In recent years, numerous exploration activities of oil and gas industry have been conducted in ultra deep water. The global offshore industry is building systems today for drilling in even deeper water, progressively...In recent years, numerous exploration activities of oil and gas industry have been conducted in ultra deep water. The global offshore industry is building systems today for drilling in even deeper water, progressively using new technologies, and significantly extending existing technologies. This is the general trend in the offshore oil and gas industry. So the technology of ultra-deepwater risers, which is the main tool in drilling oil, is more and more standard. This paper manly focuses on the global analysis of the drilling risers. And it is divided into two parts, operability analysis and hang-off analysis that are used to check the design of the riser. In this paper, the rotation angle and stress of the riser in the drilling mode are calculated to determine the operability envelop. The number of the buoyancy modules has been determined and according to the API standard, all the worked out values have been checked out. From all the above, it is concluded that the operability envelop is relatively small under harsh condition and the number of the buoyancy modules is a little large. And above all, the design of this riser is successful.展开更多
Operability problem of dividing wall column (DWC) raised by vapor split was investigated by numerically analyzing four cases defined by different compositions of a three-component mixture. DWCs were firstly designed f...Operability problem of dividing wall column (DWC) raised by vapor split was investigated by numerically analyzing four cases defined by different compositions of a three-component mixture. DWCs were firstly designed for each case by optimizing the vapor split to the two sides of the dividing wall, and then their feasibilities and total annual costs in operation were evaluated against different vapor split ratios. The analysis on the operability of the DWC for four cases was made based on two scenarios: (1) vapor split is shifted by the vapor resistance difference between the column sections in the two sides of the dividing wall and (2) the feed composition is changed. It was demonstrated that the positioning of the dividing wall and the decision on the vapor split may affect significantly the operability of a DWC.展开更多
For separating some specific four component mixtures into four products, the four-product dividing wall column(FPDWC) with two partition walls can provide the same utility consumption with the extended Petlyuk configu...For separating some specific four component mixtures into four products, the four-product dividing wall column(FPDWC) with two partition walls can provide the same utility consumption with the extended Petlyuk configuration, although with structure simplicity. However, the reluctance to implement this kind of four product dividing wall column industrially also consists in the two uncontrollable vapor splits associated with it. The vapor split ratios are set at the design stage and might not be the optimal value for changed feed composition, thus minimum energy consumption could not be ensured. In the present work, a sequential iterative optimization approach was initially employed to determine the parameters of cost-effective FPDWC. Then the effect of maintaining the vapor split ratios at their nominal value on the energy penalty was investigated for the FPDWC with two partition walls, in case of feed composition disturbance. The result shows that no more than + 2% above the optimal energy requirements could be ensured for 20% feed composition disturbances, which is encouraging for industrial implementation.展开更多
Because of the complicated interplay between the prefractionator and main distillation column involved,the black-hole problem might occur and prohibit the assignment of four specifications to dividing-wall distillatio...Because of the complicated interplay between the prefractionator and main distillation column involved,the black-hole problem might occur and prohibit the assignment of four specifications to dividing-wall distillation columns(DWDCs)(e.g., the three main product compositions plus an impurity ratio in the intermediate product), which lowers terribly process flexibility and operability. In this paper, a feed thermal condition adjustment strategy, achieved by the installation of a pre-heater in feed pipeline, is employed to eliminate the black-hole problem and serve to enhance process flexibility and operability. Through the strong influence to the overall mass and energy balance of the DWDC, the feed thermal condition adjustment can alter the interlinking flows between the thermally coupled prefractionator and main distillation column and work effectively to coordinate their relationship. A DWDC separating a benzene, toluene, and o-xylene mixture is chosen to ascertain the feasibility of the philosophy proposed. The static and dynamic studies demonstrate that the feed thermal condition adjustment is an effective way to refine process design and can completely eliminate the black-hole problem and elevate consequently process flexibility and operability.展开更多
The present study investigated the effects of touch button size on touchscreen operability and compared these effects between young adult and elderly participants. A total of 21 young adults （aged 22.3 ± 1.5 ye...The present study investigated the effects of touch button size on touchscreen operability and compared these effects between young adult and elderly participants. A total of 21 young adults （aged 22.3 ± 1.5 years） and 20 elderly adults （aged 68.1 ±4.9 years） were recruited and asked to press square number buttons （from 0 to 9） on an experimental touchscreen with their right index finger. The buttons＇ size changed during the experiment with six conditions （6, 8, 10, 12, 14 and 16 mm）. It was found that a decrease of the button size to l0 mm or below tended to increase the operation time and error rate, whereas it decreased the subjective overall operability of the touchscreen. Such effects were greater in the elderly adults than in the young adults. In addition, the reaction positions on the buttons were found to be close to the right side of them, which led the fingertip to approach the right outline of the buttons. These findings suggest that the use of small touch buttons should be minimised on touchscreens, especially for elderly users.展开更多
In this study,we used the short-distance mobility vehicles(electric wheelchair)WHILL,which is sold as a mobility support device rather than a welfare care device,and conducted test rides on campus and on public roads....In this study,we used the short-distance mobility vehicles(electric wheelchair)WHILL,which is sold as a mobility support device rather than a welfare care device,and conducted test rides on campus and on public roads.The participants in the experiment were 10 healthy men and women in their 20s to 60s who did not use electric wheelchairs in their daily lives.The results showed that about half of the experiment participants did not feel anxious about operating WHILL.On the other hand,many participants felt uneasy about the operation of moving backward diagonally.The WHILL’s steering wheel was easy to operate,and it was also very comfortable during the test drive.Before and after the test drive,the impression evaluation of WHILL changed significantly from negative to positive.An improved model of WHILL was proposed based on the results of the questionnaire survey and interview survey after the test drive.展开更多
Sixty-one intermediate and advanced esophageal carcinoma patients were examined by transesophageal ultrasonography(TEUS),including 53 squamous carcinomas and 8 adenocarcinomas. The ultrasonic images showed that there ...Sixty-one intermediate and advanced esophageal carcinoma patients were examined by transesophageal ultrasonography(TEUS),including 53 squamous carcinomas and 8 adenocarcinomas. The ultrasonic images showed that there were clearly demarcated spaces between the tumours and the important adjacent structures in 42 out of 48 patients having undergone esophagectomy,while in 10 non-resectable patients,the ultrasonic images displayed an unclear demarcation between the tumours and thoracic aorta,pulmonary vein and pericardium. The study discovered that the regional echo of thoracic aortic wall was interrupted and replaced by tumour hypoecho, and the aorta pressed,indicating carcinoma's serious invasion of the aorta. The non-resectability of carcinoma of this kind was later confirmed in operation. On 3 cases,operations couldn't be performed due to metastasis of liver.Six cases failed to be accurately assessed owing to the impassability for probe caused by esophageal stenosis or other factors. Accuracy of assessment was 85. 2%. So we believe TEUS is a useful,simple,reliable and secure method for assessing operability of esophageal carcinoma.展开更多
With the integration of sophisticated technologies and increased data connectivity,the value of a car is no longer confined to just transportation-it is also a hub of personal and operational data.This change naturall...With the integration of sophisticated technologies and increased data connectivity,the value of a car is no longer confined to just transportation-it is also a hub of personal and operational data.This change naturally leads to cybersecurity challenges from remote hacking,to breach of data privacy,and potential physical safety concerns as operational functions of a vehicle are highly vulnerable.Making IoTs interoperable,secure and private can be achieved using the framework of the existing IEEE P2933-Draft Standard for Clinical Internet of Things(IoT)Data and Device Interoperability with TIPPSS-Trust,Identity,Privacy,Protection,Safety,Security.This workshop will bring together professionals from technology developers in software,firmware,and devices;automotive manufacturing,regulatory,researchers and other related stakeholders to understand the needs for TIPPSS for IoTs in connected vehicles and the related use case requirements.展开更多
The penetration level of distributed energy resources(DERs)is increasing and has significant impact on the voltage stability of distribution networks.Based on the various types of DERs with distinct reactive power cha...The penetration level of distributed energy resources(DERs)is increasing and has significant impact on the voltage stability of distribution networks.Based on the various types of DERs with distinct reactive power characteristics(RPC),their different contributions to the system voltage stability require classification.Firstly,the features of DERs are reviewed and classified based on their RPC,to investigate different distributed generation technologies for reactive power support in distribution networks.Then,the concept of a relative available transmission capacity index(RATCI),which is based on power transfer margin of the power-voltage curve considering the non-negligible distribution network resistance,is proposed to quantify and evaluate the voltage stability by integrating DERs with the defined reactive power types.Case studies have been conducted for an IEEE 33-bus distribution network to calculate the system RATCI for the mixed integration of DERs.Results show that the multitype and multi-locational integration of DERs can improve the voltage stability of a distribution network.展开更多
The exchange of information between transmission system operators(TSOs)and distribution system operators(DSOs)is a common practice.However,the evolution of the regulatory frameworks in Europe has increased the need fo...The exchange of information between transmission system operators(TSOs)and distribution system operators(DSOs)is a common practice.However,the evolution of the regulatory frameworks in Europe has increased the need for enhancing TSO-DSO data exchange and interoperability.This paper provides an overview of the TSO-DSO data exchanges and demonstrates the best practices using International Electrotechnical Commission(IEC)common information model(CIM),including the implementation of IEC common grid model exchange standard(CGMES),and discussion of the corresponding advantages,disadvantages,and challenges.Furthermore,this paper evaluates and reports the activities already carried out within European projects,with particular focus on TSO-DSO interoperability.Finally,this paper concludes the need for TSOs and DSOs to rely on standard-based solutions when performing TSO-DSO data exchange,which enables the efficient operation and development of the future power systems.展开更多
In this article,we conduct a study on mixed quasi-martingale Hardy spaces that are defined by means of the mixed L_(p)-norm.By utilizing Doob’s inequalities,we explore the atomic decomposition and quasi-martingale in...In this article,we conduct a study on mixed quasi-martingale Hardy spaces that are defined by means of the mixed L_(p)-norm.By utilizing Doob’s inequalities,we explore the atomic decomposition and quasi-martingale inequalities of mixed quasi-martingale Hardy spaces.Moreover,we furnish sufficient conditions for the boundedness ofσ-sublinear operators in these spaces.These findings extend the existing conclusions regarding mixed quasi-martingale Hardy spaces defined with the help of the mixed L_(p)-norm.展开更多
In this article,we show the existence,uniqueness and stability of bounded solutions to the following quasilinear problems with mean curvature operator(φ'(x′(t)))′=f(t,x),t≥t_(0),lim_(t→∞)x(t)=ψ_(0),lim_(t→...In this article,we show the existence,uniqueness and stability of bounded solutions to the following quasilinear problems with mean curvature operator(φ'(x′(t)))′=f(t,x),t≥t_(0),lim_(t→∞)x(t)=ψ_(0),lim_(t→∞)x′(t)e^(t)=0,where t_(0) and ψ_(0) are real constants,φ(s)=s/√1−s^(2),s∈R with s∈(−1,1),f:[t_(0),∞)×R→R satisfies the Lipschitz or Osgood-type conditions.展开更多
Underwater pipeline inspection plays a vital role in the proactive maintenance and management of critical marine infrastructure and subaquatic systems.However,the inspection of underwater pipelines presents a challeng...Underwater pipeline inspection plays a vital role in the proactive maintenance and management of critical marine infrastructure and subaquatic systems.However,the inspection of underwater pipelines presents a challenge due to factors such as light scattering,absorption,restricted visibility,and ambient noise.The advancement of deep learning has introduced powerful techniques for processing large amounts of unstructured and imperfect data collected from underwater environments.This study evaluated the efficacy of the You Only Look Once(YOLO)algorithm,a real-time object detection and localization model based on convolutional neural networks,in identifying and classifying various types of pipeline defects in underwater settings.YOLOv8,the latest evolution in the YOLO family,integrates advanced capabilities,such as anchor-free detection,a cross-stage partial network backbone for efficient feature extraction,and a feature pyramid network+path aggregation network neck for robust multi-scale object detection,which make it particularly well-suited for complex underwater environments.Due to the lack of suitable open-access datasets for underwater pipeline defects,a custom dataset was captured using a remotely operated vehicle in a controlled environment.This application has the following assets available for use.Extensive experimentation demonstrated that YOLOv8 X-Large consistently outperformed other models in terms of pipe defect detection and classification and achieved a strong balance between precision and recall in identifying pipeline cracks,rust,corners,defective welds,flanges,tapes,and holes.This research establishes the baseline performance of YOLOv8 for underwater defect detection and showcases its potential to enhance the reliability and efficiency of pipeline inspection tasks in challenging underwater environments.展开更多
Loday introduced di-associative algebras and tri-associative algebras motivated by periodicity phenomena in algebraic K-theory.The purpose of this paper is to study the splittings of operations on di-associative algeb...Loday introduced di-associative algebras and tri-associative algebras motivated by periodicity phenomena in algebraic K-theory.The purpose of this paper is to study the splittings of operations on di-associative algebras and tri-associative algebras.We introduce the notion of a quad-dendriform algebra,which is a splitting of a di-associative algebra.We show that a relative averaging operator on dendriform algebras gives rise to a quad-dendriform algebra.Furthermore,we introduce the notion of six-dendriform algebras,which are splittings of the tri-associative algebras,and demonstrate that homomorphic relative averaging operators induce six-dendriform algebras.展开更多
This paper investigates the following mixed local and nonlocal elliptic problem fea-turing concave-convex nonlinearities and a discontinuous right-hand side:{L(u)=H(u−μ)|u|^(p−2)u+λ|u|^(q−2)u,x∈Ω,u≥0,x∈Ω,u=0,x...This paper investigates the following mixed local and nonlocal elliptic problem fea-turing concave-convex nonlinearities and a discontinuous right-hand side:{L(u)=H(u−μ)|u|^(p−2)u+λ|u|^(q−2)u,x∈Ω,u≥0,x∈Ω,u=0,x∈R^(N)\Ω,where Ω R^(N)(N>2)is a bounded domain,μ≥0 and λ>0 are real parameters,H denotes the Heaviside function(H(t)=0 for t<0,H(t)=1 for t>0),and the mixed local and nolocal operator is defined as L(u)=−Δu+(−Δ)^(s)u with(−Δ)^(s) being the restricted fractional Laplace(0<s<1).The exponents satisfy 1<q<2<p.By employing a novel non-smooth variational principle,we establish the existence of an M-solution for this problem and identify a range for the exponent p.展开更多
BACKGROUND Breast cancer is one of the most prevalent malignancies affecting women worldwide,with approximately 2.3 million new cases diagnosed annually.Breast cancer stem cells(BCSCs)play pivotal roles in tumor initi...BACKGROUND Breast cancer is one of the most prevalent malignancies affecting women worldwide,with approximately 2.3 million new cases diagnosed annually.Breast cancer stem cells(BCSCs)play pivotal roles in tumor initiation,progression,metastasis,therapeutic resistance,and disease recurrence.Cancer stem cells possess selfrenewal capacity,multipotent differentiation potential,and enhanced tumorigenic activity,but their molecular characteristics and regulatory mechanisms require further investigation.AIM To comprehensively characterize the molecular features of BCSCs through multiomics approaches,construct a prognostic prediction model based on stem cellrelated genes,reveal cell-cell communication networks within the tumor microenvironment,and provide theoretical foundation for personalized treatment strategies.METHODS Flow cytometry was employed to detect the expression of BCSC surface markers(CD34,CD45,CD29,CD90,CD105).Transcriptomic analysis was performed to identify differentially expressed genes.Least absolute shrinkage and selection operator regression analysis was utilized to screen key prognostic genes and construct a risk scoring model.Single-cell RNA sequencing and spatial transcriptomics were applied to analyze tumor heterogeneity and spatial gene expression patterns.Cell-cell communication network analysis was conducted to reveal interactions between stem cells and the microenvironment.RESULTS Flow cytometric analysis revealed the highest expression of CD105(96.30%),followed by CD90(68.43%)and CD34(62.64%),while CD29 showed lower expression(7.16%)and CD45 exhibited the lowest expression(1.19%).Transcriptomic analysis identified 3837 significantly differentially expressed genes(1478 upregulated and 2359 downregulated).Least absolute shrinkage and selection operator regression analysis selected 10 key prognostic genes,and the constructed risk scoring model effectively distinguished between high-risk and low-risk patient groups(P<0.001).Single-cell analysis revealed tumor cellular heterogeneity,and spatial transcriptomics demonstrated distinct spatial expression gradients of stem cell-related genes.MED18 gene showed significantly higher expression in malignant tissues(P<0.001)and occupied a central position in cell-cell communication networks,exhibiting significant correlations with tumor cells,macrophages,fibroblasts,and endothelial cells.CONCLUSION This study comprehensively characterized the molecular features of BCSCs through multi-omics approaches,identified reliable surface markers and key regulatory genes,and constructed a prognostic prediction model with clinical application value.展开更多
Freezing of gait is a significant and debilitating motor symptom often observed in individuals with Parkinson's disease.Resting-state functional magnetic resonance imaging,along with its multi-level feature indice...Freezing of gait is a significant and debilitating motor symptom often observed in individuals with Parkinson's disease.Resting-state functional magnetic resonance imaging,along with its multi-level feature indices,has provided a fresh perspective and valuable insight into the study of freezing of gait in Parkinson's disease.It has been revealed that Parkinson's disease is accompanied by widespread irregularities in inherent brain network activity.However,the effective integration of the multi-level indices of resting-state functional magnetic resonance imaging into clinical settings for the diagnosis of freezing of gait in Parkinson's disease remains a challenge.Although previous studies have demonstrated that radiomics can extract optimal features as biomarkers to identify or predict diseases,a knowledge gap still exists in the field of freezing of gait in Parkinson's disease.This cross-sectional study aimed to evaluate the ability of radiomics features based on multi-level indices of resting-state functional magnetic resonance imaging,along with clinical features,to distinguish between Parkinson's disease patients with and without freezing of gait.We recruited 28 patients with Parkinson's disease who had freezing of gait(15 men and 13 women,average age 63 years)and 30 patients with Parkinson's disease who had no freezing of gait(16 men and 14 women,average age 64 years).Magnetic resonance imaging scans were obtained using a 3.0T scanner to extract the mean amplitude of low-frequency fluctuations,mean regional homogeneity,and degree centrality.Neurological and clinical characteristics were also evaluated.We used the least absolute shrinkage and selection operator algorithm to extract features and established feedforward neural network models based solely on resting-state functional magnetic resonance imaging indicators.We then performed predictive analysis of three distinct groups based on resting-state functional magnetic resonance imaging indicators indicators combined with clinical features.Subsequently,we conducted 100 additional five-fold cross-validations to determine the most effective model for each classification task and evaluated the performance of the model using the area under the receiver operating characteristic curve.The results showed that when differentiating patients with Parkinson's disease who had freezing of gait from those who did not have freezing of gait,or from healthy controls,the models using only the mean regional homogeneity values achieved the highest area under the receiver operating characteristic curve values of 0.750(with an accuracy of 70.9%)and 0.759(with an accuracy of 65.3%),respectively.When classifying patients with Parkinson's disease who had freezing of gait from those who had no freezing of gait,the model using the mean amplitude of low-frequency fluctuation values combined with two clinical features achieved the highest area under the receiver operating characteristic curve of 0.847(with an accuracy of 74.3%).The most significant features for patients with Parkinson's disease who had freezing of gait were amplitude of low-frequency fluctuation alterations in the left parahippocampal gyrus and two clinical characteristics:Montreal Cognitive Assessment and Hamilton Depression Scale scores.Our findings suggest that radiomics features derived from resting-state functional magnetic resonance imaging indices and clinical information can serve as valuable indices for the identification of freezing of gait in Parkinson's disease.展开更多
Road pavements in tunnels are usually made of asphalt mixtures,which,unfortunately,are flammable materials.Hence,this type of pavement could release heat,and more specifically smoke,in the event of a tunnel fire,there...Road pavements in tunnels are usually made of asphalt mixtures,which,unfortunately,are flammable materials.Hence,this type of pavement could release heat,and more specifically smoke,in the event of a tunnel fire,thereby worsening the environmental conditions for human health.Extensive research has been conducted in recent years to enhance the fire reaction of traditional asphalt mixtures for the road pavements used in tunnels.The addition of the Flame Retardants(FRs)in conventional asphalt mixtures appears to be promising.Nevertheless,the potential effects of the FRs in terms of the reduction in consequences on tunnel users in the event of a large fire do not seem to have been sufficiently investigated by using fluid dynamics analysis as a computational tool.Given this gap of knowledge,this article aims to quantitatively evaluate whether the use of flame-retarded asphalt mixtures,as opposed to traditional ones without FRs,might mitigate the adverse effects on the safety of evacuees and fire brigade by performing numerical analyses in the case of a tunnel fire.To achieve this goal,3D Computational Fluid Dynamics(CFD)models,which were executed using the Fire Dynamics Simulator(FDS)tool,were established in the case of a major fire of a Heavy Goods Vehicle(HGV)characterized by a maximum Heat Release Rate(HRRmax)of 100 MW.The people evacuation process was also simulated,and the Evac tool was used.Compared to the traditional asphalt pavements without FRs,the simulation findings indicated that the addition of the FRs causes a reduction in CO and CO_(2)levels in the tunnel during the aforementioned fire,with a minor number of evacuees being exposed to the risk of incapacity to self-evacuate,as well as certain safety benefits for the operability of the firefighters entering the tunnel downstream of the fire when the tunnel is naturally ventilated.展开更多
Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy sources.This paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longe...Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy sources.This paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,respectively.MATLAB/Simulink was used for simulation test.The optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 yuan.Additionally,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations significantly.The proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.展开更多
基金Supported by the 111 Projects Foundation from State Administration of Foreign Experts Affairs of China and Ministry of Education of China under Grant No.B07019
文摘In recent years, numerous exploration activities of oil and gas industry have been conducted in ultra deep water. The global offshore industry is building systems today for drilling in even deeper water, progressively using new technologies, and significantly extending existing technologies. This is the general trend in the offshore oil and gas industry. So the technology of ultra-deepwater risers, which is the main tool in drilling oil, is more and more standard. This paper manly focuses on the global analysis of the drilling risers. And it is divided into two parts, operability analysis and hang-off analysis that are used to check the design of the riser. In this paper, the rotation angle and stress of the riser in the drilling mode are calculated to determine the operability envelop. The number of the buoyancy modules has been determined and according to the API standard, all the worked out values have been checked out. From all the above, it is concluded that the operability envelop is relatively small under harsh condition and the number of the buoyancy modules is a little large. And above all, the design of this riser is successful.
基金Supported by the State Key Fundamental Research Program(2012CB720500)
文摘Operability problem of dividing wall column (DWC) raised by vapor split was investigated by numerically analyzing four cases defined by different compositions of a three-component mixture. DWCs were firstly designed for each case by optimizing the vapor split to the two sides of the dividing wall, and then their feasibilities and total annual costs in operation were evaluated against different vapor split ratios. The analysis on the operability of the DWC for four cases was made based on two scenarios: (1) vapor split is shifted by the vapor resistance difference between the column sections in the two sides of the dividing wall and (2) the feed composition is changed. It was demonstrated that the positioning of the dividing wall and the decision on the vapor split may affect significantly the operability of a DWC.
基金Supported by Open Research Project of State Key Laboratory of Chemical Engineering(SKL-ChE-16B06)Yangtze Scholars and Innovative Research Team in Chinese University(IRT-17R81)
文摘For separating some specific four component mixtures into four products, the four-product dividing wall column(FPDWC) with two partition walls can provide the same utility consumption with the extended Petlyuk configuration, although with structure simplicity. However, the reluctance to implement this kind of four product dividing wall column industrially also consists in the two uncontrollable vapor splits associated with it. The vapor split ratios are set at the design stage and might not be the optimal value for changed feed composition, thus minimum energy consumption could not be ensured. In the present work, a sequential iterative optimization approach was initially employed to determine the parameters of cost-effective FPDWC. Then the effect of maintaining the vapor split ratios at their nominal value on the energy penalty was investigated for the FPDWC with two partition walls, in case of feed composition disturbance. The result shows that no more than + 2% above the optimal energy requirements could be ensured for 20% feed composition disturbances, which is encouraging for industrial implementation.
基金Supported by the National Natural Science Foundation of China(21076015,21376018,21576014,21676011)
文摘Because of the complicated interplay between the prefractionator and main distillation column involved,the black-hole problem might occur and prohibit the assignment of four specifications to dividing-wall distillation columns(DWDCs)(e.g., the three main product compositions plus an impurity ratio in the intermediate product), which lowers terribly process flexibility and operability. In this paper, a feed thermal condition adjustment strategy, achieved by the installation of a pre-heater in feed pipeline, is employed to eliminate the black-hole problem and serve to enhance process flexibility and operability. Through the strong influence to the overall mass and energy balance of the DWDC, the feed thermal condition adjustment can alter the interlinking flows between the thermally coupled prefractionator and main distillation column and work effectively to coordinate their relationship. A DWDC separating a benzene, toluene, and o-xylene mixture is chosen to ascertain the feasibility of the philosophy proposed. The static and dynamic studies demonstrate that the feed thermal condition adjustment is an effective way to refine process design and can completely eliminate the black-hole problem and elevate consequently process flexibility and operability.
文摘The present study investigated the effects of touch button size on touchscreen operability and compared these effects between young adult and elderly participants. A total of 21 young adults （aged 22.3 ± 1.5 years） and 20 elderly adults （aged 68.1 ±4.9 years） were recruited and asked to press square number buttons （from 0 to 9） on an experimental touchscreen with their right index finger. The buttons＇ size changed during the experiment with six conditions （6, 8, 10, 12, 14 and 16 mm）. It was found that a decrease of the button size to l0 mm or below tended to increase the operation time and error rate, whereas it decreased the subjective overall operability of the touchscreen. Such effects were greater in the elderly adults than in the young adults. In addition, the reaction positions on the buttons were found to be close to the right side of them, which led the fingertip to approach the right outline of the buttons. These findings suggest that the use of small touch buttons should be minimised on touchscreens, especially for elderly users.
文摘In this study,we used the short-distance mobility vehicles(electric wheelchair)WHILL,which is sold as a mobility support device rather than a welfare care device,and conducted test rides on campus and on public roads.The participants in the experiment were 10 healthy men and women in their 20s to 60s who did not use electric wheelchairs in their daily lives.The results showed that about half of the experiment participants did not feel anxious about operating WHILL.On the other hand,many participants felt uneasy about the operation of moving backward diagonally.The WHILL’s steering wheel was easy to operate,and it was also very comfortable during the test drive.Before and after the test drive,the impression evaluation of WHILL changed significantly from negative to positive.An improved model of WHILL was proposed based on the results of the questionnaire survey and interview survey after the test drive.
文摘Sixty-one intermediate and advanced esophageal carcinoma patients were examined by transesophageal ultrasonography(TEUS),including 53 squamous carcinomas and 8 adenocarcinomas. The ultrasonic images showed that there were clearly demarcated spaces between the tumours and the important adjacent structures in 42 out of 48 patients having undergone esophagectomy,while in 10 non-resectable patients,the ultrasonic images displayed an unclear demarcation between the tumours and thoracic aorta,pulmonary vein and pericardium. The study discovered that the regional echo of thoracic aortic wall was interrupted and replaced by tumour hypoecho, and the aorta pressed,indicating carcinoma's serious invasion of the aorta. The non-resectability of carcinoma of this kind was later confirmed in operation. On 3 cases,operations couldn't be performed due to metastasis of liver.Six cases failed to be accurately assessed owing to the impassability for probe caused by esophageal stenosis or other factors. Accuracy of assessment was 85. 2%. So we believe TEUS is a useful,simple,reliable and secure method for assessing operability of esophageal carcinoma.
文摘With the integration of sophisticated technologies and increased data connectivity,the value of a car is no longer confined to just transportation-it is also a hub of personal and operational data.This change naturally leads to cybersecurity challenges from remote hacking,to breach of data privacy,and potential physical safety concerns as operational functions of a vehicle are highly vulnerable.Making IoTs interoperable,secure and private can be achieved using the framework of the existing IEEE P2933-Draft Standard for Clinical Internet of Things(IoT)Data and Device Interoperability with TIPPSS-Trust,Identity,Privacy,Protection,Safety,Security.This workshop will bring together professionals from technology developers in software,firmware,and devices;automotive manufacturing,regulatory,researchers and other related stakeholders to understand the needs for TIPPSS for IoTs in connected vehicles and the related use case requirements.
基金supported by National Natural Science Foundation of China(No.51807127)the Fundamental Research Funds for the Central Universities of China(YJ201654)the Open Research Subject of Key Laboratory of Sichuan Power Electronics Energy-saving Technology and Devices(szjj2017-052).
文摘The penetration level of distributed energy resources(DERs)is increasing and has significant impact on the voltage stability of distribution networks.Based on the various types of DERs with distinct reactive power characteristics(RPC),their different contributions to the system voltage stability require classification.Firstly,the features of DERs are reviewed and classified based on their RPC,to investigate different distributed generation technologies for reactive power support in distribution networks.Then,the concept of a relative available transmission capacity index(RATCI),which is based on power transfer margin of the power-voltage curve considering the non-negligible distribution network resistance,is proposed to quantify and evaluate the voltage stability by integrating DERs with the defined reactive power types.Case studies have been conducted for an IEEE 33-bus distribution network to calculate the system RATCI for the mixed integration of DERs.Results show that the multitype and multi-locational integration of DERs can improve the voltage stability of a distribution network.
基金the OneNet,TDX-ASSIST,EU-SysFlex,and INTER-RFACE projects funded by the European Union's Horizon 2020 Research and Innovation Programme(especially under Grants No.957739,No.774500,No.773505,and No.824330).
文摘The exchange of information between transmission system operators(TSOs)and distribution system operators(DSOs)is a common practice.However,the evolution of the regulatory frameworks in Europe has increased the need for enhancing TSO-DSO data exchange and interoperability.This paper provides an overview of the TSO-DSO data exchanges and demonstrates the best practices using International Electrotechnical Commission(IEC)common information model(CIM),including the implementation of IEC common grid model exchange standard(CGMES),and discussion of the corresponding advantages,disadvantages,and challenges.Furthermore,this paper evaluates and reports the activities already carried out within European projects,with particular focus on TSO-DSO interoperability.Finally,this paper concludes the need for TSOs and DSOs to rely on standard-based solutions when performing TSO-DSO data exchange,which enables the efficient operation and development of the future power systems.
基金Supported by the National Natural Science Foundation of China(11871195)。
文摘In this article,we conduct a study on mixed quasi-martingale Hardy spaces that are defined by means of the mixed L_(p)-norm.By utilizing Doob’s inequalities,we explore the atomic decomposition and quasi-martingale inequalities of mixed quasi-martingale Hardy spaces.Moreover,we furnish sufficient conditions for the boundedness ofσ-sublinear operators in these spaces.These findings extend the existing conclusions regarding mixed quasi-martingale Hardy spaces defined with the help of the mixed L_(p)-norm.
基金Supported by the National Natural Science Foundation of China(Grant Nos.12361040,12061064)the Na-tional Science Foundation of Gansu Province(Grant No.22JR5RA264)State Scholarship Fund(Grant No.20230862021).
文摘In this article,we show the existence,uniqueness and stability of bounded solutions to the following quasilinear problems with mean curvature operator(φ'(x′(t)))′=f(t,x),t≥t_(0),lim_(t→∞)x(t)=ψ_(0),lim_(t→∞)x′(t)e^(t)=0,where t_(0) and ψ_(0) are real constants,φ(s)=s/√1−s^(2),s∈R with s∈(−1,1),f:[t_(0),∞)×R→R satisfies the Lipschitz or Osgood-type conditions.
文摘Underwater pipeline inspection plays a vital role in the proactive maintenance and management of critical marine infrastructure and subaquatic systems.However,the inspection of underwater pipelines presents a challenge due to factors such as light scattering,absorption,restricted visibility,and ambient noise.The advancement of deep learning has introduced powerful techniques for processing large amounts of unstructured and imperfect data collected from underwater environments.This study evaluated the efficacy of the You Only Look Once(YOLO)algorithm,a real-time object detection and localization model based on convolutional neural networks,in identifying and classifying various types of pipeline defects in underwater settings.YOLOv8,the latest evolution in the YOLO family,integrates advanced capabilities,such as anchor-free detection,a cross-stage partial network backbone for efficient feature extraction,and a feature pyramid network+path aggregation network neck for robust multi-scale object detection,which make it particularly well-suited for complex underwater environments.Due to the lack of suitable open-access datasets for underwater pipeline defects,a custom dataset was captured using a remotely operated vehicle in a controlled environment.This application has the following assets available for use.Extensive experimentation demonstrated that YOLOv8 X-Large consistently outperformed other models in terms of pipe defect detection and classification and achieved a strong balance between precision and recall in identifying pipeline cracks,rust,corners,defective welds,flanges,tapes,and holes.This research establishes the baseline performance of YOLOv8 for underwater defect detection and showcases its potential to enhance the reliability and efficiency of pipeline inspection tasks in challenging underwater environments.
基金Supported by the Science and Technology Program of Guizhou Province(Grant No.QKHJC QN[2025]362)the National Natural Science Foundation of China(Grant No.12361005).
文摘Loday introduced di-associative algebras and tri-associative algebras motivated by periodicity phenomena in algebraic K-theory.The purpose of this paper is to study the splittings of operations on di-associative algebras and tri-associative algebras.We introduce the notion of a quad-dendriform algebra,which is a splitting of a di-associative algebra.We show that a relative averaging operator on dendriform algebras gives rise to a quad-dendriform algebra.Furthermore,we introduce the notion of six-dendriform algebras,which are splittings of the tri-associative algebras,and demonstrate that homomorphic relative averaging operators induce six-dendriform algebras.
基金Supported by the National Natural Science Foundation of China(Grant No.12361026)the Discipline Con-struction Fund Project of Northwest Minzu University.
文摘This paper investigates the following mixed local and nonlocal elliptic problem fea-turing concave-convex nonlinearities and a discontinuous right-hand side:{L(u)=H(u−μ)|u|^(p−2)u+λ|u|^(q−2)u,x∈Ω,u≥0,x∈Ω,u=0,x∈R^(N)\Ω,where Ω R^(N)(N>2)is a bounded domain,μ≥0 and λ>0 are real parameters,H denotes the Heaviside function(H(t)=0 for t<0,H(t)=1 for t>0),and the mixed local and nolocal operator is defined as L(u)=−Δu+(−Δ)^(s)u with(−Δ)^(s) being the restricted fractional Laplace(0<s<1).The exponents satisfy 1<q<2<p.By employing a novel non-smooth variational principle,we establish the existence of an M-solution for this problem and identify a range for the exponent p.
基金the Natural Science Foundation of Yongchuan District,No.2023yc-jckx20021.
文摘BACKGROUND Breast cancer is one of the most prevalent malignancies affecting women worldwide,with approximately 2.3 million new cases diagnosed annually.Breast cancer stem cells(BCSCs)play pivotal roles in tumor initiation,progression,metastasis,therapeutic resistance,and disease recurrence.Cancer stem cells possess selfrenewal capacity,multipotent differentiation potential,and enhanced tumorigenic activity,but their molecular characteristics and regulatory mechanisms require further investigation.AIM To comprehensively characterize the molecular features of BCSCs through multiomics approaches,construct a prognostic prediction model based on stem cellrelated genes,reveal cell-cell communication networks within the tumor microenvironment,and provide theoretical foundation for personalized treatment strategies.METHODS Flow cytometry was employed to detect the expression of BCSC surface markers(CD34,CD45,CD29,CD90,CD105).Transcriptomic analysis was performed to identify differentially expressed genes.Least absolute shrinkage and selection operator regression analysis was utilized to screen key prognostic genes and construct a risk scoring model.Single-cell RNA sequencing and spatial transcriptomics were applied to analyze tumor heterogeneity and spatial gene expression patterns.Cell-cell communication network analysis was conducted to reveal interactions between stem cells and the microenvironment.RESULTS Flow cytometric analysis revealed the highest expression of CD105(96.30%),followed by CD90(68.43%)and CD34(62.64%),while CD29 showed lower expression(7.16%)and CD45 exhibited the lowest expression(1.19%).Transcriptomic analysis identified 3837 significantly differentially expressed genes(1478 upregulated and 2359 downregulated).Least absolute shrinkage and selection operator regression analysis selected 10 key prognostic genes,and the constructed risk scoring model effectively distinguished between high-risk and low-risk patient groups(P<0.001).Single-cell analysis revealed tumor cellular heterogeneity,and spatial transcriptomics demonstrated distinct spatial expression gradients of stem cell-related genes.MED18 gene showed significantly higher expression in malignant tissues(P<0.001)and occupied a central position in cell-cell communication networks,exhibiting significant correlations with tumor cells,macrophages,fibroblasts,and endothelial cells.CONCLUSION This study comprehensively characterized the molecular features of BCSCs through multi-omics approaches,identified reliable surface markers and key regulatory genes,and constructed a prognostic prediction model with clinical application value.
基金supported by the National Natural Science Foundation of China,No.82071909(to GF)the Natural Science Foundation of Liaoning Province,No.2023-MS-07(to HL)。
文摘Freezing of gait is a significant and debilitating motor symptom often observed in individuals with Parkinson's disease.Resting-state functional magnetic resonance imaging,along with its multi-level feature indices,has provided a fresh perspective and valuable insight into the study of freezing of gait in Parkinson's disease.It has been revealed that Parkinson's disease is accompanied by widespread irregularities in inherent brain network activity.However,the effective integration of the multi-level indices of resting-state functional magnetic resonance imaging into clinical settings for the diagnosis of freezing of gait in Parkinson's disease remains a challenge.Although previous studies have demonstrated that radiomics can extract optimal features as biomarkers to identify or predict diseases,a knowledge gap still exists in the field of freezing of gait in Parkinson's disease.This cross-sectional study aimed to evaluate the ability of radiomics features based on multi-level indices of resting-state functional magnetic resonance imaging,along with clinical features,to distinguish between Parkinson's disease patients with and without freezing of gait.We recruited 28 patients with Parkinson's disease who had freezing of gait(15 men and 13 women,average age 63 years)and 30 patients with Parkinson's disease who had no freezing of gait(16 men and 14 women,average age 64 years).Magnetic resonance imaging scans were obtained using a 3.0T scanner to extract the mean amplitude of low-frequency fluctuations,mean regional homogeneity,and degree centrality.Neurological and clinical characteristics were also evaluated.We used the least absolute shrinkage and selection operator algorithm to extract features and established feedforward neural network models based solely on resting-state functional magnetic resonance imaging indicators.We then performed predictive analysis of three distinct groups based on resting-state functional magnetic resonance imaging indicators indicators combined with clinical features.Subsequently,we conducted 100 additional five-fold cross-validations to determine the most effective model for each classification task and evaluated the performance of the model using the area under the receiver operating characteristic curve.The results showed that when differentiating patients with Parkinson's disease who had freezing of gait from those who did not have freezing of gait,or from healthy controls,the models using only the mean regional homogeneity values achieved the highest area under the receiver operating characteristic curve values of 0.750(with an accuracy of 70.9%)and 0.759(with an accuracy of 65.3%),respectively.When classifying patients with Parkinson's disease who had freezing of gait from those who had no freezing of gait,the model using the mean amplitude of low-frequency fluctuation values combined with two clinical features achieved the highest area under the receiver operating characteristic curve of 0.847(with an accuracy of 74.3%).The most significant features for patients with Parkinson's disease who had freezing of gait were amplitude of low-frequency fluctuation alterations in the left parahippocampal gyrus and two clinical characteristics:Montreal Cognitive Assessment and Hamilton Depression Scale scores.Our findings suggest that radiomics features derived from resting-state functional magnetic resonance imaging indices and clinical information can serve as valuable indices for the identification of freezing of gait in Parkinson's disease.
文摘Road pavements in tunnels are usually made of asphalt mixtures,which,unfortunately,are flammable materials.Hence,this type of pavement could release heat,and more specifically smoke,in the event of a tunnel fire,thereby worsening the environmental conditions for human health.Extensive research has been conducted in recent years to enhance the fire reaction of traditional asphalt mixtures for the road pavements used in tunnels.The addition of the Flame Retardants(FRs)in conventional asphalt mixtures appears to be promising.Nevertheless,the potential effects of the FRs in terms of the reduction in consequences on tunnel users in the event of a large fire do not seem to have been sufficiently investigated by using fluid dynamics analysis as a computational tool.Given this gap of knowledge,this article aims to quantitatively evaluate whether the use of flame-retarded asphalt mixtures,as opposed to traditional ones without FRs,might mitigate the adverse effects on the safety of evacuees and fire brigade by performing numerical analyses in the case of a tunnel fire.To achieve this goal,3D Computational Fluid Dynamics(CFD)models,which were executed using the Fire Dynamics Simulator(FDS)tool,were established in the case of a major fire of a Heavy Goods Vehicle(HGV)characterized by a maximum Heat Release Rate(HRRmax)of 100 MW.The people evacuation process was also simulated,and the Evac tool was used.Compared to the traditional asphalt pavements without FRs,the simulation findings indicated that the addition of the FRs causes a reduction in CO and CO_(2)levels in the tunnel during the aforementioned fire,with a minor number of evacuees being exposed to the risk of incapacity to self-evacuate,as well as certain safety benefits for the operability of the firefighters entering the tunnel downstream of the fire when the tunnel is naturally ventilated.
基金supported by a Horizontal Project on the Development of a Hybrid Energy Storage Simulation Model for Wind Power Based on an RT-LAB Simulation System(PH2023000190)the Inner Mongolia Natural Science Foundation Project and the Optimization of Exergy Efficiency of a Hybrid Energy Storage System with Crossover Control for Wind Power(2023JQ04).
文摘Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy sources.This paper proposes a wind-solar hybrid energy storage system(HESS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,respectively.MATLAB/Simulink was used for simulation test.The optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 yuan.Additionally,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations significantly.The proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.
