Our research objective was to expand the very limited knowledgebase pertaining to the ecology of fringing coral reefs in the Gulf of Suez, Egypt. Specifically, determine dominant coral species and investigate why this...Our research objective was to expand the very limited knowledgebase pertaining to the ecology of fringing coral reefs in the Gulf of Suez, Egypt. Specifically, determine dominant coral species and investigate why this reef is capable of surviving at such a high-latitude and extreme harsh environment. Data collection included annual reef surveys, randomized quadrat sampling, five permanent video transects and in situ seawater temperature. Of the known Gulf of Suez 35 taxa, only six (Acropora humilis, A. microclados, A. hemprichii, Litophyton arboretum, Stylophora pistillata, Porites columna, and P. plantulata), compose 94% of the reef's coral cover. Coral dominance across species shifted drastically during the study period. However, the six coral dominance remained unchanged, while some decreased others increased. These six coral taxa regularly experience daily changes in seawater temperature and seasonal variations that exceed These extreme temperatures variation and the fact that only six coral taxa dominance remained unchanged, suggest that these corals may have developed a mechanism to cope with extreme seawater temperatures as evidenced by their continued growth and survival over the study period. We speculate that species dominance shift occurred largely as a result of a local oil spill rather than exposure to extreme temperatures. Further scrutiny of these species and the mechanisms by which they are able to thrive is recommended, as they hold the potential to benefit other coral communities as a resilient transplant species and model for understanding coral survivability in extreme environmental conditions.展开更多
The aim of this study is comparison of fatty acid profile between wild and farmed Indian white shrimps. According to the score-plot produced by the principle component analysis the wild Indian white shrimp showed a fa...The aim of this study is comparison of fatty acid profile between wild and farmed Indian white shrimps. According to the score-plot produced by the principle component analysis the wild Indian white shrimp showed a fatty acid composition clearly different from the farmed Indian white shrimp. In both groups, palmitic acid (16:0) and oleic acid (18: 1n-9) were the main SFA and MUFA, respectively. Based on results, the wild shrimp contained a higher level (P < 0.05) of n-3 poly unsaturated fatty acids, whereas farmed shrimp contained a high level of n-6 poly unsaturated fatty (P < 0.05). Arachidonic acid (20: 4n-6), eicosapentaenoic acid (20: 5n-3) and docosahexaenoic acid (22: 6n-3) were significantly higher in wild shrimps. The n-3/n-6 fatty acids ratio was significantly higher in wild shrimps (P < 0.05). The comparison demonstrated that the nutritional value of wild shrimps is better than farmed shrimp and fatty acid profile of commercial diets should be reformed in order to maintenance of farmed shrimps nutritional value.展开更多
Introduction: Deferasirox is an oral iron chelator, approved worldwide for the treatment of chronic iron overload due to transfusion. Deferasirox was permitted two years ago in Japan, but there is little known regardi...Introduction: Deferasirox is an oral iron chelator, approved worldwide for the treatment of chronic iron overload due to transfusion. Deferasirox was permitted two years ago in Japan, but there is little known regarding its efficacy and tolerability in clinical practice. Methods: We conducted a retrospective study of 18 patients with transfusion-dependent anemias treated by deferasirox at our institution. The starting dose was individualized and ranged from 6.4 to 26.3 mg/kg/day. Routine clinical laboratory data were followed, and serum ferritin was assessed every 4 weeks. Results: The mean serum ferritin level of 18 patients at the time of deferasirox induction was 3162 ng/ml. Ten of 18 patients could sustain deferasirox treatment for at least 6 months, at an average maintenance dose of 10.8 mg/kg/day. Serum ferritin reduction was observed in 4 patients, at doses less than 20 mg/kg/day. Eighty-nine percent of the patients had adverse events, and 13 of them in all ultimately discontinued. Myelodysplastic syndrome (MDS) patients showed poor tolerability. Severe infections of grade 3 or more were documented in 6 patients, and 2 of them were fatal. Conclusions: The potential for beneficial iron chelation of deferasirox at less than the recommended 20 mg/kg dose was demonstrated. On the contrary, poor tolerability was documented, with adverse events such as severe infections, especially in MDS patients. Although it was not clearly demonstrated that deferasirox was responsible for impaired immunity, careful watching is required to administrate deferasirox.展开更多
Background: The present study was to explore the underlying mechanism of the nuclear factor-kappa B (NF-κB) and the level of monocyte chemoattractant protein-1 (MCP-1) in hyperlipidemia rats. Methods: Rats were given...Background: The present study was to explore the underlying mechanism of the nuclear factor-kappa B (NF-κB) and the level of monocyte chemoattractant protein-1 (MCP-1) in hyperlipidemia rats. Methods: Rats were given with high fat diet and vitamin D3 by intragastric administration. After four weeks, the level of the plasma cholesterol, low density lipoprotein cholesterol (LDLC), MCP-1 and NF-κB were detected by immunohistochemical method and enzyme linked immunosorbent assay (ELISA). Results: The levels of the plasma cholesterol and LDLC were higher than that of the control group. A significant in-crease for the expressions of MCP-1 and NF-κB was observed. Conclusion: This indi-cated that the activation of NF-κB could play a crucial role in glomerulus of hyperlipidemia rats.展开更多
文摘Our research objective was to expand the very limited knowledgebase pertaining to the ecology of fringing coral reefs in the Gulf of Suez, Egypt. Specifically, determine dominant coral species and investigate why this reef is capable of surviving at such a high-latitude and extreme harsh environment. Data collection included annual reef surveys, randomized quadrat sampling, five permanent video transects and in situ seawater temperature. Of the known Gulf of Suez 35 taxa, only six (Acropora humilis, A. microclados, A. hemprichii, Litophyton arboretum, Stylophora pistillata, Porites columna, and P. plantulata), compose 94% of the reef's coral cover. Coral dominance across species shifted drastically during the study period. However, the six coral dominance remained unchanged, while some decreased others increased. These six coral taxa regularly experience daily changes in seawater temperature and seasonal variations that exceed These extreme temperatures variation and the fact that only six coral taxa dominance remained unchanged, suggest that these corals may have developed a mechanism to cope with extreme seawater temperatures as evidenced by their continued growth and survival over the study period. We speculate that species dominance shift occurred largely as a result of a local oil spill rather than exposure to extreme temperatures. Further scrutiny of these species and the mechanisms by which they are able to thrive is recommended, as they hold the potential to benefit other coral communities as a resilient transplant species and model for understanding coral survivability in extreme environmental conditions.
文摘The aim of this study is comparison of fatty acid profile between wild and farmed Indian white shrimps. According to the score-plot produced by the principle component analysis the wild Indian white shrimp showed a fatty acid composition clearly different from the farmed Indian white shrimp. In both groups, palmitic acid (16:0) and oleic acid (18: 1n-9) were the main SFA and MUFA, respectively. Based on results, the wild shrimp contained a higher level (P < 0.05) of n-3 poly unsaturated fatty acids, whereas farmed shrimp contained a high level of n-6 poly unsaturated fatty (P < 0.05). Arachidonic acid (20: 4n-6), eicosapentaenoic acid (20: 5n-3) and docosahexaenoic acid (22: 6n-3) were significantly higher in wild shrimps. The n-3/n-6 fatty acids ratio was significantly higher in wild shrimps (P < 0.05). The comparison demonstrated that the nutritional value of wild shrimps is better than farmed shrimp and fatty acid profile of commercial diets should be reformed in order to maintenance of farmed shrimps nutritional value.
文摘Introduction: Deferasirox is an oral iron chelator, approved worldwide for the treatment of chronic iron overload due to transfusion. Deferasirox was permitted two years ago in Japan, but there is little known regarding its efficacy and tolerability in clinical practice. Methods: We conducted a retrospective study of 18 patients with transfusion-dependent anemias treated by deferasirox at our institution. The starting dose was individualized and ranged from 6.4 to 26.3 mg/kg/day. Routine clinical laboratory data were followed, and serum ferritin was assessed every 4 weeks. Results: The mean serum ferritin level of 18 patients at the time of deferasirox induction was 3162 ng/ml. Ten of 18 patients could sustain deferasirox treatment for at least 6 months, at an average maintenance dose of 10.8 mg/kg/day. Serum ferritin reduction was observed in 4 patients, at doses less than 20 mg/kg/day. Eighty-nine percent of the patients had adverse events, and 13 of them in all ultimately discontinued. Myelodysplastic syndrome (MDS) patients showed poor tolerability. Severe infections of grade 3 or more were documented in 6 patients, and 2 of them were fatal. Conclusions: The potential for beneficial iron chelation of deferasirox at less than the recommended 20 mg/kg dose was demonstrated. On the contrary, poor tolerability was documented, with adverse events such as severe infections, especially in MDS patients. Although it was not clearly demonstrated that deferasirox was responsible for impaired immunity, careful watching is required to administrate deferasirox.
文摘Background: The present study was to explore the underlying mechanism of the nuclear factor-kappa B (NF-κB) and the level of monocyte chemoattractant protein-1 (MCP-1) in hyperlipidemia rats. Methods: Rats were given with high fat diet and vitamin D3 by intragastric administration. After four weeks, the level of the plasma cholesterol, low density lipoprotein cholesterol (LDLC), MCP-1 and NF-κB were detected by immunohistochemical method and enzyme linked immunosorbent assay (ELISA). Results: The levels of the plasma cholesterol and LDLC were higher than that of the control group. A significant in-crease for the expressions of MCP-1 and NF-κB was observed. Conclusion: This indi-cated that the activation of NF-κB could play a crucial role in glomerulus of hyperlipidemia rats.
