Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly b...Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly becoming the preferred choice of physicians and patients for point-of-care testing due to its simplicity,cost-effectiveness,and rapid detection.Observing the optical signal change from the colloidal gold of the traditional LFIA strip has been widely applied for various biomarkers detection in body fluids.Despite the significant progress,rapid real-time detection of color changes in the colloidal gold by the naked eye still faces many limitations,such as large errors and the inability to quantify and accurately detect.New optical LFIA strip technology has emerged in recent years to extend its application scenarios for achieving quantitative detection such as fluorescence,afterglow,and chemiluminescence.Herein,we summarized the development of optical LFIA technology from single to hyphenated optical signals for biomarkers detection in body fluids from invasive and non-invasive sources.Moreover,the challenge and outlook of optical LFIA strip technology are highlighted to inspire the designing of next-generation diagnostic platforms.展开更多
Gastric cancer,including stomach tumors,poses significant health challenges due to late-stage diagnosis and limited early detection methods.Accurate imaging and precise tumor margin demarcation are critical for effect...Gastric cancer,including stomach tumors,poses significant health challenges due to late-stage diagnosis and limited early detection methods.Accurate imaging and precise tumor margin demarcation are critical for effective treatment planning and improved patient outcomes.Conventional imaging techniques,such as endoscopy and histopathology,provide valuable diagnostic information but cannot offer real-time assessment.We aim to explore the application of optical coherence tomography(OCT),combined with statistical and machine learning methods,for rapid tumor margin demarcation in gastrointestinal(GI)cancer tissues in exvivo.GI tumor specimens from 17 patients were imaged intraoperatively with OCT.Quantitative features were extracted from the images,and statistical and machine learning analyses were applied to distinguish tissue types.Subsequent histopathological evaluation was used as the reference standard for validation.The combination of OCT imaging and data-driven analysis enables clear differentiation between healthy,marginal and tumor tissues in near real-time.The KNN model achieved the highest classification accuracy(0.921±0.040),with SVM(0.906±0.038)and Extra Trees(0.901±0.034)also demonstrating robust performance in discriminating tissue margins.OCT findings demonstrate strong agreement with histopathology.Integrated with statistical and machine learning techniques,OCT enables rapid assessment of GI tumor margins.This approach provides quantitative objectivity and real-time feedback,closely approximating histopathological analysis and supporting improved surgical decision-making.展开更多
Overt and harmful diabetes mellitus(DM)has detrimental effects on individuals and,by extension,the community.Among the microvascular DM complications is diabetic retinopathy(DR).DR may cause irreversible vision deteri...Overt and harmful diabetes mellitus(DM)has detrimental effects on individuals and,by extension,the community.Among the microvascular DM complications is diabetic retinopathy(DR).DR may cause irreversible vision deterioration in cases of poor blood glucose regulation.Changes in vascular permeability are key trigger points for diabetic macular edema(DME),a condition characterized by the accumulation of fluid in the macula.The development of vascular endothelial growth factor(VEGF)pathway inhibitors has provided a pathogenesis-based treatment approach for DME.Optical coherence tomography(OCT)provides highresolution imaging of the anatomy,including the aging of DME and its structural damage,in distinct morphologic subtypes of macular edema,thereby supporting the assessment of macular edema treatment.The availability of repeated OCT monitoring provides clinical reassurance through the treatment.OCT angiography(OCTA)provides retinal blood flow maps with high spatial resolution.The ability promotes an understanding of disease pathogenesis and facilitates the implementation of new therapeutic methods.This review compares the potential of OCT and OCTA in the diagnosis and treatment of DME,as well as their respective therapeutic applications.展开更多
Optical tweezers technology has the characteristics of noncontact manipulation in three dimensions and steerable separation in solutions,and could be applied to obtain a separated sperm with high quality for intracyto...Optical tweezers technology has the characteristics of noncontact manipulation in three dimensions and steerable separation in solutions,and could be applied to obtain a separated sperm with high quality for intracytoplasmic sperm injection(ICSI).However,the effects of optical tweezers on sperm motility are still unclear.To elucidate the effects on sperm motility for optical tweezers,we systematically investigated the correlation between motility parameters and the parameters of optical tweezers(wavelength,power,trapping duration,and trapping orientation).Under three systems of optical tweezers with different laser wavelengths(1064,850,and 785 nm),the nine motility parameters of free swimming were mainly affected by trapping orientation(vertical/horizontal)and trapping duration.When 850 nm laser and 1064 nm laser are used,vertical trapping significantly reduces sperm free-swimming capability with prolonged exposure time,whereas horizontal trapping exhibits relatively minor interference on sperm motility.Notably,the 785 nm laser does not induce statistically significant changes in key parameters of sperm motility under any experimental conditions(trapping orientation and duration).For the rolling frequency of trapped sperm,horizontal trapping for three wavelengths has a negligible effect compared with vertical trapping,especially for the 785 nm laser.In conclusion,horizontal trapping can preserve sperm motility under low power(below 140mW at 1064 nm,below 100mW at 850nm,below 60mW at 785 nm)and short duration(below 4 min).This trapping duration is suffcient for the separation procedure of single live sperm in ICSI.This study provides critical parameter optimization guidelines for the safe application of optical tweezers technology in reproductive medicine.展开更多
Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the po...Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the poor structural stability and low sensitivity hindered their application scope.In this work,a new MOF Zn-450 luminescent thermometer with multiple emission fluorescence characteristics was synthesized by the combination of 3,3,5,5-biphenyl tetracarboxylic acid(H_(4)L) and Zn^(2+) ion under solvothermal conditions.Interestingly,a high relative sensitivity of 1.43 % K^(-1) was found within 80-300 K based on Zn-450.Subsequently,two high-sensitivity luminescent Ln@MOFs(Ln = Eu and Tb) were further fabricated by doping rare earth ions into Zn-450 based on the post-synthesis strategy.Among them,the Eu@Zn-450 demonstrates various luminous behaviors while achieving an increased relative sensitivity of 1.63 % K^(-1).In addition,the continuously visible red,pink,and purple luminescent emissions at the same temperature range were observed,suggesting that the Eu@Zn-450 could be utilized as a luminescent colorimetric molecular thermometer.Importantly,this work can present new possibilities for the development of rare earth-doped luminescence and its temperature sensing properties.展开更多
In the realm of secure information storage,optical encryption has emerged as a vital technique,particularly with the miniaturization of encryption devices.However,many existing systems lack the necessary reconfigurabi...In the realm of secure information storage,optical encryption has emerged as a vital technique,particularly with the miniaturization of encryption devices.However,many existing systems lack the necessary reconfigurability and dynamic functionality.This study presents a novel approach through the development of dynamic optical-to-chemical energy conversion metamaterials,which enable enhanced steganography and multilevel information storage.We introduce a micro-dynamic multiple encryption device that leverages programmable optical properties in coumarin-based metamaterials,achieved through a direct laser writing grayscale gradient strategy.This methodology allows for the dynamic regulation of photoluminescent characteristics and cross-linking networks,facilitating innovative steganographic techniques under varying light conditions.The integration of a multi-optical field control system enables real-time adjustments to the material’s properties,enhancing the device’s reconfigurability and storage capabilities.Our findings underscore the potential of these metamaterials in advancing the field of microscale optical encryption,paving the way for future applications in dynamic storage and information security.展开更多
Microscopy imaging is fundamental in analyzing bacterial morphology and dynamics,offering critical insights into bacterial physiology and pathogenicity.Image segmentation techniques enable quantitative analysis of bac...Microscopy imaging is fundamental in analyzing bacterial morphology and dynamics,offering critical insights into bacterial physiology and pathogenicity.Image segmentation techniques enable quantitative analysis of bacterial structures,facilitating precise measurement of morphological variations and population behaviors at single-cell resolution.This paper reviews advancements in bacterial image segmentation,emphasizing the shift from traditional thresholding and watershed methods to deep learning-driven approaches.Convolutional neural networks(CNNs),U-Net architectures,and three-dimensional(3D)frameworks excel at segmenting dense biofilms and resolving antibiotic-induced morphological changes.These methods combine automated feature extraction with physics-informed postprocessing.Despite progress,challenges persist in computational efficiency,cross-species generalizability,and integration with multimodal experimental workflows.Future progress will depend on improving model robustness across species and imaging modalities,integrating multimodal data for phenotype-function mapping,and developing standard pipelines that link computational tools with clinical diagnostics.These innovations will expand microbial phenotyping beyond structural analysis,enabling deeper insights into bacterial physiology and ecological interactions.展开更多
A multi-stage stress relaxation test was performed on a granodiorite sample to understand the deformation process prior to the macroscopic failure of brittle rocks,as well as the transient response during stress relax...A multi-stage stress relaxation test was performed on a granodiorite sample to understand the deformation process prior to the macroscopic failure of brittle rocks,as well as the transient response during stress relaxation.Distributed optical fiber sensing was used to measure strains across the sample surface by helically wrapping the single-mode fiber around the cylindrical sample.Close agreement was observed between the circumferential strains obtained from the optical fibers and the extensometer.The reconstructed full-field strain contours show strain heterogeneity from the crack closure phase,and the strains in the later deformation phase are dominantly localized within the former high-strain zone.The Gini coefficient was used to quantify the degree of strain localization and shows an initial increase during the crack closure phase,a decrease during the linear elastic phase,and a subsequent increase during the post-yielding phase.This behavior corresponds to a process of initial localization from an imperfect boundary condition,homogenization,and eventual relocalization prior to the macroscopic failure of the sample.The transient strain rate decay during the stress relaxation phase was quantified using the p-value in the“Omori-like"power law function.A higher initial stress at the onset of relaxation results in a lower p-value,indicating a slower strain rate decay.As the sample approaches macroscopic failure,the lowest p-value shifts from the most damaged zone to adjacent areas,suggesting stress redistribution or crack propagation in deformed crystalline rocks under stress relaxation conditions.展开更多
In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural a...In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural and anthropogenic effects on marine aerosols optical properties,as well as the applicability of multi-satellite products and IMPROVE equation.The averaged aerosol optical depth(AOD500 nm)was 0.31±0.16 andÅngström exponent440–675 nm was 0.29±0.30.In offshore China,significant anthropogenic emissions affected the marine environment.In remote WPO,dust aerosols transported from northern China,Siberia,Central Asia,and those settling from the upper troposphere originating from north Africa,Arabian peninsula,and western India,were dominant.The spatial trends of AOD were opposite in the mid-latitude and southern seas of WPO.The highest AOD,0.32±0.23,appeared along the coast of South Asia at mid-latitude,decreasing from offshore seas to remote oceans.In low-latitude and equatorial seas,AOD significantly increased from coast to remote oceans.Ångström exponent dropped significantly from the coast to remote oceans as anthropogenic influence diminished across the entire WPO.Correlation analysis showed that both MODIS-C6 and Himawari AOD prod-ucts showed similar applicability in coastal urban areas,while Himawari AOD is highly recommended for coastal background and marine environment due to its finer resolution.The extinction coefficient derived from PM_(2.5) chemical compositions using IMPROVE algorithm exhibited a significant correlation(R^(2)=0.58)with the con-currently measured AOD in the absence of long-distance transport,suggesting that the IMPROVE is a reasonable proxy of the columnar average of marine aerosol extinctions free from transport influences.展开更多
To investigate the damage evolution caused by stress-driven and sub-critical crack propagation within the Beishan granite under multi-creep triaxial compressive conditions,the distributed optical fiber sensing and X-r...To investigate the damage evolution caused by stress-driven and sub-critical crack propagation within the Beishan granite under multi-creep triaxial compressive conditions,the distributed optical fiber sensing and X-ray computed tomography were combined to obtain the strain distribution over the sample surface and internal fractures of the samples.The Gini and skewness(G-S)coefficients were used to quantify strain localization during tests,where the Gini coefficient reflects the degree of clustering of elements with high strain values,i.e.,strain localization/delocalization.The strain localization-induced asymmetry of data distribution is quantified by the skewness coefficient.A precursor to granite failure is defined by the rapid and simultaneous increase of the G-S coefficients,which are calculated from strain increment,giving an earlier warning of failure by about 8%peak stress than those from absolute strain values.Moreover,the process of damage accumulation due to stress-driven crack propagation in Beishan granite is different at various confining pressures as the stress exceeds the crack initiation stress.Concretely,strain localization is continuous until brittle failure at higher confining pressure,while both strain localization and delocalization occur at lower confining pressure.Despite the different stress conditions,a similar statistical characteristic of strain localization during the creep stage is observed.The Gini coefficient increases,and the skewness coefficient decreases slightly as the creep stress is below 95%peak stress.When the accelerated strain localization begins,the Gini and skewness coefficients increase rapidly and simultaneously.展开更多
To address the challenges of high-precision optical surface defect detection,we propose a novel design for a wide-field and broadband light field camera in this work.The proposed system can achieve a 50°field of ...To address the challenges of high-precision optical surface defect detection,we propose a novel design for a wide-field and broadband light field camera in this work.The proposed system can achieve a 50°field of view and operates at both visible and near-infrared wavelengths.Using the principles of light field imaging,the proposed design enables 3D reconstruction of optical surfaces,thus enabling vertical surface height measurements with enhanced accuracy.Using Zemax-based simulations,we evaluate the system’s modulation transfer function,its optical aberrations,and its tolerance to shape variations through Zernike coefficient adjustments.The results demonstrate that this camera can achieve the required spatial resolution while also maintaining high imaging quality and thus offers a promising solution for advanced optical surface defect inspection.展开更多
Achieving non-centrosymmetric(NCS) configurations in ABX3-type hybrid halides remains a critical challenge for nonlinear optical(NLO) materials due to the conflicting requirements of high second-harmonic generation(SH...Achieving non-centrosymmetric(NCS) configurations in ABX3-type hybrid halides remains a critical challenge for nonlinear optical(NLO) materials due to the conflicting requirements of high second-harmonic generation(SHG) response,wide bandgap,and phase-matching capabilities.Herein,we propose a triplesite modulation strategy by synergistically tailoring the A-site cations(2-methylimidazole cation/1-ethyl-3-methylimidazole cation),B-site metals(Sn^(2+)/Pb^(2+)),and X-site halogens(Cl/Br),which effectively disrupts lattice symmetry and enables NCS crystallization.Our results demonstrate a strong SHG response,an expanded optical bandgap and increased birefringence.The optimized compound C_(6)H_(11)N_(2)PbCl_(3) exhibits a moderately strong SHG efficiency of 3.8 × KDP,a wide bandgap(3.87 eV),and enhanced birefringence(0.139@1064 nm),surpassing majority hybrid NLO materials.The innovative anionic framework introduced here broadens the scope of hybrid NLO crystals,facilitating the integration of various aromatic heterocyclic cations.This research provides a robust strategic framework for the development of advanced NLO materials.展开更多
Optical imaging has been pivotal in biological research(e.g.,cellular/developmental biology)for over two centuries.Recent advances like super-resolution fluorescence and nonlinear optical microscopy enable nanoscale s...Optical imaging has been pivotal in biological research(e.g.,cellular/developmental biology)for over two centuries.Recent advances like super-resolution fluorescence and nonlinear optical microscopy enable nanoscale studies of live cells and animals,yet their application to marine mollusks-key marine ecosystem species,remains underexplored.This review summarizes optical imaging techniques and their use in investigating marine mollusks across molecular,cellular,tissue,and individual levels.It highlights promising avenues for novel imaging methods to unravel the structures and functions of these organisms in future research,with a focus on advancements in applying cutting-edge optical techniques across these hierarchical levels.Given optical imaging's significance in elucidating marine mollusks'ecological and genetic information,this field deserves substantial attention and support.The review aims to address existing gaps,providing researchers and practitioners with comprehensive insights to foster further progress in this domain.展开更多
The ability to noninvasively manipulate and isolate specific cell populations in vivo is critical for advancing real-time diagnostics,precision medicine,and immunological research.Here,we present a novel and broadly a...The ability to noninvasively manipulate and isolate specific cell populations in vivo is critical for advancing real-time diagnostics,precision medicine,and immunological research.Here,we present a novel and broadly applicable optical trapping system based on a custom-designed 2×3 optical tweezer array,which enables the real-time interception and manipulation of circulating leukocytes in live animals.By utilizing intrinsic velocity differences between leukocytes and red blood cells,the system achieves stable trapping of individual leukocytes in vessels 15-20μm in diameter and decelerates multiple cells in vessels greater than 20μm.Notably,it also enables the optical blockage of lymphatic vessels exceeding 50μm,a previously unreported capability.This label-free,noninvasive approach operates without repeated blood draws and is compatible with diverse vessel geometries and flow dynamics.The system offers a generalizable solution for in vivo cell extraction and analysis,paving the way for high-precision single-cell technologies in biomedical research and clinical translation.展开更多
Laser wakefield accelerators(LWFAs)offer acceleration gradients up to 1000 times higher than those of conventional radio-frequency accelerators,offering a pathway to significantly more compact and cost-effective accel...Laser wakefield accelerators(LWFAs)offer acceleration gradients up to 1000 times higher than those of conventional radio-frequency accelerators,offering a pathway to significantly more compact and cost-effective accelerator systems.This breakthrough opens up new possibilities for laboratory-scale light sources.All-optical inverse Compton scattering(AOCS)sources driven by LWFAs produce high-brightness,quasimonochromatic X rays with micrometer-scale source sizes,delivering the spatial coherence and resolution required for X-ray phase-contrast imaging(XPCI).These features position AOCS X-ray sources as promising tools for applications in biology,medicine,physics,and materials science.However,previous AOCS-based imaging studies have primarily focused on X-ray absorption imaging.In this work,we report successful experimental demonstrations of edge-enhanced in-line XPCI using energy-tunable,quasi-monochromatic AOCS X rays.With a spatial resolution of~20μm,our results clearly show the potential of high-resolution,AOCS-based XPCI applications.展开更多
Over the past several decades,much research effort has been dedicated to the study of optical windows,with two primary themes emerging as key focuses.The first of these centers on investigating the optical properties ...Over the past several decades,much research effort has been dedicated to the study of optical windows,with two primary themes emerging as key focuses.The first of these centers on investigating the optical properties of typical transparent single crystals under shock or ramp compression,which helps in the selection of appropriate optical windows for high-pressure experiments.The second involves the exploration of novel optical windows,particularly transparent polycrystalline ceramics,which not only match the shock impedance of the samples,but also preserve transparency under dynamic compression.In this study,we first integrate existing research on the evolution of optical properties in transparent single crystals and polycrystalline ceramics subjected to shock or ramp loading,proposing a mechanism that links mesoscopic damage to macroscopic optical transparency.Subsequently,through a systematic integration of experiments and computational analyses on polycrystalline transparent ceramics,we demonstrate that shock transparency can be enhanced by optimizing grain size and that shock impedance can be designed via compositional tuning.Notably,our results reveal that nano-grained MgAl_(2)O_(4) ceramics exhibit outstanding optical transparency under high shock pressures,highlighting a promising strategy for designing optical windows that retain transparency under extreme dynamic loading conditions.展开更多
In recent decades,optical micro/nano manipulation has made remarkable strides in the fields of biology and the physical sciences,benefiting from both theoretical and experimental advances in optical forces.The emergen...In recent decades,optical micro/nano manipulation has made remarkable strides in the fields of biology and the physical sciences,benefiting from both theoretical and experimental advances in optical forces.The emergence of optical torques has further enhanced the capabilities and possibilities of optical micro/nano manipulation,opening the door to exciting new applications.In this review,we delve into the fundamentals and recent breakthroughs in the realm of optical micro/nano manipulation using optical torques.We introduce the advancements in optical manipulation based on optical torques from engineered light fields and objects,and highlight the latest developments in applying optical torques to cutting-edge physical and biological scenarios,with a special emphasis on the detection and manipulation of biological structures.Finally,we conclude by outlining our vision for the current and future directions of this field,including the integration of optical torque and micro/nano technologies,the utilization of special light fields,and the development of deeplearning-assisted optical torque design.展开更多
Optical network-on-chip(ONoC) systems have emerged as a promising solution to overcome limitations of traditional electronic interconnects. Efficient ONoC architectures rely on optical routers, enabling high-speed dat...Optical network-on-chip(ONoC) systems have emerged as a promising solution to overcome limitations of traditional electronic interconnects. Efficient ONoC architectures rely on optical routers, enabling high-speed data transfer, efficient routing, and scalability. This paper presents a comprehensive survey analyzing optical router designs, specifically microring resonators(MRRs), Mach-Zehnder interferometers(MZIs), and hybrid architectures. Selected comparison criteria, chosen for their critical importance, significantly impact router functionality and performance. By emphasizing these criteria, valuable insights into the strengths and limitations of different designs are gained, facilitating informed decisions and advancements in optical networking. While other factors contribute to performance and efficiency, the chosen criteria consistently address fundamental elements, enabling meaningful evaluation. This work serves as a valuable resource for beginners, providing a solid foundation in understanding ONoC and optical routers. It also offers an in-depth survey for experts, laying the groundwork for further exploration. Additionally, the importance of considering design constraints and requirements when selecting an optimal router design is highlighted. Continued research and innovation will enable the development of efficient optical router solutions that meet the evolving needs of modern computing systems. This survey underscores the significance of ongoing advancements in the field and their potential impact on future technologies.展开更多
Optical phase transfer via fiber optics is the most effective method for optical frequency standard comparison on the scale below thousands of kilometers.However,the monotonic phase discrimination range of conventiona...Optical phase transfer via fiber optics is the most effective method for optical frequency standard comparison on the scale below thousands of kilometers.However,the monotonic phase discrimination range of conventional optical phase-locked loops is limited,and link delays restrict the control bandwidth,which makes it a challenge to achieve a continuously reliable optical link.This paper presents an event-timing-based phase detection method that overcomes the monotonic phase discrimination range limitation of conventional phase-locked loops through dual-edge timestamp recording,achieving an optical phase measurement resolution on the order of 10 attoseconds.With such a technique,we established a 7-segment-cascaded optical link over 1402km of commercial fiber while sharing dense wavelength division multiplexing(DWDM)channels with live telecom traffic.The system maintained continuous operation for 11.7 days without phase cycle slips despite encountering 15 km aerial fiber noise up to 21000 rad^(2)·Hz^(−1)·km^(−1)at 1 Hz.Relative instabilities of the link are 3.7×10^(−15)at 1 s and 3.9×10^(−20)at 100000 s.展开更多
Reconfigurable linear optical networks based on Mach-Zehnder interferometer(MZI)offer significant potential in optical information processing,particularly in emerging photonic quantum computing systems.However,device ...Reconfigurable linear optical networks based on Mach-Zehnder interferometer(MZI)offer significant potential in optical information processing,particularly in emerging photonic quantum computing systems.However,device losses and calibration errors accumulate as network complexity grows,posing challenges in performing precise mapping of matrix operations.Existing architectures,such as Diamond and Bokun,introduce MZI redundancy into Reck and Clements architectures to improve reliability,which increases complexity and differential path losses that limit scalability.We propose a compact topology architecture that achieves 100%fidelity by employing a symmetrical MZI to decouple optical loss from power ratio and introducing extra MZIs to enforce uniform loss distributions.This multi-level optimization enables direct monitoring pathways while supporting precise calibration,and it approaches theoretical fidelity in practical deployments with direct implications for scalable and fault-tolerant photonic computing systems.展开更多
基金supported by the National Natural Science Foundation of China (Nos.22234005,22494632,22404081)the Natural Science Foundation of Jiangsu Province (Nos.BK20222015,BK20240534)。
文摘Detecting biomarkers in body fluids by optical lateral flow immune assay(LFIA) technology provides rapid access to disease information for early diagnosis.LFIA is based on an antigen-antibody reaction and is rapidly becoming the preferred choice of physicians and patients for point-of-care testing due to its simplicity,cost-effectiveness,and rapid detection.Observing the optical signal change from the colloidal gold of the traditional LFIA strip has been widely applied for various biomarkers detection in body fluids.Despite the significant progress,rapid real-time detection of color changes in the colloidal gold by the naked eye still faces many limitations,such as large errors and the inability to quantify and accurately detect.New optical LFIA strip technology has emerged in recent years to extend its application scenarios for achieving quantitative detection such as fluorescence,afterglow,and chemiluminescence.Herein,we summarized the development of optical LFIA technology from single to hyphenated optical signals for biomarkers detection in body fluids from invasive and non-invasive sources.Moreover,the challenge and outlook of optical LFIA strip technology are highlighted to inspire the designing of next-generation diagnostic platforms.
基金supported by the financial support received from the Indian Council of Medical Research-Department of Health Research(ICMRDHR-CoE-5/3/8/5/2019/I-MDMS)Medical Device and Diagnostics Mission Secretariat(MDMS)and Foundation for Centre for Healthcare Entrepreneurship(CfHE).
文摘Gastric cancer,including stomach tumors,poses significant health challenges due to late-stage diagnosis and limited early detection methods.Accurate imaging and precise tumor margin demarcation are critical for effective treatment planning and improved patient outcomes.Conventional imaging techniques,such as endoscopy and histopathology,provide valuable diagnostic information but cannot offer real-time assessment.We aim to explore the application of optical coherence tomography(OCT),combined with statistical and machine learning methods,for rapid tumor margin demarcation in gastrointestinal(GI)cancer tissues in exvivo.GI tumor specimens from 17 patients were imaged intraoperatively with OCT.Quantitative features were extracted from the images,and statistical and machine learning analyses were applied to distinguish tissue types.Subsequent histopathological evaluation was used as the reference standard for validation.The combination of OCT imaging and data-driven analysis enables clear differentiation between healthy,marginal and tumor tissues in near real-time.The KNN model achieved the highest classification accuracy(0.921±0.040),with SVM(0.906±0.038)and Extra Trees(0.901±0.034)also demonstrating robust performance in discriminating tissue margins.OCT findings demonstrate strong agreement with histopathology.Integrated with statistical and machine learning techniques,OCT enables rapid assessment of GI tumor margins.This approach provides quantitative objectivity and real-time feedback,closely approximating histopathological analysis and supporting improved surgical decision-making.
文摘Overt and harmful diabetes mellitus(DM)has detrimental effects on individuals and,by extension,the community.Among the microvascular DM complications is diabetic retinopathy(DR).DR may cause irreversible vision deterioration in cases of poor blood glucose regulation.Changes in vascular permeability are key trigger points for diabetic macular edema(DME),a condition characterized by the accumulation of fluid in the macula.The development of vascular endothelial growth factor(VEGF)pathway inhibitors has provided a pathogenesis-based treatment approach for DME.Optical coherence tomography(OCT)provides highresolution imaging of the anatomy,including the aging of DME and its structural damage,in distinct morphologic subtypes of macular edema,thereby supporting the assessment of macular edema treatment.The availability of repeated OCT monitoring provides clinical reassurance through the treatment.OCT angiography(OCTA)provides retinal blood flow maps with high spatial resolution.The ability promotes an understanding of disease pathogenesis and facilitates the implementation of new therapeutic methods.This review compares the potential of OCT and OCTA in the diagnosis and treatment of DME,as well as their respective therapeutic applications.
基金supported by the Natural Science Foundation of Anhui Province in China(2508085MF166)Research Fund of Anhui Institute of Translational Medicine(2024zh-03)+2 种基金Key Scientific Research Foundation of Education Department of Anhui Province(2023AH040083)National Natural Science Foundation of China(12404353)Cultivation Project of Training Young and Middle-aged Teachers in Universities of Anhui Province(DTR2023013).
文摘Optical tweezers technology has the characteristics of noncontact manipulation in three dimensions and steerable separation in solutions,and could be applied to obtain a separated sperm with high quality for intracytoplasmic sperm injection(ICSI).However,the effects of optical tweezers on sperm motility are still unclear.To elucidate the effects on sperm motility for optical tweezers,we systematically investigated the correlation between motility parameters and the parameters of optical tweezers(wavelength,power,trapping duration,and trapping orientation).Under three systems of optical tweezers with different laser wavelengths(1064,850,and 785 nm),the nine motility parameters of free swimming were mainly affected by trapping orientation(vertical/horizontal)and trapping duration.When 850 nm laser and 1064 nm laser are used,vertical trapping significantly reduces sperm free-swimming capability with prolonged exposure time,whereas horizontal trapping exhibits relatively minor interference on sperm motility.Notably,the 785 nm laser does not induce statistically significant changes in key parameters of sperm motility under any experimental conditions(trapping orientation and duration).For the rolling frequency of trapped sperm,horizontal trapping for three wavelengths has a negligible effect compared with vertical trapping,especially for the 785 nm laser.In conclusion,horizontal trapping can preserve sperm motility under low power(below 140mW at 1064 nm,below 100mW at 850nm,below 60mW at 785 nm)and short duration(below 4 min).This trapping duration is suffcient for the separation procedure of single live sperm in ICSI.This study provides critical parameter optimization guidelines for the safe application of optical tweezers technology in reproductive medicine.
基金supported by the National Natural Science Foundation of China (No.21801111)the Training Plan for Young Core Teachers in Higher Education of Henan Province (No.2021GGJS131)+1 种基金Natural Science Foundation of Henan Province (No.232300421232)the Heluo Young Talent Lifting Project (No.2023HLTJ02)。
文摘Ln@MOFs by anchoring rare metal ions(Ln) into metal-organic frameworks(MOFs) are proved to have great potential in the field of luminescent molecular thermometer.Nevertheless,the current research indicated that the poor structural stability and low sensitivity hindered their application scope.In this work,a new MOF Zn-450 luminescent thermometer with multiple emission fluorescence characteristics was synthesized by the combination of 3,3,5,5-biphenyl tetracarboxylic acid(H_(4)L) and Zn^(2+) ion under solvothermal conditions.Interestingly,a high relative sensitivity of 1.43 % K^(-1) was found within 80-300 K based on Zn-450.Subsequently,two high-sensitivity luminescent Ln@MOFs(Ln = Eu and Tb) were further fabricated by doping rare earth ions into Zn-450 based on the post-synthesis strategy.Among them,the Eu@Zn-450 demonstrates various luminous behaviors while achieving an increased relative sensitivity of 1.63 % K^(-1).In addition,the continuously visible red,pink,and purple luminescent emissions at the same temperature range were observed,suggesting that the Eu@Zn-450 could be utilized as a luminescent colorimetric molecular thermometer.Importantly,this work can present new possibilities for the development of rare earth-doped luminescence and its temperature sensing properties.
基金the National Key R&D Program of China(Project No.2022YFB4700100)National Natural Science Foundation of China(Grant Nos.61973298)+2 种基金Hong Kong Research Grants Council(GRF Project Number 11216120)the CAS-RGC Joint Laboratory Funding Scheme(Project Number JLFS/E-104/18)the Innovation Promotion Research Association of the Chinese Academy of Sciences(NO.2022199)。
文摘In the realm of secure information storage,optical encryption has emerged as a vital technique,particularly with the miniaturization of encryption devices.However,many existing systems lack the necessary reconfigurability and dynamic functionality.This study presents a novel approach through the development of dynamic optical-to-chemical energy conversion metamaterials,which enable enhanced steganography and multilevel information storage.We introduce a micro-dynamic multiple encryption device that leverages programmable optical properties in coumarin-based metamaterials,achieved through a direct laser writing grayscale gradient strategy.This methodology allows for the dynamic regulation of photoluminescent characteristics and cross-linking networks,facilitating innovative steganographic techniques under varying light conditions.The integration of a multi-optical field control system enables real-time adjustments to the material’s properties,enhancing the device’s reconfigurability and storage capabilities.Our findings underscore the potential of these metamaterials in advancing the field of microscale optical encryption,paving the way for future applications in dynamic storage and information security.
基金financially supported by the Open Project Program of Wuhan National Laboratory for Optoelectronics(No.2022WNLOKF009)the National Natural Science Foundation of China(No.62475216)+2 种基金the Key Research and Development Program of Shaanxi(No.2024GH-ZDXM-37)the Fujian Provincial Natural Science Foundation of China(No.2024J01060)the Startup Program of XMU,and the Fundamental Research Funds for the Central Universities.
文摘Microscopy imaging is fundamental in analyzing bacterial morphology and dynamics,offering critical insights into bacterial physiology and pathogenicity.Image segmentation techniques enable quantitative analysis of bacterial structures,facilitating precise measurement of morphological variations and population behaviors at single-cell resolution.This paper reviews advancements in bacterial image segmentation,emphasizing the shift from traditional thresholding and watershed methods to deep learning-driven approaches.Convolutional neural networks(CNNs),U-Net architectures,and three-dimensional(3D)frameworks excel at segmenting dense biofilms and resolving antibiotic-induced morphological changes.These methods combine automated feature extraction with physics-informed postprocessing.Despite progress,challenges persist in computational efficiency,cross-species generalizability,and integration with multimodal experimental workflows.Future progress will depend on improving model robustness across species and imaging modalities,integrating multimodal data for phenotype-function mapping,and developing standard pipelines that link computational tools with clinical diagnostics.These innovations will expand microbial phenotyping beyond structural analysis,enabling deeper insights into bacterial physiology and ecological interactions.
基金support of her postdoctoral research at the GFZ Helmholtz Centre for Geosciences.P.Pan acknowledges the financial support of the National Natural Science Foundation of China(Grant No.52339001)H.Hofmann and Y.Ji acknowledge the financial support of the Helmholtz Association's Initiative and Networking Fund for the Helmholtz Young Investigator Group ARES(contract number VH-NG-1516).
文摘A multi-stage stress relaxation test was performed on a granodiorite sample to understand the deformation process prior to the macroscopic failure of brittle rocks,as well as the transient response during stress relaxation.Distributed optical fiber sensing was used to measure strains across the sample surface by helically wrapping the single-mode fiber around the cylindrical sample.Close agreement was observed between the circumferential strains obtained from the optical fibers and the extensometer.The reconstructed full-field strain contours show strain heterogeneity from the crack closure phase,and the strains in the later deformation phase are dominantly localized within the former high-strain zone.The Gini coefficient was used to quantify the degree of strain localization and shows an initial increase during the crack closure phase,a decrease during the linear elastic phase,and a subsequent increase during the post-yielding phase.This behavior corresponds to a process of initial localization from an imperfect boundary condition,homogenization,and eventual relocalization prior to the macroscopic failure of the sample.The transient strain rate decay during the stress relaxation phase was quantified using the p-value in the“Omori-like"power law function.A higher initial stress at the onset of relaxation results in a lower p-value,indicating a slower strain rate decay.As the sample approaches macroscopic failure,the lowest p-value shifts from the most damaged zone to adjacent areas,suggesting stress redistribution or crack propagation in deformed crystalline rocks under stress relaxation conditions.
基金supported by the CAS Strategic Priority Research Program(No.XDB0760102),the Ministry of Science and Technology of China(No.2022YFF0802501)the Major Science and Technology Infrastructure Maintenance and Transformation Project of the Chinese Academy of Sciences,Shanghai Science and Technology Innovation Action Plan-Phospherus Project(No.23YF1426200)the National Key Research and Development Program of China(No.2024YFE0212200).
文摘In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural and anthropogenic effects on marine aerosols optical properties,as well as the applicability of multi-satellite products and IMPROVE equation.The averaged aerosol optical depth(AOD500 nm)was 0.31±0.16 andÅngström exponent440–675 nm was 0.29±0.30.In offshore China,significant anthropogenic emissions affected the marine environment.In remote WPO,dust aerosols transported from northern China,Siberia,Central Asia,and those settling from the upper troposphere originating from north Africa,Arabian peninsula,and western India,were dominant.The spatial trends of AOD were opposite in the mid-latitude and southern seas of WPO.The highest AOD,0.32±0.23,appeared along the coast of South Asia at mid-latitude,decreasing from offshore seas to remote oceans.In low-latitude and equatorial seas,AOD significantly increased from coast to remote oceans.Ångström exponent dropped significantly from the coast to remote oceans as anthropogenic influence diminished across the entire WPO.Correlation analysis showed that both MODIS-C6 and Himawari AOD prod-ucts showed similar applicability in coastal urban areas,while Himawari AOD is highly recommended for coastal background and marine environment due to its finer resolution.The extinction coefficient derived from PM_(2.5) chemical compositions using IMPROVE algorithm exhibited a significant correlation(R^(2)=0.58)with the con-currently measured AOD in the absence of long-distance transport,suggesting that the IMPROVE is a reasonable proxy of the columnar average of marine aerosol extinctions free from transport influences.
基金supported by the National Natural Science Foundation of China(Grant No.52339001).
文摘To investigate the damage evolution caused by stress-driven and sub-critical crack propagation within the Beishan granite under multi-creep triaxial compressive conditions,the distributed optical fiber sensing and X-ray computed tomography were combined to obtain the strain distribution over the sample surface and internal fractures of the samples.The Gini and skewness(G-S)coefficients were used to quantify strain localization during tests,where the Gini coefficient reflects the degree of clustering of elements with high strain values,i.e.,strain localization/delocalization.The strain localization-induced asymmetry of data distribution is quantified by the skewness coefficient.A precursor to granite failure is defined by the rapid and simultaneous increase of the G-S coefficients,which are calculated from strain increment,giving an earlier warning of failure by about 8%peak stress than those from absolute strain values.Moreover,the process of damage accumulation due to stress-driven crack propagation in Beishan granite is different at various confining pressures as the stress exceeds the crack initiation stress.Concretely,strain localization is continuous until brittle failure at higher confining pressure,while both strain localization and delocalization occur at lower confining pressure.Despite the different stress conditions,a similar statistical characteristic of strain localization during the creep stage is observed.The Gini coefficient increases,and the skewness coefficient decreases slightly as the creep stress is below 95%peak stress.When the accelerated strain localization begins,the Gini and skewness coefficients increase rapidly and simultaneously.
基金supported by the Jilin Science and Technology Development Plan (20240101029JJ) for the following study:synchronized high-speed detection of surface shape and defects in the grinding stage of complex surfaces (KLMSZZ202305)for the high-precision wide dynamic large aperture optical inspection system for fine astronomical observation by the National Major Research Instrument Development Project (62127901)+2 种基金for ultrasmooth manufacturing technology of large diameter complex curved surface by the National Key R&D Program(2022YFB3403405)for research on the key technology of rapid synchronous detection of surface shape and subsurface defects in the grinding stage of large diameter complex surfaces by the International Cooperation Project(2025010157)The Key Laboratory of Optical System Advanced Manufacturing Technology,Chinese Academy of Sciences (2022KLOMT02-04) also supported this study
文摘To address the challenges of high-precision optical surface defect detection,we propose a novel design for a wide-field and broadband light field camera in this work.The proposed system can achieve a 50°field of view and operates at both visible and near-infrared wavelengths.Using the principles of light field imaging,the proposed design enables 3D reconstruction of optical surfaces,thus enabling vertical surface height measurements with enhanced accuracy.Using Zemax-based simulations,we evaluate the system’s modulation transfer function,its optical aberrations,and its tolerance to shape variations through Zernike coefficient adjustments.The results demonstrate that this camera can achieve the required spatial resolution while also maintaining high imaging quality and thus offers a promising solution for advanced optical surface defect inspection.
基金supported by the National Natural Science Foundation of China (No.22275052)Department of Science and Technology of Hubei Province (Nos.2025AFA111 and 2024CSA076)。
文摘Achieving non-centrosymmetric(NCS) configurations in ABX3-type hybrid halides remains a critical challenge for nonlinear optical(NLO) materials due to the conflicting requirements of high second-harmonic generation(SHG) response,wide bandgap,and phase-matching capabilities.Herein,we propose a triplesite modulation strategy by synergistically tailoring the A-site cations(2-methylimidazole cation/1-ethyl-3-methylimidazole cation),B-site metals(Sn^(2+)/Pb^(2+)),and X-site halogens(Cl/Br),which effectively disrupts lattice symmetry and enables NCS crystallization.Our results demonstrate a strong SHG response,an expanded optical bandgap and increased birefringence.The optimized compound C_(6)H_(11)N_(2)PbCl_(3) exhibits a moderately strong SHG efficiency of 3.8 × KDP,a wide bandgap(3.87 eV),and enhanced birefringence(0.139@1064 nm),surpassing majority hybrid NLO materials.The innovative anionic framework introduced here broadens the scope of hybrid NLO crystals,facilitating the integration of various aromatic heterocyclic cations.This research provides a robust strategic framework for the development of advanced NLO materials.
基金supported by the National Natural Science Foundation of China(T2421003/22327802/41806142)Guangdong Basic and Applied Basic Foundation(2025A1515011484/2022A1515011845)+1 种基金Shenzhen Key Laboratory of Photonics and Biophotonics(ZDSYS20210623092006020)Medical-Engineering Interdisciplinary Research Foundation of Shenzhen University(2023YG033).
文摘Optical imaging has been pivotal in biological research(e.g.,cellular/developmental biology)for over two centuries.Recent advances like super-resolution fluorescence and nonlinear optical microscopy enable nanoscale studies of live cells and animals,yet their application to marine mollusks-key marine ecosystem species,remains underexplored.This review summarizes optical imaging techniques and their use in investigating marine mollusks across molecular,cellular,tissue,and individual levels.It highlights promising avenues for novel imaging methods to unravel the structures and functions of these organisms in future research,with a focus on advancements in applying cutting-edge optical techniques across these hierarchical levels.Given optical imaging's significance in elucidating marine mollusks'ecological and genetic information,this field deserves substantial attention and support.The review aims to address existing gaps,providing researchers and practitioners with comprehensive insights to foster further progress in this domain.
基金funding from the National Key Research and Development Program of China(2021YFF0502900)special fund for Research on the National Major Research Instruments of China(62027824)+2 种基金the National Natural Science Foundation of China(U24A20314)the Key Research and Development Program of Anhui Province in China(2022a05020028)the Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province.
文摘The ability to noninvasively manipulate and isolate specific cell populations in vivo is critical for advancing real-time diagnostics,precision medicine,and immunological research.Here,we present a novel and broadly applicable optical trapping system based on a custom-designed 2×3 optical tweezer array,which enables the real-time interception and manipulation of circulating leukocytes in live animals.By utilizing intrinsic velocity differences between leukocytes and red blood cells,the system achieves stable trapping of individual leukocytes in vessels 15-20μm in diameter and decelerates multiple cells in vessels greater than 20μm.Notably,it also enables the optical blockage of lymphatic vessels exceeding 50μm,a previously unreported capability.This label-free,noninvasive approach operates without repeated blood draws and is compatible with diverse vessel geometries and flow dynamics.The system offers a generalizable solution for in vivo cell extraction and analysis,paving the way for high-precision single-cell technologies in biomedical research and clinical translation.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0530000)the Discipline Construction Foundation of“Double World-class Project”.
文摘Laser wakefield accelerators(LWFAs)offer acceleration gradients up to 1000 times higher than those of conventional radio-frequency accelerators,offering a pathway to significantly more compact and cost-effective accelerator systems.This breakthrough opens up new possibilities for laboratory-scale light sources.All-optical inverse Compton scattering(AOCS)sources driven by LWFAs produce high-brightness,quasimonochromatic X rays with micrometer-scale source sizes,delivering the spatial coherence and resolution required for X-ray phase-contrast imaging(XPCI).These features position AOCS X-ray sources as promising tools for applications in biology,medicine,physics,and materials science.However,previous AOCS-based imaging studies have primarily focused on X-ray absorption imaging.In this work,we report successful experimental demonstrations of edge-enhanced in-line XPCI using energy-tunable,quasi-monochromatic AOCS X rays.With a spatial resolution of~20μm,our results clearly show the potential of high-resolution,AOCS-based XPCI applications.
基金financially supported by the National Natural Science Foundation of China(Grant No.11872344)the Innovatory Development Foundation of the China Academy of Engineering Physics(Grant No.CX20210026).
文摘Over the past several decades,much research effort has been dedicated to the study of optical windows,with two primary themes emerging as key focuses.The first of these centers on investigating the optical properties of typical transparent single crystals under shock or ramp compression,which helps in the selection of appropriate optical windows for high-pressure experiments.The second involves the exploration of novel optical windows,particularly transparent polycrystalline ceramics,which not only match the shock impedance of the samples,but also preserve transparency under dynamic compression.In this study,we first integrate existing research on the evolution of optical properties in transparent single crystals and polycrystalline ceramics subjected to shock or ramp loading,proposing a mechanism that links mesoscopic damage to macroscopic optical transparency.Subsequently,through a systematic integration of experiments and computational analyses on polycrystalline transparent ceramics,we demonstrate that shock transparency can be enhanced by optimizing grain size and that shock impedance can be designed via compositional tuning.Notably,our results reveal that nano-grained MgAl_(2)O_(4) ceramics exhibit outstanding optical transparency under high shock pressures,highlighting a promising strategy for designing optical windows that retain transparency under extreme dynamic loading conditions.
基金supported by the National Natural Science Foundation of China(62192770,62305252,62205246,62020106009,62192771,61925504)National Key Research and Development Program of China(2023YFF0615604 and 2023YFF0613600)+6 种基金Science and Technology Commission of Shanghai Municipality(21JC1406100)Shanghai Municipal Science and Technology Major Project(2021SHZDZX0100)Science and Technology Commission of Shanghai Municipality(No.22ZR1432400)Shanghai Pilot Program for Basic Research,and Fundamental Research Funds for the Central Universities.D.P.T.acknowledges National Natural Science Foundation of China(No.62375232)University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region,China[Project No.AoE/P-502/20,CRF Project:C5031-22G and C1015-21E,GRF Project:CityU15303521CityU11305223,and Germany/Hong Kong Joint Research Scheme:GCityU101/22]City University of Hong Kong[Project No.9380131,9610628,and 7005867].
文摘In recent decades,optical micro/nano manipulation has made remarkable strides in the fields of biology and the physical sciences,benefiting from both theoretical and experimental advances in optical forces.The emergence of optical torques has further enhanced the capabilities and possibilities of optical micro/nano manipulation,opening the door to exciting new applications.In this review,we delve into the fundamentals and recent breakthroughs in the realm of optical micro/nano manipulation using optical torques.We introduce the advancements in optical manipulation based on optical torques from engineered light fields and objects,and highlight the latest developments in applying optical torques to cutting-edge physical and biological scenarios,with a special emphasis on the detection and manipulation of biological structures.Finally,we conclude by outlining our vision for the current and future directions of this field,including the integration of optical torque and micro/nano technologies,the utilization of special light fields,and the development of deeplearning-assisted optical torque design.
文摘Optical network-on-chip(ONoC) systems have emerged as a promising solution to overcome limitations of traditional electronic interconnects. Efficient ONoC architectures rely on optical routers, enabling high-speed data transfer, efficient routing, and scalability. This paper presents a comprehensive survey analyzing optical router designs, specifically microring resonators(MRRs), Mach-Zehnder interferometers(MZIs), and hybrid architectures. Selected comparison criteria, chosen for their critical importance, significantly impact router functionality and performance. By emphasizing these criteria, valuable insights into the strengths and limitations of different designs are gained, facilitating informed decisions and advancements in optical networking. While other factors contribute to performance and efficiency, the chosen criteria consistently address fundamental elements, enabling meaningful evaluation. This work serves as a valuable resource for beginners, providing a solid foundation in understanding ONoC and optical routers. It also offers an in-depth survey for experts, laying the groundwork for further exploration. Additionally, the importance of considering design constraints and requirements when selecting an optimal router design is highlighted. Continued research and innovation will enable the development of efficient optical router solutions that meet the evolving needs of modern computing systems. This survey underscores the significance of ongoing advancements in the field and their potential impact on future technologies.
基金supported by the National Key Research and Development Program of China(Grant No.2020YFC2200103)the Shandong Provincial Natural Science Foundation(Grant Nos.ZR2022LLZ006 and ZR2022LLZ011)+1 种基金the Innovation Program for Quantum Science and Technology(Grant Nos.2021ZD0300904 and 2021ZD0300903)the Key R&D Plan of Shandong Province(Grant No.2023CXPT105)。
文摘Optical phase transfer via fiber optics is the most effective method for optical frequency standard comparison on the scale below thousands of kilometers.However,the monotonic phase discrimination range of conventional optical phase-locked loops is limited,and link delays restrict the control bandwidth,which makes it a challenge to achieve a continuously reliable optical link.This paper presents an event-timing-based phase detection method that overcomes the monotonic phase discrimination range limitation of conventional phase-locked loops through dual-edge timestamp recording,achieving an optical phase measurement resolution on the order of 10 attoseconds.With such a technique,we established a 7-segment-cascaded optical link over 1402km of commercial fiber while sharing dense wavelength division multiplexing(DWDM)channels with live telecom traffic.The system maintained continuous operation for 11.7 days without phase cycle slips despite encountering 15 km aerial fiber noise up to 21000 rad^(2)·Hz^(−1)·km^(−1)at 1 Hz.Relative instabilities of the link are 3.7×10^(−15)at 1 s and 3.9×10^(−20)at 100000 s.
基金supported by the Innovation Program for Quantum Science and Technology(Grant Nos.2021ZD0301400 and 2023ZD0301500)the National Natural Science Foundation of China(Grant Nos.62335019 and 62475291).
文摘Reconfigurable linear optical networks based on Mach-Zehnder interferometer(MZI)offer significant potential in optical information processing,particularly in emerging photonic quantum computing systems.However,device losses and calibration errors accumulate as network complexity grows,posing challenges in performing precise mapping of matrix operations.Existing architectures,such as Diamond and Bokun,introduce MZI redundancy into Reck and Clements architectures to improve reliability,which increases complexity and differential path losses that limit scalability.We propose a compact topology architecture that achieves 100%fidelity by employing a symmetrical MZI to decouple optical loss from power ratio and introducing extra MZIs to enforce uniform loss distributions.This multi-level optimization enables direct monitoring pathways while supporting precise calibration,and it approaches theoretical fidelity in practical deployments with direct implications for scalable and fault-tolerant photonic computing systems.
