Vanadium-based materials have emerged as promising cathode candidates for aqueous zinc-ion batteries(AZIBs)due to their multivalent redox characteristics and diverse crystal structures,which enable high energy storage...Vanadium-based materials have emerged as promising cathode candidates for aqueous zinc-ion batteries(AZIBs)due to their multivalent redox characteristics and diverse crystal structures,which enable high energy storage capacity.Nevertheless,practical applications are hindered by several critical challenges,including vanadium species dissolution,side-product formation,sluggish Zn^(2+)diffusion kinetics,and low electrical conductivity.Organic functionalization,benefiting from its structural tunability and abundant functional groups,has been proven to be an effective strategy for enhancing the electrochemical performance of vanadium-based cathodes.This review systematically summarizes recent advances in organic-functionalized vanadium-based cathodes.First,the energy storage mechanism of vanadiumbased cathodes and the fundamental properties of organic compounds relevant to cathode optimization are outlined.Then,the functions of organic compounds are comprehensively analyzed from four key perspectives:capacity improvement,conductivity enhancement,Zn^(2+)diffusion kinetics optimization,and cycling stability promotion.Furthermore,the specific electrochemical performance modulation effects and practical application examples of this strategy are discussed in detail.Finally,current limitations and challenges in this field are highlighted,and corresponding solutions and future research directions are proposed,offering theoretical guidance and insights for the development of high-performance vanadium-based cathodes for AZIBs.展开更多
Fish feces affect the structure and function of aquatic ecosystems,and they are affected by the functional fish organizations.In this research,Ctenopharyngodon idellus,Hypophthalmichthys molitrix,and Cyprinus carpio w...Fish feces affect the structure and function of aquatic ecosystems,and they are affected by the functional fish organizations.In this research,Ctenopharyngodon idellus,Hypophthalmichthys molitrix,and Cyprinus carpio were selected to study the effects of different functional fish organizations on the fractal characteristics of fecal micro-structure by scanning electron microscopes(SEM),particles(pores)and cracks analysis system(PCAS).The results showed that fish feces pores mainly consisted of medium pores(cumulative pore number,97%)classified by the International Union of Pure and Applied Chemistry(IUPAC).The grain area fractal dimension D_(1) and the pore-number and pore-size fractal dimension D_(2) were 1.94-1.96 and 2.07-2.19,respectively.The distribution of fish feces pores was very close to the Sierpinski carpet structure,which is the basic fractal construction methods widely used to describe the fractal of pore surface distribution.D_(1)(1.96)and D_(2)(2.19)of Hypophthalmichthys molitrix were the maximum values of the three functional organizations.Combining with the habit of fish,it is inferred that the feces of H.molitrix,the finer the feed and the faster the swimming of fish,the higher the content of feces clay,the larger the fractal dimension of feces,the easier it is to decompose feces,and the high the content of nutrients and organic matter to release into the water.It is demined that fish functional organizations affected the fractal characteristics and the stability of fish feces in water.This study is helpful for further research on water quality prediction and the impact of functional fish organizations on the structure and function of the ecosystem.展开更多
Rechargeable zinc-ion batteries have emerged as one of the most promising candidates for large-scale energy storage applications due to their high safety and low cost.However,the use of Zn metal in batteries suffers f...Rechargeable zinc-ion batteries have emerged as one of the most promising candidates for large-scale energy storage applications due to their high safety and low cost.However,the use of Zn metal in batteries suffers from many severe issues,including dendrite growth and parasitic reactions,which often lead to short cycle lives.Herein,we propose the construction of functional organic interfacial layers(OIL)on the Zn metal anodes to address these challenges.Through a well-designed organic-assist pre-construction process,a densely packed artificial layer featuring the immobilized zwitterionic molecular brush can be constructed,which can not only efficiently facilitate the smooth Zn plating and stripping,but also introduce a stable environment for battery reactions.Through density functional theory calculations and experimental characterizations,we verify that the immobilized organic propane sulfonate on Zn anodes can significantly lower the energy barrier and increase the kinetics of Zn^(2+)transport.Thus,the Zn metal anode with the functional OIL can significantly improve the cycle life of the symmetric cell to over 3500 h stable operation.When paired with the H_(2)V_(3)O_(8)cathode,the aqueous Zn-ion full cells can be continuously cycled over 7000 cycles,marking an important milestone for Zn anode development for potential industrial applications.展开更多
Taking the Lower Silurian Longmaxi Formation shale in the Sichuan Basin as an example,this study employs atomic force microscopy-based infrared(AFM-IR)spectroscopy to analyze the submicron-scale molecular functional g...Taking the Lower Silurian Longmaxi Formation shale in the Sichuan Basin as an example,this study employs atomic force microscopy-based infrared(AFM-IR)spectroscopy to analyze the submicron-scale molecular functional groups of different types and occurrences of organic matter.Combined with the quantitative evaluation of pore development via scanning electron microscopy(SEM),the response of organic pore formation and evolution mechanisms to chemical composition and structural evolution of organic matter in overmature marine shale is investigated.The results indicate that the AFM-IR spectra of graptolite periderms and pyrobitumen in shale are dominated by the stretching vibrations of conjugated C=C bonds in aromatic compounds at approximately 1600 cm-1,with weak absorption peaks near 1375,1450 and 1720 cm-1,corresponding to aliphatic chains and carbonyl/carboxyl functional groups.Overall,the AFM-IR structural indices(A and C factors)of organic matter show a strong correlation with visible porosity in shales of equivalent maturity.Lower A and C factor values correlate with enhanced development of organic pores,which is associated with the detachment of more aliphatic chains and oxygen-containing functional groups during thermal evolution.Pyrobitumen-clay mineral composites generally exhibit superior pore development,likely attributable to clay mineral dehydration participating in hydrocarbon generation reactions that promote the removal of more functional groups.Additionally,hydrocarbon generation within organic-clay composites during high-over mature stages may induce volumetric expansion,resulting in microfracturing and hydrocarbon expulsion.The associated higher hydrocarbon expulsion rates promote the formation of larger pores and fracture-shaped pores along the flake-shaped clay minerals.This study highlights that the research of submicron-scale molecular functional groups provides a deeper understanding of organic matter evolution and pores development mechanisms in overmature shales,thereby offering critical theoretical parameters for reservoir evaluation in shale oil and gas exploration.展开更多
Background'. In recent years, much evidence has emerged to indicate that exercise can benefit people when performed properly. This reviewsummarizes the exercise interventions used in studies involving mice as they...Background'. In recent years, much evidence has emerged to indicate that exercise can benefit people when performed properly. This reviewsummarizes the exercise interventions used in studies involving mice as they are related to special diseases or physiological status. To furtherunderstand the effects of exercise interventions in treating or preventing diseases, it is important to establish a template for exercise interventionsthat can be used in future exercise-related studies.Methods'. PubMed was used as the data resource for articles. To identify studies related to the effectiveness of exercise interventions for treatingvarious diseases and organ functions in mice, we used the following search language: (exercise [Title] OR training [Title] OR physical activity[Title]) AND (mice [title/abstract] OR mouse [title/abstract] OR mus [title/abstract]). To limit the range of search results, we included 2 filters:one that limited publication dates to "in 10 years,^ and one that sorted the results as "best match^^. Then we grouped the commonly used exercisemethods according to their similarities and differences. We then evaluated the effectiveness of the exercise interventions for their impact on diseasesand organ functions in 8 different systems.Results'. A total of 331 articles were included in the analysis procedure. The articles were then segmented into 8 systems for which the exerciseinterventions were used in targeting and treating disorders: motor system (60 studies), metabolic system (45 studies), cardio-cerebral vascularsystem (58 studies), nervous system (74 studies), immune system (32 studies), respiratory system (7 studies), digestive system (1 study), and thesystem related to the development of cancer (54 studies). The methods of exercise interventions mainly involved the use of treadmills, voluntarywheel-running, forced wheel-running, swimming, and resistance training. It was found that regardless of the specific exercise method used, mostof them demonstrated positive effects on various systemic diseases and organ functions. Most diseases were remitted with exercise regardless ofthe exercise method used, although some diseases showed the best remission effects when a specific method was used.Conclusion-. Our review strongly suggests that exercise intervention is a cornerstone in disease prevention and treatment in mice. Because exerciseinterventions in humans typically focus on chronic diseases, national fitness, and body weight loss, and typically have low intervention com・pliance rates, it is important to use mice models to investigate the molecular mechanisms underlying the health benefits from exerciseinterventions in humans.展开更多
A novel adsorbent （AMPS-silica） was synthesized by bounding AMPS （2-acrylamido-2-methylpropanesulfonic acid） onto silica surface, which functioned with γ-methacryloxypropyltrimethoxysilane reagent. The adsorbent ...A novel adsorbent （AMPS-silica） was synthesized by bounding AMPS （2-acrylamido-2-methylpropanesulfonic acid） onto silica surface, which functioned with γ-methacryloxypropyltrimethoxysilane reagent. The adsorbent was characterized by nitrogen adsorption/desorption measurement, thermogravimetric analysis （TGA） and potentiometric titration analysis. The TGA result indicated that the surface modification reactions introduced some organic functional groups onto the surface of silica. The surface area of AMPSsilica was 389.7 m2/g. The adsorbent was examined for copper ion removal in series of batch adsorption experiments. Results showed that the adsorption of Cu2＋ onto AMPS-silica was pH dependent, and the adsorption capacity increased with increasing pH from 2 to 6. The adsorption kinetics showed that Cu^2＋ adsorption was fast and the data fitted well with a pseudo secondorder kinetic model. The adsorption of Cu^2＋ onto AMPS-silica obeyed both Freundlich and Langmuir isotherms, with r^2 = 0.993 and r^2 = 0.984, respectively. The maximum Cu^2＋ adsorption capacity was 19.9 mg/g. The involved mechanism might be the adsorption through metal binding with organic functional groups such as carboxyl, amino and sulfonic groups. Cu^2＋ loaded on AMPS-silica could be desorbed in HNO3 solution, and the adsorption properties remain stable after three adsorption-desorption cycles.展开更多
The relationship between trace elements in coal and organic functional groups of coal, also some of aromatic structure, was investigated by using curve fitting of infrared spectra. Cluster analysis was also performed ...The relationship between trace elements in coal and organic functional groups of coal, also some of aromatic structure, was investigated by using curve fitting of infrared spectra. Cluster analysis was also performed according to the degree of affinity of organic groups to the trace elements. The results show that there is a possibility that trace elements, especially LREE, were bound to peripheral organic functional groups of middle rank coal macromolecule. The most possible functional group that binds trace element is the hydroxyl, and to the less degree, the asymmetric -CH3 and 〉CH2 stretching, -CH3 stretching, etc. The degree of affinity of trace elements to different functional groups varies. The tendency obeys the natural structural changing law of trace elements-- the periodic law. The deviation of some trace elements from this regular trend is attributed to the deviation of intrinsic ＂confusion degree＂ （conventional molar entropy） of the matter system of coal basin, which is affected by the inner and outer factors during the evolution.展开更多
To prepare a highly efficient NiMo/Al_(2)O_(3) hydrodesulfurization catalyst,the combined effects of specific organic functional groups and alumina surface characteristics were investigated.First,the correlation betwe...To prepare a highly efficient NiMo/Al_(2)O_(3) hydrodesulfurization catalyst,the combined effects of specific organic functional groups and alumina surface characteristics were investigated.First,the correlation between the surface characteristics of four different alumina and the existing Mo species states was established.It was found that the Mo equilibrium adsorption capacity can be used as a specific descriptor to quantitatively evaluate the changes in surface characteristics of different alumina.A lower Mo equilibrium adsorption capacity for alumina means weaker metal-support interaction and the loaded Mo species are easier to transform into MoS2.However,the Mo-O-Al bonds still exist at the metal-support interface.The introduction of cationic surfactant hecadecyl trimethyl ammonium bromide(CTAB)can further improve Mo species dispersion through electrostatic attraction with Mo anions and interaction of its alkyl chain with the alumina surface;meanwhile,the introduction of ethylenediamine tetraacetic acid(EDTA)can complex with Ni ions to enhance the Ni-promoting effect on Mo.Therefore,the NiMo catalyst designed using alumina with lower Mo equilibrium adsorption capacity and the simultaneous addition of EDTA and CTAB exhibits the highest hydrodesulfurization activity for 4,6-dimethyl dibenzothiophene because of its proper metal-support interaction and more well-dispersed Ni-Mo-S active phases.展开更多
Exploration of soil environmental characteristics governing soil microbial community structure and activity may improve our understanding of biogeochemical processes and soil quality. The impact of soil environmental ...Exploration of soil environmental characteristics governing soil microbial community structure and activity may improve our understanding of biogeochemical processes and soil quality. The impact of soil environmental characteristics especially organic carbon availability after 15-yr different organic and inorganic fertilizer inputs on soil bacterial community structure and functional metabolic diversity of soil microbial communities were evaluated in a 15-yr fertilizer experiment in Changping County, Beijing, China. The experiment was a wheat-maize rotation system which was established in 1991 including four different fertilizer treatments. These treatments included： a non-amended control（CK）, a commonly used application rate of inorganic fertilizer treatment（NPK）; a commonly used application rate of inorganic fertilizer with swine manure incorporated treatment（NPKM）, and a commonly used application rate of inorganic fertilizer with maize straw incorporated treatment（NPKS）. Denaturing gradient gel electrophoresis（DGGE） of the 16 S r RNA gene was used to determine the bacterial community structure and single carbon source utilization profiles were determined to characterize the microbial community functional metabolic diversity of different fertilizer treatments using Biolog Eco plates. The results indicated that long-term fertilized treatments significantly increased soil bacterial community structure compared to CK. The use of inorganic fertilizer with organic amendments incorporated for long term（NPKM, NPKS） significantly promoted soil bacterial structure than the application of inorganic fertilizer only（NPK）, and NPKM treatment was the most important driver for increases in the soil microbial community richness（S） and structural diversity（H）. Overall utilization of carbon sources by soil microbial communities（average well color development, AWCD） and microbial substrate utilization diversity and evenness indices（H＇ and E） indicated that long-term inorganic fertilizer with organic amendments incorporated（NPKM, NPKS） could significantly stimulate soil microbial metabolic activity and functional diversity relative to CK, while no differences of them were found between NPKS and NPK treatments. Principal component analysis（PCA） based on carbon source utilization profiles also showed significant separation of soil microbial community under long-term fertilization regimes and NPKM treatment was significantly separated from the other three treatments primarily according to the higher microbial utilization of carbohydrates, carboxylic acids, polymers, phenolic compounds, and amino acid, while higher utilization of amines/amides differed soil microbial community in NPKS treatment from those in the other three treatments. Redundancy analysis（RDA） indicated that soil organic carbon（SOC） availability, especially soil microbial biomass carbon（Cmic） and Cmic/SOC ratio are the key factors of soil environmental characteristics contributing to the increase of both soil microbial community structure and functional metabolic diversity in the long-term fertilization trial. Our results showed that long-term inorganic fertilizer and swine manure application could significantly improve soil bacterial community structure and soil microbial metabolic activity through the increases in SOC availability, which could provide insights into the sustainable management of China＇s soil resource.展开更多
In this review, we highlight the recent development of organic π-functional materials as buffer layers in constructing efficient perovskite solar cells（PVSCs）. By following a brief introduction on the PVSC developm...In this review, we highlight the recent development of organic π-functional materials as buffer layers in constructing efficient perovskite solar cells（PVSCs）. By following a brief introduction on the PVSC development, device architecture and material design features, we exemplified the exciting progresses made in field by exploiting organic π-functional materials based hole and electron transport layers（HTLs and ETLs） to enable high-performance PVSCs.展开更多
Psychosomatic disorders,characterized by significant contributions of psychosocial factors to the pathogenesis and progression of somatic organic diseases or functional impairments(e.g.,diabetes,essential hypertension...Psychosomatic disorders,characterized by significant contributions of psychosocial factors to the pathogenesis and progression of somatic organic diseases or functional impairments(e.g.,diabetes,essential hypertension,asthma,inflammatory bowel disease,and neurodermatitis),present unique diagnostic and therapeutic challenges[1].Traditional diagnostic frameworks,heavily reliant on clinicians’subjective judgment and limited by the qualitative nature of psychological assessments,often result in misdiagnosis or delayed detection.As a cornerstone of the Fourth Industrial Revolution,artificial intelligence(AI)has demonstrated transformative potential in medicine.In psychosomatic medicine,AI leverages advanced data analytics,machine learning,and natural language processing to decipher the intricate interplay between psychological and physiological mechanisms,offering novel tools for diagnosis,treatment,and prevention.However,its clinical integration raises critical ethical and operational concerns that warrant rigorous examination.展开更多
The exploration and discovery of new POM species with novel structural motifs are core prerequisites and permanent missions in the field of POM chemistry.It has been nearly 30 years since the first butterflyshaped And...The exploration and discovery of new POM species with novel structural motifs are core prerequisites and permanent missions in the field of POM chemistry.It has been nearly 30 years since the first butterflyshaped Anderson-type hetreopolyanions with a centred pentavalent Sb atom,[Sb(OH)_(2)Mo_(6)O_(22)]^(5-),named as the β isomer,was discovered in 1988.Yet the corresponding β isomers with a lower valence metal as the central heteroatom and its triol-functionalized organic derivatives have never been obtained.Herein,for the first time,two novel triol-functionalized butterfly-shaped heteropolyanions,β-{Cr[RC(CH_(2)O)_(3)]_(2)Mo_(6)O_(18)}^(3-)(R=NH_(2),1;C_(2)H_(5),2),were synthesized by the reaction of common flat Anderson-type POM,α-[Cr(OH)_(6)Mo_(6)O_(18)]^(3-),and triol ligands in hot DMF.Single crystal XRD analysis reveals that β-{Cr[RC(CH_(2)O)_(3)]_(2)Mo_(6)O_(18)}^(3-)is the first triol-functionalized β isomer of common α-type Anderson POMs.This study will enrich the family of POMs and provide an oportunity for the discovery of more potential POMs-based organic–inorganic hybrid materials.展开更多
Investigation of the effect of functional groups on gas adsorption in a MOF of a given structure is undoubtedly very important because it facilitates targeting porous MOFs with enhanced storage capacities by ligand fu...Investigation of the effect of functional groups on gas adsorption in a MOF of a given structure is undoubtedly very important because it facilitates targeting porous MOFs with enhanced storage capacities by ligand functionalization.In this work,we chose an NbO-type MOF platform to evaluate the impact of organic functional groups on C_(2)H_(2)adsorption.Correspondingly,we synthesized five diisophthalate ligands with the same length but different organic functionalities(NH_(2),CH_(3),NO_(2),F,and CF_(3)),and successfully incorporated them into MOFs with underlying NbO topology.C_(2)H_(2)adsorption experiments reveal that these functional moieties can enhance the affinity towards C_(2)H_(2),but not all these compounds outperformed the unfunctionalized parent compound NOTT-101 in terms of C_(2)H_(2)uptake.At 298 K and 1 atm,the C_(2)H_(2)uptake varies from 153.7 to 193.8 cm^(3)(STP)g^(−1),depending on the attached organic functional groups.Particularly,the amine group-functionalized compound ZJNU-34(NH_(2))exhibits the maximum C_(2)H_(2)uptake of the six compounds evaluated,reaching as high as 203.6 cm^(3)(STP)g^(−1)at 295 K and 1 atm.Such a 10%increase of C_(2)H_(2)uptake compared to the parent compound might be attributed to acid-base and/or hydrogen-bonding interactions between the NH_(2)groups with adsorbed C_(2)H_(2)molecules.The fundamental understanding of the impact of functional groups on C_(2)H_(2)adsorption demonstrated in this work provides valuable information for future designing of porous MOFs with enhanced acetylene-storage capacities.展开更多
Theranostics,possessing both imaging and therapeutic functions,has emerged as a promising strategy for the efficient treatment of cancer.Aggregation-induced emission luminogen(AIEgen)functionalized inorganic-organic h...Theranostics,possessing both imaging and therapeutic functions,has emerged as a promising strategy for the efficient treatment of cancer.Aggregation-induced emission luminogen(AIEgen)functionalized inorganic-organic hybrid nanomaterials have attracted great interest in biomedicine due to their distinct advantages,such as good biocompatibility,excellent fluorescence properties,facile functionalization,etc.展开更多
The high porosity,excellent water stability and optimized supramolecular host–vip interactions of MOFs are the three key factors for their potential practical applications in many important areas including gas stor...The high porosity,excellent water stability and optimized supramolecular host–vip interactions of MOFs are the three key factors for their potential practical applications in many important areas including gas storage/separation,catalysis and so on.In this study,we designed and constructed a highly porous(3,36)-connected txt-type acylamide-functionalized metal–organic framework(HNUST-8)from a pyridine-based acylamide-linking diisophthalate and dicopper(II)-paddlewheel clusters.展开更多
Herein,by using pillaring ligands with different lengths,two copper-based metal–organic frameworks,compounds 1 (Cu_(2)(bada)_(2)(dabco)) and 2 (Cu_(2)(bada)_(2)(bipy)) (bada=4,4′-carbonylbis(azanediyl)dibenzoic acid...Herein,by using pillaring ligands with different lengths,two copper-based metal–organic frameworks,compounds 1 (Cu_(2)(bada)_(2)(dabco)) and 2 (Cu_(2)(bada)_(2)(bipy)) (bada=4,4′-carbonylbis(azanediyl)dibenzoic acid,dabco=1,4-diazabicyclo[2.2.2]octane,bipy=4,4′-bipyridine) with the urea-functionalized ligand bada,have been successfully synthesized using a pillared-layer strategy.Both 1 and 2 exhibit two-dimensional square lattice (sql) layers pillared by dabco and bipy,respectively,and feature pcu topology.Different to dabco in 1,the pillaring ligand 4,4′-bipyridine with longer length forms a doubly interpenetrated structure of 2.Both compounds display good thermal stabilities and permanent porosities.1 exhibits good performance for CO_(2)(32 cm^(3) g^(-1)),C_(2)H_(6) (58 cm^(3) g^(-1)),and C_(3)H_(8) (105 cm^(3) g^(-1)) capture among MOFs without open metal sites.In particular,1 possesses high Q_st for CO_(2)(32.8 kJ mol^(-1)),C_(2)H_(6) (37.2 kJ mol^(-1)),and C_(3)H_(8) (40.3 kJ mol^(-1)) adsorption and outstanding selectivities for CO_(2)(5.7),C_(2)H_(6) (28),and C_(3)H_(8) (224) over CH_(4) at 298 K.Density functional theory (DFT)-based calculations further prove the hydrogen-bond interactions and σ–π interactions between gas molecules and urea-based ligands.2 exhibits a gate-opening behavior for N_(2),Ar and CO_(2).Compound 1 could be seen as a significant potential material for gas storage and separation.展开更多
The luminescence response application in chemical sensing by metal–organic frameworks(MOFs)and their hybrid materials has been reported extensively in recent years.However,the reviews on this topic are mainly focused...The luminescence response application in chemical sensing by metal–organic frameworks(MOFs)and their hybrid materials has been reported extensively in recent years.However,the reviews on this topic are mainly focused on the sensing materials(MOFs and their functionalized hybrid materials)and analytes(all types of species).In this comprehensive review,the luminescence response mode and chemical sensing mechanism for lanthanide-functionalized MOF hybrids(abbreviated as LnFMOFH)are systematically summarized.Specifically,ten sections are subdivided,and importantly involve three main topics.Firstly,LnFMOFH and the luminescence responsive chemical sensing for these hybrids are introduced.Secondly,three single luminescence response modes,including“Turn-Off”,“Turn-On”“Turn–Off–On”and dual mode,as ratiometric luminescence(RL)for chemical sensing in LnFMOFH materials are summarized.Thirdly,some types of chemical sensing mechanisms observed in LnFMOFH materials are outlined,which involve the ligand–metal energy transfer(LMET)for the luminescence response in chemical sensing of enhanced or weakened analytes.展开更多
Sepsis is currently a major problem and challenge facing the medical community.With rapid development and progress of modern medicine,researchers have put more and more attention on sepsis;meanwhile,the morbidity and ...Sepsis is currently a major problem and challenge facing the medical community.With rapid development and progress of modern medicine,researchers have put more and more attention on sepsis;meanwhile,the morbidity and mortality of sepsis remains high despite great efforts from experts in various fields.According to updated guidelines,sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.Infection is the initial step of sepsis progression,and development from infection to sepsis is a complex pathophysiological process,including pathogen invasion,cytokine release,capillary leakage,microcirculation dysfunction,etc.which finally leads to organ metabolic disorders and functional failure.According to the latest recommended international guidelines of Sepsis 3.0,the presence of infection and SOFA score≥2 are considered as the diagnostic criteria for sepsis,and the"rescue"measures mainly focus on reversal of organ dysfunction.However,despite nearly two decades of efforts,the"Save Sepsis Campaign"has not achieved satisfactory results.Emergency medicine is the frontier subject of acute and severe illness which treats patients with acute infections at the earliest.If at this stage,physicians can predict the possibility of sepsis progression from demographic characteristics,localize the pathogen and infection,detect the inflammatory storms by tests of cytokines and evaluate the severity of the infection with more effective clinical scoring system,and then take effective measures to prevent infection from developing into sepsis in high-risk patients,the morbidity and mortality of sepsis in patients with acute infection will be greatly reduced.Based on this situation,Chinese emergency medicine experts proposed the concept of"preventing and blocking"sepsis,and launched the nationwide"Preventing Sepsis Campaign in China(PSCC)"nationwide.The main concept is summarized as"three early and two reduces"which includes early detection,early diagnosis and early intervention during the"pre-symptomatic"and"peri-septic"stage in order to reduce the incidence of sepsis and it proposed a new approach for diagnosis and treatment of acute severe infection.This consensus is jointly advocated,discussed and written by four academic associations in the field of emergency medicine and five scholarly publishing organizations.More than 40 experts from fields of emergency medicine,critical care medicine,infectious diseases,pharmacy and laboratory medicine have participated in several rounds of deliberation and finally reached consensus on the criteria of identifying patients with acute infection,taking anti-infective treatments,screening of high-risk patients with sepsis,detection and treatment of inflammatory storm,protection of vascular endothelial cells and the regulation of coagulation function,as well as strategies of liquid support and organ function protection etc.The consensus summarizes the commonly used clinical diagnosis criteria and treatment measures of sepsis both in Western medicine and traditional Chinese medicine for clinicians in order to provide evidence for the diagnosis and treatment of the disease.展开更多
The chars in the natural environment can affect the migration of polybrominated diphenyl ethers(PBDEs). However, there is insufficient research relating to the adsorption behavior and mechanisms of PBDEs on biochars. ...The chars in the natural environment can affect the migration of polybrominated diphenyl ethers(PBDEs). However, there is insufficient research relating to the adsorption behavior and mechanisms of PBDEs on biochars. This study examined the adsorption kinetics of 2,2′,4,4′-tetrabromodiphenyl ether(BDE-47) on maize straw-derived biochars(MSBCs) pyrolyzed at four different temperatures via batch experiments. The biochar samples were characterized using Fourier transform infrared(FTIR) spectroscopy,Raman spectra, and elemental analysis. A two-compartment first-order model and pseudo-second-order model exhibited a better fit compared to a pseudo-first-order model in describing the BDE-47 adsorption on biochars, which was dominated by a slow adsorption compartment and chemisorption. The MSBC pyrolyzed at 600 °C had the highest BDE-47 adsorption capacity owing to its relatively large specific surface area and relatively high aromaticity compared with the other three MSBCs pyrolyzed at 300, 400, and 500 ℃.However, there was no significant difference in adsorption capacity among the other three biochars. The organic functional groups coupled with the graphene structures of biochars and the hydrophobic effect of the functional groups promoted the adsorption of BDE-47. Pore diffusion was not the sole rate-limiting step;film diffusion was also involved in the adsorption process of BDE-47 on biochars. The overall results demonstrate the transport and potential treatment of PBDEs using biochars.展开更多
Background Mannan oligosaccharides(MOS)are recommended as aquaculture additives owing to their excellent antioxidant properties.In the present study,we examined the effects of dietary MOS on the head kidney and spleen...Background Mannan oligosaccharides(MOS)are recommended as aquaculture additives owing to their excellent antioxidant properties.In the present study,we examined the effects of dietary MOS on the head kidney and spleen of grass carp(Ctenopharyngodon idella)with Aeromonas hydrophila infection.Methods A total of 540 grass carp were used for the study.They were administered six gradient dosages of the MOS diet(0,200,400,600,800,and 1,000 mg/kg)for 60 d.Subsequently,we performed a 14-day Aeromonas hydrophila challenge experiment.The antioxidant capacity of the head kidney and spleen were examined using spectrophotometry,DNA fragmentation,qRT-PCR,and Western blotting.Results After infection with Aeromonas hydrophila,400-600 mg/kg MOS supplementation decreased the levels of reactive oxygen species,protein carbonyl,and malonaldehyde and increased the levels of anti-superoxide anion,antihydroxyl radical,and glutathione in the head kidney and spleen of grass carp.The activities of copper-zinc superoxide dismutase,manganese superoxide dismutase,catalase,glutathione S-transferase,glutathione reductase,and glutathione peroxidase were also enhanced by supplementation with 400-600 mg/kg MOS.Furthermore,the expression of most antioxidant enzymes and their corresponding genes increased significantly with supplementation of 200-800 mg/kg MOS.mRNA and protein levels of nuclear factor erythroid 2-related factor 2 also increased following supplementation with 400-600 mg/kg MOS.In addition,supplementation with 400-600 mg/kg MOS reduced excessive apoptosis by inhibiting the death receptor pathway and mitochondrial pathway processes.Conclusions Based on the quadratic regression analysis of the above biomarkers(reactive oxygen species,malondialdehyde,and protein carbonyl)of oxidative damage in the head kidney and spleen of on-growing grass carp,the recommended MOS supplementation is 575.21,557.58,531.86,597.35,570.16,and 553.80 mg/kg,respectively.Collectively,MOS supplementation could alleviate oxidative injury in the head kidney and spleen of grass carp infected with Aeromonas hydrophila.展开更多
基金financial support from the National Natural Science Foundation of China(No.21676036)the Natural Science Foundation of Chongqing(No.CSTB2023NSCQMSX0580)the Large-scale Equipment Sharing Fund of Chongqing University(No.202403150240 and 202503150091)。
文摘Vanadium-based materials have emerged as promising cathode candidates for aqueous zinc-ion batteries(AZIBs)due to their multivalent redox characteristics and diverse crystal structures,which enable high energy storage capacity.Nevertheless,practical applications are hindered by several critical challenges,including vanadium species dissolution,side-product formation,sluggish Zn^(2+)diffusion kinetics,and low electrical conductivity.Organic functionalization,benefiting from its structural tunability and abundant functional groups,has been proven to be an effective strategy for enhancing the electrochemical performance of vanadium-based cathodes.This review systematically summarizes recent advances in organic-functionalized vanadium-based cathodes.First,the energy storage mechanism of vanadiumbased cathodes and the fundamental properties of organic compounds relevant to cathode optimization are outlined.Then,the functions of organic compounds are comprehensively analyzed from four key perspectives:capacity improvement,conductivity enhancement,Zn^(2+)diffusion kinetics optimization,and cycling stability promotion.Furthermore,the specific electrochemical performance modulation effects and practical application examples of this strategy are discussed in detail.Finally,current limitations and challenges in this field are highlighted,and corresponding solutions and future research directions are proposed,offering theoretical guidance and insights for the development of high-performance vanadium-based cathodes for AZIBs.
基金financial support from the National Natural Science Youth Foundation of China(No.32002443)the Natural Science Foundation of Shandong Province(No.ZR2021QD 149)。
文摘Fish feces affect the structure and function of aquatic ecosystems,and they are affected by the functional fish organizations.In this research,Ctenopharyngodon idellus,Hypophthalmichthys molitrix,and Cyprinus carpio were selected to study the effects of different functional fish organizations on the fractal characteristics of fecal micro-structure by scanning electron microscopes(SEM),particles(pores)and cracks analysis system(PCAS).The results showed that fish feces pores mainly consisted of medium pores(cumulative pore number,97%)classified by the International Union of Pure and Applied Chemistry(IUPAC).The grain area fractal dimension D_(1) and the pore-number and pore-size fractal dimension D_(2) were 1.94-1.96 and 2.07-2.19,respectively.The distribution of fish feces pores was very close to the Sierpinski carpet structure,which is the basic fractal construction methods widely used to describe the fractal of pore surface distribution.D_(1)(1.96)and D_(2)(2.19)of Hypophthalmichthys molitrix were the maximum values of the three functional organizations.Combining with the habit of fish,it is inferred that the feces of H.molitrix,the finer the feed and the faster the swimming of fish,the higher the content of feces clay,the larger the fractal dimension of feces,the easier it is to decompose feces,and the high the content of nutrients and organic matter to release into the water.It is demined that fish functional organizations affected the fractal characteristics and the stability of fish feces in water.This study is helpful for further research on water quality prediction and the impact of functional fish organizations on the structure and function of the ecosystem.
基金supported by the Australian Research Council (FT180100705, DP230101579, DE240100868)CSIRO “International Hydrogen Research Collaboration ProgramRESEARCH FELLOWSHIPS”+2 种基金the National Natural Science Foundation of China (22209103)support from the “Joint International Laboratory on Environmental and Energy Frontier Materials”the “Innovation Research Team of High-Level Local Universities in Shanghai”
文摘Rechargeable zinc-ion batteries have emerged as one of the most promising candidates for large-scale energy storage applications due to their high safety and low cost.However,the use of Zn metal in batteries suffers from many severe issues,including dendrite growth and parasitic reactions,which often lead to short cycle lives.Herein,we propose the construction of functional organic interfacial layers(OIL)on the Zn metal anodes to address these challenges.Through a well-designed organic-assist pre-construction process,a densely packed artificial layer featuring the immobilized zwitterionic molecular brush can be constructed,which can not only efficiently facilitate the smooth Zn plating and stripping,but also introduce a stable environment for battery reactions.Through density functional theory calculations and experimental characterizations,we verify that the immobilized organic propane sulfonate on Zn anodes can significantly lower the energy barrier and increase the kinetics of Zn^(2+)transport.Thus,the Zn metal anode with the functional OIL can significantly improve the cycle life of the symmetric cell to over 3500 h stable operation.When paired with the H_(2)V_(3)O_(8)cathode,the aqueous Zn-ion full cells can be continuously cycled over 7000 cycles,marking an important milestone for Zn anode development for potential industrial applications.
基金Supported by the National Natural Science Foundation of China(42172148,42172142)。
文摘Taking the Lower Silurian Longmaxi Formation shale in the Sichuan Basin as an example,this study employs atomic force microscopy-based infrared(AFM-IR)spectroscopy to analyze the submicron-scale molecular functional groups of different types and occurrences of organic matter.Combined with the quantitative evaluation of pore development via scanning electron microscopy(SEM),the response of organic pore formation and evolution mechanisms to chemical composition and structural evolution of organic matter in overmature marine shale is investigated.The results indicate that the AFM-IR spectra of graptolite periderms and pyrobitumen in shale are dominated by the stretching vibrations of conjugated C=C bonds in aromatic compounds at approximately 1600 cm-1,with weak absorption peaks near 1375,1450 and 1720 cm-1,corresponding to aliphatic chains and carbonyl/carboxyl functional groups.Overall,the AFM-IR structural indices(A and C factors)of organic matter show a strong correlation with visible porosity in shales of equivalent maturity.Lower A and C factor values correlate with enhanced development of organic pores,which is associated with the detachment of more aliphatic chains and oxygen-containing functional groups during thermal evolution.Pyrobitumen-clay mineral composites generally exhibit superior pore development,likely attributable to clay mineral dehydration participating in hydrocarbon generation reactions that promote the removal of more functional groups.Additionally,hydrocarbon generation within organic-clay composites during high-over mature stages may induce volumetric expansion,resulting in microfracturing and hydrocarbon expulsion.The associated higher hydrocarbon expulsion rates promote the formation of larger pores and fracture-shaped pores along the flake-shaped clay minerals.This study highlights that the research of submicron-scale molecular functional groups provides a deeper understanding of organic matter evolution and pores development mechanisms in overmature shales,thereby offering critical theoretical parameters for reservoir evaluation in shale oil and gas exploration.
基金supported by the Major Research Plan of the National Natural Science Foundation of China (91749104)the Emergency Management Project of the National Natural Science Foundation of China (31842034)+3 种基金the Shanghai Pujiang Talent Project (18PJ1400700)the Science and Technology Innovation Action Plan of Shanghai Science and Technology Committee (18140901300)the Open Research Fund of the National Key Laboratory of Genetic Engineering (SKLGE1803)the Open Research Fund of the State Key Laboratory of Pharmaceutical Biotechnology (KF-GN201701) to TML
文摘Background'. In recent years, much evidence has emerged to indicate that exercise can benefit people when performed properly. This reviewsummarizes the exercise interventions used in studies involving mice as they are related to special diseases or physiological status. To furtherunderstand the effects of exercise interventions in treating or preventing diseases, it is important to establish a template for exercise interventionsthat can be used in future exercise-related studies.Methods'. PubMed was used as the data resource for articles. To identify studies related to the effectiveness of exercise interventions for treatingvarious diseases and organ functions in mice, we used the following search language: (exercise [Title] OR training [Title] OR physical activity[Title]) AND (mice [title/abstract] OR mouse [title/abstract] OR mus [title/abstract]). To limit the range of search results, we included 2 filters:one that limited publication dates to "in 10 years,^ and one that sorted the results as "best match^^. Then we grouped the commonly used exercisemethods according to their similarities and differences. We then evaluated the effectiveness of the exercise interventions for their impact on diseasesand organ functions in 8 different systems.Results'. A total of 331 articles were included in the analysis procedure. The articles were then segmented into 8 systems for which the exerciseinterventions were used in targeting and treating disorders: motor system (60 studies), metabolic system (45 studies), cardio-cerebral vascularsystem (58 studies), nervous system (74 studies), immune system (32 studies), respiratory system (7 studies), digestive system (1 study), and thesystem related to the development of cancer (54 studies). The methods of exercise interventions mainly involved the use of treadmills, voluntarywheel-running, forced wheel-running, swimming, and resistance training. It was found that regardless of the specific exercise method used, mostof them demonstrated positive effects on various systemic diseases and organ functions. Most diseases were remitted with exercise regardless ofthe exercise method used, although some diseases showed the best remission effects when a specific method was used.Conclusion-. Our review strongly suggests that exercise intervention is a cornerstone in disease prevention and treatment in mice. Because exerciseinterventions in humans typically focus on chronic diseases, national fitness, and body weight loss, and typically have low intervention com・pliance rates, it is important to use mice models to investigate the molecular mechanisms underlying the health benefits from exerciseinterventions in humans.
基金supported by the Fundation for Creative Research Groups of China (No. 50621804)
文摘A novel adsorbent （AMPS-silica） was synthesized by bounding AMPS （2-acrylamido-2-methylpropanesulfonic acid） onto silica surface, which functioned with γ-methacryloxypropyltrimethoxysilane reagent. The adsorbent was characterized by nitrogen adsorption/desorption measurement, thermogravimetric analysis （TGA） and potentiometric titration analysis. The TGA result indicated that the surface modification reactions introduced some organic functional groups onto the surface of silica. The surface area of AMPSsilica was 389.7 m2/g. The adsorbent was examined for copper ion removal in series of batch adsorption experiments. Results showed that the adsorption of Cu2＋ onto AMPS-silica was pH dependent, and the adsorption capacity increased with increasing pH from 2 to 6. The adsorption kinetics showed that Cu^2＋ adsorption was fast and the data fitted well with a pseudo secondorder kinetic model. The adsorption of Cu^2＋ onto AMPS-silica obeyed both Freundlich and Langmuir isotherms, with r^2 = 0.993 and r^2 = 0.984, respectively. The maximum Cu^2＋ adsorption capacity was 19.9 mg/g. The involved mechanism might be the adsorption through metal binding with organic functional groups such as carboxyl, amino and sulfonic groups. Cu^2＋ loaded on AMPS-silica could be desorbed in HNO3 solution, and the adsorption properties remain stable after three adsorption-desorption cycles.
基金supported by the National Science Foundation of China(Nos.41172143 and 40872101)Developmental Plan of Basic Research on Natural Science of Shanxi Province(20012JM5005)Science Research Plan of Shanxi education department(12JK0483)
文摘The relationship between trace elements in coal and organic functional groups of coal, also some of aromatic structure, was investigated by using curve fitting of infrared spectra. Cluster analysis was also performed according to the degree of affinity of organic groups to the trace elements. The results show that there is a possibility that trace elements, especially LREE, were bound to peripheral organic functional groups of middle rank coal macromolecule. The most possible functional group that binds trace element is the hydroxyl, and to the less degree, the asymmetric -CH3 and 〉CH2 stretching, -CH3 stretching, etc. The degree of affinity of trace elements to different functional groups varies. The tendency obeys the natural structural changing law of trace elements-- the periodic law. The deviation of some trace elements from this regular trend is attributed to the deviation of intrinsic ＂confusion degree＂ （conventional molar entropy） of the matter system of coal basin, which is affected by the inner and outer factors during the evolution.
基金funding of the National Key Research and Development Plan(Grant 2017YFB0306600)the Project of SINOPEC(NO.117006).
文摘To prepare a highly efficient NiMo/Al_(2)O_(3) hydrodesulfurization catalyst,the combined effects of specific organic functional groups and alumina surface characteristics were investigated.First,the correlation between the surface characteristics of four different alumina and the existing Mo species states was established.It was found that the Mo equilibrium adsorption capacity can be used as a specific descriptor to quantitatively evaluate the changes in surface characteristics of different alumina.A lower Mo equilibrium adsorption capacity for alumina means weaker metal-support interaction and the loaded Mo species are easier to transform into MoS2.However,the Mo-O-Al bonds still exist at the metal-support interface.The introduction of cationic surfactant hecadecyl trimethyl ammonium bromide(CTAB)can further improve Mo species dispersion through electrostatic attraction with Mo anions and interaction of its alkyl chain with the alumina surface;meanwhile,the introduction of ethylenediamine tetraacetic acid(EDTA)can complex with Ni ions to enhance the Ni-promoting effect on Mo.Therefore,the NiMo catalyst designed using alumina with lower Mo equilibrium adsorption capacity and the simultaneous addition of EDTA and CTAB exhibits the highest hydrodesulfurization activity for 4,6-dimethyl dibenzothiophene because of its proper metal-support interaction and more well-dispersed Ni-Mo-S active phases.
基金funded by the National Natural Science Foundation of China(NSFC31301843)the National Nonprofit Institute Research Grant of Chinese Academy of Agricultural Sciences(IARRP-202-5)
文摘Exploration of soil environmental characteristics governing soil microbial community structure and activity may improve our understanding of biogeochemical processes and soil quality. The impact of soil environmental characteristics especially organic carbon availability after 15-yr different organic and inorganic fertilizer inputs on soil bacterial community structure and functional metabolic diversity of soil microbial communities were evaluated in a 15-yr fertilizer experiment in Changping County, Beijing, China. The experiment was a wheat-maize rotation system which was established in 1991 including four different fertilizer treatments. These treatments included： a non-amended control（CK）, a commonly used application rate of inorganic fertilizer treatment（NPK）; a commonly used application rate of inorganic fertilizer with swine manure incorporated treatment（NPKM）, and a commonly used application rate of inorganic fertilizer with maize straw incorporated treatment（NPKS）. Denaturing gradient gel electrophoresis（DGGE） of the 16 S r RNA gene was used to determine the bacterial community structure and single carbon source utilization profiles were determined to characterize the microbial community functional metabolic diversity of different fertilizer treatments using Biolog Eco plates. The results indicated that long-term fertilized treatments significantly increased soil bacterial community structure compared to CK. The use of inorganic fertilizer with organic amendments incorporated for long term（NPKM, NPKS） significantly promoted soil bacterial structure than the application of inorganic fertilizer only（NPK）, and NPKM treatment was the most important driver for increases in the soil microbial community richness（S） and structural diversity（H）. Overall utilization of carbon sources by soil microbial communities（average well color development, AWCD） and microbial substrate utilization diversity and evenness indices（H＇ and E） indicated that long-term inorganic fertilizer with organic amendments incorporated（NPKM, NPKS） could significantly stimulate soil microbial metabolic activity and functional diversity relative to CK, while no differences of them were found between NPKS and NPK treatments. Principal component analysis（PCA） based on carbon source utilization profiles also showed significant separation of soil microbial community under long-term fertilization regimes and NPKM treatment was significantly separated from the other three treatments primarily according to the higher microbial utilization of carbohydrates, carboxylic acids, polymers, phenolic compounds, and amino acid, while higher utilization of amines/amides differed soil microbial community in NPKS treatment from those in the other three treatments. Redundancy analysis（RDA） indicated that soil organic carbon（SOC） availability, especially soil microbial biomass carbon（Cmic） and Cmic/SOC ratio are the key factors of soil environmental characteristics contributing to the increase of both soil microbial community structure and functional metabolic diversity in the long-term fertilization trial. Our results showed that long-term inorganic fertilizer and swine manure application could significantly improve soil bacterial community structure and soil microbial metabolic activity through the increases in SOC availability, which could provide insights into the sustainable management of China＇s soil resource.
基金financial support from the 973 program(No.2014CB643503)the National Natural Science Foundation of China(No.21474088)+2 种基金financial support from NSFC(No.21674093)the National 1000 Young Talents Program hosted by China100 Talents Program by Zhejiang University
文摘In this review, we highlight the recent development of organic π-functional materials as buffer layers in constructing efficient perovskite solar cells（PVSCs）. By following a brief introduction on the PVSC development, device architecture and material design features, we exemplified the exciting progresses made in field by exploiting organic π-functional materials based hole and electron transport layers（HTLs and ETLs） to enable high-performance PVSCs.
文摘Psychosomatic disorders,characterized by significant contributions of psychosocial factors to the pathogenesis and progression of somatic organic diseases or functional impairments(e.g.,diabetes,essential hypertension,asthma,inflammatory bowel disease,and neurodermatitis),present unique diagnostic and therapeutic challenges[1].Traditional diagnostic frameworks,heavily reliant on clinicians’subjective judgment and limited by the qualitative nature of psychological assessments,often result in misdiagnosis or delayed detection.As a cornerstone of the Fourth Industrial Revolution,artificial intelligence(AI)has demonstrated transformative potential in medicine.In psychosomatic medicine,AI leverages advanced data analytics,machine learning,and natural language processing to decipher the intricate interplay between psychological and physiological mechanisms,offering novel tools for diagnosis,treatment,and prevention.However,its clinical integration raises critical ethical and operational concerns that warrant rigorous examination.
基金the financial support from the National Natural Science Foundation of China(NSFC No.21471087,21225103,21631007 and 21221062)the State Key Laboratory of Natural and Biomimetic Drugs+1 种基金the Specialized Research Fund for the Doctoral Program of Higher Education of ChinaTsinghua University Initiative Foundation Research Program(No.20131089204).
文摘The exploration and discovery of new POM species with novel structural motifs are core prerequisites and permanent missions in the field of POM chemistry.It has been nearly 30 years since the first butterflyshaped Anderson-type hetreopolyanions with a centred pentavalent Sb atom,[Sb(OH)_(2)Mo_(6)O_(22)]^(5-),named as the β isomer,was discovered in 1988.Yet the corresponding β isomers with a lower valence metal as the central heteroatom and its triol-functionalized organic derivatives have never been obtained.Herein,for the first time,two novel triol-functionalized butterfly-shaped heteropolyanions,β-{Cr[RC(CH_(2)O)_(3)]_(2)Mo_(6)O_(18)}^(3-)(R=NH_(2),1;C_(2)H_(5),2),were synthesized by the reaction of common flat Anderson-type POM,α-[Cr(OH)_(6)Mo_(6)O_(18)]^(3-),and triol ligands in hot DMF.Single crystal XRD analysis reveals that β-{Cr[RC(CH_(2)O)_(3)]_(2)Mo_(6)O_(18)}^(3-)is the first triol-functionalized β isomer of common α-type Anderson POMs.This study will enrich the family of POMs and provide an oportunity for the discovery of more potential POMs-based organic–inorganic hybrid materials.
基金supported by the Natural Science Foundation of Zhejiang province,China(LR16B010001)the National Natural Science Foundation of China(no.21301156)the Qianjiang Talents Project in Zhejiang province(ZC304015017).
文摘Investigation of the effect of functional groups on gas adsorption in a MOF of a given structure is undoubtedly very important because it facilitates targeting porous MOFs with enhanced storage capacities by ligand functionalization.In this work,we chose an NbO-type MOF platform to evaluate the impact of organic functional groups on C_(2)H_(2)adsorption.Correspondingly,we synthesized five diisophthalate ligands with the same length but different organic functionalities(NH_(2),CH_(3),NO_(2),F,and CF_(3)),and successfully incorporated them into MOFs with underlying NbO topology.C_(2)H_(2)adsorption experiments reveal that these functional moieties can enhance the affinity towards C_(2)H_(2),but not all these compounds outperformed the unfunctionalized parent compound NOTT-101 in terms of C_(2)H_(2)uptake.At 298 K and 1 atm,the C_(2)H_(2)uptake varies from 153.7 to 193.8 cm^(3)(STP)g^(−1),depending on the attached organic functional groups.Particularly,the amine group-functionalized compound ZJNU-34(NH_(2))exhibits the maximum C_(2)H_(2)uptake of the six compounds evaluated,reaching as high as 203.6 cm^(3)(STP)g^(−1)at 295 K and 1 atm.Such a 10%increase of C_(2)H_(2)uptake compared to the parent compound might be attributed to acid-base and/or hydrogen-bonding interactions between the NH_(2)groups with adsorbed C_(2)H_(2)molecules.The fundamental understanding of the impact of functional groups on C_(2)H_(2)adsorption demonstrated in this work provides valuable information for future designing of porous MOFs with enhanced acetylene-storage capacities.
基金supported by the National Natural Science Foundation of China(No.21501063)the Science and Technology Development Program of Jilin Province(No.20180520015JH)the Open Funds of National Engineering Research Center of Near-Net-Shape Forming for Metallic Materials(2018011)。
文摘Theranostics,possessing both imaging and therapeutic functions,has emerged as a promising strategy for the efficient treatment of cancer.Aggregation-induced emission luminogen(AIEgen)functionalized inorganic-organic hybrid nanomaterials have attracted great interest in biomedicine due to their distinct advantages,such as good biocompatibility,excellent fluorescence properties,facile functionalization,etc.
基金supported by the National Natural Science Foundation of China(Grant No.21401055,21371150 and 21201062)Hunan Provincial Natural Science Foundation of China(Grant No.2018JJ2113 and 2017JJ2095)State Key Laboratory of Coordination Chemistry(Grant No.SKLCC1417).
文摘The high porosity,excellent water stability and optimized supramolecular host–vip interactions of MOFs are the three key factors for their potential practical applications in many important areas including gas storage/separation,catalysis and so on.In this study,we designed and constructed a highly porous(3,36)-connected txt-type acylamide-functionalized metal–organic framework(HNUST-8)from a pyridine-based acylamide-linking diisophthalate and dicopper(II)-paddlewheel clusters.
基金supported by the National Natural Science Foundation of China(No.21771078,21671074,and 21621001)the 111 Project(B17020)the National Key Research and Development Program of China(2016YFB0701100)。
文摘Herein,by using pillaring ligands with different lengths,two copper-based metal–organic frameworks,compounds 1 (Cu_(2)(bada)_(2)(dabco)) and 2 (Cu_(2)(bada)_(2)(bipy)) (bada=4,4′-carbonylbis(azanediyl)dibenzoic acid,dabco=1,4-diazabicyclo[2.2.2]octane,bipy=4,4′-bipyridine) with the urea-functionalized ligand bada,have been successfully synthesized using a pillared-layer strategy.Both 1 and 2 exhibit two-dimensional square lattice (sql) layers pillared by dabco and bipy,respectively,and feature pcu topology.Different to dabco in 1,the pillaring ligand 4,4′-bipyridine with longer length forms a doubly interpenetrated structure of 2.Both compounds display good thermal stabilities and permanent porosities.1 exhibits good performance for CO_(2)(32 cm^(3) g^(-1)),C_(2)H_(6) (58 cm^(3) g^(-1)),and C_(3)H_(8) (105 cm^(3) g^(-1)) capture among MOFs without open metal sites.In particular,1 possesses high Q_st for CO_(2)(32.8 kJ mol^(-1)),C_(2)H_(6) (37.2 kJ mol^(-1)),and C_(3)H_(8) (40.3 kJ mol^(-1)) adsorption and outstanding selectivities for CO_(2)(5.7),C_(2)H_(6) (28),and C_(3)H_(8) (224) over CH_(4) at 298 K.Density functional theory (DFT)-based calculations further prove the hydrogen-bond interactions and σ–π interactions between gas molecules and urea-based ligands.2 exhibits a gate-opening behavior for N_(2),Ar and CO_(2).Compound 1 could be seen as a significant potential material for gas storage and separation.
基金supported by the National Natural Science Foundation of China(21971194).
文摘The luminescence response application in chemical sensing by metal–organic frameworks(MOFs)and their hybrid materials has been reported extensively in recent years.However,the reviews on this topic are mainly focused on the sensing materials(MOFs and their functionalized hybrid materials)and analytes(all types of species).In this comprehensive review,the luminescence response mode and chemical sensing mechanism for lanthanide-functionalized MOF hybrids(abbreviated as LnFMOFH)are systematically summarized.Specifically,ten sections are subdivided,and importantly involve three main topics.Firstly,LnFMOFH and the luminescence responsive chemical sensing for these hybrids are introduced.Secondly,three single luminescence response modes,including“Turn-Off”,“Turn-On”“Turn–Off–On”and dual mode,as ratiometric luminescence(RL)for chemical sensing in LnFMOFH materials are summarized.Thirdly,some types of chemical sensing mechanisms observed in LnFMOFH materials are outlined,which involve the ligand–metal energy transfer(LMET)for the luminescence response in chemical sensing of enhanced or weakened analytes.
基金supported by CAMS Innovation Fund for Medical Sciences(2019-I2M-5-023)
文摘Sepsis is currently a major problem and challenge facing the medical community.With rapid development and progress of modern medicine,researchers have put more and more attention on sepsis;meanwhile,the morbidity and mortality of sepsis remains high despite great efforts from experts in various fields.According to updated guidelines,sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.Infection is the initial step of sepsis progression,and development from infection to sepsis is a complex pathophysiological process,including pathogen invasion,cytokine release,capillary leakage,microcirculation dysfunction,etc.which finally leads to organ metabolic disorders and functional failure.According to the latest recommended international guidelines of Sepsis 3.0,the presence of infection and SOFA score≥2 are considered as the diagnostic criteria for sepsis,and the"rescue"measures mainly focus on reversal of organ dysfunction.However,despite nearly two decades of efforts,the"Save Sepsis Campaign"has not achieved satisfactory results.Emergency medicine is the frontier subject of acute and severe illness which treats patients with acute infections at the earliest.If at this stage,physicians can predict the possibility of sepsis progression from demographic characteristics,localize the pathogen and infection,detect the inflammatory storms by tests of cytokines and evaluate the severity of the infection with more effective clinical scoring system,and then take effective measures to prevent infection from developing into sepsis in high-risk patients,the morbidity and mortality of sepsis in patients with acute infection will be greatly reduced.Based on this situation,Chinese emergency medicine experts proposed the concept of"preventing and blocking"sepsis,and launched the nationwide"Preventing Sepsis Campaign in China(PSCC)"nationwide.The main concept is summarized as"three early and two reduces"which includes early detection,early diagnosis and early intervention during the"pre-symptomatic"and"peri-septic"stage in order to reduce the incidence of sepsis and it proposed a new approach for diagnosis and treatment of acute severe infection.This consensus is jointly advocated,discussed and written by four academic associations in the field of emergency medicine and five scholarly publishing organizations.More than 40 experts from fields of emergency medicine,critical care medicine,infectious diseases,pharmacy and laboratory medicine have participated in several rounds of deliberation and finally reached consensus on the criteria of identifying patients with acute infection,taking anti-infective treatments,screening of high-risk patients with sepsis,detection and treatment of inflammatory storm,protection of vascular endothelial cells and the regulation of coagulation function,as well as strategies of liquid support and organ function protection etc.The consensus summarizes the commonly used clinical diagnosis criteria and treatment measures of sepsis both in Western medicine and traditional Chinese medicine for clinicians in order to provide evidence for the diagnosis and treatment of the disease.
基金financially supported by the Outstanding Youth Fund of the Natural Science Foundation of Jiangsu, China (No. BK20150050)the National Key Research and Development Program, China (No. 2016YFD0800204)+2 种基金the National Natural Science Foundation of China (No. 21677149)the Institute of Soil Science, Chinese Academy of Sciences (No. ISSASIP1616)the Key Program of Frontier Sciences, Chinese Academy of Sciences (No. QYZDJSSW-DQC035)
文摘The chars in the natural environment can affect the migration of polybrominated diphenyl ethers(PBDEs). However, there is insufficient research relating to the adsorption behavior and mechanisms of PBDEs on biochars. This study examined the adsorption kinetics of 2,2′,4,4′-tetrabromodiphenyl ether(BDE-47) on maize straw-derived biochars(MSBCs) pyrolyzed at four different temperatures via batch experiments. The biochar samples were characterized using Fourier transform infrared(FTIR) spectroscopy,Raman spectra, and elemental analysis. A two-compartment first-order model and pseudo-second-order model exhibited a better fit compared to a pseudo-first-order model in describing the BDE-47 adsorption on biochars, which was dominated by a slow adsorption compartment and chemisorption. The MSBC pyrolyzed at 600 °C had the highest BDE-47 adsorption capacity owing to its relatively large specific surface area and relatively high aromaticity compared with the other three MSBCs pyrolyzed at 300, 400, and 500 ℃.However, there was no significant difference in adsorption capacity among the other three biochars. The organic functional groups coupled with the graphene structures of biochars and the hydrophobic effect of the functional groups promoted the adsorption of BDE-47. Pore diffusion was not the sole rate-limiting step;film diffusion was also involved in the adsorption process of BDE-47 on biochars. The overall results demonstrate the transport and potential treatment of PBDEs using biochars.
基金financially supported by the National Key R&D Program of China(2019YFD0900200,2018YFD0900400)Supported by the earmarked fund for CARS(CARS-45)+2 种基金National Natural Science Foundation of China for Outstanding Youth Science Foundation(31922086)the Young Top-Notch Talent Support ProgramSichuan Science and Technology Program(2019YFN0036)。
文摘Background Mannan oligosaccharides(MOS)are recommended as aquaculture additives owing to their excellent antioxidant properties.In the present study,we examined the effects of dietary MOS on the head kidney and spleen of grass carp(Ctenopharyngodon idella)with Aeromonas hydrophila infection.Methods A total of 540 grass carp were used for the study.They were administered six gradient dosages of the MOS diet(0,200,400,600,800,and 1,000 mg/kg)for 60 d.Subsequently,we performed a 14-day Aeromonas hydrophila challenge experiment.The antioxidant capacity of the head kidney and spleen were examined using spectrophotometry,DNA fragmentation,qRT-PCR,and Western blotting.Results After infection with Aeromonas hydrophila,400-600 mg/kg MOS supplementation decreased the levels of reactive oxygen species,protein carbonyl,and malonaldehyde and increased the levels of anti-superoxide anion,antihydroxyl radical,and glutathione in the head kidney and spleen of grass carp.The activities of copper-zinc superoxide dismutase,manganese superoxide dismutase,catalase,glutathione S-transferase,glutathione reductase,and glutathione peroxidase were also enhanced by supplementation with 400-600 mg/kg MOS.Furthermore,the expression of most antioxidant enzymes and their corresponding genes increased significantly with supplementation of 200-800 mg/kg MOS.mRNA and protein levels of nuclear factor erythroid 2-related factor 2 also increased following supplementation with 400-600 mg/kg MOS.In addition,supplementation with 400-600 mg/kg MOS reduced excessive apoptosis by inhibiting the death receptor pathway and mitochondrial pathway processes.Conclusions Based on the quadratic regression analysis of the above biomarkers(reactive oxygen species,malondialdehyde,and protein carbonyl)of oxidative damage in the head kidney and spleen of on-growing grass carp,the recommended MOS supplementation is 575.21,557.58,531.86,597.35,570.16,and 553.80 mg/kg,respectively.Collectively,MOS supplementation could alleviate oxidative injury in the head kidney and spleen of grass carp infected with Aeromonas hydrophila.
