Treprostinil is a relatively new tricyclic prostacyclin analog with a stable str-ucture,extended half-life and improved potency.Currently,treprostinil is indicated by the Food and Drug Administration in the United Sta...Treprostinil is a relatively new tricyclic prostacyclin analog with a stable str-ucture,extended half-life and improved potency.Currently,treprostinil is indicated by the Food and Drug Administration in the United States for the treatment of pulmonary arterial hypertension(group 1 in the pulmonary hy-pertension classification of the World Health Organization).It has a potent vasodilating effect along with the inhibition of platelet aggregation and the attenuation of the inflammatory response in pulmonary and systemic circulation.It is available in the following formulations:Subcutaneous,intravenous,inhaled and oral.Although unknown to many clinicians,several encouraging reports of off-label treprostinil use in the adult population suggest its potential effectiveness in other clinical conditions.Currently under investigation are digital ischemia secondary to systemic sclerosis,chronic limb ischemia,hepatic ischemia-reper-fusion injury and group 3 and 4 pulmonary hypertension.Based on review and analysis of the available literature,this article provides a thorough update on the off-label use of treprostinil in adult patients.展开更多
Aim: To analyse antibiotic prescriptions in a cohort of extremely low birth weight neonates admitted to Italian level III Neonatal intensive Care Units. Methods: An online questionnaire was used to collect detailed in...Aim: To analyse antibiotic prescriptions in a cohort of extremely low birth weight neonates admitted to Italian level III Neonatal intensive Care Units. Methods: An online questionnaire was used to collect detailed information for each newborn. Antibiotic prescriptions were classified about their license status and compared with British National Formulary for Children (BNFC) and with a practical guide prepared by the Italian Society of Neonatology (ISN). Results: During the study period (May-July 2014) among 93 neonates admitted to 30 Italian Neonatal intensive Care Units, 56 (60%) received at least an antibiotic (92 prescriptions in total). Ampicillin, gentamicin and vancomycin were the antibiotics most commonly used for the prevention/treatment of bacterial infections. 56/92 antibiotic prescriptions (61%) resulted off-label mainly as regards dosing frequency, while 13 prescriptions (14%) regarded antibiotics used in absence of specific indication for newborns (meropenem, imipenem, piperacillin/tazobactam, clindamycin, clarithromycin). 50/56 neonates (89.3%) received at least one off-label antibiotic prescription. Differences have been observed in dosing regimens between current study and recommendations contained in BNFC, while prescriptions adhered more frequently to ISN indications. Conclusions: Our results confirm the high prevalence of off-label antibiotic use in ELBW neonates and underline a better adherence to indications based on clinical practice.展开更多
Off-label use is defined by the prescription of a marketed drug outside the conditions described in the summary of product characteristics.In oncology,off-label prescribing of targeted therapies may occur in patients ...Off-label use is defined by the prescription of a marketed drug outside the conditions described in the summary of product characteristics.In oncology,off-label prescribing of targeted therapies may occur in patients with other tumor types expressing the same target.Agents associated to phenotypic approaches such as therapies against the tumoral vasculature(anti-angiogenic drugs) and new immunotherapies(checkpoint inhibitors) also carry the potential of alternative indications or combinations.Off-label use of targeted therapies is little documented and appears to be in the same range than that regarding older drugs with wide variations among agents.When compared with older agents,off-label use of targeted therapies is probably more rational through tumoral genotyping but is faced with a limited clinical support,reimbursement challenges related to the very high pricing and the cost of genotyping or molecular profiling,when applicable.展开更多
Background Off-label use of psychotropic prescriptions for pediatric patients has been increasing in Japan.This study sought to clarify pediatric patients' off-label use of psychotropics approved only for adults i...Background Off-label use of psychotropic prescriptions for pediatric patients has been increasing in Japan.This study sought to clarify pediatric patients' off-label use of psychotropics approved only for adults in Japan.Methods This retrospective study on psychotropic utilization employed a pharmaceutical health insurance claims database supplied by a pharmacy for the fiscal year 2016.Seven psychotropic drugs were examined.For each drug,we calculated the proportion of patients aged < 16 years or who were under the approved age limit set in the United States out of all patients.The maximum daily dose of each drug within the study period was plotted by age.Results Data of 45,715 patients (female:26,799,male:18,916) with 331,920 prescriptions were examined in this study.For each drug,the proportion of pediatric patients aged < 16 years ranged from 0.15 to 1.1%,while the proportion of those under the approved age limit in the United States ranged from 0 to 0.27%.Olanzapine had the highest reported proportion.No drugs other than olanzapine were taken under the approved age limit in the United States.Conclusions We identified the pediatric off-label use of psychotropics that were limited to adult use in Japan.The results indicated the possibility of referring to international guidelines or evidence in clinical practice,but these factors do not discount the existing problems with off-label use.More clinical trials within the pediatric population in Japan are needed to address the issue of off-label use and obtain useful and reliable information in the package inserts for rational use in future pediatric patients.展开更多
Background:Weight-related self-stigma(WRSS)is prevalent among individuals with different types of weight status and is associated with a range of negative health outcomes.Social support and coping models explain how i...Background:Weight-related self-stigma(WRSS)is prevalent among individuals with different types of weight status and is associated with a range of negative health outcomes.Social support and coping models explain how individuals may use different coping methods to deal with their mental health needs.Psychological distress(e.g.,depression and stress)could lead to overuse of social media and smartphones.When using social media or smartphones,individuals are likely to be exposed to negative comments regarding weight/shape/size posted on the social media.Consequently,individuals who experience problematic social media use(PSMU)or problematic smartphone use(PSPU)may develop WRSS.Therefore,the present study examined the roles of PSMU and PSPU as mediators in the relationship between psychological distress and WRSS.Methods:Using convenience sampling via an online survey,622 participants with a mean age of 23.70 years(SD=4.33)completed questions assessing sociodemographic variables,psychological distress,PSMU,PSPU,WRSS,and self-reported weight and height.Results:The hierarchical regression models showed that sex(β=0.08,p=0.01),BMI(β=0.39,p<0.001),depression(β=0.21,p=0.001),stress(β=0.18,p=0.01),PSMU(β=0.09,p=0.045),and PSPU(β=0.14,p=0.001)were significant factors for WRSS.Conclusion:The mediation models showed that both PSMU and PSPU were significant mediators in the relationships between depression and stress with WRSS.The present findings provide some evidence for understanding WRSS and has important implications for developing interventions to reduce its negative impact on individuals’health and well-being.展开更多
Water use efficiency(WUE),as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ecosyste...Water use efficiency(WUE),as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ecosystems.However,in the context of global warming,WUE evolution and its primary drivers on the Tibetan Plateau remain unclear.This study employed the ensemble empirical mode decomposition method and the random forest algorithm to decipher the nonlinear trends and drivers of WUE on the Tibetan Plateau in 2001–2020.Results indicated an annual mean WUE of 0.8088 gC/mm·m^(2)across the plateau,with a spatial gradient reflecting decrease from the southeast toward the northwest.Areas manifesting monotonous trends of increase or decrease in WUE accounted for 23.64%and 9.69%of the total,respectively.Remarkably,66.67%of the region exhibited trend reversals,i.e.,39.94%of the area of the Tibetan Plateau showed transition from a trend of increase to a trend of decrease,and 26.73%of the area demonstrated a shift from a trend of decrease to a trend of increase.Environmental factors accounted for 70.79%of the variability in WUE.The leaf area index and temperature served as the major driving forces of WUE variation.展开更多
Land use transformations in Sonipat District,Haryana,driven by urbanization,industrialization,and land acquisitions,have posed significant ecological and socio-economic challenges,particularly concerning food security...Land use transformations in Sonipat District,Haryana,driven by urbanization,industrialization,and land acquisitions,have posed significant ecological and socio-economic challenges,particularly concerning food security.This study investigates the interplay between these land use changes and their environmental implications at macro(district)and micro(village)levels,focusing on agricultural productivity and resource sustainability.The study employs a mixed-method approach,integrating secondary data from official datasets and primary data gathered through structured household surveys,focus group discussions,and visual analysis techniques.Data from 20 villages,selected based on predominant land use characteristics,were analysed using statistical and geospatial tools,including ArcGIS and STATA,to quantify food grain losses and evaluate environmental degradation.Findings of this study reveal a 19%reduction in agricultural land over two decades(2000-2024),correlating with increased residential and industrial areas.Groundwater resources face severe overexploitation,with pollution from industrial clusters further degrading water and soil quality.The study estimates a total food grain loss of 1.5 million kilograms across surveyed villages due to land acquisitions.A strong positive correlation(R^(2)=0.98)between land acquisition and food loss underscores the direct impact of urbanization on agricultural output.The research underscores the urgency of sustainable land management practices,including preserving agricultural lands,optimizing groundwater usage,and enhancing community involvement in planning.By addressing these challenges,the study advocates for balanced urban expansion and food security to ensure ecological and economic resilience in the region.展开更多
The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use e...The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use efficiency and enhancing crop stress resistance.Nevertheless,the precise interaction between soil warming(SW)and SN remains unclear.In order to ascertain the impact of SW on maize growth and whether SN can improve the tolerance of maize to SW,a two-year field experiment was conducted(2022-2023).The aim was to examine the influence of two SW ranges(MT,warming 1.40℃;HT,warming 2.75℃)and two nitrogen application methods(N1,one-time basal application of nitrogen fertilizer;N2,one third of base nitrogen fertilizer+two thirds of jointing stage supplemental nitrogen fertilizer)on maize root growth,photosynthetic characteristics,nitrogen use efficiency,and yield.The results demonstrated that SW impeded root growth and precipitated the premature aging of maize leaves following anthesis,particularly in the HT,which led to a notable reduction in maize yield.In comparison to N1,SN has been shown to increase root length density by 8.54%,root bleeding rate by 8.57%,and enhance root distribution ratio in the middle soil layers(20-60 cm).The interaction between SW and SN had a notable impact on maize growth and yield.The SN improved the absorption and utilization efficiency of nitrogen by promoting root development and downward canopy growth,thus improving the tolerance of maize to SW at the later stage of growth.In particular,the N2HT resulted in a 14.51%increase in the photosynthetic rate,a 18.58%increase in nitrogen absorption efficiency,and a 18.32%increase in maize yield compared with N1HT.It can be posited that the SN represents a viable nitrogen management measure with the potential to enhance maize tolerance to soil high-temperature stress.展开更多
Human well-being and livelihoods depend on natural ecosystem services(ESs).Following the increment of population,ESs have been deteriorated over time.Ultimately,land use/land cover(LULC)changes have a profound impact ...Human well-being and livelihoods depend on natural ecosystem services(ESs).Following the increment of population,ESs have been deteriorated over time.Ultimately,land use/land cover(LULC)changes have a profound impact on the change of ecosystem.The primary goal of this study is to determine the impacts of LULC changes on ecosystem service values(ESVs)in the upper Gilgel Abbay watershed,Ethiopia.Changes in LULC types were studied using three Landsat images representing 1986,2003,and 2021.The Landsat images were classified using a supervised image classification technique in Earth Resources Data Analysis System(ERDAS)Imagine 2014.We classified ESs in this study into four categories(including provisioning,regulating,supporting,and cultural services)based on global ES classification scheme.The adjusted ESV coefficient benefit approach was employed to measure the impacts of LULC changes on ESVs.Five LULC types were identified in this study,including cultivated land,forest,shrubland,grassland,and water body.The result revealed that the area of cultivated land accounted for 64.50%,71.50%,and 61.50%of the total area in 1986,2003,and 2021,respectively.The percentage of the total area covered by forest was 9.50%,5.90%,and 14.80%in 1986,2003,and 2021,respectively.Result revealed that the total ESV decreased from 7.42×10^(7) to 6.44×10^(7) USD between 1986 and 2003.This is due to the expansion of cultivated land at the expense of forest and shrubland.However,the total ESV increased from 6.44×10^(7) to 7.76×10^(7) USD during 2003-2021,because of the increment of forest and shrubland.The expansion of cultivated land and the reductions of forest and shrubland reduced most individual ESs during 1986-2003.Nevertheless,the increase in forest and shrubland at the expense of cultivated land enhanced many ESs during 2003-2021.Therefore,the findings suggest that appropriate land use practices should be scaled-up to sustainably maintain ESs.展开更多
[Objectives]This study was conducted to promote the rational use of special use level of antibiotics in clinic and delay the emergence of drug resistance.[Methods]The application of antibiotics for special use among i...[Objectives]This study was conducted to promote the rational use of special use level of antibiotics in clinic and delay the emergence of drug resistance.[Methods]The application of antibiotics for special use among inpatients of a hospital in 2019 was analyzed.The data in the drug information management system of the hospital were queried,and the collected expert consultation records of special-use antibiotics were sorted out.Indicators including the use rate of special-use antibiotics,antibiotic use density(AUD),defined daily dose system(DDDs)and defined daily dose system cost(DDDc)of each drug,the annual pathogen detection rate,disease distribution and pathogenic microorganism detection were summarized and analyzed for inpatients in the hospital retrospectively.[Results]In 2019,the average annual use rate of special-use antibiotics in the hospital was 1.53%,and the average annual use density was 1.59 DDDs.The antibiotics with the top three DDDs were imipenem and cilastatin,meropenem and cefepime.The antibiotics with the top three DDDc were voriconazole dispersible tablets,voriconazole for injection,and meropenem for injection.The average annual detection rate of microorganisms was 85.77%.The diseases were mainly diagnosed as respiratory infections such as pneumonia and secondary infections after radiotherapy and chemotherapy before medication,and the detected pathogens were mainly Candida and its subspecies,Escherichia coli,and Klebsiella and its subspecies.[Conclusions]The clinical use of special-use antibiotics in the hospital was basically reasonable,but there were still some problems.It is necessary to increase management efforts,strengthen training for relevant medical personnel,and provide management ideas for further standardizing the use of antibiotics in the hospital.展开更多
The implementation of long-term shelterbelt programs in the middle reaches of the Yellow River(MRYR),China not only has improved the overall ecological environment,but also has led to the changes of land use pattern,c...The implementation of long-term shelterbelt programs in the middle reaches of the Yellow River(MRYR),China not only has improved the overall ecological environment,but also has led to the changes of land use pattern,causing carbon storage exchanges.However,the relationship between carbon storage and land use change in the MRYR is not concerned,which results in the uncertainty in the simulation of carbon storage in this area.Land use changes directly affect the carbon storage capacity of ecosystems,and as an indicator reflecting the overall state of land use,land use degree has an important relationship with carbon storage.In this study,land use data and the integrated valuation of ecosystem services and trade-offs(InVEST)model were used to assess the trends in land use degree and carbon storage in the MRYR during 1980-2020.The potential impact index and the standard deviation ellipse(SDE)algorithm were applied to quantify and analyze the characteristics of the impact of land use changes on carbon storage.Subsequently,land use transitions that led to carbon storage variations and their spatial variations were determined.The results showed that:(1)the most significant periods of carbon storage changes and land use transitions were observed during 1990-1995 and 1995-2020,with the most changed areas locating in the east of Fenhe River and in northwestern Henan Province;(2)the positive impact of land use degree on carbon storage may be related to the environmental protection measures implemented along the Yellow River,while the negative impact may be associated with the expansion of construction land in plain areas;and(3)the conversion of other land use types to grassland was the primary factor affecting carbon storage changes during 1980-2020.In future land use planning,attention should be given to the direction of grassland conversion,and focus on reasonably limiting the development of construction land.To enhance carbon storage,it will be crucial to increase the area of high-carbon-density land types,such as forest land and grassland under the condition that the area of permanent farmland does not decrease.展开更多
BACKGROUND Cytomegalovirus(CMV)infections can cause significant morbidity and mortality in immunocompromised individuals.CMV targets dysfunctional lymphocytes.Chronic rituximab(RTX)therapy can cause B-lymphocyte dysfu...BACKGROUND Cytomegalovirus(CMV)infections can cause significant morbidity and mortality in immunocompromised individuals.CMV targets dysfunctional lymphocytes.Chronic rituximab(RTX)therapy can cause B-lymphocyte dysfunction,increasing CMV risk.Rarely,CMV infections present with critical illness such as septic shock.CASE SUMMARY A 64-year-old African American woman presented with generalized weakness and non-bloody watery diarrhea of 4-6 weeks duration.She did not have nausea,vomiting or,abdominal pain.She had been on monthly RTX infusions for neuromyelitis optica.She was admitted for septic shock due to pancolitis.Blood investigations suggested pancytopenia and serology detected significantly elevated CMV DNA.Valganciclovir treatment led to disease resolution.CONCLUSION This case illustrates an extremely rare case of CMV colitis associated with RTX use presenting with septic shock.High suspicion for rare opportunistic infections is imperative in individuals with long-term RTX use.展开更多
Land use/cover change(LUCC)constitutes the spatial and temporal patterns of ecological security,and the construction of ecological networks is an effective way to ensure ecological security.Exploring the spatial and t...Land use/cover change(LUCC)constitutes the spatial and temporal patterns of ecological security,and the construction of ecological networks is an effective way to ensure ecological security.Exploring the spatial and temporal change characteristics of ecological network and analyzing the integrated relationship between LUCC and ecological security are crucial for ensuring regional ecological security.Gansu is one of the provinces with fragile ecological environment in China,and rapid changes in land use patterns in recent decades have threatened ecological security.Therefore,taking Gansu Province as the study area,this study simulated its land use pattern in 2050 using patch-generating land use simulation(PLUS)model based on the LUCC trend from 2000 to 2020 and integrated the LUCC into morphological spatial pattern analysis(MSPA)to identify ecological sources and extract the ecological corridors to construct ecological network using circuit theory.The results revealed that,according to the prediction results in 2050,the areas of cultivated land,forest land,grassland,water body,construction land,and unused land would be 63,447.52,39,510.80,148,115.18,4605.21,8368.89,and 161,752.40 km^(2),respectively.The number of ecological sources in Gansu Province would increase to 80,with a total area of 99,927.18 km^(2).The number of ecological corridors would increase to 191,with an estimated total length of 6120.66 km.Both ecological sources and ecological corridors showed a sparse distribution in the northwest and dense distribution in the southeast of the province at the spatial scale.The number of ecological pinch points would reach 312 and the total area would expect to increase to 842.84 km^(2),with the most pronounced increase in the Longdong region.Compared with 2020,the number and area of ecological barriers in 2050 would decrease significantly by 63 and 370.71 km^(2),respectively.In general,based on the prediction results,the connectivity of ecological network of Gansu Province would increase in 2050.To achieve the predicted ecological network in 2050,emphasis should be placed on the protection of cultivated land and ecological land,the establishment of ecological sources in desert areas,the reinforcement of the protection for existing ecological sources,and the construction of ecological corridors to enhance the stability of ecological network.This study provides valuable theoretical support and references for the future construction of ecological networks and regional land resource management decision-making.展开更多
Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and ...Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.展开更多
Background:Resilience is crucial for medical college students to thrive in the highly stressful environment of medical education.However,the prevalence of problematic internet use(PIU)in this population may negatively...Background:Resilience is crucial for medical college students to thrive in the highly stressful environment of medical education.However,the prevalence of problematic internet use(PIU)in this population may negatively impact their resilience.This study investigated the influence of problematic online gaming(PG)and problematic social media use(PSMU)on the resilience of medical college students in China.Methods:A sample of 5075 first-year medical college students from four Chinese universities was studied.PG served as the independent variable,resilience as the dependent variable,fatigue as the mediator,and PSMU as the moderator.Structural equation modeling was conducted using LISREL 8.80.Additionally,a moderated mediation model was evaluated using the jAMM module in jamovi 2.6.13.Results:The study’s findings revealed significant negative correlations between resilience and the variables of PG,PSMU,and fatigue.Fatigue mediated the relationship between PG and resilience(B=−0.04,95%CI=[−0.05,−0.03]).PSMU moderated the direct relationship between PG and resilience with the interaction term PG×PSMU significant(B=−0.004,t=−6.501,p<0.001)and the first stage(PG→fatigue)of the mediation with PG×PSMU significant(B=0.055,t=8.351,p<0.001).The detrimental effects of PG on resilience were more pronounced among individuals with lower levels of PSMU.Conclusion:This study concluded that addressing PIU,particularly PG,is essential for fostering resilience in medical college students.While PSMU itself is maladaptive,the underlying social media engagement may serve a protective role through social support in mitigating the adverse effects of PG on resilience.展开更多
Ridge-furrow film mulching has been widely used as a water-saving and yield-increasing planting pattern in arid and semiarid regions.Planting density is also a vitally important factor influencing crop yield,and the o...Ridge-furrow film mulching has been widely used as a water-saving and yield-increasing planting pattern in arid and semiarid regions.Planting density is also a vitally important factor influencing crop yield,and the optimal planting density will vary in different environments(such as ridge-furrow film mulching).How the combination of film mulching and planting density will affect the growth,physiology,yield,and water and radiation use efficiencies of winter oilseed rape is not clear yet.Therefore,a three-year field experiment was conducted from 2017 to 2020 to explore the responses of leaf chlorophyll(Chl)content,net photosynthetic rate(P_(n)),leaf area index(LAI),aboveground dry matter(ADM),root growth and distribution,yield,evapotranspiration(ET),water use efficiency(WUE),and radiation use efficiency(RUE)of winter oilseed rape to different film mulching patterns(F,ridge-furrow planting with plastic film mulching over the ridges;N,flat planting without mulching)and planting densities(LD,100,000 plants ha^(-1);MD,150,000 plants ha^(-1);HD,200,000 plants ha^(-1)).The results showed that the F treatments led to significantly greater leaf Chl contents,P_(n),LAI,and ADM,and a stronger root system than treatments without film mulching throughout the whole winter rapeseed growing seasons.Winter oilseed rape in the MD treatments had better physiological(leaf Chl contents and P_(n))and growth(LAI,ADM,taproot,and lateral root)conditions than in LD and HD at the late growth period after stem-elongation.Grain yield in FMD was the greatest,and it was significantly greater by 34.8-46.0%,6.7-9.6%,87.8-108.3%,38.7-50.3%,and 50.2-61.8%compared to those of FLD,FHD,NLD,NMD,and NHD,respectively.Furthermore,the ET in FMD was equivalent to FLD and FHD,but was markedly lower by 12.2-18.4%,14.5-20.3%,and 14.6-20.4%than in NLD,NMD,and NHD.Finally,the WUE and RUE in FMD were significantly improved by 88.5-94.0%and 29.0-41.8%compared to NHD(the local conventional planting pattern and planting density for winter rapeseed).In summary,FMD is a favorable cultivation management strategy to save water,increase yield and improve resource utilization efficiencies in winter oilseed rape in Northwest China.展开更多
I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised us...I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised uses of substances which might alter perception,mood,and/or behaviour.展开更多
Jaipur,India,is experiencing rapid urbanization that is significantly altering its land use and land cover(LULC)patterns,presenting both challenges and opportunities for sustainable development and socio-economic adva...Jaipur,India,is experiencing rapid urbanization that is significantly altering its land use and land cover(LULC)patterns,presenting both challenges and opportunities for sustainable development and socio-economic advancement.This study utilizes advanced geospatial and remote sensing technologies to assess these changes and project future scenarios.Specifically,satellite data were processed using Google Earth Engine,land cover was accurately classified using the Random Forest algorithm,and future projections were modeled through QGIS-MOLUSCE using a polynomial-based Cellular Automata–Artificial Neural Network(CA-ANN)approach.Analysis of Landsat imagery for the years 2000 and 2020 reveals a dramatic 188.59%increase in urban built-up areas and a 145.44%rise in vegetation cover,largely due to successful afforestation efforts.Meanwhile,barren land declined by 47.37%,and water bodies exhibited fluctuating trends,reflecting the intricate interplay between urban development and climatic variability.Looking ahead to 2045,model projections estimate that built-up areas will expand to approximately 1303.08 square kilometres,potentially threatening the integrity of vital green spaces and aquatic ecosystems.These findings highlight the urgent need for integrated policy interventions aimed at mitigating environmental risks such as urban heat island effects and biodiversity loss.By providing a detailed account of past and present LULC dynamics,this research delivers actionable,data-driven insights to support sustainable urban planning.Moreover,the integration of urban growth models with climate resilience strategies offers a replicable framework for managing urban expansion in other rapidly developing cities,particularly those situated in semi-arid regions.展开更多
Adaptation to different environments can lead to local adaptations that facilitate morphological divergence between closely related taxa,potentially leading to speciation.Quantifying habitat variation can thus provide...Adaptation to different environments can lead to local adaptations that facilitate morphological divergence between closely related taxa,potentially leading to speciation.Quantifying habitat variation can thus provide valuable insights into evolutionary processes.Arboreal dwarf chameleons of the genus Bradypodion exhibit 3 distinct ecomorphological forms:forest,shrub,and“little brown chameleons”(LBCs).It is assumed these ecomorphs are the result of convergence among species that are in similar habitats regardless of ancestry,or in some cases,morphological conservatism and retention of an ancestral form that is adapted to a shared habitat type.If so,then the habitat of different ecomorphs would differ in vegetation structure.Our results show that vegetation structure in fynbos/grassy habitats is characterized by significantly narrower perches than shrubby habitats,but both have a largely vertical perch orientation.In contrast,forests have significantly fewer vertical perches than fynbos/grassy habitats with significantly thicker diameter perches.Accordingly,LBC and shrub species used more vertically oriented perches than forest species,suggesting that perch use corresponds with the most widely available perch angles.Although LBC chameleons used the smallest diameter perches,when corrected for body size,there was no difference in perch diameter among ecomorphs.These results suggest that the body size of LBC chameleons is constrained by the prevalence of small-diameter perches in their habitat.Species in habitats with wider perches attain larger body size.These findings support the notion that variation in perch structure is critical for phenotypic convergence that has resulted in the 3 Bradypodion ecomorphs.展开更多
Nitrogen(N)and phosphorus(P)are mineral nutrients essential for plant growth and development,playing a crucial role throughout the plant life cycle.Cotton,a globally significant textile crop,has a particularly high de...Nitrogen(N)and phosphorus(P)are mineral nutrients essential for plant growth and development,playing a crucial role throughout the plant life cycle.Cotton,a globally significant textile crop,has a particularly high demand for N fertilizer across its developmental stages.This review explores the effects of adequate or deficient N and P levels on cotton growth phases,focusing on their influence on physiological processes and molecular mechanisms.Key topics include the regulation of N-and P-related enzymes,hormones,and genes,as well as the complex interplay of N-and P-related signaling pathways from the aspects of N-P signaling integration to regulate root development,N-P signaling integration to regulate nutrient uptake,and regulation of N-P interactions—a frontier in current research.Strategies for improving N and P use efficiency are also discussed,including developing high-efficiency cotton cultivars and identifying functional genes to enhance productivity.Generally speaking,we take model plants as a reference in the hope of coming up with new strategies for the efficient utilization of N and P in cotton.展开更多
文摘Treprostinil is a relatively new tricyclic prostacyclin analog with a stable str-ucture,extended half-life and improved potency.Currently,treprostinil is indicated by the Food and Drug Administration in the United States for the treatment of pulmonary arterial hypertension(group 1 in the pulmonary hy-pertension classification of the World Health Organization).It has a potent vasodilating effect along with the inhibition of platelet aggregation and the attenuation of the inflammatory response in pulmonary and systemic circulation.It is available in the following formulations:Subcutaneous,intravenous,inhaled and oral.Although unknown to many clinicians,several encouraging reports of off-label treprostinil use in the adult population suggest its potential effectiveness in other clinical conditions.Currently under investigation are digital ischemia secondary to systemic sclerosis,chronic limb ischemia,hepatic ischemia-reper-fusion injury and group 3 and 4 pulmonary hypertension.Based on review and analysis of the available literature,this article provides a thorough update on the off-label use of treprostinil in adult patients.
文摘Aim: To analyse antibiotic prescriptions in a cohort of extremely low birth weight neonates admitted to Italian level III Neonatal intensive Care Units. Methods: An online questionnaire was used to collect detailed information for each newborn. Antibiotic prescriptions were classified about their license status and compared with British National Formulary for Children (BNFC) and with a practical guide prepared by the Italian Society of Neonatology (ISN). Results: During the study period (May-July 2014) among 93 neonates admitted to 30 Italian Neonatal intensive Care Units, 56 (60%) received at least an antibiotic (92 prescriptions in total). Ampicillin, gentamicin and vancomycin were the antibiotics most commonly used for the prevention/treatment of bacterial infections. 56/92 antibiotic prescriptions (61%) resulted off-label mainly as regards dosing frequency, while 13 prescriptions (14%) regarded antibiotics used in absence of specific indication for newborns (meropenem, imipenem, piperacillin/tazobactam, clindamycin, clarithromycin). 50/56 neonates (89.3%) received at least one off-label antibiotic prescription. Differences have been observed in dosing regimens between current study and recommendations contained in BNFC, while prescriptions adhered more frequently to ISN indications. Conclusions: Our results confirm the high prevalence of off-label antibiotic use in ELBW neonates and underline a better adherence to indications based on clinical practice.
文摘Off-label use is defined by the prescription of a marketed drug outside the conditions described in the summary of product characteristics.In oncology,off-label prescribing of targeted therapies may occur in patients with other tumor types expressing the same target.Agents associated to phenotypic approaches such as therapies against the tumoral vasculature(anti-angiogenic drugs) and new immunotherapies(checkpoint inhibitors) also carry the potential of alternative indications or combinations.Off-label use of targeted therapies is little documented and appears to be in the same range than that regarding older drugs with wide variations among agents.When compared with older agents,off-label use of targeted therapies is probably more rational through tumoral genotyping but is faced with a limited clinical support,reimbursement challenges related to the very high pricing and the cost of genotyping or molecular profiling,when applicable.
文摘Background Off-label use of psychotropic prescriptions for pediatric patients has been increasing in Japan.This study sought to clarify pediatric patients' off-label use of psychotropics approved only for adults in Japan.Methods This retrospective study on psychotropic utilization employed a pharmaceutical health insurance claims database supplied by a pharmacy for the fiscal year 2016.Seven psychotropic drugs were examined.For each drug,we calculated the proportion of patients aged < 16 years or who were under the approved age limit set in the United States out of all patients.The maximum daily dose of each drug within the study period was plotted by age.Results Data of 45,715 patients (female:26,799,male:18,916) with 331,920 prescriptions were examined in this study.For each drug,the proportion of pediatric patients aged < 16 years ranged from 0.15 to 1.1%,while the proportion of those under the approved age limit in the United States ranged from 0 to 0.27%.Olanzapine had the highest reported proportion.No drugs other than olanzapine were taken under the approved age limit in the United States.Conclusions We identified the pediatric off-label use of psychotropics that were limited to adult use in Japan.The results indicated the possibility of referring to international guidelines or evidence in clinical practice,but these factors do not discount the existing problems with off-label use.More clinical trials within the pediatric population in Japan are needed to address the issue of off-label use and obtain useful and reliable information in the package inserts for rational use in future pediatric patients.
基金supported in part by(received funding from)the Ministry of Science and Technology,Taiwan(MOST 110-2410-H-006-115,MOST 111-2410-H-006-100)the National Science and Technology Council,Taiwan(NSTC 112-2410-H-006-089-SS2)+1 种基金the Higher Education Sprout Project,the Ministry of Education at the Headquarters of University Advancement at the National Cheng Kung University(NCKU)the 2021 Southeast and South Asia and Taiwan Universities Joint Research Scheme(NCKU 31).
文摘Background:Weight-related self-stigma(WRSS)is prevalent among individuals with different types of weight status and is associated with a range of negative health outcomes.Social support and coping models explain how individuals may use different coping methods to deal with their mental health needs.Psychological distress(e.g.,depression and stress)could lead to overuse of social media and smartphones.When using social media or smartphones,individuals are likely to be exposed to negative comments regarding weight/shape/size posted on the social media.Consequently,individuals who experience problematic social media use(PSMU)or problematic smartphone use(PSPU)may develop WRSS.Therefore,the present study examined the roles of PSMU and PSPU as mediators in the relationship between psychological distress and WRSS.Methods:Using convenience sampling via an online survey,622 participants with a mean age of 23.70 years(SD=4.33)completed questions assessing sociodemographic variables,psychological distress,PSMU,PSPU,WRSS,and self-reported weight and height.Results:The hierarchical regression models showed that sex(β=0.08,p=0.01),BMI(β=0.39,p<0.001),depression(β=0.21,p=0.001),stress(β=0.18,p=0.01),PSMU(β=0.09,p=0.045),and PSPU(β=0.14,p=0.001)were significant factors for WRSS.Conclusion:The mediation models showed that both PSMU and PSPU were significant mediators in the relationships between depression and stress with WRSS.The present findings provide some evidence for understanding WRSS and has important implications for developing interventions to reduce its negative impact on individuals’health and well-being.
基金National Nonprofit Institute Research Grant of CAF,No.CAFYBB2018ZA004,No.CAFYBB2023ZA009Fengyun Application Pioneering Project,No.FY-APP-ZX-2023.02。
文摘Water use efficiency(WUE),as a pivotal indicator of the coupling degree within the carbon–water cycle of ecosystems,holds considerable importance in assessment of the carbon–water balance within terrestrial ecosystems.However,in the context of global warming,WUE evolution and its primary drivers on the Tibetan Plateau remain unclear.This study employed the ensemble empirical mode decomposition method and the random forest algorithm to decipher the nonlinear trends and drivers of WUE on the Tibetan Plateau in 2001–2020.Results indicated an annual mean WUE of 0.8088 gC/mm·m^(2)across the plateau,with a spatial gradient reflecting decrease from the southeast toward the northwest.Areas manifesting monotonous trends of increase or decrease in WUE accounted for 23.64%and 9.69%of the total,respectively.Remarkably,66.67%of the region exhibited trend reversals,i.e.,39.94%of the area of the Tibetan Plateau showed transition from a trend of increase to a trend of decrease,and 26.73%of the area demonstrated a shift from a trend of decrease to a trend of increase.Environmental factors accounted for 70.79%of the variability in WUE.The leaf area index and temperature served as the major driving forces of WUE variation.
文摘Land use transformations in Sonipat District,Haryana,driven by urbanization,industrialization,and land acquisitions,have posed significant ecological and socio-economic challenges,particularly concerning food security.This study investigates the interplay between these land use changes and their environmental implications at macro(district)and micro(village)levels,focusing on agricultural productivity and resource sustainability.The study employs a mixed-method approach,integrating secondary data from official datasets and primary data gathered through structured household surveys,focus group discussions,and visual analysis techniques.Data from 20 villages,selected based on predominant land use characteristics,were analysed using statistical and geospatial tools,including ArcGIS and STATA,to quantify food grain losses and evaluate environmental degradation.Findings of this study reveal a 19%reduction in agricultural land over two decades(2000-2024),correlating with increased residential and industrial areas.Groundwater resources face severe overexploitation,with pollution from industrial clusters further degrading water and soil quality.The study estimates a total food grain loss of 1.5 million kilograms across surveyed villages due to land acquisitions.A strong positive correlation(R^(2)=0.98)between land acquisition and food loss underscores the direct impact of urbanization on agricultural output.The research underscores the urgency of sustainable land management practices,including preserving agricultural lands,optimizing groundwater usage,and enhancing community involvement in planning.By addressing these challenges,the study advocates for balanced urban expansion and food security to ensure ecological and economic resilience in the region.
基金supported by the Natural Science Fund of China(31771724)the Key Research and Development Project of Shaanxi Province(2024NC-ZDCYL-01-10).
文摘The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use efficiency and enhancing crop stress resistance.Nevertheless,the precise interaction between soil warming(SW)and SN remains unclear.In order to ascertain the impact of SW on maize growth and whether SN can improve the tolerance of maize to SW,a two-year field experiment was conducted(2022-2023).The aim was to examine the influence of two SW ranges(MT,warming 1.40℃;HT,warming 2.75℃)and two nitrogen application methods(N1,one-time basal application of nitrogen fertilizer;N2,one third of base nitrogen fertilizer+two thirds of jointing stage supplemental nitrogen fertilizer)on maize root growth,photosynthetic characteristics,nitrogen use efficiency,and yield.The results demonstrated that SW impeded root growth and precipitated the premature aging of maize leaves following anthesis,particularly in the HT,which led to a notable reduction in maize yield.In comparison to N1,SN has been shown to increase root length density by 8.54%,root bleeding rate by 8.57%,and enhance root distribution ratio in the middle soil layers(20-60 cm).The interaction between SW and SN had a notable impact on maize growth and yield.The SN improved the absorption and utilization efficiency of nitrogen by promoting root development and downward canopy growth,thus improving the tolerance of maize to SW at the later stage of growth.In particular,the N2HT resulted in a 14.51%increase in the photosynthetic rate,a 18.58%increase in nitrogen absorption efficiency,and a 18.32%increase in maize yield compared with N1HT.It can be posited that the SN represents a viable nitrogen management measure with the potential to enhance maize tolerance to soil high-temperature stress.
文摘Human well-being and livelihoods depend on natural ecosystem services(ESs).Following the increment of population,ESs have been deteriorated over time.Ultimately,land use/land cover(LULC)changes have a profound impact on the change of ecosystem.The primary goal of this study is to determine the impacts of LULC changes on ecosystem service values(ESVs)in the upper Gilgel Abbay watershed,Ethiopia.Changes in LULC types were studied using three Landsat images representing 1986,2003,and 2021.The Landsat images were classified using a supervised image classification technique in Earth Resources Data Analysis System(ERDAS)Imagine 2014.We classified ESs in this study into four categories(including provisioning,regulating,supporting,and cultural services)based on global ES classification scheme.The adjusted ESV coefficient benefit approach was employed to measure the impacts of LULC changes on ESVs.Five LULC types were identified in this study,including cultivated land,forest,shrubland,grassland,and water body.The result revealed that the area of cultivated land accounted for 64.50%,71.50%,and 61.50%of the total area in 1986,2003,and 2021,respectively.The percentage of the total area covered by forest was 9.50%,5.90%,and 14.80%in 1986,2003,and 2021,respectively.Result revealed that the total ESV decreased from 7.42×10^(7) to 6.44×10^(7) USD between 1986 and 2003.This is due to the expansion of cultivated land at the expense of forest and shrubland.However,the total ESV increased from 6.44×10^(7) to 7.76×10^(7) USD during 2003-2021,because of the increment of forest and shrubland.The expansion of cultivated land and the reductions of forest and shrubland reduced most individual ESs during 1986-2003.Nevertheless,the increase in forest and shrubland at the expense of cultivated land enhanced many ESs during 2003-2021.Therefore,the findings suggest that appropriate land use practices should be scaled-up to sustainably maintain ESs.
基金Supported by National TCM Advantage Speciality Construction Project:Clinical Pharmacy(GZYYYZH[2024]90)Guizhou Provincial Key Discipline Construction Project of Traditional Chinese Medicine and Ethnic Medicine:Clinical Traditional Chinese pharmacy(QZYYZDXK(JS)-2023-04).
文摘[Objectives]This study was conducted to promote the rational use of special use level of antibiotics in clinic and delay the emergence of drug resistance.[Methods]The application of antibiotics for special use among inpatients of a hospital in 2019 was analyzed.The data in the drug information management system of the hospital were queried,and the collected expert consultation records of special-use antibiotics were sorted out.Indicators including the use rate of special-use antibiotics,antibiotic use density(AUD),defined daily dose system(DDDs)and defined daily dose system cost(DDDc)of each drug,the annual pathogen detection rate,disease distribution and pathogenic microorganism detection were summarized and analyzed for inpatients in the hospital retrospectively.[Results]In 2019,the average annual use rate of special-use antibiotics in the hospital was 1.53%,and the average annual use density was 1.59 DDDs.The antibiotics with the top three DDDs were imipenem and cilastatin,meropenem and cefepime.The antibiotics with the top three DDDc were voriconazole dispersible tablets,voriconazole for injection,and meropenem for injection.The average annual detection rate of microorganisms was 85.77%.The diseases were mainly diagnosed as respiratory infections such as pneumonia and secondary infections after radiotherapy and chemotherapy before medication,and the detected pathogens were mainly Candida and its subspecies,Escherichia coli,and Klebsiella and its subspecies.[Conclusions]The clinical use of special-use antibiotics in the hospital was basically reasonable,but there were still some problems.It is necessary to increase management efforts,strengthen training for relevant medical personnel,and provide management ideas for further standardizing the use of antibiotics in the hospital.
基金funded by the National Natural Science Foundation of China(52079103)the Outstanding Youth Science Fund of Xi'an University of Science and Technology(2024YQ2-02).
文摘The implementation of long-term shelterbelt programs in the middle reaches of the Yellow River(MRYR),China not only has improved the overall ecological environment,but also has led to the changes of land use pattern,causing carbon storage exchanges.However,the relationship between carbon storage and land use change in the MRYR is not concerned,which results in the uncertainty in the simulation of carbon storage in this area.Land use changes directly affect the carbon storage capacity of ecosystems,and as an indicator reflecting the overall state of land use,land use degree has an important relationship with carbon storage.In this study,land use data and the integrated valuation of ecosystem services and trade-offs(InVEST)model were used to assess the trends in land use degree and carbon storage in the MRYR during 1980-2020.The potential impact index and the standard deviation ellipse(SDE)algorithm were applied to quantify and analyze the characteristics of the impact of land use changes on carbon storage.Subsequently,land use transitions that led to carbon storage variations and their spatial variations were determined.The results showed that:(1)the most significant periods of carbon storage changes and land use transitions were observed during 1990-1995 and 1995-2020,with the most changed areas locating in the east of Fenhe River and in northwestern Henan Province;(2)the positive impact of land use degree on carbon storage may be related to the environmental protection measures implemented along the Yellow River,while the negative impact may be associated with the expansion of construction land in plain areas;and(3)the conversion of other land use types to grassland was the primary factor affecting carbon storage changes during 1980-2020.In future land use planning,attention should be given to the direction of grassland conversion,and focus on reasonably limiting the development of construction land.To enhance carbon storage,it will be crucial to increase the area of high-carbon-density land types,such as forest land and grassland under the condition that the area of permanent farmland does not decrease.
文摘BACKGROUND Cytomegalovirus(CMV)infections can cause significant morbidity and mortality in immunocompromised individuals.CMV targets dysfunctional lymphocytes.Chronic rituximab(RTX)therapy can cause B-lymphocyte dysfunction,increasing CMV risk.Rarely,CMV infections present with critical illness such as septic shock.CASE SUMMARY A 64-year-old African American woman presented with generalized weakness and non-bloody watery diarrhea of 4-6 weeks duration.She did not have nausea,vomiting or,abdominal pain.She had been on monthly RTX infusions for neuromyelitis optica.She was admitted for septic shock due to pancolitis.Blood investigations suggested pancytopenia and serology detected significantly elevated CMV DNA.Valganciclovir treatment led to disease resolution.CONCLUSION This case illustrates an extremely rare case of CMV colitis associated with RTX use presenting with septic shock.High suspicion for rare opportunistic infections is imperative in individuals with long-term RTX use.
基金supported by the Science Fund for the Gansu Provincial Natural Science Foundation Project(22JR5RA339).
文摘Land use/cover change(LUCC)constitutes the spatial and temporal patterns of ecological security,and the construction of ecological networks is an effective way to ensure ecological security.Exploring the spatial and temporal change characteristics of ecological network and analyzing the integrated relationship between LUCC and ecological security are crucial for ensuring regional ecological security.Gansu is one of the provinces with fragile ecological environment in China,and rapid changes in land use patterns in recent decades have threatened ecological security.Therefore,taking Gansu Province as the study area,this study simulated its land use pattern in 2050 using patch-generating land use simulation(PLUS)model based on the LUCC trend from 2000 to 2020 and integrated the LUCC into morphological spatial pattern analysis(MSPA)to identify ecological sources and extract the ecological corridors to construct ecological network using circuit theory.The results revealed that,according to the prediction results in 2050,the areas of cultivated land,forest land,grassland,water body,construction land,and unused land would be 63,447.52,39,510.80,148,115.18,4605.21,8368.89,and 161,752.40 km^(2),respectively.The number of ecological sources in Gansu Province would increase to 80,with a total area of 99,927.18 km^(2).The number of ecological corridors would increase to 191,with an estimated total length of 6120.66 km.Both ecological sources and ecological corridors showed a sparse distribution in the northwest and dense distribution in the southeast of the province at the spatial scale.The number of ecological pinch points would reach 312 and the total area would expect to increase to 842.84 km^(2),with the most pronounced increase in the Longdong region.Compared with 2020,the number and area of ecological barriers in 2050 would decrease significantly by 63 and 370.71 km^(2),respectively.In general,based on the prediction results,the connectivity of ecological network of Gansu Province would increase in 2050.To achieve the predicted ecological network in 2050,emphasis should be placed on the protection of cultivated land and ecological land,the establishment of ecological sources in desert areas,the reinforcement of the protection for existing ecological sources,and the construction of ecological corridors to enhance the stability of ecological network.This study provides valuable theoretical support and references for the future construction of ecological networks and regional land resource management decision-making.
基金funded by a Grant-in-Aid for Scientific Research(B)(Japan Society for The Promotion of Science,21H02849)Grant-in-Aid for Scientific Research(C)(Japan Society for The Promotion of Science,23K07013)+2 种基金Grant-in-Aid for Transformative Research Areas(A)(Japan Society for The Promotion of Science,JP21H05173)Grant-in-Aid by the Smoking Research FoundationGrant-in-Aid by the Telecommunications Advancement Foundation.
文摘Background Ongoing debates question the harm of internet use with the evolving technology,as many individuals transition from regular to problematic internet use(PIU).The habenula(Hb),located between the thalamus and the third ventricle,is implicated in various psychiatric disorders.In addition,personality features have been suggested to play a role in the pathophysiology of PIU.Aims This study aimed to investigate Hb volumetry in individuals with subclinical PIU and the mediating effect of personality traits on this relationship.Methods 110 healthy adults in this cross-sectional study underwent structural magnetic resonance imaging.Hb segmentation was performed using a deep learning technique.The Internet Addiction Test(IAT)and the NEO Five-Factor Inventory were used to assess the PIU level and personality,respectively.Partial Spearman's correlation analyses were performed to explore the reiationships between Hb volumetry,IAT and NEO.Multiple regression analysis was applied to identify personality traits that predict IAT scores.The significant trait was then treated as a mediator between Hb volume and IAT correlation in mediation analysis with a bootstrap value of 5000.Results Relative Hb volume was negatively correlated with IAT scores(partial rho=-0.142,p=0.009).The IAT score was positively correlated with neuroticism(partial rho=0.430,p<0.001)and negatively correlated with extraversion,agreeableness and conscientiousness(partial rho=-0.213,p<0.001;partial rho=-0.279,p<0.001;and partial rho=-0.327,p<0.001).There was a significant indirect effect of Hb volume on this model(β=-0.061,p=0.048,boot 95%confidence interval:-0.149 to-0.001).Conclusions This study uncovered a crucial link between reduced Hb volume and heightened PIU.Our findings highlight neuroticism as a key risk factor for developing PIU.Moreover,neuroticism was shown to mediate the relationship between Hb volume and PIU tendency,offering valuable insight into the complexities of this interaction.
基金supported by General Education Project of the National Social Science Foundation in 2020:“Multi-Dimensional Reconstruction of Peer Review Mechanisms in the Evaluation of Scientific and Technological Talents in Universities(BIA200167).”。
文摘Background:Resilience is crucial for medical college students to thrive in the highly stressful environment of medical education.However,the prevalence of problematic internet use(PIU)in this population may negatively impact their resilience.This study investigated the influence of problematic online gaming(PG)and problematic social media use(PSMU)on the resilience of medical college students in China.Methods:A sample of 5075 first-year medical college students from four Chinese universities was studied.PG served as the independent variable,resilience as the dependent variable,fatigue as the mediator,and PSMU as the moderator.Structural equation modeling was conducted using LISREL 8.80.Additionally,a moderated mediation model was evaluated using the jAMM module in jamovi 2.6.13.Results:The study’s findings revealed significant negative correlations between resilience and the variables of PG,PSMU,and fatigue.Fatigue mediated the relationship between PG and resilience(B=−0.04,95%CI=[−0.05,−0.03]).PSMU moderated the direct relationship between PG and resilience with the interaction term PG×PSMU significant(B=−0.004,t=−6.501,p<0.001)and the first stage(PG→fatigue)of the mediation with PG×PSMU significant(B=0.055,t=8.351,p<0.001).The detrimental effects of PG on resilience were more pronounced among individuals with lower levels of PSMU.Conclusion:This study concluded that addressing PIU,particularly PG,is essential for fostering resilience in medical college students.While PSMU itself is maladaptive,the underlying social media engagement may serve a protective role through social support in mitigating the adverse effects of PG on resilience.
基金supported by the National Natural Science Foundation of China(52479049 and 51909221)the National Key R&D Program of China(2021YFD1900700)+1 种基金the Key R&D Program of Shaanxi Province,China(2024NC-ZDCYL-02-08)the Key Laboratory of Crop Water Use and Regulation,Ministry of Agriculture and Rural Affairs,China(IFI-CWUR202402).
文摘Ridge-furrow film mulching has been widely used as a water-saving and yield-increasing planting pattern in arid and semiarid regions.Planting density is also a vitally important factor influencing crop yield,and the optimal planting density will vary in different environments(such as ridge-furrow film mulching).How the combination of film mulching and planting density will affect the growth,physiology,yield,and water and radiation use efficiencies of winter oilseed rape is not clear yet.Therefore,a three-year field experiment was conducted from 2017 to 2020 to explore the responses of leaf chlorophyll(Chl)content,net photosynthetic rate(P_(n)),leaf area index(LAI),aboveground dry matter(ADM),root growth and distribution,yield,evapotranspiration(ET),water use efficiency(WUE),and radiation use efficiency(RUE)of winter oilseed rape to different film mulching patterns(F,ridge-furrow planting with plastic film mulching over the ridges;N,flat planting without mulching)and planting densities(LD,100,000 plants ha^(-1);MD,150,000 plants ha^(-1);HD,200,000 plants ha^(-1)).The results showed that the F treatments led to significantly greater leaf Chl contents,P_(n),LAI,and ADM,and a stronger root system than treatments without film mulching throughout the whole winter rapeseed growing seasons.Winter oilseed rape in the MD treatments had better physiological(leaf Chl contents and P_(n))and growth(LAI,ADM,taproot,and lateral root)conditions than in LD and HD at the late growth period after stem-elongation.Grain yield in FMD was the greatest,and it was significantly greater by 34.8-46.0%,6.7-9.6%,87.8-108.3%,38.7-50.3%,and 50.2-61.8%compared to those of FLD,FHD,NLD,NMD,and NHD,respectively.Furthermore,the ET in FMD was equivalent to FLD and FHD,but was markedly lower by 12.2-18.4%,14.5-20.3%,and 14.6-20.4%than in NLD,NMD,and NHD.Finally,the WUE and RUE in FMD were significantly improved by 88.5-94.0%and 29.0-41.8%compared to NHD(the local conventional planting pattern and planting density for winter rapeseed).In summary,FMD is a favorable cultivation management strategy to save water,increase yield and improve resource utilization efficiencies in winter oilseed rape in Northwest China.
文摘I applaud Adekeye AP and the journal for publishing‘Smoking of Carica papaya in Nigeria:The rationale,the public health effects and policies for intervention’.It is important to draw attention to newly recognised uses of substances which might alter perception,mood,and/or behaviour.
文摘Jaipur,India,is experiencing rapid urbanization that is significantly altering its land use and land cover(LULC)patterns,presenting both challenges and opportunities for sustainable development and socio-economic advancement.This study utilizes advanced geospatial and remote sensing technologies to assess these changes and project future scenarios.Specifically,satellite data were processed using Google Earth Engine,land cover was accurately classified using the Random Forest algorithm,and future projections were modeled through QGIS-MOLUSCE using a polynomial-based Cellular Automata–Artificial Neural Network(CA-ANN)approach.Analysis of Landsat imagery for the years 2000 and 2020 reveals a dramatic 188.59%increase in urban built-up areas and a 145.44%rise in vegetation cover,largely due to successful afforestation efforts.Meanwhile,barren land declined by 47.37%,and water bodies exhibited fluctuating trends,reflecting the intricate interplay between urban development and climatic variability.Looking ahead to 2045,model projections estimate that built-up areas will expand to approximately 1303.08 square kilometres,potentially threatening the integrity of vital green spaces and aquatic ecosystems.These findings highlight the urgent need for integrated policy interventions aimed at mitigating environmental risks such as urban heat island effects and biodiversity loss.By providing a detailed account of past and present LULC dynamics,this research delivers actionable,data-driven insights to support sustainable urban planning.Moreover,the integration of urban growth models with climate resilience strategies offers a replicable framework for managing urban expansion in other rapidly developing cities,particularly those situated in semi-arid regions.
基金funded by the National Research Foundation of South Africa,Dimensions of Biodiversity Program(Grant no.136381).
文摘Adaptation to different environments can lead to local adaptations that facilitate morphological divergence between closely related taxa,potentially leading to speciation.Quantifying habitat variation can thus provide valuable insights into evolutionary processes.Arboreal dwarf chameleons of the genus Bradypodion exhibit 3 distinct ecomorphological forms:forest,shrub,and“little brown chameleons”(LBCs).It is assumed these ecomorphs are the result of convergence among species that are in similar habitats regardless of ancestry,or in some cases,morphological conservatism and retention of an ancestral form that is adapted to a shared habitat type.If so,then the habitat of different ecomorphs would differ in vegetation structure.Our results show that vegetation structure in fynbos/grassy habitats is characterized by significantly narrower perches than shrubby habitats,but both have a largely vertical perch orientation.In contrast,forests have significantly fewer vertical perches than fynbos/grassy habitats with significantly thicker diameter perches.Accordingly,LBC and shrub species used more vertically oriented perches than forest species,suggesting that perch use corresponds with the most widely available perch angles.Although LBC chameleons used the smallest diameter perches,when corrected for body size,there was no difference in perch diameter among ecomorphs.These results suggest that the body size of LBC chameleons is constrained by the prevalence of small-diameter perches in their habitat.Species in habitats with wider perches attain larger body size.These findings support the notion that variation in perch structure is critical for phenotypic convergence that has resulted in the 3 Bradypodion ecomorphs.
基金supported by Supported by National Key Laboratory of Cotton Bio-breeding and Integrated Utilization(CB2023C07)Xinjiang Autonomous Region"Three Agricultural"Backbone Talent Training Program(2022SNGGNT024)Xinjiang Huyanghe City Science and Technology Program(2023C08).
文摘Nitrogen(N)and phosphorus(P)are mineral nutrients essential for plant growth and development,playing a crucial role throughout the plant life cycle.Cotton,a globally significant textile crop,has a particularly high demand for N fertilizer across its developmental stages.This review explores the effects of adequate or deficient N and P levels on cotton growth phases,focusing on their influence on physiological processes and molecular mechanisms.Key topics include the regulation of N-and P-related enzymes,hormones,and genes,as well as the complex interplay of N-and P-related signaling pathways from the aspects of N-P signaling integration to regulate root development,N-P signaling integration to regulate nutrient uptake,and regulation of N-P interactions—a frontier in current research.Strategies for improving N and P use efficiency are also discussed,including developing high-efficiency cotton cultivars and identifying functional genes to enhance productivity.Generally speaking,we take model plants as a reference in the hope of coming up with new strategies for the efficient utilization of N and P in cotton.
