The onset,cessation,and length of the rainy season are crucial for global water resources,agricultural practices,and food security.However,the response of precipitation seasonality to global warming remains uncertain....The onset,cessation,and length of the rainy season are crucial for global water resources,agricultural practices,and food security.However,the response of precipitation seasonality to global warming remains uncertain.In this study,we analyze how global warming levels(GWLs)of 1.5℃ and 2℃ could affect the timing of rainfall onset(RODs),rainfall cessation(RCDs),and the overall duration of the rainy season(LRS)over global land monsoon(GLM)regions using simulations from CMIP6 under the SSP2-4.5 and SSP5-8.5 scenarios.With high model consensus,our results reveal that RODs are projected to occur later over Southern Africa,North Africa,and South America,but earlier over South Asia and Australia,in a warmer climate.The projected early RODs in Australia are more pronounced at the 2℃ GWL under SSP5-8.5.On the other hand,early RCDs are projected over South America and East Asia,while late RCDs are projected over North Africa,with high inter-model agreement.These changes are associated with a future decrease in LRS in most GLM regions.Additionally,we found that continuous warming over 1.5℃ will further reduce the length of the rainy season,especially over the South America,North Africa,and Southern Africa monsoon regions.The findings underscore the urgent need to mitigate global warming.展开更多
BACKGROUND The atherogenic index of plasma(AIP)has been shown to be positively correlated with cardiovascular disease in previous studies.However,it is unclear whether elderly people with long-term high AIP levels are...BACKGROUND The atherogenic index of plasma(AIP)has been shown to be positively correlated with cardiovascular disease in previous studies.However,it is unclear whether elderly people with long-term high AIP levels are more likely to develop coronary heart disease(CHD).Therefore,the aim of this study was to investigate the relationship between AIP trajectory and CHD incidence in elderly people.METHODS 19,194 participants aged≥60 years who had three AIP measurements between 2018 and 2020 were included in this study.AIP was defined as log10(triglyceride/high-density lipoprotein cholesterol).The group-based trajectory model was used to identify different trajectory patterns of AIP from 2018 to 2020.Cox proportional hazards models were used to estimate the hazard ratio(HR)with 95%CI of CHD events between different trajectory groups from 2020 to 2023.RESULTS Three different trajectory patterns were identified through group-based trajectory model:the low-level group(n=7410,mean AIP:-0.25 to-0.17),the medium-level group(n=9981,mean AIP:0.02-0.08),and the high-level group(n=1803,mean AIP:0.38-0.42).During a mean follow-up of 2.65 years,a total of 1391 participants developed CHD.After adjusting for potential confounders,compared with the participants in the low-level group,the HR with 95%CI of the medium-level group and the high-level group were estimated to be 1.24(1.10-1.40)and 1.43(1.19-1.73),respectively.These findings remained consistent in subgroup analyses and sensitivity analyses.CONCLUSIONS There was a significant correlation between persistent high AIP level and increased CHD risk in the elderly.This suggests that monitoring the long-term changes in AIP is helpful to identify individuals at high CHD risk in elderly people.展开更多
Dear Editor,We present the reported case of rapid onset bull’s eye maculopathy.Chloroquine(CQ)and its safer,more widely used analogue,hydroxychloroquine(HCQ),were originally developed as antimalarial medications.Howe...Dear Editor,We present the reported case of rapid onset bull’s eye maculopathy.Chloroquine(CQ)and its safer,more widely used analogue,hydroxychloroquine(HCQ),were originally developed as antimalarial medications.However,they have since become essential in the treatment of various autoimmune disorders due to their anti-inflammatory and immunomodulatory properties.HCQ is also being investigated for potential applications in diabetes mellitus,coronavirus disease 2019,heart disease,and as an adjunct in cancer therapy^([1-2]).展开更多
Spinal subarachnoid hemorrhage(SSAH)is a relatively uncommon but significant cause of acute and progressive neurological impairment.It represents less than 1.5%of all instances of bleeding within the subarachnoid spac...Spinal subarachnoid hemorrhage(SSAH)is a relatively uncommon but significant cause of acute and progressive neurological impairment.It represents less than 1.5%of all instances of bleeding within the subarachnoid space.[1]The early stages of SSAH often present atypical clinical symptoms,making diagnosis challenging and potentially leading to treatment delays,which further result in irreversible neurological damage.Lower back pain is a common complaint in the emergency department(ED).[2]Common causes include overuse resulting in back strain.展开更多
Although the Chinese new-generation Fengyun-4B(FY-4B) geostationary satellite Atmospheric Motion Vector(AMV) products became operational in June 2022, their accuracy and utility remain largely unexamined. This study c...Although the Chinese new-generation Fengyun-4B(FY-4B) geostationary satellite Atmospheric Motion Vector(AMV) products became operational in June 2022, their accuracy and utility remain largely unexamined. This study comprehensively evaluates FY-4B AMV products for August and October 2023, as well as January and April 2024,exploring their application in monitoring the South China Sea Summer Monsoon(SCSSM) onset. The results indicate that AMV products derived from the upper-level water vapor absorption channel(AMV_WV) and the infrared channel(AMV_IR) demonstrate high accuracy when compared with ERA5 reanalysis data. The root mean square error(RMSE) is mostly between 4.5 m s^(–1)and 6.4 m s^(–1), with coefficients of determination(R2) values ranging from 0.7 to 0.8, indicating the overall reliability of FY-4B AMVs. The observation errors of AMVs exhibit significant vertical structure characteristics. Specifically, the AMV_WV products demonstrate superior accuracy above 350 h Pa, while the AMV_IR products exhibit reduced errors in the layers between 200–500 h Pa and 700–950 h Pa. Spatially, most areas exhibit low observation errors for AMVs, while clear-sky weather and deep convective cloud systems can increase errors. A lack of clouds or water vapor may reduce the number of observation samples in some areas, leading to unstable RMSE performance, which is particularly evident for AMV_WV RMSE around 25°–30°N in January and near 25°S in August. Deep convective cloud systems can influence AMV retrieval results, leading to systematic observation errors, especially for the infrared channel.Additionally, AMV_WV is more reliable during the daytime, with a lower RMSE compared to nighttime, while AMV_IR exhibits a diverging diurnal variation pattern. Finally, the FY-4B AMV_WV products were applied to monitor the SCSSM event in 2024. Significant zonal wind direction reversal characteristics were observed in key regions around the onset date,indicating that AMVs can serve as effective indicators for monitoring the SCSSM onset.展开更多
Colorectal cancer(CRC) is one of the leading causes of cancer related mortality worldwide. Although young-onset CRC raises the possibility of a hereditary component, hereditary CRC syndromes only explain a minority of...Colorectal cancer(CRC) is one of the leading causes of cancer related mortality worldwide. Although young-onset CRC raises the possibility of a hereditary component, hereditary CRC syndromes only explain a minority of young-onset CRC cases. There is evidence to suggest that young-onset CRC have a different molecular profile than late-onset CRC. While the pathogenesis of young-onset CRC is well characterized in individuals with an inherited CRC syndrome, knowledge regarding the molecular features of sporadic young-onset CRC is limited. Understanding the molecular mechanisms of young-onset CRC can help us tailor specific screening and management strategies. While the incidence of late-onset CRC has been decreasing, mainly attributed to an increase in CRC screening, the incidence of young-onset CRC is increasing. Differences in the molecular biology of these tumors and low suspicion of CRC in young symptomatic individuals, may be possible explanations. Currently there is no evidence that supports that screening of average risk individuals less than 50 years of age will translate into early detection or increased survival. However, increasing understanding of the underlying molecular mechanisms of young-onset CRC could help us tailor specific screening and management strategies. The purpose of this review is to evaluate the current knowledge about young-onset CRC, its clinicopathologic features, and the newly recognized molecular alterations involved in tumor progression.展开更多
Background Increased levels of inflammatory markers have been documented in various settings of coronary artery disease. The vulnerability of coronary lesions in acute myocardial infarction(AMI) at the time of onset m...Background Increased levels of inflammatory markers have been documented in various settings of coronary artery disease. The vulnerability of coronary lesions in acute myocardial infarction(AMI) at the time of onset may be related to serum levels of C reactive protein(CRP) on admission, before CRP levels are affected by myocardial damage.Objective This study assessed the predictive value of CRP levels within six hours after the onset of acute anterior myocardial infarction with primary percutaneous coronary intervention(PCI).Methods The plasma CRP of 76 patients with first acute anterior myocardial infarction was measured within 6 hours after onset. They were divided into 2 groups: group 1( n =20) with elevated CRP( ≥0.3mg/dl ) on admission within 6 hours after onset and group 2( n =56) with normal CRP( <0.3mg/dl ) within 6 hours after onset. All patients were treated by primary PCI. The primary combined end points, including death due to cardiac causes, re MI related to the infarction artery(RIA) and repeat intervention of the RIA, and the restenosis rate were assessed in relation to CRP levels within 6 hours after onset. Left ventricular end diastolic volume index(EDVI),end systolic volume index(ESVI),and ejection fraction(EF) on admission and 6 month after the onset were assessed by left ventriculography. Changes in EDVI(ΔEDVI),ESVI(ΔESVI), and EF(ΔEF) were obtained by subtracting respective on admission values from corresponding 6 month follow up values. Results There were no significant differences in baseline characteristics between the two groups. The primary combined end points were significantly more frequent in group 1(20%) than those in group 2( 1.79% , P <0.01 ).In addition, restenosis rates were significantly higher in group 1 than in group 2(41.18% vs 16.07%, P<0.05). Group 1 showed greater increases in left ventricular volume and less improvement in EF compared with group 2(ΔEDVI 6.31 ±2.17 vs 3.29 ±9.46ml/m 2 , ΔESVI 5.92 ±2.31 vs 3.86 ±1.08ml/m 2 , ΔEF 1.92 ±0.47 vs 4.79 ±1.73% , P <0.05 , respectively).Conclusions CRP levels within 6 hours after the onset of AMI might predict adverse outcome after primary PCI and progressive ventricular remodeling within 6 month of AMI.展开更多
BACKGROUND Preeclampsia(PE)is a multisystemic metabolic disease with an undetermined etiology.PE is a worldwide cause of maternal and perinatal morbidity,subdivided into early(EoPE)and late-onset(LoPE)according to 34 ...BACKGROUND Preeclampsia(PE)is a multisystemic metabolic disease with an undetermined etiology.PE is a worldwide cause of maternal and perinatal morbidity,subdivided into early(EoPE)and late-onset(LoPE)according to 34 wk of gestation as a divider.Many researchers investigated biomarkers for predicting PE to halt its consequences on the feto-maternal outcome.Elabela(Ela)is a newly discovered peptide hormone that was implicated in PE pathogenesis.Earlier rodent studies discussed Ela’s role in controlling blood pressure.Moreover,Ela deficiency was associated with PE development.AIM To test whether plasma Ela could serve as a reliable marker for predicting PE based on the time of onset(EoPE vs LoPE)compared to age and body mass matched healthy controls since no definitive treatment exists for PE but to terminate a pregnancy.METHODS This case-control study recruited(n=90)pregnant who fulfilled inclusion criteria;they were allocated into three groups:EoPE(30/90)(<34 wk of gestation);LoPE(30/90)(≥34 wk of gestation);and healthy pregnant(30/90).Demographic criteria;biochemical,hematological,and maternal plasma Ela levels were recorded for comparison.RESULTS Serum Ela was significantly reduced in EoPE compared to LoPE and healthy controls(P=0.0023).The correlation confirmed a strong inverse relationship with mean atrial blood pressure(r=-0.7,P<0.001),while gestational age and platelets count showed a moderate correlation with(r=0.4 with P<0.0001).No correlation was confirmed between the body mass index(BMI)and urine albumin.The predictive ability of 25 centile serum Ela had an Odds ratio of 5.21,95%confidence interval(1.28,21.24),P=0.02 for predicting EoPE.The receiver operator characteristic curve defined the Ela cutoff value at>9.156 with 96.7%and 93.3%sensitivity and specificity,P<0.0001 in predicting EoPE.CONCLUSION A strong correlation of serum Ela with PE parameters with excellent sensitivity and specificity in distinguishing EoPE independent of the BMI,age,and blood pressure which makes Ela a recommendable marker in screening.Further research is warranted to explore prognostic and therapeutic applications for Ela in PE.展开更多
Alzheimer’s disease is quickly becoming one of the most known diseases in the country due to its devastating effects and lack of treatment options. Within this lethal disease, there is a smaller group, those individu...Alzheimer’s disease is quickly becoming one of the most known diseases in the country due to its devastating effects and lack of treatment options. Within this lethal disease, there is a smaller group, those individuals that are diagnosed with early-onset Alzheimer’s disease. It is understood that these individuals see faster effects of the disease and die considerably sooner, but it is not understood why. This review compares the early-onset (EOAD) and late-onset (LOAD) types to try and determine some of the most blaring differences between the two. The genetic basis linking EOAD and LOAD has been the apolipoprotein E gene (APOE) to indicate metabolic alteration with the ε4 allele specifically. The topographical atrophy disparities between EOAD and LOAD supported the more noticeable cognitive differences between the two Alzheimer’s disease categories. The faster and wider spread atrophy of EOAD patients correlates with the difficulty they experience with attention, language, visuo-spatial, and executive functions. Finally, brain metabolism differs between both AD subtypes as well, where EOAD indicates the wide spread damage and metabolic breakdown across more diverse regions of the brain.展开更多
Based on summarizing previous achievements and characteristics of Asian summer monsoon and the role using data as long and new as possible, the onset of Asian-Australian ＂land bridge＂ in the onset of summer monsoon ...Based on summarizing previous achievements and characteristics of Asian summer monsoon and the role using data as long and new as possible, the onset of Asian-Australian ＂land bridge＂ in the onset of summer monsoon are further discussed. In particular, the earliest onset area of Asian summer monsoon is comparatively analyzed, and the sudden and progressive characteristics of the onset of summer monsoon in different regions are discussed, Furthermore, the relationships among such critical events during the onset of Asian summer monsoon as the splitting of subtropical high belt over the Bay of Bengal （BOB）, the initiation of convection over Indo-China Peninsula, the westward advance, reestablishment of South Asian High, and the rapid northward progression of convection originated from Sumatra in early summer are studied. The important impact of the proper collocation of she latent heating over Indo-China Peninsula and the sensible heating over Indian Peninsula on the splitting of the subtropical high belt, the deepening of BOB trough, the activating of Sri Lanka vortex （twin vortexes in the Northern and Southern Hemispheres）, and the subsequent onset of South China Sea summer monsoon are emphasized.展开更多
Through analyzing the NCEP/NCAR reanalysis data, the satellite observational data and the ATLAS-2 mooring buoy observational data, it is shown that May 21 is the onset date of the South China Sea summer monsoon in 199...Through analyzing the NCEP/NCAR reanalysis data, the satellite observational data and the ATLAS-2 mooring buoy observational data, it is shown that May 21 is the onset date of the South China Sea summer monsoon in 1998. There were abrupt variations in the general circulation pattern at the lower troposphere and the upper troposphere, in upper jet stream location and in the convection and rainfall over the South China Sea region corresponding to the outbreak of the South China Sea summer monsoon. It is also indicated that there was rainfall in the southern China coastal region before onset of summer monsoon, but it resulted from the (cold) front activity and cannot be regarded as the sign of summer monsoon outbreak in the South China Sea. Key words Onset - South China Sea summer monsoon - General circulation pattern, Jet stream - Convection This work was supported by the State Key Project for Research—“ The South China Sea Monsoon Experiment”, CAS (KZ951-B1-408) and CNSF (49823002).展开更多
Climatic changes in the onset of spring in northern China associated with changes in the annual cycle and with a recent warming trend were quantified using a recently developed adaptive data analysis tool, the Ensembl...Climatic changes in the onset of spring in northern China associated with changes in the annual cycle and with a recent warming trend were quantified using a recently developed adaptive data analysis tool, the Ensemble Empirical Mode Decomposition. The study was based on a homogenized daily surface air temperature （SAT） dataset for the period 1955–2003. The annual cycle here is referred to as a refined modulated annual cycle （MAC）. The results show that spring at Beijing has arrived significantly earlier by about 2.98 d （10 yr）-1, of which about 1.85 d （10 yr）-1 is due to changes in the annual cycle and 1.13 d （10 yr）-1 due to the long-term warming trend. Variations in the MAC component explain about 92.5% of the total variance in the Beijing daily SAT series and could cause as much as a 20-day shift in the onset of spring from one year to another. The onset of spring has been advancing all over northern China, but more significant in the east than in the west part of the region. These differences are somehow unexplainable by the zonal pattern of the warming trend over the whole region, but can be explained by opposite changes in the spring phase of the MAC, i.e. advancing in the east while delaying in the west. In the east of northern China, the change in the spring phase of MAC explains 40%–60% of the spring onset trend and is attributable to a weakening Asian winter monsoon. The average sea level pressure in Siberia （55°–80°N, 50°–110°E）, an index of the strength of the winter monsoon, could serve as a potential short-term predictor for the onset of spring in the east of northern China.展开更多
The thermal characteristics during the South China Sea (SCS) summer monsoon onset period near the Indo-China Peninsula are analyzed by using the South China Sea Monsoon Experiment (SCSMEX) reanalysis data from 1 May t...The thermal characteristics during the South China Sea (SCS) summer monsoon onset period near the Indo-China Peninsula are analyzed by using the South China Sea Monsoon Experiment (SCSMEX) reanalysis data from 1 May to 31 August 1998 and the NCEP/ NCAR pentad-mean reanalysis data from January 1980 to December 1995. The possible relationships between the anomaly of thermal features near the Indo-China Peninsula and the SCS monsoon onset are investigated, and the mechanism causing the SCS summer monsoon onset is also discussed. Results from the 1998 SCSMEX reanalysis data show that there exists a strong persistent surface sensible heating near the Indo-China Peninsula prior to the SCS monsoon onset, which has apparent low frequency oscillation features. This sensible healing leads lo a warmer center in the lower atmosphere near the Indo-China Peninsula and strong local horizontal temperature and geopotential height gradients which are favorable to strengthening the southwest wind over the Indo-China Peninsula. It is also found that stronger convergent winds at lower levels and stronger divergent winds at high levels appear, which provide a favorable configuration for the development of vertical motion, enhancement of precipitation, and onset of the SCS monsoon. These results can be verified by analysis of the multi-year mean data. Additionally, it is found that the temperature at 850 hPa increases more rapidly over the Indo-China Peninsula than the South China Sea prior to the SCS monsoon onset, which leads to a strengthening of the temperature difference between the Indo-China Peninsula and the South China Sea. Moreover, results from the analysis of the longitudinal temperature and geopotential height differences show that the eastern retreat of the subtropical high over the Indo-China Peninsula during the period of SCS monsoon onset is associated with the temperature increase over the Indo-China Peninsula and the eastern extension of low trough over the Bay of Bengal.展开更多
The onset process of the tropical eastern Indian Ocean （TEIO） summer monsoon （TEIOSM） and its relationship with the cross-equatorial flows are investigated via climatological analysis. Climatologically, results in...The onset process of the tropical eastern Indian Ocean （TEIO） summer monsoon （TEIOSM） and its relationship with the cross-equatorial flows are investigated via climatological analysis. Climatologically, results indicate that the earliest onset process of the Asian summer monsoon occurs over the TEIO at pentad 22 （April 15-20）. Unlike the abrupt onset of the South China Sea （SCS） summer monsoon, the TEIOSM onset process displays a stepwise advance. Moreover, a close relationship between the TEIOSM development and the northward push of the cross-equatorial flows over 80^-90~E is revealed. A difference vorticity center, together with the counterpart over the southern Indian Ocean, constitutes a pair of difference cyclonic vortices, which strengthens the southwesterly wind over the TEIO and the northerly wind to the west of the Indian Peninsula from the end of March to late May. Therefore, the occurrence of the southwesterly wind over the TEIO is earlier than its counterpart over the tropical western Indian Ocean, and the cross-equatorial flows emerge firstly over the TEIO rather than over the Somali area. The former increases in intensity during its northward propagation, which provides a precondition for the TEIOSM onset and its northward advance.展开更多
The reproducibility and future changes of the onset of the Asian summer monsoon were analyzed based on the simulations and projections under the Representative Concentration Pathways （RCP） scenario in which anthropo...The reproducibility and future changes of the onset of the Asian summer monsoon were analyzed based on the simulations and projections under the Representative Concentration Pathways （RCP） scenario in which anthropogenic emissions continue to rise throughout the 21 st century （i.e. RCP8.5） by all realizations from four Chinese models that participated in the Coupled Model Intercomparison Project Phase 5 （CMIP5）. Delayed onset of the monsoon over the Arabian Sea was evident in all simulations for present-day climate, which was associated with a too weak simulation of the low-level Somali jet in May. A consistent advanced onset of the monsoon was found only over the Arabian Sea in the projections, where the advanced onset of the monsoon was accompanied by an increase of rainfall and an anomalous anticyclone over the northern Indian Ocean. In all the models except FGOALS-g2, the enhanced low-level Somali jet transported more water vapor to the Arabian Sea, whereas in FGOALS-g2 the enhanced rainfall was determined more by the increased wind convergence. Furthermore, and again in all models except FGOALS-g2, the equatorial SST warming, with maximum increase over the eastern Pacific, enhanced convection in the central West Pacific and reduced convection over the eastern Indian Ocean and Maritime Continent region, which drove the anomalous anticyclonic circulation over the western Indian Ocean. In contrast, in FGOALS-g2, there was minimal （near-zero） warming of projected SST in the central equatorial Pacific, with decreased convection in the central West Pacific and enhanced convection over the Maritime Continent. The broader-scale differences among the models across the Pacific were related to both the differences in the projected SST pattern and in the present-day simulations.展开更多
Using observed and reanalysis datasets,the South China Sea summer monsoon(SCSSM)onset process is analyzed in each year from 1997 to 2014.Regional mean(5-20°N,110-120°E)850 hPa zonal wind,precipitation,and SS...Using observed and reanalysis datasets,the South China Sea summer monsoon(SCSSM)onset process is analyzed in each year from 1997 to 2014.Regional mean(5-20°N,110-120°E)850 hPa zonal wind,precipitation,and SST are used as indices to describe SCSSM onset.Three distinct onset types are identified:among the 18 years studied,nine are normal onset years,which are characterized by a well-established westerly wind and associated precipitation over the South China Sea(SCS);eight are intermittent onset years,in which monsoon precipitation does not occur continuously following the establishment of the westerly wind over the SCS;and one year,2014,is a delayed onset year,in which the western Pacific subtropical high dominates over the SCS after the seasonal transition and prevents the monsoon onset.A comparison of the first two types suggests that a positive SST gradient in the northern Indian Ocean and local SST warming in the SCS are two key factors in the normal SCSSM onset type.With regard to the influence of the El Nio-Southern Oscillation background,there are four late onset years(1997,1998,2007,and 2010)that coincide with El Nino events,but only two early-onset years(1999 and 2012)out of the six years featuring La Nina events.Further analysis suggests that the zonal thermal contrast across the Indian and western Pacific oceans modulates monsoon onset in La Nina years.展开更多
AIM: To investigate the efficacy and safety of the treatment of endoscopic trans-ethmosphenoid optic canal decompression(ETOCD) with combination of steroid in patients with newly onset indirect traumatic optic neuropa...AIM: To investigate the efficacy and safety of the treatment of endoscopic trans-ethmosphenoid optic canal decompression(ETOCD) with combination of steroid in patients with newly onset indirect traumatic optic neuropathy(ITON) and compare the outcome between immediate ETOCD treatment and ETOCD with preoperative steroid treatment. METHODS: Patients presented as newly onset ITON(suffered trauma within 3 d) at a tertiary medical center between Mar 1 st, 2016 and Mar 1 st, 2018 were enrolled in this study. All patients were equally and randomly divided into 2 groups. Cases in group A were performed ETOCD immediately after admition while cases in group B were prescribed by methylprednisolone(20 mg/kg · d) for 3 d before ETOCD. Methylprednisolone(20 mg/kg · d) was used after surgery for 6 d in group A and 3 d in group B. Follow-up was up to 3 mo in all cases. Visual acuity(VA) before and after treatment between the two groups were taken into comparison. RESULTS: Complete postoperative data were acquired from 34 patients in group A and from 32 patients in group B. Group A had significantly higher effective rate in VA than group B(χ~2 =4.905, P=0.027).CONCLUSION: For patients with newly onset ITON, combination treatment of ETOCD with high-dose steroid is an effective and safe way. Immediate surgery will lead to better prognosis for these cases.展开更多
Global gridded daily mean data from the NCEP/NCAR Reanalysis(1948-2012) are used to obtain the onset date,retreat date and duration time series of the South China Sea summer monsoon(SCSSM) for the past 65 years.The su...Global gridded daily mean data from the NCEP/NCAR Reanalysis(1948-2012) are used to obtain the onset date,retreat date and duration time series of the South China Sea summer monsoon(SCSSM) for the past 65 years.The summer monsoon onset(retreat) date is defined as the time when the mean zonal wind at 850 hPa shifts steadily from easterly(westerly) to westerly(easterly) and the pseudo-equivalent potential temperature at the same level remains steady at greater than 335 K(less than 335 K) in the South China Sea area[110-120°E(10-20°N)].The clockwise vortex of the equatorial Indian Ocean region,together with the cross-equatorial flow and the subtropical high,plays a decisive role in the burst of the SCSSM.The onset date of the SCSSM is closely related to its intensity.With late(early) onset of the summer monsoon,its intensity is relatively strong(weak),and the zonal wind undergoes an early(late) abrupt change in the upper troposphere.Climate warming significantly affects the onset and retreat dates of the SCSSM and its intensity.With climate warming,the number of early-onset(-retreat) years of the SCSSM is clearly greater(less),and the SCSSM is clearly weakened.展开更多
The influence of soil moisture on Asian monsoon simulation/prediction was less studied, partly due to a lack of available and reliable soil moisture datasets. In this study, we firstly compare several soil moisture da...The influence of soil moisture on Asian monsoon simulation/prediction was less studied, partly due to a lack of available and reliable soil moisture datasets. In this study, we firstly compare several soil moisture datasets over the Tibetan Plateau, and find that the remote sensing products from the Advanced Microwave Scanning Radiometer for Earth Observing System （AMSR-E） can capture realistic temporal variations of soil moisture better than the two reanalyses （NCEP and ECMWF） during the pre-monsoon seasons. Using the AMSR-E soil moisture product, we investigate the impacts of soil moisture over the Tibetan Plateau on Asian summer monsoon onset based on a Spectral Atmospheric Model developed at IAP/LASG （SAMIL）. Comparison between results with and without the assimilation of remotely sensed soil moisture data demonstrates that with soil moisture assimilated into SAMIL, the land-sea thermal contrast during pre-monsoon seasons is more realistic. Accordingly, the simulation of summer monsoon onset dates over both the Bay of Bengal and South China Sea regions are more accurate with AMSR-E soil moisture assimilated. This study reveals that the application of the soil moisture remote sensing products in a numerical model could potentially improve prediction of the Asian summer monsoon onset.展开更多
Observations of the South China Sea summer monsoon （SCSSM） demonstrate the different features between the early and late onsets of the monsoon. The determining factor related to the onset and the resultant monsoon r...Observations of the South China Sea summer monsoon （SCSSM） demonstrate the different features between the early and late onsets of the monsoon. The determining factor related to the onset and the resultant monsoon rainfall might be the off-equatorial ITCZ besides the land-sea thermal contrast. The northward-propagating cumulus convection over the northern Indian Ocean could enhance the monsoon trough so that the effect of the horizontal advection of moisture and heat is substantially increased, thus westerlies can eventually penetrate and prevail over the South China Sea （SCS） region.展开更多
基金supported by the Australian Research Council(Grant No.CE230100012)。
文摘The onset,cessation,and length of the rainy season are crucial for global water resources,agricultural practices,and food security.However,the response of precipitation seasonality to global warming remains uncertain.In this study,we analyze how global warming levels(GWLs)of 1.5℃ and 2℃ could affect the timing of rainfall onset(RODs),rainfall cessation(RCDs),and the overall duration of the rainy season(LRS)over global land monsoon(GLM)regions using simulations from CMIP6 under the SSP2-4.5 and SSP5-8.5 scenarios.With high model consensus,our results reveal that RODs are projected to occur later over Southern Africa,North Africa,and South America,but earlier over South Asia and Australia,in a warmer climate.The projected early RODs in Australia are more pronounced at the 2℃ GWL under SSP5-8.5.On the other hand,early RCDs are projected over South America and East Asia,while late RCDs are projected over North Africa,with high inter-model agreement.These changes are associated with a future decrease in LRS in most GLM regions.Additionally,we found that continuous warming over 1.5℃ will further reduce the length of the rainy season,especially over the South America,North Africa,and Southern Africa monsoon regions.The findings underscore the urgent need to mitigate global warming.
基金supported by the National Key Research and Development Program of China(2017YFC1307705).
文摘BACKGROUND The atherogenic index of plasma(AIP)has been shown to be positively correlated with cardiovascular disease in previous studies.However,it is unclear whether elderly people with long-term high AIP levels are more likely to develop coronary heart disease(CHD).Therefore,the aim of this study was to investigate the relationship between AIP trajectory and CHD incidence in elderly people.METHODS 19,194 participants aged≥60 years who had three AIP measurements between 2018 and 2020 were included in this study.AIP was defined as log10(triglyceride/high-density lipoprotein cholesterol).The group-based trajectory model was used to identify different trajectory patterns of AIP from 2018 to 2020.Cox proportional hazards models were used to estimate the hazard ratio(HR)with 95%CI of CHD events between different trajectory groups from 2020 to 2023.RESULTS Three different trajectory patterns were identified through group-based trajectory model:the low-level group(n=7410,mean AIP:-0.25 to-0.17),the medium-level group(n=9981,mean AIP:0.02-0.08),and the high-level group(n=1803,mean AIP:0.38-0.42).During a mean follow-up of 2.65 years,a total of 1391 participants developed CHD.After adjusting for potential confounders,compared with the participants in the low-level group,the HR with 95%CI of the medium-level group and the high-level group were estimated to be 1.24(1.10-1.40)and 1.43(1.19-1.73),respectively.These findings remained consistent in subgroup analyses and sensitivity analyses.CONCLUSIONS There was a significant correlation between persistent high AIP level and increased CHD risk in the elderly.This suggests that monitoring the long-term changes in AIP is helpful to identify individuals at high CHD risk in elderly people.
文摘Dear Editor,We present the reported case of rapid onset bull’s eye maculopathy.Chloroquine(CQ)and its safer,more widely used analogue,hydroxychloroquine(HCQ),were originally developed as antimalarial medications.However,they have since become essential in the treatment of various autoimmune disorders due to their anti-inflammatory and immunomodulatory properties.HCQ is also being investigated for potential applications in diabetes mellitus,coronavirus disease 2019,heart disease,and as an adjunct in cancer therapy^([1-2]).
基金National Natural Science Foundation of China(82472218)National Key Clinical Specialist Construction Project(Z155080000004)+4 种基金National Key Research and Development Program of China(2024YFC3044400)Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0506502)the Science and Technology of Shanghai Committee(23Y31900100)Shen Kang Hospital Development Center Project for Technical Standardization Management and Promotion(SHDC22023239)Key Supporting Discipline of Shanghai Healthcare System(2023ZDFC0102).
文摘Spinal subarachnoid hemorrhage(SSAH)is a relatively uncommon but significant cause of acute and progressive neurological impairment.It represents less than 1.5%of all instances of bleeding within the subarachnoid space.[1]The early stages of SSAH often present atypical clinical symptoms,making diagnosis challenging and potentially leading to treatment delays,which further result in irreversible neurological damage.Lower back pain is a common complaint in the emergency department(ED).[2]Common causes include overuse resulting in back strain.
基金Science and Technology Planning Project of Guangdong Province (2023B1212060019)Natural Science Foundation of China (42175086)Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)(SML2023SP208)。
文摘Although the Chinese new-generation Fengyun-4B(FY-4B) geostationary satellite Atmospheric Motion Vector(AMV) products became operational in June 2022, their accuracy and utility remain largely unexamined. This study comprehensively evaluates FY-4B AMV products for August and October 2023, as well as January and April 2024,exploring their application in monitoring the South China Sea Summer Monsoon(SCSSM) onset. The results indicate that AMV products derived from the upper-level water vapor absorption channel(AMV_WV) and the infrared channel(AMV_IR) demonstrate high accuracy when compared with ERA5 reanalysis data. The root mean square error(RMSE) is mostly between 4.5 m s^(–1)and 6.4 m s^(–1), with coefficients of determination(R2) values ranging from 0.7 to 0.8, indicating the overall reliability of FY-4B AMVs. The observation errors of AMVs exhibit significant vertical structure characteristics. Specifically, the AMV_WV products demonstrate superior accuracy above 350 h Pa, while the AMV_IR products exhibit reduced errors in the layers between 200–500 h Pa and 700–950 h Pa. Spatially, most areas exhibit low observation errors for AMVs, while clear-sky weather and deep convective cloud systems can increase errors. A lack of clouds or water vapor may reduce the number of observation samples in some areas, leading to unstable RMSE performance, which is particularly evident for AMV_WV RMSE around 25°–30°N in January and near 25°S in August. Deep convective cloud systems can influence AMV retrieval results, leading to systematic observation errors, especially for the infrared channel.Additionally, AMV_WV is more reliable during the daytime, with a lower RMSE compared to nighttime, while AMV_IR exhibits a diverging diurnal variation pattern. Finally, the FY-4B AMV_WV products were applied to monitor the SCSSM event in 2024. Significant zonal wind direction reversal characteristics were observed in key regions around the onset date,indicating that AMVs can serve as effective indicators for monitoring the SCSSM onset.
文摘Colorectal cancer(CRC) is one of the leading causes of cancer related mortality worldwide. Although young-onset CRC raises the possibility of a hereditary component, hereditary CRC syndromes only explain a minority of young-onset CRC cases. There is evidence to suggest that young-onset CRC have a different molecular profile than late-onset CRC. While the pathogenesis of young-onset CRC is well characterized in individuals with an inherited CRC syndrome, knowledge regarding the molecular features of sporadic young-onset CRC is limited. Understanding the molecular mechanisms of young-onset CRC can help us tailor specific screening and management strategies. While the incidence of late-onset CRC has been decreasing, mainly attributed to an increase in CRC screening, the incidence of young-onset CRC is increasing. Differences in the molecular biology of these tumors and low suspicion of CRC in young symptomatic individuals, may be possible explanations. Currently there is no evidence that supports that screening of average risk individuals less than 50 years of age will translate into early detection or increased survival. However, increasing understanding of the underlying molecular mechanisms of young-onset CRC could help us tailor specific screening and management strategies. The purpose of this review is to evaluate the current knowledge about young-onset CRC, its clinicopathologic features, and the newly recognized molecular alterations involved in tumor progression.
文摘Background Increased levels of inflammatory markers have been documented in various settings of coronary artery disease. The vulnerability of coronary lesions in acute myocardial infarction(AMI) at the time of onset may be related to serum levels of C reactive protein(CRP) on admission, before CRP levels are affected by myocardial damage.Objective This study assessed the predictive value of CRP levels within six hours after the onset of acute anterior myocardial infarction with primary percutaneous coronary intervention(PCI).Methods The plasma CRP of 76 patients with first acute anterior myocardial infarction was measured within 6 hours after onset. They were divided into 2 groups: group 1( n =20) with elevated CRP( ≥0.3mg/dl ) on admission within 6 hours after onset and group 2( n =56) with normal CRP( <0.3mg/dl ) within 6 hours after onset. All patients were treated by primary PCI. The primary combined end points, including death due to cardiac causes, re MI related to the infarction artery(RIA) and repeat intervention of the RIA, and the restenosis rate were assessed in relation to CRP levels within 6 hours after onset. Left ventricular end diastolic volume index(EDVI),end systolic volume index(ESVI),and ejection fraction(EF) on admission and 6 month after the onset were assessed by left ventriculography. Changes in EDVI(ΔEDVI),ESVI(ΔESVI), and EF(ΔEF) were obtained by subtracting respective on admission values from corresponding 6 month follow up values. Results There were no significant differences in baseline characteristics between the two groups. The primary combined end points were significantly more frequent in group 1(20%) than those in group 2( 1.79% , P <0.01 ).In addition, restenosis rates were significantly higher in group 1 than in group 2(41.18% vs 16.07%, P<0.05). Group 1 showed greater increases in left ventricular volume and less improvement in EF compared with group 2(ΔEDVI 6.31 ±2.17 vs 3.29 ±9.46ml/m 2 , ΔESVI 5.92 ±2.31 vs 3.86 ±1.08ml/m 2 , ΔEF 1.92 ±0.47 vs 4.79 ±1.73% , P <0.05 , respectively).Conclusions CRP levels within 6 hours after the onset of AMI might predict adverse outcome after primary PCI and progressive ventricular remodeling within 6 month of AMI.
基金approved by the Scientific-Ethical Committee of the Mustansiriyah University(Approval No.IRB126).
文摘BACKGROUND Preeclampsia(PE)is a multisystemic metabolic disease with an undetermined etiology.PE is a worldwide cause of maternal and perinatal morbidity,subdivided into early(EoPE)and late-onset(LoPE)according to 34 wk of gestation as a divider.Many researchers investigated biomarkers for predicting PE to halt its consequences on the feto-maternal outcome.Elabela(Ela)is a newly discovered peptide hormone that was implicated in PE pathogenesis.Earlier rodent studies discussed Ela’s role in controlling blood pressure.Moreover,Ela deficiency was associated with PE development.AIM To test whether plasma Ela could serve as a reliable marker for predicting PE based on the time of onset(EoPE vs LoPE)compared to age and body mass matched healthy controls since no definitive treatment exists for PE but to terminate a pregnancy.METHODS This case-control study recruited(n=90)pregnant who fulfilled inclusion criteria;they were allocated into three groups:EoPE(30/90)(<34 wk of gestation);LoPE(30/90)(≥34 wk of gestation);and healthy pregnant(30/90).Demographic criteria;biochemical,hematological,and maternal plasma Ela levels were recorded for comparison.RESULTS Serum Ela was significantly reduced in EoPE compared to LoPE and healthy controls(P=0.0023).The correlation confirmed a strong inverse relationship with mean atrial blood pressure(r=-0.7,P<0.001),while gestational age and platelets count showed a moderate correlation with(r=0.4 with P<0.0001).No correlation was confirmed between the body mass index(BMI)and urine albumin.The predictive ability of 25 centile serum Ela had an Odds ratio of 5.21,95%confidence interval(1.28,21.24),P=0.02 for predicting EoPE.The receiver operator characteristic curve defined the Ela cutoff value at>9.156 with 96.7%and 93.3%sensitivity and specificity,P<0.0001 in predicting EoPE.CONCLUSION A strong correlation of serum Ela with PE parameters with excellent sensitivity and specificity in distinguishing EoPE independent of the BMI,age,and blood pressure which makes Ela a recommendable marker in screening.Further research is warranted to explore prognostic and therapeutic applications for Ela in PE.
文摘Alzheimer’s disease is quickly becoming one of the most known diseases in the country due to its devastating effects and lack of treatment options. Within this lethal disease, there is a smaller group, those individuals that are diagnosed with early-onset Alzheimer’s disease. It is understood that these individuals see faster effects of the disease and die considerably sooner, but it is not understood why. This review compares the early-onset (EOAD) and late-onset (LOAD) types to try and determine some of the most blaring differences between the two. The genetic basis linking EOAD and LOAD has been the apolipoprotein E gene (APOE) to indicate metabolic alteration with the ε4 allele specifically. The topographical atrophy disparities between EOAD and LOAD supported the more noticeable cognitive differences between the two Alzheimer’s disease categories. The faster and wider spread atrophy of EOAD patients correlates with the difficulty they experience with attention, language, visuo-spatial, and executive functions. Finally, brain metabolism differs between both AD subtypes as well, where EOAD indicates the wide spread damage and metabolic breakdown across more diverse regions of the brain.
基金the National Key Program for Developing Basic Sciences under Grant Nos. 2006CB403607 the National Natural Science Foundation of China under Grant Nos. 40305005 and 40135020.
文摘Based on summarizing previous achievements and characteristics of Asian summer monsoon and the role using data as long and new as possible, the onset of Asian-Australian ＂land bridge＂ in the onset of summer monsoon are further discussed. In particular, the earliest onset area of Asian summer monsoon is comparatively analyzed, and the sudden and progressive characteristics of the onset of summer monsoon in different regions are discussed, Furthermore, the relationships among such critical events during the onset of Asian summer monsoon as the splitting of subtropical high belt over the Bay of Bengal （BOB）, the initiation of convection over Indo-China Peninsula, the westward advance, reestablishment of South Asian High, and the rapid northward progression of convection originated from Sumatra in early summer are studied. The important impact of the proper collocation of she latent heating over Indo-China Peninsula and the sensible heating over Indian Peninsula on the splitting of the subtropical high belt, the deepening of BOB trough, the activating of Sri Lanka vortex （twin vortexes in the Northern and Southern Hemispheres）, and the subsequent onset of South China Sea summer monsoon are emphasized.
基金the State Key Project for Research-u The South China Sea MonsoonExperiment", !CAS (KZ95 1-B I-408) and CNSF (49823002).
文摘Through analyzing the NCEP/NCAR reanalysis data, the satellite observational data and the ATLAS-2 mooring buoy observational data, it is shown that May 21 is the onset date of the South China Sea summer monsoon in 1998. There were abrupt variations in the general circulation pattern at the lower troposphere and the upper troposphere, in upper jet stream location and in the convection and rainfall over the South China Sea region corresponding to the outbreak of the South China Sea summer monsoon. It is also indicated that there was rainfall in the southern China coastal region before onset of summer monsoon, but it resulted from the (cold) front activity and cannot be regarded as the sign of summer monsoon outbreak in the South China Sea. Key words Onset - South China Sea summer monsoon - General circulation pattern, Jet stream - Convection This work was supported by the State Key Project for Research—“ The South China Sea Monsoon Experiment”, CAS (KZ951-B1-408) and CNSF (49823002).
基金sponsored by the National Basic Research Program of China(Grant Nos. 2011CB952000, 2006CB400504)the Na-tional Natural Science Foundation of China (Grant No.41005039)+1 种基金Wu was sponsored by the National Science Foundation of USA (ATM-0917743)Yan was sponsored by the National Basic Research Program of China(Grant No. 2009CB421401)
文摘Climatic changes in the onset of spring in northern China associated with changes in the annual cycle and with a recent warming trend were quantified using a recently developed adaptive data analysis tool, the Ensemble Empirical Mode Decomposition. The study was based on a homogenized daily surface air temperature （SAT） dataset for the period 1955–2003. The annual cycle here is referred to as a refined modulated annual cycle （MAC）. The results show that spring at Beijing has arrived significantly earlier by about 2.98 d （10 yr）-1, of which about 1.85 d （10 yr）-1 is due to changes in the annual cycle and 1.13 d （10 yr）-1 due to the long-term warming trend. Variations in the MAC component explain about 92.5% of the total variance in the Beijing daily SAT series and could cause as much as a 20-day shift in the onset of spring from one year to another. The onset of spring has been advancing all over northern China, but more significant in the east than in the west part of the region. These differences are somehow unexplainable by the zonal pattern of the warming trend over the whole region, but can be explained by opposite changes in the spring phase of the MAC, i.e. advancing in the east while delaying in the west. In the east of northern China, the change in the spring phase of MAC explains 40%–60% of the spring onset trend and is attributable to a weakening Asian winter monsoon. The average sea level pressure in Siberia （55°–80°N, 50°–110°E）, an index of the strength of the winter monsoon, could serve as a potential short-term predictor for the onset of spring in the east of northern China.
基金This study is supported by the Nationul Natural Science Foundation of China under Grant No. 40175021is purtly funded by the Ministry of Education through the start-up project for scientists who have returned from abroud.
文摘The thermal characteristics during the South China Sea (SCS) summer monsoon onset period near the Indo-China Peninsula are analyzed by using the South China Sea Monsoon Experiment (SCSMEX) reanalysis data from 1 May to 31 August 1998 and the NCEP/ NCAR pentad-mean reanalysis data from January 1980 to December 1995. The possible relationships between the anomaly of thermal features near the Indo-China Peninsula and the SCS monsoon onset are investigated, and the mechanism causing the SCS summer monsoon onset is also discussed. Results from the 1998 SCSMEX reanalysis data show that there exists a strong persistent surface sensible heating near the Indo-China Peninsula prior to the SCS monsoon onset, which has apparent low frequency oscillation features. This sensible healing leads lo a warmer center in the lower atmosphere near the Indo-China Peninsula and strong local horizontal temperature and geopotential height gradients which are favorable to strengthening the southwest wind over the Indo-China Peninsula. It is also found that stronger convergent winds at lower levels and stronger divergent winds at high levels appear, which provide a favorable configuration for the development of vertical motion, enhancement of precipitation, and onset of the SCS monsoon. These results can be verified by analysis of the multi-year mean data. Additionally, it is found that the temperature at 850 hPa increases more rapidly over the Indo-China Peninsula than the South China Sea prior to the SCS monsoon onset, which leads to a strengthening of the temperature difference between the Indo-China Peninsula and the South China Sea. Moreover, results from the analysis of the longitudinal temperature and geopotential height differences show that the eastern retreat of the subtropical high over the Indo-China Peninsula during the period of SCS monsoon onset is associated with the temperature increase over the Indo-China Peninsula and the eastern extension of low trough over the Bay of Bengal.
文摘The onset process of the tropical eastern Indian Ocean （TEIO） summer monsoon （TEIOSM） and its relationship with the cross-equatorial flows are investigated via climatological analysis. Climatologically, results indicate that the earliest onset process of the Asian summer monsoon occurs over the TEIO at pentad 22 （April 15-20）. Unlike the abrupt onset of the South China Sea （SCS） summer monsoon, the TEIOSM onset process displays a stepwise advance. Moreover, a close relationship between the TEIOSM development and the northward push of the cross-equatorial flows over 80^-90~E is revealed. A difference vorticity center, together with the counterpart over the southern Indian Ocean, constitutes a pair of difference cyclonic vortices, which strengthens the southwesterly wind over the TEIO and the northerly wind to the west of the Indian Peninsula from the end of March to late May. Therefore, the occurrence of the southwesterly wind over the TEIO is earlier than its counterpart over the tropical western Indian Ocean, and the cross-equatorial flows emerge firstly over the TEIO rather than over the Somali area. The former increases in intensity during its northward propagation, which provides a precondition for the TEIOSM onset and its northward advance.
基金jointly supported by the National Natural Science Foundation of China (Grant Nos. 41330423, 41205080, and 41023002)the Carbon Budget and Related Issues project of the Chinese Academy of Sciences (Grant No. XDA05110301)the Joint Center for Global Change Studies (Project No. 105019), Beijing, China
文摘The reproducibility and future changes of the onset of the Asian summer monsoon were analyzed based on the simulations and projections under the Representative Concentration Pathways （RCP） scenario in which anthropogenic emissions continue to rise throughout the 21 st century （i.e. RCP8.5） by all realizations from four Chinese models that participated in the Coupled Model Intercomparison Project Phase 5 （CMIP5）. Delayed onset of the monsoon over the Arabian Sea was evident in all simulations for present-day climate, which was associated with a too weak simulation of the low-level Somali jet in May. A consistent advanced onset of the monsoon was found only over the Arabian Sea in the projections, where the advanced onset of the monsoon was accompanied by an increase of rainfall and an anomalous anticyclone over the northern Indian Ocean. In all the models except FGOALS-g2, the enhanced low-level Somali jet transported more water vapor to the Arabian Sea, whereas in FGOALS-g2 the enhanced rainfall was determined more by the increased wind convergence. Furthermore, and again in all models except FGOALS-g2, the equatorial SST warming, with maximum increase over the eastern Pacific, enhanced convection in the central West Pacific and reduced convection over the eastern Indian Ocean and Maritime Continent region, which drove the anomalous anticyclonic circulation over the western Indian Ocean. In contrast, in FGOALS-g2, there was minimal （near-zero） warming of projected SST in the central equatorial Pacific, with decreased convection in the central West Pacific and enhanced convection over the Maritime Continent. The broader-scale differences among the models across the Pacific were related to both the differences in the projected SST pattern and in the present-day simulations.
基金funded by the National Basic Research Program of China[grant number 2014CB953904]Strategic Priority Research Program of the Chinese Academy of Sciences[grant number XDA11010402]+1 种基金National Natural Science Foundation of China[grant numbers 41305068,41405091,41305065,and 91337110]China Postdoctoral Science Foundation[2013M541011]
文摘Using observed and reanalysis datasets,the South China Sea summer monsoon(SCSSM)onset process is analyzed in each year from 1997 to 2014.Regional mean(5-20°N,110-120°E)850 hPa zonal wind,precipitation,and SST are used as indices to describe SCSSM onset.Three distinct onset types are identified:among the 18 years studied,nine are normal onset years,which are characterized by a well-established westerly wind and associated precipitation over the South China Sea(SCS);eight are intermittent onset years,in which monsoon precipitation does not occur continuously following the establishment of the westerly wind over the SCS;and one year,2014,is a delayed onset year,in which the western Pacific subtropical high dominates over the SCS after the seasonal transition and prevents the monsoon onset.A comparison of the first two types suggests that a positive SST gradient in the northern Indian Ocean and local SST warming in the SCS are two key factors in the normal SCSSM onset type.With regard to the influence of the El Nio-Southern Oscillation background,there are four late onset years(1997,1998,2007,and 2010)that coincide with El Nino events,but only two early-onset years(1999 and 2012)out of the six years featuring La Nina events.Further analysis suggests that the zonal thermal contrast across the Indian and western Pacific oceans modulates monsoon onset in La Nina years.
基金Supported by the Natural Science Foundation of China(No.81371028)Natural Science Foundation of Zhejiang Province,China(No.LY12H12006)
文摘AIM: To investigate the efficacy and safety of the treatment of endoscopic trans-ethmosphenoid optic canal decompression(ETOCD) with combination of steroid in patients with newly onset indirect traumatic optic neuropathy(ITON) and compare the outcome between immediate ETOCD treatment and ETOCD with preoperative steroid treatment. METHODS: Patients presented as newly onset ITON(suffered trauma within 3 d) at a tertiary medical center between Mar 1 st, 2016 and Mar 1 st, 2018 were enrolled in this study. All patients were equally and randomly divided into 2 groups. Cases in group A were performed ETOCD immediately after admition while cases in group B were prescribed by methylprednisolone(20 mg/kg · d) for 3 d before ETOCD. Methylprednisolone(20 mg/kg · d) was used after surgery for 6 d in group A and 3 d in group B. Follow-up was up to 3 mo in all cases. Visual acuity(VA) before and after treatment between the two groups were taken into comparison. RESULTS: Complete postoperative data were acquired from 34 patients in group A and from 32 patients in group B. Group A had significantly higher effective rate in VA than group B(χ~2 =4.905, P=0.027).CONCLUSION: For patients with newly onset ITON, combination treatment of ETOCD with high-dose steroid is an effective and safe way. Immediate surgery will lead to better prognosis for these cases.
基金National Key Basic Research and Development Planning Program of China(Program 973)(2013CB430202)Basic Research Program of Jiangsu Province,China(BK20130997)+1 种基金National Natural Science Fund of China(91337109)Project Funded by the Priority Academic program Development of Jiangsu Higher Education Institutions(PAPD)
文摘Global gridded daily mean data from the NCEP/NCAR Reanalysis(1948-2012) are used to obtain the onset date,retreat date and duration time series of the South China Sea summer monsoon(SCSSM) for the past 65 years.The summer monsoon onset(retreat) date is defined as the time when the mean zonal wind at 850 hPa shifts steadily from easterly(westerly) to westerly(easterly) and the pseudo-equivalent potential temperature at the same level remains steady at greater than 335 K(less than 335 K) in the South China Sea area[110-120°E(10-20°N)].The clockwise vortex of the equatorial Indian Ocean region,together with the cross-equatorial flow and the subtropical high,plays a decisive role in the burst of the SCSSM.The onset date of the SCSSM is closely related to its intensity.With late(early) onset of the summer monsoon,its intensity is relatively strong(weak),and the zonal wind undergoes an early(late) abrupt change in the upper troposphere.Climate warming significantly affects the onset and retreat dates of the SCSSM and its intensity.With climate warming,the number of early-onset(-retreat) years of the SCSSM is clearly greater(less),and the SCSSM is clearly weakened.
基金supported by the 973 Program of China (2006CB403607)the Chinese Academy of Sciences (ZKCX2-YW-Q11-04)+3 种基金the National Natural Science Foundation of China (40805038,40821092, 40890054)the National Science & Technology Pillar Program of China (2007BAC29B03)the Chinese Academy of Sciences (KZCX2-YW-Q11-04)LASG Free Exploration Fund
文摘The influence of soil moisture on Asian monsoon simulation/prediction was less studied, partly due to a lack of available and reliable soil moisture datasets. In this study, we firstly compare several soil moisture datasets over the Tibetan Plateau, and find that the remote sensing products from the Advanced Microwave Scanning Radiometer for Earth Observing System （AMSR-E） can capture realistic temporal variations of soil moisture better than the two reanalyses （NCEP and ECMWF） during the pre-monsoon seasons. Using the AMSR-E soil moisture product, we investigate the impacts of soil moisture over the Tibetan Plateau on Asian summer monsoon onset based on a Spectral Atmospheric Model developed at IAP/LASG （SAMIL）. Comparison between results with and without the assimilation of remotely sensed soil moisture data demonstrates that with soil moisture assimilated into SAMIL, the land-sea thermal contrast during pre-monsoon seasons is more realistic. Accordingly, the simulation of summer monsoon onset dates over both the Bay of Bengal and South China Sea regions are more accurate with AMSR-E soil moisture assimilated. This study reveals that the application of the soil moisture remote sensing products in a numerical model could potentially improve prediction of the Asian summer monsoon onset.
文摘Observations of the South China Sea summer monsoon （SCSSM） demonstrate the different features between the early and late onsets of the monsoon. The determining factor related to the onset and the resultant monsoon rainfall might be the off-equatorial ITCZ besides the land-sea thermal contrast. The northward-propagating cumulus convection over the northern Indian Ocean could enhance the monsoon trough so that the effect of the horizontal advection of moisture and heat is substantially increased, thus westerlies can eventually penetrate and prevail over the South China Sea （SCS） region.
