Two-photon microscopy normally suffers from the scattering of the tissue in biological imaging.Multidither coberent optical adaptive technique(COAT)can correct the scattered wavefront in parallel.However,the determina...Two-photon microscopy normally suffers from the scattering of the tissue in biological imaging.Multidither coberent optical adaptive technique(COAT)can correct the scattered wavefront in parallel.However,the determination of the corrective phases may not be completely accurate using conventional method,which undermines the performance of this technique.In this paper,we theoretically demonstrate a method that can obtain more accurate corrective phases by determining the phase values from the square root of the fuorescence signal.A numnerical simulation model is established to study the performance of adaptive optics in two-photon micros-copy by combining scalar diffraction theory with vector diffraction theory.The results show that the distortion of the wavefront can be corrected more thoroughly with our method in two-photon imaging.In our simulation,with the scattering from a 450-mn-thick mouse brain tissue,excitation focal spots with higher peak-to background ratio(PBR)and images with higher contrast can be obtained.Hence,further enhancement of the multidither COAT correction performance in two-photon imaging can be expected.展开更多
Despite the unique advantages of optical microscopy for molecular specific high resolution imaging of living structure in both space and time,curent applications are mostly limited to research settings.This is due to ...Despite the unique advantages of optical microscopy for molecular specific high resolution imaging of living structure in both space and time,curent applications are mostly limited to research settings.This is due to the aberrations and multiple scattering that is induced by the inhomogeneous refractive boundaries that are inherent to biological systems.However,recent developments in adaptive optics and wavefront shaping have shown that high resolution optical imaging is not fundamentally limited only to the observation of single cells,but can be significantly enhanced to realize deep tissue imaging.To provide insight into how these two closely related fields can expand the limits of bio imaging,we review the recent progresses in their performance and applicable range of studies as well as potential future research directions to push the limits of deep tissuse imnaging.展开更多
Adaptive optics has been widely used in biological science to recover high-resolution optical image deep into the tissue,where optical distortion detection with high speed and accuracy is strongly required.Here,we int...Adaptive optics has been widely used in biological science to recover high-resolution optical image deep into the tissue,where optical distortion detection with high speed and accuracy is strongly required.Here,we introduce convolutional neural networks,one of the most popular machine learning models,into Shack-Hartmann wavefront sensor(SHWS)to simplify optical distortion detection processes.Without image segmentation or centroid positioning algorithm,the trained network could estimate up to 36th Zernike mode coefficients directly from a full SHWS image within 1.227ms on a personal computer,and achieves prediction accuracy up to 97.4%.The simulation results show that the average root mean squared error in phase residuals of our method is 75.64%lower than that with the modal-based SHWS method.With the high detection accuracy and simplified detection processes,this work has the potential to be applied in wavefront sensor-based adaptive optics for in vivo deep tissue imaging.展开更多
A tilt-correction adaptive optical system installed on the 430 mm Solar Telescope of Nanjing University has been put in operation. It consists of a tip-tilt mirror, a correlation tracker and an imaging CCD camera. An ...A tilt-correction adaptive optical system installed on the 430 mm Solar Telescope of Nanjing University has been put in operation. It consists of a tip-tilt mirror, a correlation tracker and an imaging CCD camera. An absolute difference algorithm is used for detecting image motion in the correlation tracker. The sampling frequency of the system is 419 Hz. We give a description of the system's configuration, an analysis of its performance and a report of our observational results. A residual jitter of 0.14 arcsec has been achieved. The error rejection bandwidth of the system can be adjusted in the range 5-28 Hz according to the beacon size and the strength of atmospheric turbulence.展开更多
Even in the early stage,endocrine metabolism disease may lead to micro aneurysms in retinal capillaries whose diameters are less than 10 μm.However,the fundus cameras used in clinic diagnosis can only obtain images o...Even in the early stage,endocrine metabolism disease may lead to micro aneurysms in retinal capillaries whose diameters are less than 10 μm.However,the fundus cameras used in clinic diagnosis can only obtain images of vessels larger than 20 μm in diameter.The human retina is a thin and multiple layer tissue,and the layer of capillaries less than10 μm in diameter only exists in the inner nuclear layer.The layer thickness of capillaries less than 10 μm in diameter is about 40 μm and the distance range to rod＆cone cell surface is tens of micrometers,which varies from person to person.Therefore,determining reasonable capillary layer（CL） position in different human eyes is very difficult.In this paper,we propose a method to determine the position of retinal CL based on the rod＆cone cell layer.The public positions of CL are recognized with 15 subjects from 40 to 59 years old,and the imaging planes of CL are calculated by the effective focal length of the human eye.High resolution retinal capillary imaging results obtained from 17 subjects with a liquid crystal adaptive optics system（LCAOS） validate our method.All of the subjects＇ CLs have public positions from 127 μm to 147 μm from the rod＆cone cell layer,which is influenced by the depth of focus.展开更多
Adaptive optics(AO)has significantly advanced high-resolution solar observations by mitigating atmospheric turbulence.However,traditional post-focal AO systems suffer from external configurations that introduce excess...Adaptive optics(AO)has significantly advanced high-resolution solar observations by mitigating atmospheric turbulence.However,traditional post-focal AO systems suffer from external configurations that introduce excessive optical surfaces,reduced light throughput,and instrumental polarization.To address these limitations,we propose an embedded solar adaptive optics telescope(ESAOT)that intrinsically incorporates the solar AO(SAO)subsystem within the telescope's optical train,featuring a co-designed correction chain with a single Hartmann-Shack full-wavefront sensor(HS f-WFS)and a deformable secondary mirror(DSM).The HS f-WFS uses temporal-spatial hybrid sampling technique to simultane-ously resolve tip-tilt and high-order aberrations,while the DSM performs real-time compensation through adaptive modal optimization.This unified architecture achieves symmetrical polarization suppression and high system throughput by min-imizing optical surfaces.A 600 mm ESAOT prototype incorporating a 12×12 micro-lens array HS f-WFS and 61-actuator piezoelectric DSM has been developed and successfully conducted on-sky photospheric observations.Validations in-cluding turbulence simulations,optical bench testing,and practical observations at the Lijiang observatory collectively confirm the system's capability to maintain aboutλ/10 wavefront error during active region tracking.This architectural breakthrough of the ESAOT addresses long-standing SAO integration challenges in solar astronomy and provides scala-bility analyses confirming direct applicability to the existing and future large solar observation facilities.展开更多
This study presents high-power mode-selective operation in a large-mode-area(LMA)fiber laser.A spatial modeadaptive control system incorporating a 5×1 photonic lantern was employed to facilitate mode conversion b...This study presents high-power mode-selective operation in a large-mode-area(LMA)fiber laser.A spatial modeadaptive control system incorporating a 5×1 photonic lantern was employed to facilitate mode conversion between the LP01 and LP11 modes.The coherence length between the five single-mode arms and the stimulated Brillouin scattering threshold in the amplifier were well balanced by tuning the seed linewidth.In addition,the specific design of the fiber amplifier's bending radius enabled stable mode-selective output with high mode purity.Consequently,a nearfundamental mode control was achieved in a 42-μm LMA fiber laser,yielding a beam quality M^(2)factor of 1.97 at an output power of 1 kW.Subsequently,a stable LP_(11)mode laser output with an output power of 219 W and an optical conversion efficiency of 75%was obtained.This research provides a significant technical foundation for the modeselective operation of high-power LMA fiber lasers.展开更多
In this article,we have modeled the astroclimatic parameters using data from the fifth reanalysis series(ERA5)from the European Centre for Medium-Range Weather Forecasts over the period 2010-2020.These data have been ...In this article,we have modeled the astroclimatic parameters using data from the fifth reanalysis series(ERA5)from the European Centre for Medium-Range Weather Forecasts over the period 2010-2020.These data have been projected onto the site of the Roque de los Muchachos Observatory(ORM).The analysis covers the main parameters influencing the quality of astronomical observation,notably the vertical profiles of temperature,potential temperature,and optical turbulence(C_(n)~2),as well as the vertical wind distributions and seasonal behaviors of atmospheric turbulence,which are treated in detail by specifying the wind speed at the 200 hPa level(V200).Around this level,the wind at high altitude presents moderate speeds and a generally stable direction,conditions favorable for adaptive optics.The thermal profiles show good agreement with standard atmospheric models,with a well-defined tropopause and a stable stratosphere,as well as the integrated parameters such as seeing(free and total),isoplanatic angle,and coherence time.The results reveal a stratified and stable atmosphere,with turbulence predominantly concentrated in the lower troposphere.The thermal profiles show a good agreement with standard atmospheric models,with a well-defined tropopause and a stable stratosphere.The seasonality of the astroclimatic parameters indicates conditions particularly favorable for observation during the winter months,with the median of free seeing,total seeing,isoplanatic angle and a coherence time as respectively 0″.48,0″.72,2″,and 6 ms.These results confirm the strong potential of ORM as a reference astronomical site,capable of hosting high-precision observation instruments.The methodological approach employed also provides a replicable basis for the characterization of other candidate sites for the installation of ground-based telescopes.As a preliminary study,this work establishes a scientific basis for further on-site monitoring and detailed characterization of the ORM site.展开更多
AIM:To assess the variations in photoreceptor cell packing density(PCPD)across the retina among young healthy individuals with emmetropia,low and moderate myopia.METHODS:High-resolution adaptive optics scanning laser ...AIM:To assess the variations in photoreceptor cell packing density(PCPD)across the retina among young healthy individuals with emmetropia,low and moderate myopia.METHODS:High-resolution adaptive optics scanning laser ophthalmoscopy(AOSLO)systems were utilized for retinal imaging with a large sampling window of 700μm×700μm.The study cohort included 14 emmetropic[spherical equivalent(SE)ranged+0.5 to-0.5 D],15 low myopic(SE ranged-0.5 to-3 D)and 21 moderate myopic(SE ranged-3 to-6 D)healthy young adults.Photoreceptors at 3°temporal,6°superior and inferior 6°were captured.Statistical analysis was then performed to obtain PCPD and cell spacing.RESULTS:The average age of participants was 22.54±2.86(ranged 20–30y)with no difference among 3 groups.At 3°temporal,the emmetropic group exhibited the highest PCPD of 15186.16±2050.54 cells/mm^(2),while the low and moderate myopic groups had PCPD of 14009.15±1073.01 and 13466.92±1121.71 cells/mm2,respectively.At 3°temporal,the emmetropic group also had the smallest cell spacing at 6.66±0.26 mm,compared to 6.85±0.26 and 6.91±0.28 mm for the low and moderate myopic groups,respectively.Compared to the emmetropic group,at 3°temporal,the myopic groups showed significantly reduced PCPD(low myopia:P=0.032;moderate myopia:P=0.001).At 6°inferior,the moderate myopic group exhibited a significant decrease in PCPD(P=0.013),while at 6°superior,there were no significant statistical differences in PCPD for the low and moderate myopic groups(P>0.05).In comparison to the emmetropic group,only the moderate myopic group showed significantly increased cell spacing at all three positions(temporal 3°:P=0.011,superior 6°:P=0.046,inferior 6°:P=0.013).Correlation analysis revealed a positive correlation between PCPD and axial length changes(P<0.05).CONCLUSION:Reduced PCPD and increased cell spacing strongly correlated with refractive error in mild to moderate myopic eyes,especially at 6°inferior to the fovea and the decreased PCPD in the macular region of myopic patients may be associated with increased axial lengthinduced retinal stretching.展开更多
On the basis of Hartmann Shack sensor imaging analysis, a new method is presented with which the wavefront slope can be obtained when the object is incoherent and extended. This method, which is demonstrated by both ...On the basis of Hartmann Shack sensor imaging analysis, a new method is presented with which the wavefront slope can be obtained when the object is incoherent and extended. This method, which is demonstrated by both theoretical interpreting and computer simulation, explains how to measure the wavefront slope difference between two sub apertures through the determination of image displacements on detector plane. It includes a fast and accurate digital algorithm for detecting wavefront disturbance, which is much suitable for realization in such electrical hardwares as digital signal processors.展开更多
Based on the regularities of temperature fluctuation,the atmo- sphere below an altitude of 71km above ground is divided into 6 sublayers. For each of them the calculation formulae of temperature and pressure are deriv...Based on the regularities of temperature fluctuation,the atmo- sphere below an altitude of 71km above ground is divided into 6 sublayers. For each of them the calculation formulae of temperature and pressure are derived.The calculated results at any altitude in the range under considera- tion agree well with the values laid down in the table of“U.S.Standard At- mosphere”.From this the formula for the refractive-index structure coeffi- cient C_N^2,of much importance in the research of adaptive optics,is obtained for the corresponding altitudes.展开更多
A wavefront sensing and correction correction is proposed that would allow the field of view (FOV) of an adaptive optics spstem to be increased in size by a factor of several tens. This concept is based on the idea of...A wavefront sensing and correction correction is proposed that would allow the field of view (FOV) of an adaptive optics spstem to be increased in size by a factor of several tens. This concept is based on the idea of placing multiple deformable mirrors (DMs) at locations that are conjugate to corresponding. layers of atmospheric turbulence. In order to control properly each DM, a tomographic method for determining the phase distortion contributed by each atmospheric layer has been developed and used in dealing with the circumstance of two layers.展开更多
Adaptive optics techniques have been developed over the past half century and routinely used in large ground-based telescopes for more than 30 years.Although this technique has already been used in various application...Adaptive optics techniques have been developed over the past half century and routinely used in large ground-based telescopes for more than 30 years.Although this technique has already been used in various applications,the basic setup and methods have not changed over the past 40 years.In recent years,with the rapid development of artificial in-telligence,adaptive optics will be boosted dramatically.In this paper,the recent advances on almost all aspects of adapt-ive optics based on machine learning are summarized.The state-of-the-art performance of intelligent adaptive optics are reviewed.The potential advantages and deficiencies of intelligent adaptive optics are also discussed.展开更多
Coherent optical control within or through scattering media via wavefront shaping has seen broad applications since its invention around 2007.Wavefront shaping is aimed at overcoming the strong scattering,featured by ...Coherent optical control within or through scattering media via wavefront shaping has seen broad applications since its invention around 2007.Wavefront shaping is aimed at overcoming the strong scattering,featured by random interference,namely speckle patterns.This randomness occurs due to the refractive index inhomogeneity in complex media like biological tissue or the modal dispersion in multimode fiber,yet this randomness is actually deterministic and potentially can be time reversal or precompensated.Various wavefront shaping approaches,such as optical phase conjugation,iterative optimization,and transmission matrix measurement,have been developed to generate tight and intense optical delivery or high-resolution image of an optical object behind or within a scattering medium.The performance of these modula-tions,however,is far from satisfaction.Most recently,artifcial intelligence has brought new inspirations to this field,providing exciting hopes to tackle the challenges by mapping the input and output optical patterns and building a neuron network that inherently links them.In this paper,we survey the developments to date on this topic and briefly discuss our views on how to harness machine learning(deep learning in particular)for further advancements in the field.展开更多
Coupling plane wave into a single-mode fiber （SMF） with high and steady coupling efficiency is crucial for fiber- based free-space laser systems, where random angular jitters are the main influencing factors of fibe...Coupling plane wave into a single-mode fiber （SMF） with high and steady coupling efficiency is crucial for fiber- based free-space laser systems, where random angular jitters are the main influencing factors of fiber coupling. In this paper, we verified a new adaptive-optic device named adaptive fiber coupler （AFC） which could compensate angular jitters and improve the SMF coupling efficiency in some degree. Experiments of SMF coupling under the angular jitter situation using AFC have been achieved. Stochastic parallel gradient descent （SPGD） algorithm is employed as the control strategy, of which the iteration rate is 625 Hz. In closed loop, the coupling efficiency keeps above 65% when angular errors are below 80/3tad. The compensation bandwidth is 35 Hz at sine-jitter of 15 ~rad amplitude with average coupling efficiency of above 60%. Also, experiments with simulated turbulence have been studied. The average coupling efficiency increases from 31.97% in open loop to 61.33% in closed loop, and mean square error （MSE） of coupling efficiency drops from 7.43% to 1.75%.展开更多
The portable adaptive optics(PAO)device is a low-cost and compact system,designed for 4-meter class telescopes that have no adaptive optics(AO)system,because of the physical space limitation at the Nasmyth or Cassegra...The portable adaptive optics(PAO)device is a low-cost and compact system,designed for 4-meter class telescopes that have no adaptive optics(AO)system,because of the physical space limitation at the Nasmyth or Cassegrain focus and the historically high cost of conventional AO.The initial scientific observations of the PAO are focused on the direct imaging of exoplanets and sub-stellar companions.This paper discusses the concept of PAO and the associated high-contrast imaging performance in our recent observational runs.PAO deliver a Strehl ratio better than 60%in H band under median seeing conditions of 1".Combined with our dedicated image rotation and subtraction(IRS)technique and the optimized IRS(O-IRS)algorithm,the averaged contrast ratio for a 5≤V_(mag)≤9 primary star is 1.3×10^(-5)and3.3×10^(-6)at angular distance of 0.36"with exposure time of 7 minutes and 2 hours,respectively.PAO has successfully revealed the known exoplanet ofκAnd b in our recent observation with the 3.5-meter ARC telescope at Apache Point Observatory.We have performed the associated astrometry and photometry analysis of the recoveredκAnd b planet,which gives a projected separation of 0.98"±0.05",a position angle of 51.1°±0.5°and a mass of 10.15_(-1.255)^(+2.19) MJup.These results demonstrate that PAO can be used for direct imaging of exoplanets with medium-sized telescopes.展开更多
Feedback-based wavefront shaping focuses light through scattering media by employing phase optimization algorithms.Genetic algorithms(GAs),inspired by the process of natural selection,are well suited for phase optimiz...Feedback-based wavefront shaping focuses light through scattering media by employing phase optimization algorithms.Genetic algorithms(GAs),inspired by the process of natural selection,are well suited for phase optimization in wavelfront shaping problems.In 2012,Conkey et al.first introduced a GA into feedback-based wavefront shaping to find the optimum phase map.Since then,due to its siuperior performance in noisy environment,the GA has been widely adopted by lots of implementations.However,there have been limited studies discussing and optimizing the detailed procedures of the GA.To fill this blank,in this study,we performed a thorough study on the performance of the GA for focusing light through scattering media.Using numerical tools,we evaluated certain procedures that can be potentially improved and provided guidance on how to choose certain parameters appropriately.This study is beneficial in improving the performance of wavefront shaping systems with GAs.展开更多
Cone photoreceptor cell identication is important for the early diagnosis of retinopathy.In this study,an object detection algorithm is used for cone cell identication in confocal adaptive optics scanning laser ophtha...Cone photoreceptor cell identication is important for the early diagnosis of retinopathy.In this study,an object detection algorithm is used for cone cell identication in confocal adaptive optics scanning laser ophthalmoscope(AOSLO)images.An effectiveness evaluation of identication using the proposed method reveals precision,recall,and F_(1)-score of 95.8%,96.5%,and 96.1%,respectively,considering manual identication as the ground truth.Various object detection and identication results from images with different cone photoreceptor cell distributions further demonstrate the performance of the proposed method.Overall,the proposed method can accurately identify cone photoreceptor cells on confocal adaptive optics scanning laser ophthalmoscope images,being comparable to manual identication.展开更多
Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) is one of the major national projects under construction in China. Active optics is one of the most important technologies for new large telescopes. I...Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) is one of the major national projects under construction in China. Active optics is one of the most important technologies for new large telescopes. It is used for correcting telescope errors generated by gravitational and thermal changes. Here, however, we use this technology to realize the configuration of LAMOST,—a task that cannot be done in the traditional way. A comprehensive and intensive research on the active optics used in LAMOST is also reported, including an open-loop control method and an auxiliary closed-loop control method. Another important development is in our pre-calibration method of open-loop control, which is with some new features: simultaneous calculation of the forces and displacements of force actuators and displacement actuators; the profile of mirror can be arbitrary; the mirror surface shape is not expressed by a fitting polynomial, but is derived from the mirror surface shape formula which is highly accurate; a proof is given that the solution of the pre-calibration method is the same as the least squares solution.展开更多
Integrating deformable mirrors within the optical train of an adaptive telescope was one of the major innovations in astronomical observation technology,distinguished by its high optical throughput,reduced optical sur...Integrating deformable mirrors within the optical train of an adaptive telescope was one of the major innovations in astronomical observation technology,distinguished by its high optical throughput,reduced optical surfaces,and the incorporation of the deformable mirror.Typically,voice-coil actuators are used,which require additional position sensors,internal control electronics,and cooling systems,leading to a very complex structure.Piezoelectric deformable secondary mirror technologies were proposed to overcome these problems.Recently,a high-order piezoelectric deformable secondary mirror has been developed and installed on the 1.8-m telescope at Lijiang Observatory in China to make it an adaptive telescope.The system consists of a 241-actuator piezoelectric deformable secondary mirror,a 192-sub-aperture Shack-Hartmann wavefront sensor,and a multi-core-based real-time controller.The actuator spacing of the PDSM measures 19.3 mm,equivalent to approximately 12.6 cm when mapped onto the primary mirror,significantly less than the voicecoil-based adaptive telescopes such as LBT,Magellan and VLT.As a result,stellar images with Strehl ratios above 0.49 in the R band have been obtained.To our knowledge,these are the highest R band images captured by an adaptive telescope with deformable secondary mirrors.Here,we report the system description and on-sky performance of this adaptive telescope.展开更多
基金supported by National Natural Science Foundation of China(Nos.31571110 and 81771877)Natural Science Foundation of Zhejiang Province of China(LZ17F050001)the Fundamental Research Funds for the Central Universities.
文摘Two-photon microscopy normally suffers from the scattering of the tissue in biological imaging.Multidither coberent optical adaptive technique(COAT)can correct the scattered wavefront in parallel.However,the determination of the corrective phases may not be completely accurate using conventional method,which undermines the performance of this technique.In this paper,we theoretically demonstrate a method that can obtain more accurate corrective phases by determining the phase values from the square root of the fuorescence signal.A numnerical simulation model is established to study the performance of adaptive optics in two-photon micros-copy by combining scalar diffraction theory with vector diffraction theory.The results show that the distortion of the wavefront can be corrected more thoroughly with our method in two-photon imaging.In our simulation,with the scattering from a 450-mn-thick mouse brain tissue,excitation focal spots with higher peak-to background ratio(PBR)and images with higher contrast can be obtained.Hence,further enhancement of the multidither COAT correction performance in two-photon imaging can be expected.
基金supported by the National Research Foundation of Korea(Nos.2016R1C1B201530 and 2017M3C7A1044966)the Agency for Defense Development(UD170075FD)the TJ Park Foundation.
文摘Despite the unique advantages of optical microscopy for molecular specific high resolution imaging of living structure in both space and time,curent applications are mostly limited to research settings.This is due to the aberrations and multiple scattering that is induced by the inhomogeneous refractive boundaries that are inherent to biological systems.However,recent developments in adaptive optics and wavefront shaping have shown that high resolution optical imaging is not fundamentally limited only to the observation of single cells,but can be significantly enhanced to realize deep tissue imaging.To provide insight into how these two closely related fields can expand the limits of bio imaging,we review the recent progresses in their performance and applicable range of studies as well as potential future research directions to push the limits of deep tissuse imnaging.
基金supported by the National Natural Science Foundation of China(31571110,61735016,81771877)the Natural Science Foundation of Zhejiang Province of China(LZ17F050001)+1 种基金Zhe-jiang Lab(2018EB0ZX01)the Fundamental Research Funds for the Central Universities
文摘Adaptive optics has been widely used in biological science to recover high-resolution optical image deep into the tissue,where optical distortion detection with high speed and accuracy is strongly required.Here,we introduce convolutional neural networks,one of the most popular machine learning models,into Shack-Hartmann wavefront sensor(SHWS)to simplify optical distortion detection processes.Without image segmentation or centroid positioning algorithm,the trained network could estimate up to 36th Zernike mode coefficients directly from a full SHWS image within 1.227ms on a personal computer,and achieves prediction accuracy up to 97.4%.The simulation results show that the average root mean squared error in phase residuals of our method is 75.64%lower than that with the modal-based SHWS method.With the high detection accuracy and simplified detection processes,this work has the potential to be applied in wavefront sensor-based adaptive optics for in vivo deep tissue imaging.
基金Supported by the National Natural Science Foundation of China
文摘A tilt-correction adaptive optical system installed on the 430 mm Solar Telescope of Nanjing University has been put in operation. It consists of a tip-tilt mirror, a correlation tracker and an imaging CCD camera. An absolute difference algorithm is used for detecting image motion in the correlation tracker. The sampling frequency of the system is 419 Hz. We give a description of the system's configuration, an analysis of its performance and a report of our observational results. A residual jitter of 0.14 arcsec has been achieved. The error rejection bandwidth of the system can be adjusted in the range 5-28 Hz according to the beacon size and the strength of atmospheric turbulence.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11174274,11174279,61205021,11204299,61475152,and 61405194)
文摘Even in the early stage,endocrine metabolism disease may lead to micro aneurysms in retinal capillaries whose diameters are less than 10 μm.However,the fundus cameras used in clinic diagnosis can only obtain images of vessels larger than 20 μm in diameter.The human retina is a thin and multiple layer tissue,and the layer of capillaries less than10 μm in diameter only exists in the inner nuclear layer.The layer thickness of capillaries less than 10 μm in diameter is about 40 μm and the distance range to rod＆cone cell surface is tens of micrometers,which varies from person to person.Therefore,determining reasonable capillary layer（CL） position in different human eyes is very difficult.In this paper,we propose a method to determine the position of retinal CL based on the rod＆cone cell layer.The public positions of CL are recognized with 15 subjects from 40 to 59 years old,and the imaging planes of CL are calculated by the effective focal length of the human eye.High resolution retinal capillary imaging results obtained from 17 subjects with a liquid crystal adaptive optics system（LCAOS） validate our method.All of the subjects＇ CLs have public positions from 127 μm to 147 μm from the rod＆cone cell layer,which is influenced by the depth of focus.
基金support from the National Science Foundation of China(NSFC)(Grants No.12293031 and No.61905252)the National Science Foundation for Distinguished Young Scholars(Grant No.12022308)the National Key R&D Program of China(Grants No.2021YFC2202200 and No.2021YFC2202204).
文摘Adaptive optics(AO)has significantly advanced high-resolution solar observations by mitigating atmospheric turbulence.However,traditional post-focal AO systems suffer from external configurations that introduce excessive optical surfaces,reduced light throughput,and instrumental polarization.To address these limitations,we propose an embedded solar adaptive optics telescope(ESAOT)that intrinsically incorporates the solar AO(SAO)subsystem within the telescope's optical train,featuring a co-designed correction chain with a single Hartmann-Shack full-wavefront sensor(HS f-WFS)and a deformable secondary mirror(DSM).The HS f-WFS uses temporal-spatial hybrid sampling technique to simultane-ously resolve tip-tilt and high-order aberrations,while the DSM performs real-time compensation through adaptive modal optimization.This unified architecture achieves symmetrical polarization suppression and high system throughput by min-imizing optical surfaces.A 600 mm ESAOT prototype incorporating a 12×12 micro-lens array HS f-WFS and 61-actuator piezoelectric DSM has been developed and successfully conducted on-sky photospheric observations.Validations in-cluding turbulence simulations,optical bench testing,and practical observations at the Lijiang observatory collectively confirm the system's capability to maintain aboutλ/10 wavefront error during active region tracking.This architectural breakthrough of the ESAOT addresses long-standing SAO integration challenges in solar astronomy and provides scala-bility analyses confirming direct applicability to the existing and future large solar observation facilities.
基金supported by the National Natural Science Foundation of China(Grant No.12074432)。
文摘This study presents high-power mode-selective operation in a large-mode-area(LMA)fiber laser.A spatial modeadaptive control system incorporating a 5×1 photonic lantern was employed to facilitate mode conversion between the LP01 and LP11 modes.The coherence length between the five single-mode arms and the stimulated Brillouin scattering threshold in the amplifier were well balanced by tuning the seed linewidth.In addition,the specific design of the fiber amplifier's bending radius enabled stable mode-selective output with high mode purity.Consequently,a nearfundamental mode control was achieved in a 42-μm LMA fiber laser,yielding a beam quality M^(2)factor of 1.97 at an output power of 1 kW.Subsequently,a stable LP_(11)mode laser output with an output power of 219 W and an optical conversion efficiency of 75%was obtained.This research provides a significant technical foundation for the modeselective operation of high-power LMA fiber lasers.
文摘In this article,we have modeled the astroclimatic parameters using data from the fifth reanalysis series(ERA5)from the European Centre for Medium-Range Weather Forecasts over the period 2010-2020.These data have been projected onto the site of the Roque de los Muchachos Observatory(ORM).The analysis covers the main parameters influencing the quality of astronomical observation,notably the vertical profiles of temperature,potential temperature,and optical turbulence(C_(n)~2),as well as the vertical wind distributions and seasonal behaviors of atmospheric turbulence,which are treated in detail by specifying the wind speed at the 200 hPa level(V200).Around this level,the wind at high altitude presents moderate speeds and a generally stable direction,conditions favorable for adaptive optics.The thermal profiles show good agreement with standard atmospheric models,with a well-defined tropopause and a stable stratosphere,as well as the integrated parameters such as seeing(free and total),isoplanatic angle,and coherence time.The results reveal a stratified and stable atmosphere,with turbulence predominantly concentrated in the lower troposphere.The thermal profiles show a good agreement with standard atmospheric models,with a well-defined tropopause and a stable stratosphere.The seasonality of the astroclimatic parameters indicates conditions particularly favorable for observation during the winter months,with the median of free seeing,total seeing,isoplanatic angle and a coherence time as respectively 0″.48,0″.72,2″,and 6 ms.These results confirm the strong potential of ORM as a reference astronomical site,capable of hosting high-precision observation instruments.The methodological approach employed also provides a replicable basis for the characterization of other candidate sites for the installation of ground-based telescopes.As a preliminary study,this work establishes a scientific basis for further on-site monitoring and detailed characterization of the ORM site.
基金Supported by National Natural Science Foundation of China(No.82271107).
文摘AIM:To assess the variations in photoreceptor cell packing density(PCPD)across the retina among young healthy individuals with emmetropia,low and moderate myopia.METHODS:High-resolution adaptive optics scanning laser ophthalmoscopy(AOSLO)systems were utilized for retinal imaging with a large sampling window of 700μm×700μm.The study cohort included 14 emmetropic[spherical equivalent(SE)ranged+0.5 to-0.5 D],15 low myopic(SE ranged-0.5 to-3 D)and 21 moderate myopic(SE ranged-3 to-6 D)healthy young adults.Photoreceptors at 3°temporal,6°superior and inferior 6°were captured.Statistical analysis was then performed to obtain PCPD and cell spacing.RESULTS:The average age of participants was 22.54±2.86(ranged 20–30y)with no difference among 3 groups.At 3°temporal,the emmetropic group exhibited the highest PCPD of 15186.16±2050.54 cells/mm^(2),while the low and moderate myopic groups had PCPD of 14009.15±1073.01 and 13466.92±1121.71 cells/mm2,respectively.At 3°temporal,the emmetropic group also had the smallest cell spacing at 6.66±0.26 mm,compared to 6.85±0.26 and 6.91±0.28 mm for the low and moderate myopic groups,respectively.Compared to the emmetropic group,at 3°temporal,the myopic groups showed significantly reduced PCPD(low myopia:P=0.032;moderate myopia:P=0.001).At 6°inferior,the moderate myopic group exhibited a significant decrease in PCPD(P=0.013),while at 6°superior,there were no significant statistical differences in PCPD for the low and moderate myopic groups(P>0.05).In comparison to the emmetropic group,only the moderate myopic group showed significantly increased cell spacing at all three positions(temporal 3°:P=0.011,superior 6°:P=0.046,inferior 6°:P=0.013).Correlation analysis revealed a positive correlation between PCPD and axial length changes(P<0.05).CONCLUSION:Reduced PCPD and increased cell spacing strongly correlated with refractive error in mild to moderate myopic eyes,especially at 6°inferior to the fovea and the decreased PCPD in the macular region of myopic patients may be associated with increased axial lengthinduced retinal stretching.
文摘On the basis of Hartmann Shack sensor imaging analysis, a new method is presented with which the wavefront slope can be obtained when the object is incoherent and extended. This method, which is demonstrated by both theoretical interpreting and computer simulation, explains how to measure the wavefront slope difference between two sub apertures through the determination of image displacements on detector plane. It includes a fast and accurate digital algorithm for detecting wavefront disturbance, which is much suitable for realization in such electrical hardwares as digital signal processors.
文摘Based on the regularities of temperature fluctuation,the atmo- sphere below an altitude of 71km above ground is divided into 6 sublayers. For each of them the calculation formulae of temperature and pressure are derived.The calculated results at any altitude in the range under considera- tion agree well with the values laid down in the table of“U.S.Standard At- mosphere”.From this the formula for the refractive-index structure coeffi- cient C_N^2,of much importance in the research of adaptive optics,is obtained for the corresponding altitudes.
文摘A wavefront sensing and correction correction is proposed that would allow the field of view (FOV) of an adaptive optics spstem to be increased in size by a factor of several tens. This concept is based on the idea of placing multiple deformable mirrors (DMs) at locations that are conjugate to corresponding. layers of atmospheric turbulence. In order to control properly each DM, a tomographic method for determining the phase distortion contributed by each atmospheric layer has been developed and used in dealing with the circumstance of two layers.
基金funded by the National Natural Science Foundation of China(12173041,11733005,11727805)Youth Innovation Promotion Association,Chinese Academy of Sciences (No.2020376)+2 种基金Frontier Research Fund of Institute of Optics and Electronics,Chinese Academy of Sciences (No.C21K002)Research Equipment Development Project of the Chinese Academy of Sciences (No.YA18K019)Laboratory Innovation Foundation of the Chinese Academy of Sciences (No.YJ20K002)
文摘Adaptive optics techniques have been developed over the past half century and routinely used in large ground-based telescopes for more than 30 years.Although this technique has already been used in various applications,the basic setup and methods have not changed over the past 40 years.In recent years,with the rapid development of artificial in-telligence,adaptive optics will be boosted dramatically.In this paper,the recent advances on almost all aspects of adapt-ive optics based on machine learning are summarized.The state-of-the-art performance of intelligent adaptive optics are reviewed.The potential advantages and deficiencies of intelligent adaptive optics are also discussed.
基金supported by the National Natural Science Foundation of China(Nos.81671726 and 81627805)the Hong Kong Research Grant Council(No.25204416)+1 种基金the Shenzhen Science and Technology Innovation Commission(No.JCYJ20170818104421564)the Hong Kong Innovation and Technology Commission(No.ITS/022/18).
文摘Coherent optical control within or through scattering media via wavefront shaping has seen broad applications since its invention around 2007.Wavefront shaping is aimed at overcoming the strong scattering,featured by random interference,namely speckle patterns.This randomness occurs due to the refractive index inhomogeneity in complex media like biological tissue or the modal dispersion in multimode fiber,yet this randomness is actually deterministic and potentially can be time reversal or precompensated.Various wavefront shaping approaches,such as optical phase conjugation,iterative optimization,and transmission matrix measurement,have been developed to generate tight and intense optical delivery or high-resolution image of an optical object behind or within a scattering medium.The performance of these modula-tions,however,is far from satisfaction.Most recently,artifcial intelligence has brought new inspirations to this field,providing exciting hopes to tackle the challenges by mapping the input and output optical patterns and building a neuron network that inherently links them.In this paper,we survey the developments to date on this topic and briefly discuss our views on how to harness machine learning(deep learning in particular)for further advancements in the field.
基金Project supported by the National Natural Science Foundation of China （Grant No. 61205069）.
文摘Coupling plane wave into a single-mode fiber （SMF） with high and steady coupling efficiency is crucial for fiber- based free-space laser systems, where random angular jitters are the main influencing factors of fiber coupling. In this paper, we verified a new adaptive-optic device named adaptive fiber coupler （AFC） which could compensate angular jitters and improve the SMF coupling efficiency in some degree. Experiments of SMF coupling under the angular jitter situation using AFC have been achieved. Stochastic parallel gradient descent （SPGD） algorithm is employed as the control strategy, of which the iteration rate is 625 Hz. In closed loop, the coupling efficiency keeps above 65% when angular errors are below 80/3tad. The compensation bandwidth is 35 Hz at sine-jitter of 15 ~rad amplitude with average coupling efficiency of above 60%. Also, experiments with simulated turbulence have been studied. The average coupling efficiency increases from 31.97% in open loop to 61.33% in closed loop, and mean square error （MSE） of coupling efficiency drops from 7.43% to 1.75%.
基金supported by the National Natural Science Foundation of China(Grant Nos.11827804,U2031210)。
文摘The portable adaptive optics(PAO)device is a low-cost and compact system,designed for 4-meter class telescopes that have no adaptive optics(AO)system,because of the physical space limitation at the Nasmyth or Cassegrain focus and the historically high cost of conventional AO.The initial scientific observations of the PAO are focused on the direct imaging of exoplanets and sub-stellar companions.This paper discusses the concept of PAO and the associated high-contrast imaging performance in our recent observational runs.PAO deliver a Strehl ratio better than 60%in H band under median seeing conditions of 1".Combined with our dedicated image rotation and subtraction(IRS)technique and the optimized IRS(O-IRS)algorithm,the averaged contrast ratio for a 5≤V_(mag)≤9 primary star is 1.3×10^(-5)and3.3×10^(-6)at angular distance of 0.36"with exposure time of 7 minutes and 2 hours,respectively.PAO has successfully revealed the known exoplanet ofκAnd b in our recent observation with the 3.5-meter ARC telescope at Apache Point Observatory.We have performed the associated astrometry and photometry analysis of the recoveredκAnd b planet,which gives a projected separation of 0.98"±0.05",a position angle of 51.1°±0.5°and a mass of 10.15_(-1.255)^(+2.19) MJup.These results demonstrate that PAO can be used for direct imaging of exoplanets with medium-sized telescopes.
文摘Feedback-based wavefront shaping focuses light through scattering media by employing phase optimization algorithms.Genetic algorithms(GAs),inspired by the process of natural selection,are well suited for phase optimization in wavelfront shaping problems.In 2012,Conkey et al.first introduced a GA into feedback-based wavefront shaping to find the optimum phase map.Since then,due to its siuperior performance in noisy environment,the GA has been widely adopted by lots of implementations.However,there have been limited studies discussing and optimizing the detailed procedures of the GA.To fill this blank,in this study,we performed a thorough study on the performance of the GA for focusing light through scattering media.Using numerical tools,we evaluated certain procedures that can be potentially improved and provided guidance on how to choose certain parameters appropriately.This study is beneficial in improving the performance of wavefront shaping systems with GAs.
基金the Natural Science Foundation of Jiangsu Province(BK20200214)National Key R&D Program of China(2017YFB0403701)+5 种基金Jiangsu Province Key R&D Program(BE2019682 and BE2018667)National Natural Science Foundation of China(61605210,61675226,and 62075235)Youth Innovation Promotion Association of Chinese Academy of Sciences(2019320)Frontier Science Research Project of the Chinese Academy of Sciences(QYZDB-SSW-JSC03)Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02060000)and Entrepreneurship and Innova-tion Talents in Jiangsu Province(Innovation of Scienti¯c Research Institutes).
文摘Cone photoreceptor cell identication is important for the early diagnosis of retinopathy.In this study,an object detection algorithm is used for cone cell identication in confocal adaptive optics scanning laser ophthalmoscope(AOSLO)images.An effectiveness evaluation of identication using the proposed method reveals precision,recall,and F_(1)-score of 95.8%,96.5%,and 96.1%,respectively,considering manual identication as the ground truth.Various object detection and identication results from images with different cone photoreceptor cell distributions further demonstrate the performance of the proposed method.Overall,the proposed method can accurately identify cone photoreceptor cells on confocal adaptive optics scanning laser ophthalmoscope images,being comparable to manual identication.
文摘Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) is one of the major national projects under construction in China. Active optics is one of the most important technologies for new large telescopes. It is used for correcting telescope errors generated by gravitational and thermal changes. Here, however, we use this technology to realize the configuration of LAMOST,—a task that cannot be done in the traditional way. A comprehensive and intensive research on the active optics used in LAMOST is also reported, including an open-loop control method and an auxiliary closed-loop control method. Another important development is in our pre-calibration method of open-loop control, which is with some new features: simultaneous calculation of the forces and displacements of force actuators and displacement actuators; the profile of mirror can be arbitrary; the mirror surface shape is not expressed by a fitting polynomial, but is derived from the mirror surface shape formula which is highly accurate; a proof is given that the solution of the pre-calibration method is the same as the least squares solution.
基金funded by the National Natural Science Foundation of China(No.11733005,12173041,11727805)Youth Innovation Promotion Association,Chinese Academy of Sciences(No.2020376)Frontier Research Fund of Institute of Optics and Electronics,Chinese Academy of Sciences(No.C21K002).
文摘Integrating deformable mirrors within the optical train of an adaptive telescope was one of the major innovations in astronomical observation technology,distinguished by its high optical throughput,reduced optical surfaces,and the incorporation of the deformable mirror.Typically,voice-coil actuators are used,which require additional position sensors,internal control electronics,and cooling systems,leading to a very complex structure.Piezoelectric deformable secondary mirror technologies were proposed to overcome these problems.Recently,a high-order piezoelectric deformable secondary mirror has been developed and installed on the 1.8-m telescope at Lijiang Observatory in China to make it an adaptive telescope.The system consists of a 241-actuator piezoelectric deformable secondary mirror,a 192-sub-aperture Shack-Hartmann wavefront sensor,and a multi-core-based real-time controller.The actuator spacing of the PDSM measures 19.3 mm,equivalent to approximately 12.6 cm when mapped onto the primary mirror,significantly less than the voicecoil-based adaptive telescopes such as LBT,Magellan and VLT.As a result,stellar images with Strehl ratios above 0.49 in the R band have been obtained.To our knowledge,these are the highest R band images captured by an adaptive telescope with deformable secondary mirrors.Here,we report the system description and on-sky performance of this adaptive telescope.
