BACKGROUND Dry eye disease(DED)is a multifactorial ocular surface disorder with rising prevalence.It is closely related to systemic health and psychological factors,such as sleep and mood disorders,which significantly...BACKGROUND Dry eye disease(DED)is a multifactorial ocular surface disorder with rising prevalence.It is closely related to systemic health and psychological factors,such as sleep and mood disorders,which significantly impact the quality of life of patients.AIM To explore the correlations between ocular surface function,sleep quality,and anxiety/depression in patients with DED.METHODS This was a cross-sectional investigative study that included 358 patients with DED between January 2022 and January 2025.Ocular surface was assessed using the ocular surface disease index(OSDI),tear film break-up time,fluorescein staining score,and Schirmer I test.The Pittsburgh Sleep Quality Index(PSQI),Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used to evaluate sleep quality and anxiety/depression levels.Correlation and linear regression analyses were used to explore the relationships.RESULTS The mean PSQI score of the patients was 9.94±2.18;the mean SAS score was 47.30±4.90,and the mean SDS score was 50.08±5.52.These suggested a prevalence of sleep and psychological abnormalities.There was a significant correlation between the indicators of ocular surface function(OSDI,tear film break-up time,fluorescein staining,and Schirmer I test)and PSQI,SAS,and SDS scores(P<0.05).Moreover,multiple regression revealed that age≥50 years(β=1.55,P=0.029),PSQI scores(β=0.58,P<0.001),SAS scores(β=0.17,P=0.017),and SDS scores(β=0.15,P=0.019)were independent predictors of the OSDI scores.CONCLUSION Ocular surface function in patients with DED is closely related to sleep quality and anxiety/depression,emphasizing the need for holistic clinical management.展开更多
Objective:To explore the value of cyclosporin eye drops in treating dry eye after cataract surgery.Methods:A total of 150 patients with dry eye after cataract surgery were randomly divided into group A(n=50),group B(n...Objective:To explore the value of cyclosporin eye drops in treating dry eye after cataract surgery.Methods:A total of 150 patients with dry eye after cataract surgery were randomly divided into group A(n=50),group B(n=50),and group C(n=50).Artificial tears combined with cyclosporin eye drops were used in group A,artificial tears were used in group B,and no dry eye medication was used in group C.The clinical efficacy,ocular surface function and tear inflammatory factor level before and after surgery were compared between the groups.Results:The total effective rate of group A was 96.00%,which was significantly higher than that of group B and group C(p<.05);three months after surgery,the levels of cornealfluorescein staining score(FL score),tear meniscus height(TMH)and tear inflammatory factors[interleukin 6(IL-6),interleukin 8(IL-8),tumor necrosis factorα(TNF-α)]in group A were lower than those in group B,and those indicators in group B were lower than those in group C,and the difference between the two groups was statistically significant(p<.05);three months after surgery,Schirmer test(SIT)and break-up time(BUT)in group A were higher than those in group B,and those indicators in group B were higher than those in group C,and the difference between the two groups was statistically significant(p<.05).Conclusions:The effect of cyclosporin eye drops in treating dry eye after cataract surgery is satisfactory,significantly improving the ocular surface function and reducing the level of tear inflammatory factors,which is worthy of promotion.展开更多
文摘BACKGROUND Dry eye disease(DED)is a multifactorial ocular surface disorder with rising prevalence.It is closely related to systemic health and psychological factors,such as sleep and mood disorders,which significantly impact the quality of life of patients.AIM To explore the correlations between ocular surface function,sleep quality,and anxiety/depression in patients with DED.METHODS This was a cross-sectional investigative study that included 358 patients with DED between January 2022 and January 2025.Ocular surface was assessed using the ocular surface disease index(OSDI),tear film break-up time,fluorescein staining score,and Schirmer I test.The Pittsburgh Sleep Quality Index(PSQI),Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used to evaluate sleep quality and anxiety/depression levels.Correlation and linear regression analyses were used to explore the relationships.RESULTS The mean PSQI score of the patients was 9.94±2.18;the mean SAS score was 47.30±4.90,and the mean SDS score was 50.08±5.52.These suggested a prevalence of sleep and psychological abnormalities.There was a significant correlation between the indicators of ocular surface function(OSDI,tear film break-up time,fluorescein staining,and Schirmer I test)and PSQI,SAS,and SDS scores(P<0.05).Moreover,multiple regression revealed that age≥50 years(β=1.55,P=0.029),PSQI scores(β=0.58,P<0.001),SAS scores(β=0.17,P=0.017),and SDS scores(β=0.15,P=0.019)were independent predictors of the OSDI scores.CONCLUSION Ocular surface function in patients with DED is closely related to sleep quality and anxiety/depression,emphasizing the need for holistic clinical management.
文摘Objective:To explore the value of cyclosporin eye drops in treating dry eye after cataract surgery.Methods:A total of 150 patients with dry eye after cataract surgery were randomly divided into group A(n=50),group B(n=50),and group C(n=50).Artificial tears combined with cyclosporin eye drops were used in group A,artificial tears were used in group B,and no dry eye medication was used in group C.The clinical efficacy,ocular surface function and tear inflammatory factor level before and after surgery were compared between the groups.Results:The total effective rate of group A was 96.00%,which was significantly higher than that of group B and group C(p<.05);three months after surgery,the levels of cornealfluorescein staining score(FL score),tear meniscus height(TMH)and tear inflammatory factors[interleukin 6(IL-6),interleukin 8(IL-8),tumor necrosis factorα(TNF-α)]in group A were lower than those in group B,and those indicators in group B were lower than those in group C,and the difference between the two groups was statistically significant(p<.05);three months after surgery,Schirmer test(SIT)and break-up time(BUT)in group A were higher than those in group B,and those indicators in group B were higher than those in group C,and the difference between the two groups was statistically significant(p<.05).Conclusions:The effect of cyclosporin eye drops in treating dry eye after cataract surgery is satisfactory,significantly improving the ocular surface function and reducing the level of tear inflammatory factors,which is worthy of promotion.
