Merging into the highway from the on-ramp is an essential scenario for automated driving.The decision-making in this scenario needs to balance safety and efficiency to optimize a long-term objective,which is challengi...Merging into the highway from the on-ramp is an essential scenario for automated driving.The decision-making in this scenario needs to balance safety and efficiency to optimize a long-term objective,which is challenging due to the dynamic,stochastic,and adversarial characteristics.The existing learning-based methods struggle to meet the safety requirements.This paper proposes a reinforcement-learning-based decision-making method under a framework of offline training and online correction,called the Shielded Distributional Soft Actor-critic(Shielded DSAC).The Shielded DSAC adopts the policy evaluation with safety considerations in offline training,and a safety shield parameterized with the barrier function in online correction.These two measures support each other in achieving better safety without sacrificing efficiency performance.The study verified the Shielded DSAC in a simulated on-ramp merge scenario.The results indicate that the Shielded DSAC has the best safety performance compared to baseline algorithms and achieves efficient driving simultaneously.展开更多
Merged satellite altimeter products are widely used in ocean-related fields.Currently,the altimeter merged products of archiving validation and interpretation of satellite oceanographic(AVISO)data are widely used inte...Merged satellite altimeter products are widely used in ocean-related fields.Currently,the altimeter merged products of archiving validation and interpretation of satellite oceanographic(AVISO)data are widely used internationally.Chinese National Satellite Ocean Application Service also released merged altimeter products(ALT MUL)in 2023.However,there are few studies on the quality assessment of ALT MUL.Based on the data of AVISO merged products,Jason3 satellite,tide gauge and drifter buoy,the quality assessment and effect analysis of ALT MUL merged products were carried out by means of error evaluation index,interpolation along rails,velocity inversion and power spectrum.The result shows that the average sea level anomaly(SLA)of ALT MUL is about 2 cm smaller than that of AVISO.And they are consistent with the large-scale characteristics and spatial distribution.These two SLA products are both in accordance with normal distribution.Results indicate a lesser congruence between ALT MUL and Jason3 satellite compared to AVISO.This difference may be attributed to the fact that AVISO products use Jason3 satellite as crosscalibrated reference satellite during the merged process.Comparing the matching effect of the two merged products with the tide gauge and drifter buoy,ALT MUL merged products are superior to AVISO in general.The energy spectral density was calculated by using Jason3 satellite data along the orbit,and the two merged products were interpolated to the data points along the orbit.The effective resolution of AVISO and ALT MUL merged products was 180 km and 210 km respectively through spectral calculation,indicating that AVISO merged products have higher effective resolution.展开更多
目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,...目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,所有患者均接受常规MRI扫描及3D MERGE、3D SPACE STIR序列扫描,对比3D MERGE、3D SPACE STIR序列测量神经根直径的一致性,评价两种序列的图像质量参数[信噪比(SNR)、对比噪声比(CNR)]、图像清晰度评分。结果:3D MERGE和3D SPACE STIR序列测量的L3~S1神经根直径比较差异无统计学意义(P>0.05),且两组序列测量的L3、L4、L5和S1直径均显示出较高相关性(r=0.957,0.986,0.975,0.972,P<0.05);3D MERGE序列的SNR及CNR均高于3D SPACE STIR序列,神经根显示分级、图像清晰度评分优于3D SPACE STIR序列,差异有统计学意义(P<0.05)。结论:3D MERGE、3D SPACE STIR序列在LDH神经根直径测量中具有极高一致性,3D MERGE序列较3D SPACE STIR序列能够更清晰显示神经跟的解剖形态,图像质量更好。展开更多
Pharmacophore is a commonly used method for molecular simulation, including ligand-based pharmacophore （LBP） and structure-based pharmacophore （SBP）. LBP can be utilized to identify active compounds usual with low...Pharmacophore is a commonly used method for molecular simulation, including ligand-based pharmacophore （LBP） and structure-based pharmacophore （SBP）. LBP can be utilized to identify active compounds usual with lower accuracy, and SBP is able to use for distin- guishing active compounds from inactive compounds with frequently higher missing rates. Merged pharmacophore （MP） is presented to integrate advantages and avoid shortcomings of LBP and SBP. In this work, LBP and SBP models were constructed for the study of per- oxisome proliferator receptor-alpha （PPARα） agonists. According to the comparison of the two types of pharmacophore models, mainly and secondarily pharmacological features were identified. The weight and tolerance values of these pharmacological features were adjusted to construct MP models by single-factor explorations and orthogonal experimental design based on SBP model. Then, the reliability and screening efficiency of the best MP model were validated by three databases. The best MP model was utilized to compute PPARα activity of compounds from traditional Chinese medicine. The screening efficiency of MP model outperformed individual LBP or SBP model for PPARα agonists, and was similar to combinatorial screening of LBP and SBP. However, MP model might have an advantage over the combination of LBP and SBP in evaluating the activity of compounds and avoiding the inconsistent prediction of LBP and SBP, which would be beneficial to guide drug design and optimization.展开更多
To establish the empirical capacity model of an on- ramp merging section, the Erlang distribution is first selected to define the time headway distribution, and then the gap acceptance theory is applied to develop the...To establish the empirical capacity model of an on- ramp merging section, the Erlang distribution is first selected to define the time headway distribution, and then the gap acceptance theory is applied to develop the basic capacity model of the on-ramp merging section. Since not all the time headways on the shoulder lane can be made full use of by on- ramp vehicles, a modified capacity model is developed, which takes the usage probability of time headway into consideration. Then, a model of capacity discount coefficient ~： is developed. Finally, based on the modified capacity model and the model of capacity discount coefficient, an empirical merge capacity model which contains the shoulder lane volume, critical gap, and the distance from nose to merging point, is constructed. Results show that, compared with other models, the proposed model is more reasonable since it takes merging section geometry into consideration, and it is easy to apply. The merge capacity varies with the shoulder lane volume, the critical gap, the distance between the nose and the merging point, and the design velocity of the shoulder lane and ramp.展开更多
在循证医学时代下,依托规范的技术方法和标准化的操作规程发掘中医药独特优势,是实现中医药现代化、国际化发展并惠泽人类的必由之路。中医理论、人用经验和研究证据三结合证据体系的提出标志着中医药特色评价体系思维方法取得了重要进...在循证医学时代下,依托规范的技术方法和标准化的操作规程发掘中医药独特优势,是实现中医药现代化、国际化发展并惠泽人类的必由之路。中医理论、人用经验和研究证据三结合证据体系的提出标志着中医药特色评价体系思维方法取得了重要进步,经过恰当方法整合后的多元证据体是中医药临床指南推荐意见和循证卫生决策的有力支撑。本文基于当前国际证据合成与分级方法学前沿进展,初步提出中医药多元证据整合的方法学框架——MERGE(Merge Evidence-based Research and artificial intelliGence to support smart dEcision)框架,以期为中医药循证医学方法学体系的完善和发展提供借鉴和参考。展开更多
Wave energy resources are abundant in both offshore and nearshore areas of the China＇s seas. A reliable assessment of the wave energy resources must be performed before they can be exploited. First, for a water depth...Wave energy resources are abundant in both offshore and nearshore areas of the China＇s seas. A reliable assessment of the wave energy resources must be performed before they can be exploited. First, for a water depth in offshore waters of China, a parameterized wave power density model that considers the effects of the water depth is introduced to improve the calculating accuracy of the wave power density. Second, wave heights and wind speeds on the surface of the China＇s seas are retrieved from an AVISO multi-satellite altim-eter data set for the period from 2009 to 2013. Three mean wave period inversion models are developed and used to calculate the wave energy period. Third, a practical application value for developing the wave energy is analyzed based on buoy data. Finally, the wave power density is then calculated using the wave field data. Using the distribution of wave power density, the energy level frequency, the time variability indexes, the to-tal wave energy and the distribution of total wave energy density according to a wave state, the offshore wave energy in the China＇s seas is assessed. The results show that the areas of abundant and stable wave energy are primarily located in the north-central part of the South China Sea, the Luzon Strait, southeast of Taiwan in the China＇s seas; the wave power density values in these areas are approximately 14.0–18.5 kW/m. The wave energy in the China’s seas presents obvious seasonal variations and optimal seasons for a wave energy utilization are in winter and autumn. Except for very coastal waters, in other sea areas in the China＇s seas, the energy is primarily from the wave state with 0.5 m≤Hs≤4 m, 4 s≤Te≤10 s whereHs is a significant wave height andTe is an energy period; within this wave state, the wave energy accounts for 80% above of the total wave energy. This characteristic is advantageous to designing wave energy convertors （WECs）. The practical application value of the wave energy is higher which can be as an effective supplement for an energy con-sumption in some areas. The above results are consistent with the wave model which indicates fully that this new microwave remote sensing method altimeter is effective and feasible for the wave energy assessment.展开更多
基金the NSF China under Grants 52202487 and 62273256the Fundamental Research Funds for the Central Universities under Grant FRF-OT-23-02the Young Elite Scientists Sponsorship Program by CAST under Grant 2023QNRC001.
文摘Merging into the highway from the on-ramp is an essential scenario for automated driving.The decision-making in this scenario needs to balance safety and efficiency to optimize a long-term objective,which is challenging due to the dynamic,stochastic,and adversarial characteristics.The existing learning-based methods struggle to meet the safety requirements.This paper proposes a reinforcement-learning-based decision-making method under a framework of offline training and online correction,called the Shielded Distributional Soft Actor-critic(Shielded DSAC).The Shielded DSAC adopts the policy evaluation with safety considerations in offline training,and a safety shield parameterized with the barrier function in online correction.These two measures support each other in achieving better safety without sacrificing efficiency performance.The study verified the Shielded DSAC in a simulated on-ramp merge scenario.The results indicate that the Shielded DSAC has the best safety performance compared to baseline algorithms and achieves efficient driving simultaneously.
基金The National Key R&D Program of China under contract No.2021YFC3101503the National Natural Science Foundation of China under contract Nos 42276205 and 42406195+1 种基金the Hunan Provincial Natural Science Foundation of China under contract No.2023JJ10053the Youth Independent Innovation Science Foundation under contract No.ZK24-54.
文摘Merged satellite altimeter products are widely used in ocean-related fields.Currently,the altimeter merged products of archiving validation and interpretation of satellite oceanographic(AVISO)data are widely used internationally.Chinese National Satellite Ocean Application Service also released merged altimeter products(ALT MUL)in 2023.However,there are few studies on the quality assessment of ALT MUL.Based on the data of AVISO merged products,Jason3 satellite,tide gauge and drifter buoy,the quality assessment and effect analysis of ALT MUL merged products were carried out by means of error evaluation index,interpolation along rails,velocity inversion and power spectrum.The result shows that the average sea level anomaly(SLA)of ALT MUL is about 2 cm smaller than that of AVISO.And they are consistent with the large-scale characteristics and spatial distribution.These two SLA products are both in accordance with normal distribution.Results indicate a lesser congruence between ALT MUL and Jason3 satellite compared to AVISO.This difference may be attributed to the fact that AVISO products use Jason3 satellite as crosscalibrated reference satellite during the merged process.Comparing the matching effect of the two merged products with the tide gauge and drifter buoy,ALT MUL merged products are superior to AVISO in general.The energy spectral density was calculated by using Jason3 satellite data along the orbit,and the two merged products were interpolated to the data points along the orbit.The effective resolution of AVISO and ALT MUL merged products was 180 km and 210 km respectively through spectral calculation,indicating that AVISO merged products have higher effective resolution.
文摘目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,所有患者均接受常规MRI扫描及3D MERGE、3D SPACE STIR序列扫描,对比3D MERGE、3D SPACE STIR序列测量神经根直径的一致性,评价两种序列的图像质量参数[信噪比(SNR)、对比噪声比(CNR)]、图像清晰度评分。结果:3D MERGE和3D SPACE STIR序列测量的L3~S1神经根直径比较差异无统计学意义(P>0.05),且两组序列测量的L3、L4、L5和S1直径均显示出较高相关性(r=0.957,0.986,0.975,0.972,P<0.05);3D MERGE序列的SNR及CNR均高于3D SPACE STIR序列,神经根显示分级、图像清晰度评分优于3D SPACE STIR序列,差异有统计学意义(P<0.05)。结论:3D MERGE、3D SPACE STIR序列在LDH神经根直径测量中具有极高一致性,3D MERGE序列较3D SPACE STIR序列能够更清晰显示神经跟的解剖形态,图像质量更好。
文摘Pharmacophore is a commonly used method for molecular simulation, including ligand-based pharmacophore （LBP） and structure-based pharmacophore （SBP）. LBP can be utilized to identify active compounds usual with lower accuracy, and SBP is able to use for distin- guishing active compounds from inactive compounds with frequently higher missing rates. Merged pharmacophore （MP） is presented to integrate advantages and avoid shortcomings of LBP and SBP. In this work, LBP and SBP models were constructed for the study of per- oxisome proliferator receptor-alpha （PPARα） agonists. According to the comparison of the two types of pharmacophore models, mainly and secondarily pharmacological features were identified. The weight and tolerance values of these pharmacological features were adjusted to construct MP models by single-factor explorations and orthogonal experimental design based on SBP model. Then, the reliability and screening efficiency of the best MP model were validated by three databases. The best MP model was utilized to compute PPARα activity of compounds from traditional Chinese medicine. The screening efficiency of MP model outperformed individual LBP or SBP model for PPARα agonists, and was similar to combinatorial screening of LBP and SBP. However, MP model might have an advantage over the combination of LBP and SBP in evaluating the activity of compounds and avoiding the inconsistent prediction of LBP and SBP, which would be beneficial to guide drug design and optimization.
基金The National Natural Science Foundation of China(No.51278520 51278220)the Science and Technology Development Project of Jilin Province(No.20130206093SF)
文摘To establish the empirical capacity model of an on- ramp merging section, the Erlang distribution is first selected to define the time headway distribution, and then the gap acceptance theory is applied to develop the basic capacity model of the on-ramp merging section. Since not all the time headways on the shoulder lane can be made full use of by on- ramp vehicles, a modified capacity model is developed, which takes the usage probability of time headway into consideration. Then, a model of capacity discount coefficient ~： is developed. Finally, based on the modified capacity model and the model of capacity discount coefficient, an empirical merge capacity model which contains the shoulder lane volume, critical gap, and the distance from nose to merging point, is constructed. Results show that, compared with other models, the proposed model is more reasonable since it takes merging section geometry into consideration, and it is easy to apply. The merge capacity varies with the shoulder lane volume, the critical gap, the distance between the nose and the merging point, and the design velocity of the shoulder lane and ramp.
文摘在循证医学时代下,依托规范的技术方法和标准化的操作规程发掘中医药独特优势,是实现中医药现代化、国际化发展并惠泽人类的必由之路。中医理论、人用经验和研究证据三结合证据体系的提出标志着中医药特色评价体系思维方法取得了重要进步,经过恰当方法整合后的多元证据体是中医药临床指南推荐意见和循证卫生决策的有力支撑。本文基于当前国际证据合成与分级方法学前沿进展,初步提出中医药多元证据整合的方法学框架——MERGE(Merge Evidence-based Research and artificial intelliGence to support smart dEcision)框架,以期为中医药循证医学方法学体系的完善和发展提供借鉴和参考。
基金The Ocean Renewable Energy Special Fund Project of the State Oceanic Administration of China under contract No.GHME2011ZC07the Dragon Ⅲ Project of the European Space Agency and Ministry of Science and Technology of China under contract No.10412
文摘Wave energy resources are abundant in both offshore and nearshore areas of the China＇s seas. A reliable assessment of the wave energy resources must be performed before they can be exploited. First, for a water depth in offshore waters of China, a parameterized wave power density model that considers the effects of the water depth is introduced to improve the calculating accuracy of the wave power density. Second, wave heights and wind speeds on the surface of the China＇s seas are retrieved from an AVISO multi-satellite altim-eter data set for the period from 2009 to 2013. Three mean wave period inversion models are developed and used to calculate the wave energy period. Third, a practical application value for developing the wave energy is analyzed based on buoy data. Finally, the wave power density is then calculated using the wave field data. Using the distribution of wave power density, the energy level frequency, the time variability indexes, the to-tal wave energy and the distribution of total wave energy density according to a wave state, the offshore wave energy in the China＇s seas is assessed. The results show that the areas of abundant and stable wave energy are primarily located in the north-central part of the South China Sea, the Luzon Strait, southeast of Taiwan in the China＇s seas; the wave power density values in these areas are approximately 14.0–18.5 kW/m. The wave energy in the China’s seas presents obvious seasonal variations and optimal seasons for a wave energy utilization are in winter and autumn. Except for very coastal waters, in other sea areas in the China＇s seas, the energy is primarily from the wave state with 0.5 m≤Hs≤4 m, 4 s≤Te≤10 s whereHs is a significant wave height andTe is an energy period; within this wave state, the wave energy accounts for 80% above of the total wave energy. This characteristic is advantageous to designing wave energy convertors （WECs）. The practical application value of the wave energy is higher which can be as an effective supplement for an energy con-sumption in some areas. The above results are consistent with the wave model which indicates fully that this new microwave remote sensing method altimeter is effective and feasible for the wave energy assessment.
