Cell cultured meat has been extensively studied as an environmentally friendly,energy-saving and more effective technology.However,there are many technical bottlenecks,especially the regulatory mechanism and manufactu...Cell cultured meat has been extensively studied as an environmentally friendly,energy-saving and more effective technology.However,there are many technical bottlenecks,especially the regulatory mechanism and manufacturing method of in vitro myogenesis.Based on an edible modified silk protein scaffold,with 3D culturing,in situ differentiated and transcriptome analysis,this study describes novel scaffolds and fabrication methods for cell cultured meat.The results showed that the effective space and utilization efficiency for cell culture of the scaffold is 26–1000 that of the traditional culture dish;it could form a tissue-like structure.Transcriptomics revealed the regulatory pathways and key factors of different cycles.It clarifies that the multi-cycle process of myoblast myogenesis in vitro is different from the single feedback regulation in vivo.More importantly,a novel scaffold-based cell cultured meat manufacturing method was developed,further develop a new tissue culture solution that is different from existing cell culture meat production.For manufacturing processes,it provides a new cell culture meat technology system,provides a theoretical basis for the regulation of cell proliferation and muscle growth,and lays the technical foundation for in situ tissue culture of cell cultured meat in vitro.展开更多
This paper addresses some of the requirements of the advance organizers and prediction activities for DDL(Data-Driv en Learning) based on multi-modal corpora for learning English as a second language.It analyzes preli...This paper addresses some of the requirements of the advance organizers and prediction activities for DDL(Data-Driv en Learning) based on multi-modal corpora for learning English as a second language.It analyzes preliminary advantages and dis advantages of using multi-modal corpora for DDL and focuses on key methodological issues related to self-guided learning and corpus operation.Pedagogical suggestions are provided on how to make the multi-modal corpora based DDL engaging in accor dance with Krashen' s Language Input Hypothesis with the assistance of advance organizers and prediction activities.展开更多
With the development of online social networks,a special group of online users named organized posters(or Internet water army,Internet paid posters in some literatures) have fl ooded the social network communities. Th...With the development of online social networks,a special group of online users named organized posters(or Internet water army,Internet paid posters in some literatures) have fl ooded the social network communities. They are organized in groups to post with specific purposes and sometimes even confuse or mislead normal users.In this paper,we study the individual and group characteristics of organized posters. A classifier is constructed based on the individual and group characteristics to detect them. Extensive experimental results on three real datasets demonstrate that our method based on individual and group characteristics using SVM model(IGCSVM) is effective in detecting organized posters and better than existing methods. We take a first look at finding the promoters based on the detected organized posters of our IGCSVM method. Our experiments show that it is effective in detecting promoters.展开更多
BACKGROUND Complicated cataract surgery is challenging,especially in cases of hard nuclear cataract with severe anterior capsule organization.It is important to avoid the risk of surgery and improve the surgical skill...BACKGROUND Complicated cataract surgery is challenging,especially in cases of hard nuclear cataract with severe anterior capsule organization.It is important to avoid the risk of surgery and improve the surgical skills of surgeons.CASE SUMMARY A 60-year-old man presented with severe cataract and visual impairment.The anterior capsule of the lens was irregularly organized and pulled to the surrounding capsule,and white porcelain organized cord and brown-black lens nucleus were clearly visible.In phacoemulsification,maintaining the anterior capsule round and intact plays a key role in a successful surgery.In this case,if the conventional capsule treatment method was used,the anterior capsule would be torn.Therefore,we adopted a segmented anterior capsule treatment method,and a blasting method to release energy when dealing with the lens nucleus,and achieved good surgical results.CONCLUSION Complicated cataract surgery is challenging and requires precise skills.Operation plans should be made reasonably to predict the risk of surgery,and improve the visual quality of the patients.展开更多
The author puts forward the proposition of Complexity and Self Organized Criticality of Solid Earth System in the light of: (1) the science of complexity studies the mechanisms of emergence of complexity and is...The author puts forward the proposition of Complexity and Self Organized Criticality of Solid Earth System in the light of: (1) the science of complexity studies the mechanisms of emergence of complexity and is the science of the 21st century, (2) the study of complexity of the earth system would be one of the growing points occupying a strategic position in the development of geosciences in the 21st century. By the proposition we try to cogitate from a new viewpoint the ancient yet ever new solid earth system. The author abstracts the fundamental problem of the solid earth system from the essence of the generalized geological systems and processes which reads: the complexity and self organized criticality of the global nature, structure and dynamical behavior of the whole solid earth system emerging from the multiple coupling and superposition of non linear interactions among the multicomponents of the earths material and the multiple generalized geological (geological, geophysical, and geochemical) processes . Starting from this cognizance the author proposes eight major themes and the methodology of researches on the complexity and self organized criticality of the solid earth system.展开更多
The dynamical behavior in the cortical brain network of macaque is studied by modelling each cortical areawith a subnetwork of interacting excitable neurons.We find that the avalanche of our model on different levels ...The dynamical behavior in the cortical brain network of macaque is studied by modelling each cortical areawith a subnetwork of interacting excitable neurons.We find that the avalanche of our model on different levels exhibitspower-law.Furthermore the power-law exponent of the distribution and the average avalanche size are affected by thetopology of the network.展开更多
Xenopus organizer specific gene Noggin possessesnearly all the characterestic properties of the action of or-ganizer to specify the embryonic body axis. To analyzehow the maternal inherited factors cofltrol its expres...Xenopus organizer specific gene Noggin possessesnearly all the characterestic properties of the action of or-ganizer to specify the embryonic body axis. To analyzehow the maternal inherited factors cofltrol its expressionpattern, we cloned the 5’ regulatory region of noggn gene.The 1.5 kb upstream sequense could direct reporter geneto express in vivo and data from deletion analysis indi-cated that a 229 base pair fragmet is essential for acti-vating noggn expression. We further demonstrated thatthe response elements within this regulatory region wereindeed under the control of growth factor activin and Wntsignaling pathway components.展开更多
Dear Editor,The timing of spiking activity across neurons is believed to play an important role in information coding in brain circuits1[1].At the cellular level,neurons can fire spikes with millisecond precision and ...Dear Editor,The timing of spiking activity across neurons is believed to play an important role in information coding in brain circuits1[1].At the cellular level,neurons can fire spikes with millisecond precision and the relative timing of pre-and postsynaptic spikes can determine the direction and extent of synaptic modification[2].When such spike-timing-dependent plasticity(STDP)and other physiological and anatomical properties are implemented in theoretical models,the simulated networks of interconnected spiking neurons exhibit neuronal groups with stereotypical time-locked spatiotemporal firing patterns with millisecond temporal precision[3].展开更多
The origin of power-law distributions in self-organized criticality is investigated by treating the variation of the number of active sites in the system as a stochastic process. An avalanche is then regarded as a fir...The origin of power-law distributions in self-organized criticality is investigated by treating the variation of the number of active sites in the system as a stochastic process. An avalanche is then regarded as a first-return random walk process in a one-dimensional lattice. We assume that the variation of the number of active sites has three possibilities in each update： to increase by 1 with probability f1, to decrease by 1 with probability f2, or remain unchanged with probability 1 - f1 - f2. This mimics the dynamics in the system. Power-law distributions of the lifetime are found when the random walk is unbiased with equal probability to move in opposite directions. This shows that power-law distributions in self-organized criticality may be caused by the balance of competitive interactions.展开更多
The present work studied the application of AgNOR count to differential diagnosis between cutaneous T cell lymphoma (CTCL) and cutaneous pseudolymphoma (CPL). Paraffin sections from 50 mycosis fungoides (22 MFI-Premyc...The present work studied the application of AgNOR count to differential diagnosis between cutaneous T cell lymphoma (CTCL) and cutaneous pseudolymphoma (CPL). Paraffin sections from 50 mycosis fungoides (22 MFI-Premycotic stage, 24 MF Ⅰ infiltrative stage and 4 MF Ⅲ - tumor stage), 2 nonepidermotropic cutaneous T cell lymphoma (NECTCL) and 9 CPL were investigated. In each case, 200 cells randomly selected were examined using a × 100 oil immersion lens. The mean number, standard deviation and standard error of the mean of AgNOR counts were as follows: MFⅠ 1.17±0.09, SEM = 0.01; MⅡ 1.17±0.01, SEM = 0.01; MF Ⅲ. 3.55±0.87, SEM = 0.43; NECTCL 4.5±0.28, SEM -0.199; CPL 1.17±0.1, SEM ± 0.03. The results revealed a highly significant difference between CTCL (MFⅢ+NECTCL) and CPL (t = 4.75, P<0.001), tumor stage (MF Ⅲ) and pretumor stage (MFI, MF Ⅱ) of mycosis fungoides (t = 4.75, P<0.001). Thus. AgNOR count is valuable in differential diagnosis.展开更多
The cooperative evolutionary stability under self-organized organization is discussed in this paper. The differences between the objects studied by cooperative game theory and the ones studied by cooperative game in s...The cooperative evolutionary stability under self-organized organization is discussed in this paper. The differences between the objects studied by cooperative game theory and the ones studied by cooperative game in science ＆ technology alliance are analyzed. The mutant probability of agent＇s utility under endoge- nous technical factor condition is analyzed. By clarifying the connotation of Pareto-dominate institution in cooperative game, the efficient and feasible managerial definition of Pareto-dominate Institution in science ＆ technology alliance is presented. The evolutionarily cooperative game for the agent in Pareto-dominate institution is explained. And then the necessary condition of cooperative evolutionary stabilization based on multi-agent utility＇s dynamic equilibrium is put forward. Finally, the model of alliance＇s utility＇s dynamic equilibrium under self-organization is established.展开更多
The effect of a self-organized SiNs interlayer on the defect density of （1122） semipolar GaN grown on 7n-plane sapphire is studied by transmission electron microscopy, atomic force microscopy and high resolution x-r...The effect of a self-organized SiNs interlayer on the defect density of （1122） semipolar GaN grown on 7n-plane sapphire is studied by transmission electron microscopy, atomic force microscopy and high resolution x-ray diffrac- tion. The SiNx interlayer reduces the c-type dislocation density from 2.5 ×10^10 cm^-2 to 5 ×10^8 cm 2. The SiNx interlayer produces regions that are free from basal plane stacking faults （BSFs） and dislocations. The overall BSF density is reduced from 2.1×10^5 cm-1 to 1.3×10^4 cm^-1. The large dislocations and BSF reduction in semipolar （1122） GaN with the SiNx, interlayer result from two primary mechanisms. The first mechanism is the direct dislocation blocking by the SiNx interlayer, and the second mechanism is associated with the unique structure character of （1122） semipolar GaN.展开更多
Taking its development in Baoding City as an example, we introduced service fields of rural cooperative economic organized united association. It mainly includes setting up service platform and providing scientific an...Taking its development in Baoding City as an example, we introduced service fields of rural cooperative economic organized united association. It mainly includes setting up service platform and providing scientific and technological services; organizing economic and trade negotiation and exchange, and promoting farmer-supermarket partnership; providing financial services and solving fund-raising problems. In line with these fields, we analyzed existing problems: (i) regional development is unbalanced and organization lacks internal connection; (ii) the development in some counties (cities) is to be improved, and the promotion effect is not significant; (iii) there is shortage of talent and the innovation strength is not enough; and (iv) it lacks system and management lacks restriction mechanism. Finally, we put forward countermeasures and recommendations: strengthen propaganda and cultivate farmers' cooperative awareness; incorporate rural cooperative economic organized united association into formal system arrangement, and absorb professional talents; innovate upon organization system of rural cooperative economic organized united association and improve service methods; improve internal operating mechanism and innovate upon working contents of rural cooperative economic organized united association at new development background.展开更多
Objective： To evaluate the relation between argyrophilic nucleolar organizer region （AgNOR）-associated proteins and clinicopathological parameters and survival in non-small-cell lung cancer （NSCLC）. Methods： A t...Objective： To evaluate the relation between argyrophilic nucleolar organizer region （AgNOR）-associated proteins and clinicopathological parameters and survival in non-small-cell lung cancer （NSCLC）. Methods： A total of 207 surgical specimens diagnosed as NSCLC were included in this study. Double-staining procedures were performed using antigen Ki-67 （clone MIB-1） and silver nitrate by immunohistochemical and AgNOR-staining methods. Results： The AgNOR area in MIB-l-positive cells of NSCLC is related to clinicopathological parameters under the TNM （tumor, node, and metastasis） system. The survival of patients with small AgNOR area in MIB-1-positive cells is better than that of patients with large AgNOR area. Molecular, biological （AgNOR area in MIB-l-positive cells）, and clinicopathological （greatest tumor dimension, metastases to regional lymph nodes, histology, and differentiation） parameters are independent prognostic factors of NSCLC.Conclusion： The AgNOR area in MIB- 1-positive cells is related to clinicopathological parameters and survival in NSCLC.展开更多
The argyrophil method for nucleolar organizer regions (AgNOR) known as the AgNor technique and mucin histochemical stain were applied to Investigate the dysplasia and cancaration in ulcerative colitis Including 58 cas...The argyrophil method for nucleolar organizer regions (AgNOR) known as the AgNor technique and mucin histochemical stain were applied to Investigate the dysplasia and cancaration in ulcerative colitis Including 58 cases of biopsy specimens and three cases operative specimens. The numbers of AgNOR have been gradully increased with the grades of dasplasls. Similarly the percentage of sialomucin having vicinal diols on side chain of sialic acid also gradully Increased with the grades of dysplasia. The AgNOR reflects rDNA transcriptional activity responsible for degrees of differentiation of cell. Epithelial cells secreting a heterogeneous mucin, could be taken as a signal of abnormal cellular differentiation. AgNOR and mucln chages might be assumed as a criteria In representing malignant transformation.展开更多
Criminal networks erode the legitimacy of democratic politics, affecting regions as diverse as Latin America （Briscoe, Perdomo, ＆ Uribe Burcher, 2014）, the Baltic States （Villaveces-Izquierdo ＆ Uribe Burcher, 201...Criminal networks erode the legitimacy of democratic politics, affecting regions as diverse as Latin America （Briscoe, Perdomo, ＆ Uribe Burcher, 2014）, the Baltic States （Villaveces-Izquierdo ＆ Uribe Burcher, 2013）, and West Africa （Aning ＆ Edu-Afful, 2013a; 2013b）. Contemporary research on this topic describes various factors that might increase the vulnerability of political actors, institutions, and processes to organized crime （Uribe Burcher, 2017）. In addition, there is a need to identify strategies to strengthen those political actors, institutions, and processes, making them resilient against criminal influence. Drawing from extensive field research conducted in Latin America, Africa, and West Asia in 2015-2016 （Perdomo ＆ Uribe Burcher, 2016; Hunter ＆ Reitano, 2016; Briscoe ＆ Goff, 2016a; 2016b）, as well as additional desk research conducted during the same period, this paper maps a set of 28 actions that may increase these institutions＇ and actors＇ resilience to the influence of organized crime networks based on documented global experiences implementing such measures. The paper also reflects some of the findings from a pilot experience to assess the threat of nexus between organized crime in democratic politics in Peru conducted in 2015-2016, which used some of the proposed action points to build a prevention and mitigation plan.展开更多
基金funded under the National key research and development plan(2021YFC2101404)Chinese Academy of Engineering Strategic Research and Consulting Project(2023-XZ-79,2022-30-19).
文摘Cell cultured meat has been extensively studied as an environmentally friendly,energy-saving and more effective technology.However,there are many technical bottlenecks,especially the regulatory mechanism and manufacturing method of in vitro myogenesis.Based on an edible modified silk protein scaffold,with 3D culturing,in situ differentiated and transcriptome analysis,this study describes novel scaffolds and fabrication methods for cell cultured meat.The results showed that the effective space and utilization efficiency for cell culture of the scaffold is 26–1000 that of the traditional culture dish;it could form a tissue-like structure.Transcriptomics revealed the regulatory pathways and key factors of different cycles.It clarifies that the multi-cycle process of myoblast myogenesis in vitro is different from the single feedback regulation in vivo.More importantly,a novel scaffold-based cell cultured meat manufacturing method was developed,further develop a new tissue culture solution that is different from existing cell culture meat production.For manufacturing processes,it provides a new cell culture meat technology system,provides a theoretical basis for the regulation of cell proliferation and muscle growth,and lays the technical foundation for in situ tissue culture of cell cultured meat in vitro.
文摘This paper addresses some of the requirements of the advance organizers and prediction activities for DDL(Data-Driv en Learning) based on multi-modal corpora for learning English as a second language.It analyzes preliminary advantages and dis advantages of using multi-modal corpora for DDL and focuses on key methodological issues related to self-guided learning and corpus operation.Pedagogical suggestions are provided on how to make the multi-modal corpora based DDL engaging in accor dance with Krashen' s Language Input Hypothesis with the assistance of advance organizers and prediction activities.
基金supported by 973 Program of China(Grant No.2013CB329601, 2013CB329602,2013CB329604)NSFC of China(Grant No.60933005,91124002)+1 种基金863 Program of China(Grant No.2012AA01A401, 2012AA01A402)National Key Technology RD Program of China(Grant No.2012BAH38B04, 2012BAH38B06)
文摘With the development of online social networks,a special group of online users named organized posters(or Internet water army,Internet paid posters in some literatures) have fl ooded the social network communities. They are organized in groups to post with specific purposes and sometimes even confuse or mislead normal users.In this paper,we study the individual and group characteristics of organized posters. A classifier is constructed based on the individual and group characteristics to detect them. Extensive experimental results on three real datasets demonstrate that our method based on individual and group characteristics using SVM model(IGCSVM) is effective in detecting organized posters and better than existing methods. We take a first look at finding the promoters based on the detected organized posters of our IGCSVM method. Our experiments show that it is effective in detecting promoters.
文摘BACKGROUND Complicated cataract surgery is challenging,especially in cases of hard nuclear cataract with severe anterior capsule organization.It is important to avoid the risk of surgery and improve the surgical skills of surgeons.CASE SUMMARY A 60-year-old man presented with severe cataract and visual impairment.The anterior capsule of the lens was irregularly organized and pulled to the surrounding capsule,and white porcelain organized cord and brown-black lens nucleus were clearly visible.In phacoemulsification,maintaining the anterior capsule round and intact plays a key role in a successful surgery.In this case,if the conventional capsule treatment method was used,the anterior capsule would be torn.Therefore,we adopted a segmented anterior capsule treatment method,and a blasting method to release energy when dealing with the lens nucleus,and achieved good surgical results.CONCLUSION Complicated cataract surgery is challenging and requires precise skills.Operation plans should be made reasonably to predict the risk of surgery,and improve the visual quality of the patients.
文摘The author puts forward the proposition of Complexity and Self Organized Criticality of Solid Earth System in the light of: (1) the science of complexity studies the mechanisms of emergence of complexity and is the science of the 21st century, (2) the study of complexity of the earth system would be one of the growing points occupying a strategic position in the development of geosciences in the 21st century. By the proposition we try to cogitate from a new viewpoint the ancient yet ever new solid earth system. The author abstracts the fundamental problem of the solid earth system from the essence of the generalized geological systems and processes which reads: the complexity and self organized criticality of the global nature, structure and dynamical behavior of the whole solid earth system emerging from the multiple coupling and superposition of non linear interactions among the multicomponents of the earths material and the multiple generalized geological (geological, geophysical, and geochemical) processes . Starting from this cognizance the author proposes eight major themes and the methodology of researches on the complexity and self organized criticality of the solid earth system.
基金National Natural Science Foundation of China under Grant No.10675060
文摘The dynamical behavior in the cortical brain network of macaque is studied by modelling each cortical areawith a subnetwork of interacting excitable neurons.We find that the avalanche of our model on different levels exhibitspower-law.Furthermore the power-law exponent of the distribution and the average avalanche size are affected by thetopology of the network.
文摘Xenopus organizer specific gene Noggin possessesnearly all the characterestic properties of the action of or-ganizer to specify the embryonic body axis. To analyzehow the maternal inherited factors cofltrol its expressionpattern, we cloned the 5’ regulatory region of noggn gene.The 1.5 kb upstream sequense could direct reporter geneto express in vivo and data from deletion analysis indi-cated that a 229 base pair fragmet is essential for acti-vating noggn expression. We further demonstrated thatthe response elements within this regulatory region wereindeed under the control of growth factor activin and Wntsignaling pathway components.
基金supported in part by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200)the National Natural Science Foundation of China(U20A6005,31621002,and 31070935)973 Program(2013CB835100).
文摘Dear Editor,The timing of spiking activity across neurons is believed to play an important role in information coding in brain circuits1[1].At the cellular level,neurons can fire spikes with millisecond precision and the relative timing of pre-and postsynaptic spikes can determine the direction and extent of synaptic modification[2].When such spike-timing-dependent plasticity(STDP)and other physiological and anatomical properties are implemented in theoretical models,the simulated networks of interconnected spiking neurons exhibit neuronal groups with stereotypical time-locked spatiotemporal firing patterns with millisecond temporal precision[3].
基金The project supported in part by National Natural Science Foundation of China under Grant Nos.10635020 and 10475032the Major Project of the Ministry of Education of China under Grant No.306022.
文摘The origin of power-law distributions in self-organized criticality is investigated by treating the variation of the number of active sites in the system as a stochastic process. An avalanche is then regarded as a first-return random walk process in a one-dimensional lattice. We assume that the variation of the number of active sites has three possibilities in each update： to increase by 1 with probability f1, to decrease by 1 with probability f2, or remain unchanged with probability 1 - f1 - f2. This mimics the dynamics in the system. Power-law distributions of the lifetime are found when the random walk is unbiased with equal probability to move in opposite directions. This shows that power-law distributions in self-organized criticality may be caused by the balance of competitive interactions.
文摘The present work studied the application of AgNOR count to differential diagnosis between cutaneous T cell lymphoma (CTCL) and cutaneous pseudolymphoma (CPL). Paraffin sections from 50 mycosis fungoides (22 MFI-Premycotic stage, 24 MF Ⅰ infiltrative stage and 4 MF Ⅲ - tumor stage), 2 nonepidermotropic cutaneous T cell lymphoma (NECTCL) and 9 CPL were investigated. In each case, 200 cells randomly selected were examined using a × 100 oil immersion lens. The mean number, standard deviation and standard error of the mean of AgNOR counts were as follows: MFⅠ 1.17±0.09, SEM = 0.01; MⅡ 1.17±0.01, SEM = 0.01; MF Ⅲ. 3.55±0.87, SEM = 0.43; NECTCL 4.5±0.28, SEM -0.199; CPL 1.17±0.1, SEM ± 0.03. The results revealed a highly significant difference between CTCL (MFⅢ+NECTCL) and CPL (t = 4.75, P<0.001), tumor stage (MF Ⅲ) and pretumor stage (MFI, MF Ⅱ) of mycosis fungoides (t = 4.75, P<0.001). Thus. AgNOR count is valuable in differential diagnosis.
基金Sponsored by Humanities and Social Sciences Fund of Ministry of Education of the People’s Republic of China (MEPRC) (07JA880011)the Eleventh Fives Educational Plan Fund of Beijing Municipal Commission of Education (ADA07067)the Graduate Educational Inno-vation Program of MEPRC (P-0801)
文摘The cooperative evolutionary stability under self-organized organization is discussed in this paper. The differences between the objects studied by cooperative game theory and the ones studied by cooperative game in science ＆ technology alliance are analyzed. The mutant probability of agent＇s utility under endoge- nous technical factor condition is analyzed. By clarifying the connotation of Pareto-dominate institution in cooperative game, the efficient and feasible managerial definition of Pareto-dominate Institution in science ＆ technology alliance is presented. The evolutionarily cooperative game for the agent in Pareto-dominate institution is explained. And then the necessary condition of cooperative evolutionary stabilization based on multi-agent utility＇s dynamic equilibrium is put forward. Finally, the model of alliance＇s utility＇s dynamic equilibrium under self-organization is established.
基金Supported by the National Natural Science Foundation of China under Grant Nos 61204006 and 61574108the Fundamental Research Funds for the Central Universities under Grant No JB141101the Foundation of Key Laboratory of Nanodevices and Applications of Suzhou Institute of Nano-Tech and Nano-Bionics of Chinese Academy of Sciences under Grant No 15CS01
文摘The effect of a self-organized SiNs interlayer on the defect density of （1122） semipolar GaN grown on 7n-plane sapphire is studied by transmission electron microscopy, atomic force microscopy and high resolution x-ray diffrac- tion. The SiNx interlayer reduces the c-type dislocation density from 2.5 ×10^10 cm^-2 to 5 ×10^8 cm 2. The SiNx interlayer produces regions that are free from basal plane stacking faults （BSFs） and dislocations. The overall BSF density is reduced from 2.1×10^5 cm-1 to 1.3×10^4 cm^-1. The large dislocations and BSF reduction in semipolar （1122） GaN with the SiNx, interlayer result from two primary mechanisms. The first mechanism is the direct dislocation blocking by the SiNx interlayer, and the second mechanism is associated with the unique structure character of （1122） semipolar GaN.
基金Supported by social science project of Hebei province(HB12YJ092)Development Funds of Agricultural University of Hebei(SK201111)
文摘Taking its development in Baoding City as an example, we introduced service fields of rural cooperative economic organized united association. It mainly includes setting up service platform and providing scientific and technological services; organizing economic and trade negotiation and exchange, and promoting farmer-supermarket partnership; providing financial services and solving fund-raising problems. In line with these fields, we analyzed existing problems: (i) regional development is unbalanced and organization lacks internal connection; (ii) the development in some counties (cities) is to be improved, and the promotion effect is not significant; (iii) there is shortage of talent and the innovation strength is not enough; and (iv) it lacks system and management lacks restriction mechanism. Finally, we put forward countermeasures and recommendations: strengthen propaganda and cultivate farmers' cooperative awareness; incorporate rural cooperative economic organized united association into formal system arrangement, and absorb professional talents; innovate upon organization system of rural cooperative economic organized united association and improve service methods; improve internal operating mechanism and innovate upon working contents of rural cooperative economic organized united association at new development background.
文摘Objective： To evaluate the relation between argyrophilic nucleolar organizer region （AgNOR）-associated proteins and clinicopathological parameters and survival in non-small-cell lung cancer （NSCLC）. Methods： A total of 207 surgical specimens diagnosed as NSCLC were included in this study. Double-staining procedures were performed using antigen Ki-67 （clone MIB-1） and silver nitrate by immunohistochemical and AgNOR-staining methods. Results： The AgNOR area in MIB-l-positive cells of NSCLC is related to clinicopathological parameters under the TNM （tumor, node, and metastasis） system. The survival of patients with small AgNOR area in MIB-1-positive cells is better than that of patients with large AgNOR area. Molecular, biological （AgNOR area in MIB-l-positive cells）, and clinicopathological （greatest tumor dimension, metastases to regional lymph nodes, histology, and differentiation） parameters are independent prognostic factors of NSCLC.Conclusion： The AgNOR area in MIB- 1-positive cells is related to clinicopathological parameters and survival in NSCLC.
文摘The argyrophil method for nucleolar organizer regions (AgNOR) known as the AgNor technique and mucin histochemical stain were applied to Investigate the dysplasia and cancaration in ulcerative colitis Including 58 cases of biopsy specimens and three cases operative specimens. The numbers of AgNOR have been gradully increased with the grades of dasplasls. Similarly the percentage of sialomucin having vicinal diols on side chain of sialic acid also gradully Increased with the grades of dysplasia. The AgNOR reflects rDNA transcriptional activity responsible for degrees of differentiation of cell. Epithelial cells secreting a heterogeneous mucin, could be taken as a signal of abnormal cellular differentiation. AgNOR and mucln chages might be assumed as a criteria In representing malignant transformation.
文摘Criminal networks erode the legitimacy of democratic politics, affecting regions as diverse as Latin America （Briscoe, Perdomo, ＆ Uribe Burcher, 2014）, the Baltic States （Villaveces-Izquierdo ＆ Uribe Burcher, 2013）, and West Africa （Aning ＆ Edu-Afful, 2013a; 2013b）. Contemporary research on this topic describes various factors that might increase the vulnerability of political actors, institutions, and processes to organized crime （Uribe Burcher, 2017）. In addition, there is a need to identify strategies to strengthen those political actors, institutions, and processes, making them resilient against criminal influence. Drawing from extensive field research conducted in Latin America, Africa, and West Asia in 2015-2016 （Perdomo ＆ Uribe Burcher, 2016; Hunter ＆ Reitano, 2016; Briscoe ＆ Goff, 2016a; 2016b）, as well as additional desk research conducted during the same period, this paper maps a set of 28 actions that may increase these institutions＇ and actors＇ resilience to the influence of organized crime networks based on documented global experiences implementing such measures. The paper also reflects some of the findings from a pilot experience to assess the threat of nexus between organized crime in democratic politics in Peru conducted in 2015-2016, which used some of the proposed action points to build a prevention and mitigation plan.
