Background Recent studies have found that there is a certain correlation between gut microbiota(GM)and oral cavity cancer(OCC).Materials and methods In this Two-Sample Mendelian Randomization Study,GWAS of the microbi...Background Recent studies have found that there is a certain correlation between gut microbiota(GM)and oral cavity cancer(OCC).Materials and methods In this Two-Sample Mendelian Randomization Study,GWAS of the microbiome from the MiBioGen consortium(18,340 samples from 24 population-based cohorts)were used as exposure data.In addition,outcome data(357 OCC cases and 372,016 controls)were extracted from the IEU Open GWAS project.To examine the characteristics of potentially pathogenic bacteria in OCC,we performed two-sample Mendelian randomization(MR)analyses-based genome-wide association study(GWAS)summary statistics with the use of inversevariance-weighting or Wald ratio.Subsequently,sensitivity analyses were performed to explore the robustness of the primary results.Finally,we performed reverse MR analysis to mitigate reverse causality.Result A total of 2,699 single nucleotide polymorphisms(SNPs)associated with 196 bacterial genera were screened as instrumental variables(IVs),and the results suggested that 11 of them could increase the risk of OCC,while 5 of them exhibited a protective effect against OCC.Conclusion Bacillus orders,Bacillus phylums and Proteobacteria are associated with an increased risk of OCC,while Genus Butyrivibrio,genus Eggerthella,and genus Clostridium reduce the risk of OCC development.展开更多
Management of clinically negative necks(cN0)in oral cavity(OCSCC)and oropharyngeal(OPSCC)squamous cell carcinoma(SCC)has evolved over time.Historically,the clinically negative neck has been managed with elective neck ...Management of clinically negative necks(cN0)in oral cavity(OCSCC)and oropharyngeal(OPSCC)squamous cell carcinoma(SCC)has evolved over time.Historically,the clinically negative neck has been managed with elective neck dissection(END)or observation,but more recently sentinel lymph node biopsy(SLNB)has emerged as a technique to detect occult metastases.In this review,we will discuss the role of SLNB in early-stage OCSCC and in the management of OPSCC.展开更多
Sentinel lymph node biopsy has become a well-established and commonplace prac-tice in many oncologic disease sites as a means to stage the regional lymphatics, avoid unnec-essary surgery and decrease patient morbidity...Sentinel lymph node biopsy has become a well-established and commonplace prac-tice in many oncologic disease sites as a means to stage the regional lymphatics, avoid unnec-essary surgery and decrease patient morbidity. In the head and neck, its role is well established for cutaneous melanoma with proven fidelity and survival benefit. Its role in use for other sites such as oral cavity carcinoma continues to develop with promising results from several recent trials. Although not widely adopted, the potential benefits of sentinel lymph node biopsy in the management of oral cavity carcinoma are apparent. Refinements in tech-nology and protocols including development of novel radiopharmaceutical tracers, routine incorporation of detailed anatomic imaging, increasing surgeon experience and development of new intraoperative identification aids will likely lead to improvements in the use and accu-racy of this technique. Copyright a 2016 Chinese Medical Association. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).展开更多
基金supported by the National Outstanding Youth Science Fund Project of National Natural Science Foundation of China(No.82202780).
文摘Background Recent studies have found that there is a certain correlation between gut microbiota(GM)and oral cavity cancer(OCC).Materials and methods In this Two-Sample Mendelian Randomization Study,GWAS of the microbiome from the MiBioGen consortium(18,340 samples from 24 population-based cohorts)were used as exposure data.In addition,outcome data(357 OCC cases and 372,016 controls)were extracted from the IEU Open GWAS project.To examine the characteristics of potentially pathogenic bacteria in OCC,we performed two-sample Mendelian randomization(MR)analyses-based genome-wide association study(GWAS)summary statistics with the use of inversevariance-weighting or Wald ratio.Subsequently,sensitivity analyses were performed to explore the robustness of the primary results.Finally,we performed reverse MR analysis to mitigate reverse causality.Result A total of 2,699 single nucleotide polymorphisms(SNPs)associated with 196 bacterial genera were screened as instrumental variables(IVs),and the results suggested that 11 of them could increase the risk of OCC,while 5 of them exhibited a protective effect against OCC.Conclusion Bacillus orders,Bacillus phylums and Proteobacteria are associated with an increased risk of OCC,while Genus Butyrivibrio,genus Eggerthella,and genus Clostridium reduce the risk of OCC development.
文摘Management of clinically negative necks(cN0)in oral cavity(OCSCC)and oropharyngeal(OPSCC)squamous cell carcinoma(SCC)has evolved over time.Historically,the clinically negative neck has been managed with elective neck dissection(END)or observation,but more recently sentinel lymph node biopsy(SLNB)has emerged as a technique to detect occult metastases.In this review,we will discuss the role of SLNB in early-stage OCSCC and in the management of OPSCC.
文摘Sentinel lymph node biopsy has become a well-established and commonplace prac-tice in many oncologic disease sites as a means to stage the regional lymphatics, avoid unnec-essary surgery and decrease patient morbidity. In the head and neck, its role is well established for cutaneous melanoma with proven fidelity and survival benefit. Its role in use for other sites such as oral cavity carcinoma continues to develop with promising results from several recent trials. Although not widely adopted, the potential benefits of sentinel lymph node biopsy in the management of oral cavity carcinoma are apparent. Refinements in tech-nology and protocols including development of novel radiopharmaceutical tracers, routine incorporation of detailed anatomic imaging, increasing surgeon experience and development of new intraoperative identification aids will likely lead to improvements in the use and accu-racy of this technique. Copyright a 2016 Chinese Medical Association. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
