitative assessments and visual results.展开更多
基金supported by the Natural Scientific Foundation of Zhejiang Province,China (No.LTGY23H160007).
文摘Epidermal growth factor receptor(EGFR)-positive nonsmall cell lung cancer is a dynamic entity,with tumor progression and resistance to tyrosine kinase inhibitors(TKls)stemming from the accumulation of mutations over time and across different disease sites,leading to temporal and spatial heterogeneity.
基金supported by National Natural Science Foundation of China(22175193,22261132517,22108286),QIBEBT(S202306)Shandong Provincial Natural Science Foundation(ZR2021MB058).
文摘Propylene is an important feedstock for polymer production.The greater abundance of propane in shale gas has led to a switch in the industrial feedstocks for propylene from naphtha to propane[1].Catalytic dehydrogenation of propane can convert propane directly into propylene in a distributed fashion and fills the so-called propylene supply gap in steam cracking process of ethane.
文摘Apical microsurgery is accurate and minimally invasive,produces few complications,and has a success rate of more than 90%.However,due to the lack of awareness and understanding of apical microsurgery by dental general practitioners and even endodontists,many clinical problems remain to be overcome.The consensus has gathered well-known domestic experts to hold a series of special discussions and reached the consensus.This document specifies the indications,contraindications,preoperative preparations,operational procedures,complication prevention measures,and efficacy evaluation of apical microsurgery and is applicable to dentists who perform apical microsurgery after systematic training.
文摘A group of 16 humanoid robots,developed by Chinese startup Unitree Robotics,wore folkloric jackets and performed the traditional yangge dance with fluid handkerchief movements and precise formations at CCTV’s popular Spring Festival Gala.While showcasing a fusion of cutting-edge technology and traditional culture,the performance also brought China’s humanoid development into the spotlight.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62476230 and 61976246)the Natural Science Foundation of Chongqing(Grant No.CSTB2023NSCQ-MSX0018)Fundamental Research Funds for the Central Universities(Grant No.SWUKR22046)。
文摘Brain-inspired intelligence is considered to be a computational model with the most promising potential to overcome the shortcomings of the von Neumann architecture,making it a current research hotspot.Due to advantages such as nonvolatility,high density,low power consumption,and high response ratio,memristors are regarded as devices with promising applications in brain-inspired intelligence.This paper proposes a physical Ag/HfO_(x)/FeO_(x)/Pt memristor model.The Ag/HfO_(x)/FeO_(x)/Pt memristor is first fabricated using magnetron sputtering,and its internal principles and characteristics are then thoroughly analyzed.Furthermore,we construct a corresponding physical memristor model which achieves a simulation accuracy of up to 99.72%for the physical memristor.We design a fully functional Pavlovian associative memory circuit,realizing functions including generalization,primary differentiation,secondary differentiation,and forgetting.Finally,the circuit is validated through PSPICE simulation and analysis.
文摘With the booming of Industrial Internet of Things(IIoT)and Artificial Intelligence(AI),the objective of the work in Cai et al.(2022)is to explore the utilizing of data-driven methodology for the prediction of the burst strength of cor‐roded pipelines,which can hopefully overcome the com‐mon drawbacks of widely-used traditional Finite Element Method(FEM)and the needs of sufficient domain knowl‐edge.The authors in Cai et al.(2022)are not aiming to overthrow the functionality and beneficence introduced by physical-based methods and widely-used empirical/semi-emprical engineering expressions,such as the DNV standars(DNVGL,2017)in offshore engineering.
文摘Last year marked the golden jubilee of Malaysia-China diplomatic relations—a milestone that underscored the enduring friendship and collaboration between the two nations.Over the past five decades,Malaysia and China have overcome many challenges together,fostering strong bilateral ties built on mutual respect,economic cooperation,cultural exchange,and shared aspirations for regional peace and prosperity.
文摘On July 10,2025,General Secretary of the Communist Party of China(CPC)Central Committee Xi Jinping,also the President of the People’s Republic of China,sent a congratulatory letter to the Global Civilizations Dialogue Ministerial Meeting.Xi pointed out that amidst intertwined global transformations and uncertainties,humanity stands at a new crossroads,urgently requiring transcending civilizational estrangement through exchanges and overcoming civilizational clashes through mutual learning.
文摘The year 2024 marks the tenth anniversary of General Secretary Xi Jinping’s proposal for a new energy security strategy and the start of the second decade of the Belt and Road Initiative.During this year,the international situation grew increasingly complex,with intensifying rivalries among major powers and sporadic occurrences of geopolitical conflicts and localized disturbances.CNPC’s international operations focus on maintaining stability while making progress,successfully overcoming various intertwined risks and achieving new milestones in international business development.For six consecutive years,the overseas equity production has maintained an equivalent of 100 million tons.International trade has achieved stable progress,and engineering services have made new breakthroughs in market expansion,contributing new momentum to CNPC’s establishment as a world-class enterprise.
文摘Recent information about Jinwang Bismuth Industrial reveals that the company has developed the world’s first oxygen-rich sideblown redox duplex furnace technology,solving the long-standing problems of environmental protection and resource recycling in bismuth smelting.It’s learned that the company recovers up to100,000 tons of bismuth-containing lead-
文摘The superresolution microscopy that broadens the detection range in the spatial frequency domain through the spatialfrequency-shift(SFS)effect[1-5]shows intriguing advantages including a large field of view,high speed,and good modularity.Significantly,it captures pictures in the wide-field mode and allows a universal implementation without using special fluorophores labeling.To enable the sub-diffraction resolution in the SFS microscopy,it is essential to use the evanescent wave illumination with a large wave vector,which can be built on the integrated photonic configuration,paving the way for a compact nanoscopy on a thin chip[6-8].However,the lack of an approach to actively tune the SFS value in a large range hampers the progress to achieve deep-subwavelength resolution through evanescent illumination with ultra-large wave vectors.When the wave vector of the illumination surpasses twice the cutoff frequency of the objective,a missing band exists between the shifted components and the zeroth component in the spatial frequency domain,which causes severe artifacts and a distortion in the image.As a result,the resolution of current linear SFS microscopy has been restricted less than thrice the Abbe diffraction limit of the detection system.
基金This work was supported by NSFC,China(No.82170177/H0809,and 81670154/H0812)Projects(No.2020KTSCX10,and 2021A1515011334)from the Foundation of Innovation Projects of General Colleges and Universities in Guangdong Province and GD-NSF,China,KeyDiscipline of Guangzhou Education Bureau(Basic Medicine)(No.201851839),Chinathe project(No.202201010811)from the Foundation of Guangzhou Science and Technology Innovation Committee,China to XS.
文摘The key pathogenesis of chronic myeloid leukemia(CML)is the formation of BCR-ABL fusion gene,encoding a 210 kDa Bcr-Abl tyrosine kinase,which is crucial for the occurrence and development of CML.Imatinib(IM)is the first targeted anticancer drug approved by FDA for the treatment of CML;however,some patients,especially those in accelerated phase and blastic phase,develop primary or secondary drug resistance to IM.Particularly,the most challenging resistance is caused by T315I mutation of Bcr-Abl,which represents approximately 15%–20%of all acquired mutations and renders cell resistant to a variety of tyrosine kinase inhibitors.1,2 Thus,there is an urgent need to develop novel strategies to overcome Bcr-Abl T315I-meidated IM resistance.
文摘We regret that an error was made in“A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance”(Genes Dis 2019 Dec;694:419e430).In Fig.1C of the original manuscript,the right panel(showing the migration ability of the MHCCLM3 cells)was erroneously duplicated with the left panel(showing the migration ability of the Huh7 cells)when the figures were assembled.We have now checked the original data and request to replace the right panel with the correct data for MHCCLM3 cells.The corrected Fig.
基金the National Natural Science Foundation of China (Grants 82170844 and 82270613)the Sichuan Science and Technology Program (Grants 2022YFH0045 and 2022YFH0102)+5 种基金the 111 Project (Grant B18035)the 1·3·5 project for Disciplines of Excellence at West China Hospital, Sichuan University (Grant ZYGD22007 and ZYJC21004)Ningbo Top Medical and Health Research Program (No.2023030514)Ningbo Medical and Health Brand Discipline (Grant No.PPXK2018–02)Ningbo Clinical Research Center for Otolaryngology Head and Neck Disease (Grant No.2022L005)the Ministry of Education, Singapore, (Grant MOE-000395-00) to LYC.
文摘Osteoporosis,a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture,has led to a high risk of fatal osteoporotic fractures worldwide.Accumulating evidence has revealed that sexual dimorphism is a notable feature of osteoporosis,with sex-specific differences in epidemiology and pathogenesis.Specifically,females are more susceptible than males to osteoporosis,while males are more prone to disability or death from the disease.To date,sex chromosome abnormalities and steroid hormones have been proven to contribute greatly to sexual dimorphism in osteoporosis by regulating the functions of bone cells.Understanding the sex-specific differences in osteoporosis and its related complications is essential for improving treatment strategies tailored to women and men.This literature review focuses on the mechanisms underlying sexual dimorphism in osteoporosis,mainly in a population of aging patients,chronic glucocorticoid administration,and diabetes.Moreover,we highlight the implications of sexual dimorphism for developing therapeutics and preventive strategies and screening approaches tailored to women and men.Additionally,the challenges in translating bench research to bedside treatments and future directions to overcome these obstacles will be discussed.
基金supported in part by the Japan Society for the Promotion of Science (JSPS) KAKENHI (JP22H 03643)the Japan Science and Technology Agency (JST) (the establishment of university fellowships towards the creation of science technology innovation) (JPMJFS2115)。
文摘Dear Editor, This letter is concerned with the evolution strategy for addressing multi-objective feature selection problems in classification. Previous methods suffer from limitations such as being trapped in local optima and lacking stability. To overcome them, we propose a novel eliteguided mechanism based on information theory. Firstly, an elite solution is generated through a dimension reduction strategy and incorporated to the initialization population.
文摘Intelligent and connected vehicles(ICVs)are confronted with critically complex traffic scenarios and safety challenges that have attracted increasing attention from academia and industry.The intelligent safety of ICVs involves several technologies and requires the common efforts of researchers and engineers,including the safety of the intended functionality(SOTIF),the safety of artificial intelligence,the intricacies of cybersecurity,and ethical dilemmas.Ensuring the intelligent safety of ICVs presents substantial chal-lenges in both research and commercialization,particularly SOTIF,which refers to the absence of unreasonable risk owing to hazards resulting from functional insufficiencies of the intended functiona-lity or reasonably foreseeable misuse by person.Because of the limited scene coverage ability of training samples and the practical application conditions without boundary restrictions,it is very dif-ficult to find the functional insufficiency of the intended function-ality and overcome it under dynamic unknown scenarios,which is also the source of SOTIF.
基金the Japan Agency for Medical Research and Development(Grant Nos.20lk0201002j0001,21lk0201005j0001,and 22lk0201007j0001)。
文摘Precision medicine is a growing field worldwide.Despite its potential benefit to many patients,several major obstacles must be overcome before precision medicine can be more widely used in clinical practice.The main obstacles are associated with the quality of samples used for genomic analysis。
基金the National Key Research and Development Program of China(2021YFD1401001)Shaanxi Province Postdoctoral Science Foundation(2023BSHEDZZ121)the National"111 plan"of China(BP0719026).
文摘The obligate biotrophic basidiomycete fungus Puccinia striformis f.sp.tritici(Pst)is the causative agent of wheat stripe(yellow)rust,a disease that results in severe damage to global wheat production(Chen and Kang,2017).This pathogen has a mixed reproductive mode encompassing both asexual and sexual reproduction.The asexual stage is accomplished by reinfecting wheat with urediniospores,while the sexual cycle involves five different spore types and two phylogenetically unrelated plant hosts wheat,which is the primary host,and barberry,which is the alternate host(Zhao et al.,2016).This extremely complex lifecycle facilitates large genetic variation among Pst populations,which is conducive to the emergence of new virulent races that can overcome wheat resistance genes,resulting in epidemics(Chen and Kang,2017).Secreted effector proteins,the key virulence factors in fungal pathogens,can not only suppress plant immune systems but also trigger host immune responses following recognition by plant receptors(Toruno et al.,2016).
基金supported by the National Key R&D Program of China(No.2018YFB1307802)the Tianjin Science and Technology Plan Project(No.18PTLCSY00070)。
文摘The detection and localization of bone joint regions in medical X-ray images are essential for contemporary medical diagnostics.Traditional methods rely on subjective interpretation by physicians,leading to variability and potential errors.Automated bone joint detection techniques have become feasible with advancements in general-purpose object detection.However,applying these algorithms to X-ray images faces challenges due to the domain gap.To overcome these challenges,a novel framework called effective and efficient network(EAE-Net)is proposed.It incorporates a context augment module(CAM)to leverage global structural information and a ghost bottleneck module(GBM)to reduce redundant features.The EAE-Net model achieves exceptional detection performance,striking a balance between accuracy and speed.This advancement improves efficiency,enabling clinicians to focus on critical aspects of diagnosis and treatment.
基金supported by the National Natural Science Foundation of China(No.62072256).
文摘This paper proposes a method for learning background restoration for infrared small target detection,employing a local sparse dictionary alongside an equalized structural texture representation.The method is specifically designed for the detection of small infrared targets,accommodating various levels of brightness,spatial size,and intensity.Our proposed model intelligently combines global low-rankness and local sparsity to estimate the rank of the background tensor,leveraging spatial and structural information to overcome the limitations posed by insufficient detailed texture knowledge.Subsequently,a structural texture representation,combining local gradient maps and local intensity maps,is applied to emphasize small objects.By comparing our method with nine advanced and representative approaches and quantifying the comparison using various metrics,the experimental results indicate that our proposed method has achieved favorable outcomes in both quantitative assessments and visual results.
