Theincreasing prevalence of gestational diabetesmellitus(GDM)is associated with an array of pregnancy complications and enduring health challenges in bothmothers and their offspring.Studies have indicated that exposur...Theincreasing prevalence of gestational diabetesmellitus(GDM)is associated with an array of pregnancy complications and enduring health challenges in bothmothers and their offspring.Studies have indicated that exposure to the intrauterine environment can prompt adaptations in the offspring,thereby programming transgenerational inheritance.Physical activity during pregnancy,as a non-pharmacological intervention,mitigates metabolic risks through epigenetic modifications,mediating placental adaptations,the action of exercise factors,and gut microbiota.Here,we provide a review summarizing how regular exercise can reduce the risk of GDM and positively influence pregnancy outcomes.It also discusses the exercise-induced reduction in obesity,insulin resistance,and fatty liver disease in the offspring of GDM,outlining the mechanisms that underpin these health benefits.This review underscores the importance of exercise in safeguarding the health of GDM mothers and their offspring.展开更多
Since the introduction of intracytoplasmic sperm injection （ICSI） using single sperm isolated from testicular tissue in men with obstructive and non-obstructive azoospermia, or using ejaculated sperm in those with p...Since the introduction of intracytoplasmic sperm injection （ICSI） using single sperm isolated from testicular tissue in men with obstructive and non-obstructive azoospermia, or using ejaculated sperm in those with poor semen quality, there have been concerns that this might have adverse effects on the offspring compared to conventional in vitrofertilisation （IVF） and natural conceptions. ICSI is done for reasons other than male factor infertility, and on the whole has not been shown to have any more negative effects than those seen with IVF. There have however, been very few studies of ICSI with a focus on, or large enough numbers to examine, the specific outcomes associated with male factor infertility. From the limited information available in relation to the source of the sperm and aetiology of infertility in the presence of ICSI, there appears to be no increased risk of congenital malformations. There is, however, a small increase in both de novoand inherited chromosome abnormalities. In terms of growth and neurodevelopment, there are very few studies, and so far, no adverse outcomes have been found in young children whose fathers have a sperm defect. The origin of the sperm used in ICSI does not have a major influence on the early life outcomes for the offspring, but transgenerational and epigenetic effects remain unknown. When the male factor infertility is known or thought to be due to a Y-chromosome deletion, this information should be given to the young male offspring at a time that will ensure his own reproductive health and plans are optimized.展开更多
基金supported by grants from the National Natural Science Foundation of China(Grant No.82401994)the Top Medical Expert Team of the Wuxi Taihu Talent Plan(Grant Nos.DJTD202106,GDTD202105)+1 种基金the Medical Key Discipline Program of theWuxi Health Commission(Grant Nos.ZDXK2021007,CXTD2021005)Top Talent Support Program for Young and Middle-Aged People of Wuxi Health Committee(Grant No.HB2023079).
文摘Theincreasing prevalence of gestational diabetesmellitus(GDM)is associated with an array of pregnancy complications and enduring health challenges in bothmothers and their offspring.Studies have indicated that exposure to the intrauterine environment can prompt adaptations in the offspring,thereby programming transgenerational inheritance.Physical activity during pregnancy,as a non-pharmacological intervention,mitigates metabolic risks through epigenetic modifications,mediating placental adaptations,the action of exercise factors,and gut microbiota.Here,we provide a review summarizing how regular exercise can reduce the risk of GDM and positively influence pregnancy outcomes.It also discusses the exercise-induced reduction in obesity,insulin resistance,and fatty liver disease in the offspring of GDM,outlining the mechanisms that underpin these health benefits.This review underscores the importance of exercise in safeguarding the health of GDM mothers and their offspring.
文摘Since the introduction of intracytoplasmic sperm injection （ICSI） using single sperm isolated from testicular tissue in men with obstructive and non-obstructive azoospermia, or using ejaculated sperm in those with poor semen quality, there have been concerns that this might have adverse effects on the offspring compared to conventional in vitrofertilisation （IVF） and natural conceptions. ICSI is done for reasons other than male factor infertility, and on the whole has not been shown to have any more negative effects than those seen with IVF. There have however, been very few studies of ICSI with a focus on, or large enough numbers to examine, the specific outcomes associated with male factor infertility. From the limited information available in relation to the source of the sperm and aetiology of infertility in the presence of ICSI, there appears to be no increased risk of congenital malformations. There is, however, a small increase in both de novoand inherited chromosome abnormalities. In terms of growth and neurodevelopment, there are very few studies, and so far, no adverse outcomes have been found in young children whose fathers have a sperm defect. The origin of the sperm used in ICSI does not have a major influence on the early life outcomes for the offspring, but transgenerational and epigenetic effects remain unknown. When the male factor infertility is known or thought to be due to a Y-chromosome deletion, this information should be given to the young male offspring at a time that will ensure his own reproductive health and plans are optimized.
