One of the leading causes of death worldwide is cardiovascular disease, hence searching for a cure is an important endeavor. The totally safe, edible, and inexpensive Boswellia plant exudate, known as olibanum or fran...One of the leading causes of death worldwide is cardiovascular disease, hence searching for a cure is an important endeavor. The totally safe, edible, and inexpensive Boswellia plant exudate, known as olibanum or frankincense, is considered to possess diverse medicinal values in traditional medicine and from recent biological studies. Investigating the cardioprotective and antioxidant activities of olibanum from a Bo~＇wellia species, family Bursearaceae, namely Boswellia carteri Birdw. was the aim of this study. Cardioprotective activity was evaluated using a model of myocardial infarction induced by isoprenaline （ISO）, while antioxidant activity was tested adopting nitric oxide scavenging （NOS） and azino-bis-3-ethyl benzthiazoline-6-sulfonic acid （ABTS） assays. The results revealed a mild cardioprotecfive effect and weak antioxidant activity.展开更多
Objective The objective of this study was to screen the therapeutic target of olibanum and myrrha on acute soft tissue injury(ASTI)by network pharmacology and to clarify their mechanisms.Methods The main chemical cons...Objective The objective of this study was to screen the therapeutic target of olibanum and myrrha on acute soft tissue injury(ASTI)by network pharmacology and to clarify their mechanisms.Methods The main chemical constituents and the targets of olibanum and myrrha were obtained by using traditional Chinese medicine systems pharmacology database and analysis platform database.The disease targets of ASTI were searched by GeneCards.The intersection targets of herbs and diseases were selected for protein interaction analysis,protein–protein interaction network was constructed,and potential protein functional modules in the network were explored.A compound–target–disease network was constructed using Cytoscape3.8.2 software.The targets were analyzed by gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes enrichment analysis based on the Metascape database.Results The core active components of olibanum and myrrha were quercetin,β-sitosterol,and stigmasterol.The core targets were PGR,NCOA2,PTGS2,PRKCA,and NR3C2.Pathways in cancer,AGE-RAGE signaling pathway in diabetic complications might play a potential role in olibanum and myrrha in the treatment of ASTI.Conclusion Olibanum and myrrha have the characteristics of multiple components,multiple targets,and overall regulation in the treatment of ASTI.展开更多
目的运用CiteSpace软件对乳香Olibanum相关研究文献进行可视化分析,旨在系统梳理近20年来国内外乳香研究的发展脉络,揭示研究热点及未来研究趋势,为乳香的基础研究与临床应用提供理论支持。方法分别检索中国知网、万方数据和Web of Scie...目的运用CiteSpace软件对乳香Olibanum相关研究文献进行可视化分析,旨在系统梳理近20年来国内外乳香研究的发展脉络,揭示研究热点及未来研究趋势,为乳香的基础研究与临床应用提供理论支持。方法分别检索中国知网、万方数据和Web of Science核心合集数据库中2005年1月1日—2025年5月26日发表的乳香相关中英文文献。利用NoteExpress软件对检索结果进行去重与筛选,最终采用CiteSpace对发文数量、作者、机构、关键词共现与突现等信息进行知识图谱可视化分析。结果共纳入中文文献943篇,英文文献43篇。年发文量整体呈上升趋势,中文文献发文量较多的作者为刘军,英文文献中代表性作者为Ding Yi(丁一);作者合作网络显示国内作者合作密切但跨机构合作有限。主要研究机构包括北京中医药大学、南京中医药大学、广州中医药大学等。关键词共现与突现分析结果显示,中文文献研究聚焦于数据挖掘、用药规律等;英文文献研究则多集中于抗炎作用、活性成分(如乳香酸)、网络药理学及作用机制等方面。结论乳香在中医药防治骨关节病、乳腺病变、糖尿病足等疾病方面的研究热度持续上升,现代研究手段如网络药理学、分子机制解析和数据挖掘技术的广泛应用为乳香的科学研究提供了新的突破口。未来应加强多学科协作,深入挖掘乳香活性成分与靶向机制,以推动乳香在中药现代化与临床转化中的深入发展。展开更多
目的通过对近年来乳香相关研究的文献的分析,探析乳香研究领域的相关热点与前沿。方法以中国知网、Web of Science数据库为数据来源,运用CiteSpace软件对文献年度发文量、机构、关键词、作者等方面进行分析,绘制可视化图谱。结果共获得...目的通过对近年来乳香相关研究的文献的分析,探析乳香研究领域的相关热点与前沿。方法以中国知网、Web of Science数据库为数据来源,运用CiteSpace软件对文献年度发文量、机构、关键词、作者等方面进行分析,绘制可视化图谱。结果共获得中文文献689篇,英文文献406篇。文献数量整体呈上升趋势;发文量最多的中文机构为中国食品药品检定研究院(24篇)、英文机构为University of Nizwa(31篇)。发文量最高的中、英文作者分别为刘振丽(17篇)、Al-Harrasi,Ahmed(31篇)。刊载量最多的中、英文期刊分别是《中草药》(25篇)与Molecules(11篇)。中、英文关键词显示,对乳香的主要研究集中在药理作用、化学成分上。结论乳香研究目前处于稳定发展阶段,预测该领域的未来研究热点在乳香酸、挥发油、炎症、乳腺癌、口腔癌上,且国内外应加强团队间交流、合作,更深入研究。展开更多
文摘One of the leading causes of death worldwide is cardiovascular disease, hence searching for a cure is an important endeavor. The totally safe, edible, and inexpensive Boswellia plant exudate, known as olibanum or frankincense, is considered to possess diverse medicinal values in traditional medicine and from recent biological studies. Investigating the cardioprotective and antioxidant activities of olibanum from a Bo~＇wellia species, family Bursearaceae, namely Boswellia carteri Birdw. was the aim of this study. Cardioprotective activity was evaluated using a model of myocardial infarction induced by isoprenaline （ISO）, while antioxidant activity was tested adopting nitric oxide scavenging （NOS） and azino-bis-3-ethyl benzthiazoline-6-sulfonic acid （ABTS） assays. The results revealed a mild cardioprotecfive effect and weak antioxidant activity.
基金supported by the Science and Technology Project of Xi 'an Science and Technology Bureau [201805093YX1SF27(16)]Scientific Research Project of Shaanxi Provincial Administration of Traditional Chinese Medicine (15-JC014).
文摘Objective The objective of this study was to screen the therapeutic target of olibanum and myrrha on acute soft tissue injury(ASTI)by network pharmacology and to clarify their mechanisms.Methods The main chemical constituents and the targets of olibanum and myrrha were obtained by using traditional Chinese medicine systems pharmacology database and analysis platform database.The disease targets of ASTI were searched by GeneCards.The intersection targets of herbs and diseases were selected for protein interaction analysis,protein–protein interaction network was constructed,and potential protein functional modules in the network were explored.A compound–target–disease network was constructed using Cytoscape3.8.2 software.The targets were analyzed by gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes enrichment analysis based on the Metascape database.Results The core active components of olibanum and myrrha were quercetin,β-sitosterol,and stigmasterol.The core targets were PGR,NCOA2,PTGS2,PRKCA,and NR3C2.Pathways in cancer,AGE-RAGE signaling pathway in diabetic complications might play a potential role in olibanum and myrrha in the treatment of ASTI.Conclusion Olibanum and myrrha have the characteristics of multiple components,multiple targets,and overall regulation in the treatment of ASTI.
文摘目的运用CiteSpace软件对乳香Olibanum相关研究文献进行可视化分析,旨在系统梳理近20年来国内外乳香研究的发展脉络,揭示研究热点及未来研究趋势,为乳香的基础研究与临床应用提供理论支持。方法分别检索中国知网、万方数据和Web of Science核心合集数据库中2005年1月1日—2025年5月26日发表的乳香相关中英文文献。利用NoteExpress软件对检索结果进行去重与筛选,最终采用CiteSpace对发文数量、作者、机构、关键词共现与突现等信息进行知识图谱可视化分析。结果共纳入中文文献943篇,英文文献43篇。年发文量整体呈上升趋势,中文文献发文量较多的作者为刘军,英文文献中代表性作者为Ding Yi(丁一);作者合作网络显示国内作者合作密切但跨机构合作有限。主要研究机构包括北京中医药大学、南京中医药大学、广州中医药大学等。关键词共现与突现分析结果显示,中文文献研究聚焦于数据挖掘、用药规律等;英文文献研究则多集中于抗炎作用、活性成分(如乳香酸)、网络药理学及作用机制等方面。结论乳香在中医药防治骨关节病、乳腺病变、糖尿病足等疾病方面的研究热度持续上升,现代研究手段如网络药理学、分子机制解析和数据挖掘技术的广泛应用为乳香的科学研究提供了新的突破口。未来应加强多学科协作,深入挖掘乳香活性成分与靶向机制,以推动乳香在中药现代化与临床转化中的深入发展。
文摘目的通过对近年来乳香相关研究的文献的分析,探析乳香研究领域的相关热点与前沿。方法以中国知网、Web of Science数据库为数据来源,运用CiteSpace软件对文献年度发文量、机构、关键词、作者等方面进行分析,绘制可视化图谱。结果共获得中文文献689篇,英文文献406篇。文献数量整体呈上升趋势;发文量最多的中文机构为中国食品药品检定研究院(24篇)、英文机构为University of Nizwa(31篇)。发文量最高的中、英文作者分别为刘振丽(17篇)、Al-Harrasi,Ahmed(31篇)。刊载量最多的中、英文期刊分别是《中草药》(25篇)与Molecules(11篇)。中、英文关键词显示,对乳香的主要研究集中在药理作用、化学成分上。结论乳香研究目前处于稳定发展阶段,预测该领域的未来研究热点在乳香酸、挥发油、炎症、乳腺癌、口腔癌上,且国内外应加强团队间交流、合作,更深入研究。
