Nanoscience and technology have shown promise in revitalizing the agricultural sector and industries.This tool has gained the interest of many researchers as it can be utilized to drive sustainable agriculture by sugg...Nanoscience and technology have shown promise in revitalizing the agricultural sector and industries.This tool has gained the interest of many researchers as it can be utilized to drive sustainable agriculture by suggesting long-lasting solutions to different problems in the agricultural space.However,there is a paucity of data on its health implications for the environment,plants,animals,and humans.This review evaluated the cost-effectiveness and productivity of nanoscience and technologies.The review highlighted the underlying health implications of nanoscience and technology from a One Health perspective.展开更多
Improper disposal of solid waste,predominantly illegal dumping,can lead to severe air and water pollution,land degradation,climate change,and health hazards due to the persistence of hazardous materials.As a result,it...Improper disposal of solid waste,predominantly illegal dumping,can lead to severe air and water pollution,land degradation,climate change,and health hazards due to the persistence of hazardous materials.As a result,it is threatening public and animal health,environmental sustainability,and economic development.The One Health approach,which acknowledges the interconnectedness of human,animal,and environmental health,offers a comprehensive solution.This systematic review examines the impact of improper municipal solid waste on fostering One Health approaches at the national level of Ethiopia by identifying key challenges and opportunities.Publications were retrieved from peer-reviewed,indexed journal publications,government documents(policies,proclamations,regulations,and guidelines),and credible non-governmental organization publications from selected electronic databases(Google scholar,PubMed,EMBASE,Global Health,Web of Science,etc.),and governmental offices.Despite efforts to advance the One Health approach in Ethiopia through the formation of the National One Health Steering Committee and technical working groups,implementation is hindered by challenges such as poor sectoral integration,insufficient advocacy,financial constraints,and limited research.These challenges contribute to worsening zoonotic and infectious diseases and environmental issues due to inadequate solid waste management.Nonetheless,opportunities exist through One Health integration via holistic programs,interdisciplinary collaboration,community engagement,policy enhancement,institutional capacity building,and public-private partnerships.Therefore,enhancing sectoral integration and increasing advocacy efforts and securing financial support is necessary to back waste management initiatives and related research.Further research is crucial to understand the impact of solid waste management and the potential benefits of the One Health approach in Ethiopia.展开更多
The global community is seeking novel approaches to address major global challenges such as climate change,sea-level rise,biodiversity loss,and public health.Nature-based Solutions(NbS)and the One Health Approach(OHA)...The global community is seeking novel approaches to address major global challenges such as climate change,sea-level rise,biodiversity loss,and public health.Nature-based Solutions(NbS)and the One Health Approach(OHA)are two promising pathways.NbS are actions to leverage the power of healthy ecosystems to protect people and nature and safeguard a stable and sustainable future[1].OHA is a pathway to safeguard water,food,and nutrient security and enhance our ability to tackle global health threats by emphasizing the interdependence be-tween people,plants,animals,and their shared environment[2].Obvi-ously,these two concepts share identical core values,that is,promoting ecosystem sustainability,mitigating global change,and benefiting nature and people in an integrative way.展开更多
Background: Antimicrobial resistance (AMR) is a global health challenge that has escalated due to the inappropriate use of antimicrobials in humans, animals, and the environment. Developing and implementing strategies...Background: Antimicrobial resistance (AMR) is a global health challenge that has escalated due to the inappropriate use of antimicrobials in humans, animals, and the environment. Developing and implementing strategies to reduce and combat AMR is critical. Purpose: This study aimed to highlight some global strategies that can be implemented to address AMR using a One Health approach. Methods: This study employed a narrative review design that included studies published from January 2002 to July 2023. The study searched for literature on AMR and antimicrobial stewardship (AMS) in PubMed and Google Scholar using the 2020 PRISMA guidelines. Results: This study reveals that AMR remains a significant global public health problem. Its severity has been markedly exacerbated by inappropriate use of antimicrobials in humans, animals, and the broader ecological environment. Several strategies have been developed to address AMR, including the Global Action Plan (GAP), National Action Plans (NAPs), AMS programs, and implementation of the AWaRe classification of antimicrobials. These strategies also involve strengthening surveillance of antimicrobial consumption and resistance, encouraging the development of new antimicrobials, and enhancing regulations around antimicrobial prescribing, dispensing, and usage. Additional measures include promoting global partnerships, combating substandard and falsified antimicrobials, advocating for vaccinations, sanitation, hygiene and biosecurity, as well as exploring alternatives to antimicrobials. However, the implementation of these strategies faces various challenges. These challenges include low awareness and knowledge of AMR, a shortage of human resources and capacity building for AMR and AMS, in adequate funding for AMR and AMS initiatives, limited laboratory capacities for surveillance, behavioural change issues, and ineffective leadership and multidisciplinary teams. Conclusion: In conclusion, this study established that AMR is prevalent among humans, animals, and the environment. Successfully addressing AMR calls for a collaborative, multifaceted One Health approach. Despite this, some gaps remain effectively implementing strategies currently recommended to combat AMR. As a result, it is essential to reinforce the strategies that are deployed to counter AMR across the human, animal, and environmental sectors.展开更多
The global pandemic caused by the coronavirus disease 2019 not only exposed the fragility of global preparedness and response to public health emergence,but also illustrated the fragmentation and gaps of research and ...The global pandemic caused by the coronavirus disease 2019 not only exposed the fragility of global preparedness and response to public health emergence,but also illustrated the fragmentation and gaps of research and development ecosystem.This emphasizes the need for planned actions against the potentiality of new pandemics and requires research to better understand how viruses bridge the animal/human divide making human-to-human transmission of new diseases possible.Major challenges to response to new epidemics under the current health framework reside in the so called 4-CC approach that focuses on Concept,Communication,Coherence,and Continuity.There is a need to also add a One Health perspective with emphasis on governance,surveillance,capacity building and multi-disciplinary research to achieve a holistic and better integrated system.Using a regulatory framework to equip professionals might facilitate the function of a multi-sector approach that recognizes the value of their mandates and a One Health approach in their work.Collaborative,multisectoral actions under the global regulations and guidance would make evidence-based One Health approaches sustainable and accessible to everyone.展开更多
Schistosomiasis,also known as bilharzia,is a widespread neglected tropical disease(NTD)in Africa,with more sig-nificant research and development(R&D)challenges and gaps compared to other preventive chemotherapy NT...Schistosomiasis,also known as bilharzia,is a widespread neglected tropical disease(NTD)in Africa,with more sig-nificant research and development(R&D)challenges and gaps compared to other preventive chemotherapy NTDs(PC-NTDs)like onchocerciasis,lymphatic flariasis,and trachoma.In response to this challenge,some global initiatives have advocated for bridging this gap,focusing on coordinated engagement with research donors.In this opinion article we highlight key R&D priorities for combating schistosomiasis in the WHO Africa region.These include defining morbidity indicators,expanding prevention,and developing innovative diagnostics,treatments,and public health strategies like test-and-treat.We emphasize integrating efforts with broader health campaigns,assessing zoonotic transmission through One Health,and using environmental surveillance tools like xenomonitoring and eDNA.We stress the need to study climate and environmental impacts on transmission,zoonotic transmission,schistosome hybridization,and snail ecology,advancing snail control,and developing vaccines,while calling for new treatments beyond praziquantel,addressing drug resistance,and improving access for children and remote populations.Fur-ther,operational research should refine hotspot interventions,enhance water,sanitation and hygiene integration,and address socio-cultural barriers.Lastly,sustainable funding and global collaboration are vital to achieve 2030 NTD Roadmap goals.展开更多
We evaluated the impact of man-made conflict events and climate change impact in guiding evidence-based community“One Health”epidemiology and emergency response practice against re-/emerging epidemics.Increasing evi...We evaluated the impact of man-made conflict events and climate change impact in guiding evidence-based community“One Health”epidemiology and emergency response practice against re-/emerging epidemics.Increasing evidence of emerging and re-emerging zoonotic diseases including recent Lassa fever outbreaks in almost 20 states in Nigeria led to 101 deaths and 175 suspected and confirmed cases since August 2015.Of the 75 laboratory confirmed cases,90 deaths occurred representing 120%laboratory-confirmed case fatality.The outbreak has been imported into neighbouring country such as Benin,where 23 deaths out of 68 cases has also been reported.This study assesses the current trends in re-emerging Lassa fever outbreak in understanding spatiogeographical reservoir(s),risk factors pattern and Lassa virus incidence mapping,inherent gaps and raising challenges in health systems.It is shown that Lassa fever peak endemicity incidence and prevalence overlap the dry season(within January to March)and reduced during the wet season(of May to November)annually in Sierra Leone,Senegal to Eastern Nigeria.We documented a scarcity of consistent data on rodent(reservoirs)-linked Lassa fever outbreak,weak culturally and socio-behavioural effective prevention and control measures integration,weak or limited community knowledge and awareness to inadequate preparedness capacity and access to affordable case management in affected countries.Hence,robust sub/regional leadership commitment and investment in Lassa fever is urgently needed in building integrated and effective community“One Health”surveillance and rapid response approach practice coupled with pest management and phytosanitation measures against Lassa fever epidemic.This offers new opportunities in understanding human-animal interactions in strengthening Lassa fever outbreak early detection and surveillance,warning alerts and rapid response implementation in vulnerable settings.Leveraging on Africa CDC centre,advances in cloud-sourcing and social media tools and solutions is core in developing and integrating evidence-based and timely risk communication,and reporting systems in improving contextual community-based immunization and control decision making policy to effectively defeat Lassa fever outbreak and other emerging pandemics public health emergencies in Africa and worldwide.展开更多
Introduction:Suidae-associated zoonotic viruses represent a significant global public health threat through cross-species transmission events.Current research remains limited to localized outbreak investigations and l...Introduction:Suidae-associated zoonotic viruses represent a significant global public health threat through cross-species transmission events.Current research remains limited to localized outbreak investigations and lacks comprehensive,systematic global analysis.Methods:We collected human-Suidae virus data from the National Center for Biotechnology Information(NCBI)Virus Database,integrating viral characteristics,host information,and environmental and anthropogenic factors.Boosted Regression Trees(BRT)models were employed to evaluate cross-species transmission risk and identify key predictive factors.Results:A total of 43 human-Suidae zoonotic viruses reported durng 1882-2022 were evaluated.The Boosted Regression Trees(BRT)model achieved area under the curve(AUC)values of 0.924(training)and 0.804(testing).Host-human phylogenetic distance and viral genome size emerged as the primary predictors.Porcine circovirus 3(PCV3)demonstrated the highest predicted risk(>0.9).Conclusions:This study establishes a data-driven framework for assessing cross-species transmission risk,supporting early warning systems and targeted prevention strategies.The findings underscore the critical importance of One Health approaches and recommend enhanced surveillance and biosecurity measures for high-risk viruses such as PCV3.展开更多
文摘Nanoscience and technology have shown promise in revitalizing the agricultural sector and industries.This tool has gained the interest of many researchers as it can be utilized to drive sustainable agriculture by suggesting long-lasting solutions to different problems in the agricultural space.However,there is a paucity of data on its health implications for the environment,plants,animals,and humans.This review evaluated the cost-effectiveness and productivity of nanoscience and technologies.The review highlighted the underlying health implications of nanoscience and technology from a One Health perspective.
文摘Improper disposal of solid waste,predominantly illegal dumping,can lead to severe air and water pollution,land degradation,climate change,and health hazards due to the persistence of hazardous materials.As a result,it is threatening public and animal health,environmental sustainability,and economic development.The One Health approach,which acknowledges the interconnectedness of human,animal,and environmental health,offers a comprehensive solution.This systematic review examines the impact of improper municipal solid waste on fostering One Health approaches at the national level of Ethiopia by identifying key challenges and opportunities.Publications were retrieved from peer-reviewed,indexed journal publications,government documents(policies,proclamations,regulations,and guidelines),and credible non-governmental organization publications from selected electronic databases(Google scholar,PubMed,EMBASE,Global Health,Web of Science,etc.),and governmental offices.Despite efforts to advance the One Health approach in Ethiopia through the formation of the National One Health Steering Committee and technical working groups,implementation is hindered by challenges such as poor sectoral integration,insufficient advocacy,financial constraints,and limited research.These challenges contribute to worsening zoonotic and infectious diseases and environmental issues due to inadequate solid waste management.Nonetheless,opportunities exist through One Health integration via holistic programs,interdisciplinary collaboration,community engagement,policy enhancement,institutional capacity building,and public-private partnerships.Therefore,enhancing sectoral integration and increasing advocacy efforts and securing financial support is necessary to back waste management initiatives and related research.Further research is crucial to understand the impact of solid waste management and the potential benefits of the One Health approach in Ethiopia.
基金financially supported by the National Natural Science Foundation of China(Nos.42477224 and 41773123).
文摘The global community is seeking novel approaches to address major global challenges such as climate change,sea-level rise,biodiversity loss,and public health.Nature-based Solutions(NbS)and the One Health Approach(OHA)are two promising pathways.NbS are actions to leverage the power of healthy ecosystems to protect people and nature and safeguard a stable and sustainable future[1].OHA is a pathway to safeguard water,food,and nutrient security and enhance our ability to tackle global health threats by emphasizing the interdependence be-tween people,plants,animals,and their shared environment[2].Obvi-ously,these two concepts share identical core values,that is,promoting ecosystem sustainability,mitigating global change,and benefiting nature and people in an integrative way.
文摘Background: Antimicrobial resistance (AMR) is a global health challenge that has escalated due to the inappropriate use of antimicrobials in humans, animals, and the environment. Developing and implementing strategies to reduce and combat AMR is critical. Purpose: This study aimed to highlight some global strategies that can be implemented to address AMR using a One Health approach. Methods: This study employed a narrative review design that included studies published from January 2002 to July 2023. The study searched for literature on AMR and antimicrobial stewardship (AMS) in PubMed and Google Scholar using the 2020 PRISMA guidelines. Results: This study reveals that AMR remains a significant global public health problem. Its severity has been markedly exacerbated by inappropriate use of antimicrobials in humans, animals, and the broader ecological environment. Several strategies have been developed to address AMR, including the Global Action Plan (GAP), National Action Plans (NAPs), AMS programs, and implementation of the AWaRe classification of antimicrobials. These strategies also involve strengthening surveillance of antimicrobial consumption and resistance, encouraging the development of new antimicrobials, and enhancing regulations around antimicrobial prescribing, dispensing, and usage. Additional measures include promoting global partnerships, combating substandard and falsified antimicrobials, advocating for vaccinations, sanitation, hygiene and biosecurity, as well as exploring alternatives to antimicrobials. However, the implementation of these strategies faces various challenges. These challenges include low awareness and knowledge of AMR, a shortage of human resources and capacity building for AMR and AMS, in adequate funding for AMR and AMS initiatives, limited laboratory capacities for surveillance, behavioural change issues, and ineffective leadership and multidisciplinary teams. Conclusion: In conclusion, this study established that AMR is prevalent among humans, animals, and the environment. Successfully addressing AMR calls for a collaborative, multifaceted One Health approach. Despite this, some gaps remain effectively implementing strategies currently recommended to combat AMR. As a result, it is essential to reinforce the strategies that are deployed to counter AMR across the human, animal, and environmental sectors.
基金supported by the Excellence Action Plan for Science and Technology Journals in China(C-084)。
文摘The global pandemic caused by the coronavirus disease 2019 not only exposed the fragility of global preparedness and response to public health emergence,but also illustrated the fragmentation and gaps of research and development ecosystem.This emphasizes the need for planned actions against the potentiality of new pandemics and requires research to better understand how viruses bridge the animal/human divide making human-to-human transmission of new diseases possible.Major challenges to response to new epidemics under the current health framework reside in the so called 4-CC approach that focuses on Concept,Communication,Coherence,and Continuity.There is a need to also add a One Health perspective with emphasis on governance,surveillance,capacity building and multi-disciplinary research to achieve a holistic and better integrated system.Using a regulatory framework to equip professionals might facilitate the function of a multi-sector approach that recognizes the value of their mandates and a One Health approach in their work.Collaborative,multisectoral actions under the global regulations and guidance would make evidence-based One Health approaches sustainable and accessible to everyone.
文摘Schistosomiasis,also known as bilharzia,is a widespread neglected tropical disease(NTD)in Africa,with more sig-nificant research and development(R&D)challenges and gaps compared to other preventive chemotherapy NTDs(PC-NTDs)like onchocerciasis,lymphatic flariasis,and trachoma.In response to this challenge,some global initiatives have advocated for bridging this gap,focusing on coordinated engagement with research donors.In this opinion article we highlight key R&D priorities for combating schistosomiasis in the WHO Africa region.These include defining morbidity indicators,expanding prevention,and developing innovative diagnostics,treatments,and public health strategies like test-and-treat.We emphasize integrating efforts with broader health campaigns,assessing zoonotic transmission through One Health,and using environmental surveillance tools like xenomonitoring and eDNA.We stress the need to study climate and environmental impacts on transmission,zoonotic transmission,schistosome hybridization,and snail ecology,advancing snail control,and developing vaccines,while calling for new treatments beyond praziquantel,addressing drug resistance,and improving access for children and remote populations.Fur-ther,operational research should refine hotspot interventions,enhance water,sanitation and hygiene integration,and address socio-cultural barriers.Lastly,sustainable funding and global collaboration are vital to achieve 2030 NTD Roadmap goals.
文摘We evaluated the impact of man-made conflict events and climate change impact in guiding evidence-based community“One Health”epidemiology and emergency response practice against re-/emerging epidemics.Increasing evidence of emerging and re-emerging zoonotic diseases including recent Lassa fever outbreaks in almost 20 states in Nigeria led to 101 deaths and 175 suspected and confirmed cases since August 2015.Of the 75 laboratory confirmed cases,90 deaths occurred representing 120%laboratory-confirmed case fatality.The outbreak has been imported into neighbouring country such as Benin,where 23 deaths out of 68 cases has also been reported.This study assesses the current trends in re-emerging Lassa fever outbreak in understanding spatiogeographical reservoir(s),risk factors pattern and Lassa virus incidence mapping,inherent gaps and raising challenges in health systems.It is shown that Lassa fever peak endemicity incidence and prevalence overlap the dry season(within January to March)and reduced during the wet season(of May to November)annually in Sierra Leone,Senegal to Eastern Nigeria.We documented a scarcity of consistent data on rodent(reservoirs)-linked Lassa fever outbreak,weak culturally and socio-behavioural effective prevention and control measures integration,weak or limited community knowledge and awareness to inadequate preparedness capacity and access to affordable case management in affected countries.Hence,robust sub/regional leadership commitment and investment in Lassa fever is urgently needed in building integrated and effective community“One Health”surveillance and rapid response approach practice coupled with pest management and phytosanitation measures against Lassa fever epidemic.This offers new opportunities in understanding human-animal interactions in strengthening Lassa fever outbreak early detection and surveillance,warning alerts and rapid response implementation in vulnerable settings.Leveraging on Africa CDC centre,advances in cloud-sourcing and social media tools and solutions is core in developing and integrating evidence-based and timely risk communication,and reporting systems in improving contextual community-based immunization and control decision making policy to effectively defeat Lassa fever outbreak and other emerging pandemics public health emergencies in Africa and worldwide.
文摘Introduction:Suidae-associated zoonotic viruses represent a significant global public health threat through cross-species transmission events.Current research remains limited to localized outbreak investigations and lacks comprehensive,systematic global analysis.Methods:We collected human-Suidae virus data from the National Center for Biotechnology Information(NCBI)Virus Database,integrating viral characteristics,host information,and environmental and anthropogenic factors.Boosted Regression Trees(BRT)models were employed to evaluate cross-species transmission risk and identify key predictive factors.Results:A total of 43 human-Suidae zoonotic viruses reported durng 1882-2022 were evaluated.The Boosted Regression Trees(BRT)model achieved area under the curve(AUC)values of 0.924(training)and 0.804(testing).Host-human phylogenetic distance and viral genome size emerged as the primary predictors.Porcine circovirus 3(PCV3)demonstrated the highest predicted risk(>0.9).Conclusions:This study establishes a data-driven framework for assessing cross-species transmission risk,supporting early warning systems and targeted prevention strategies.The findings underscore the critical importance of One Health approaches and recommend enhanced surveillance and biosecurity measures for high-risk viruses such as PCV3.
