Introduction:To investigate an occupational trichloromethane-induced hepatotoxicity incident at a Shenzhen printing enterprise,identify its root causes,evaluate intervention effectiveness,and provide evidence for occu...Introduction:To investigate an occupational trichloromethane-induced hepatotoxicity incident at a Shenzhen printing enterprise,identify its root causes,evaluate intervention effectiveness,and provide evidence for occupational health regulation and corporate solvent management.Methods:Routine occupational health examinations in October 2024 identified 34 workers with elevated alanine aminotransferase(ALT)levels.This finding,combined with four hospital-reported cases of abnormal liver function,triggered a comprehensive multisectoral investigation.Thirty-nine solvents and nine air samples were collected for gas chromatography-mass spectrometry(GC-MS)analysis.A case-control study was conducted(18 cases vs.49 job-matched controls),and multisectoral coordination was implemented throughout the response.Results:Forty-three cases of occupational liver injury were confirmed(83.7%asymptomatic;10 requiring medical intervention).Both“eco-friendly adhesive-tape cleaner”(57.65%trichloromethane)and“adhesivetape cleaning restorer”(66.59%trichloromethane)exceeded the 20%concentration limit mandated by GB 38508-2020.The peak airborne trichloromethane concentration in the printing workshop reached 110.3 mg/m^(3)(5.5-fold above the GBZ 2.1-2019 occupational exposure limit).Solvent exposure was the primary risk factor[cleaner:odds ratio(OR)=32,95%confidence interval(CI):13.89–73.46;restorer:OR=23,95%CI:18.23–56.93].No new cases emerged following intervention implementation.Conclusion:The incident originated from the enterprise’s solvent reformulation to meet environmental standards without addressing occupational health risks.Occupational health examinations and multisectoral coordination were pivotal for containment.We recommend:1)including trichloromethane in priority volatile organic compound(VOC)control lists;2)strengthening corporate solvent verification;3)enforcing ventilation management.展开更多
ObjectiveToinvestigatethe interactionof workplace noise,body mass index(BMI)and systemic inflammatory response on hypertension.Methods In January 2019,1124 male workers from an automobile factory in Wuhan were selecte...ObjectiveToinvestigatethe interactionof workplace noise,body mass index(BMI)and systemic inflammatory response on hypertension.Methods In January 2019,1124 male workers from an automobile factory in Wuhan were selected by cluster random sampling method.The study population was divided into normal body weight group(BMI<24 kg/m^(2))and overweight group(BMI≥24 kg/m^(2))according to BMI,and were followed up for 3 years.The occupational health examination of the workers was carried out every year,blood routine and blood biochemical indexes were collected,and the information of the workers'age,BMI,type of work and age of exposure to injury were collected through field questionnaires.The noise intensity of the workplace of theenterpriseewas measured for 3 consecutive years,and the equivalent sound level was calculated according to the working time.Normal and skewness measurements were described by Mean±SD and[M(Q_(1),Q_(3))],respectively.t-test or Wilcoxon rank sumtestwasusedfor inter-group comparisons.Categorical variables were expressed by frequency and percentage(%),and Chi-square test was used for intergroup comparisons.Mixed effects models and generalized estimationequations were fitted toanalyzethe relationshipbetween occupational noise,systemic inflammation,and their interactionterms with blood pressure and hypertensionrisk.Results Univariate analysis revealed that the white blood cell counts,neutrophil counts,lymphocyte counts and eosinophil counts were positively associated with systolic blood pressure and diastolic blood pressure in overweight group(n=467),respectively(P<0.05).The participants with white blood cell counts≥5.94×10^(9)/L,neutrophil counts≥3.31×10^(9)/L,lymphocyte counts≥2.03×10^(9)/L,and eosinophil counts≥0.12×10^(9)/L had increased risk of hypertension by 52%(RR=1.52,95%CI:1.11-2.05),37%(RR=1.37,95%CI:1.01-1.83),58%(RR=1.58,95%CI:1.18-2.09),and 52%(RR=1.52,95%CI:1.12-2.06),respectively(all P<0.05).Multivariate analysis found a positive association between BMI and the risk of hypertension in the overweight group(P<0.05),the participants with lymphocyte counts≥2.03×10^(9)/L and eosinophil counts≥0.12×10^(9)/L had increased risk of hypertension by 39%(RR=1.39,95%CI:1.01-1.89)and 46%(RR=1.46,95%CI:1.06-1.98),respectively(all P<0.05).There was no correlation between BMI and the risk of hypertension in normal weight group(P>0.05).The multiplicative interaction of occupational noise(≥80 dB)with white blood cell counts(≥5.94×10^(9)/L)and lymphocyte counts(≥2.03×10^(9)/L)increased the risk of hypertension by 100%(RR=2.00,95%CI:1.06-3.55)and 89%(RR=1.89,95%CI:1.01-3.32)(all P<0.05)in overweight group,respectively.Additionally,a significant additive interaction was observed between noise exposure(≥80 dB)and basophil counts(≥0.03×10^(9)/L)on hypertension risk in the overweight group(RERI=0.49,95%CI:0.02-0.96,P<0.05).Conclusion The combined exposure of occupational noise and systemic inflammation may increase the risk of hypertension in overweight workers in automobile manufacturing plants,and the two have additive and multiplicative interactions.展开更多
基金Supported by the National Natural Science Foundation of China(grant number 32000137).
文摘Introduction:To investigate an occupational trichloromethane-induced hepatotoxicity incident at a Shenzhen printing enterprise,identify its root causes,evaluate intervention effectiveness,and provide evidence for occupational health regulation and corporate solvent management.Methods:Routine occupational health examinations in October 2024 identified 34 workers with elevated alanine aminotransferase(ALT)levels.This finding,combined with four hospital-reported cases of abnormal liver function,triggered a comprehensive multisectoral investigation.Thirty-nine solvents and nine air samples were collected for gas chromatography-mass spectrometry(GC-MS)analysis.A case-control study was conducted(18 cases vs.49 job-matched controls),and multisectoral coordination was implemented throughout the response.Results:Forty-three cases of occupational liver injury were confirmed(83.7%asymptomatic;10 requiring medical intervention).Both“eco-friendly adhesive-tape cleaner”(57.65%trichloromethane)and“adhesivetape cleaning restorer”(66.59%trichloromethane)exceeded the 20%concentration limit mandated by GB 38508-2020.The peak airborne trichloromethane concentration in the printing workshop reached 110.3 mg/m^(3)(5.5-fold above the GBZ 2.1-2019 occupational exposure limit).Solvent exposure was the primary risk factor[cleaner:odds ratio(OR)=32,95%confidence interval(CI):13.89–73.46;restorer:OR=23,95%CI:18.23–56.93].No new cases emerged following intervention implementation.Conclusion:The incident originated from the enterprise’s solvent reformulation to meet environmental standards without addressing occupational health risks.Occupational health examinations and multisectoral coordination were pivotal for containment.We recommend:1)including trichloromethane in priority volatile organic compound(VOC)control lists;2)strengthening corporate solvent verification;3)enforcing ventilation management.
文摘ObjectiveToinvestigatethe interactionof workplace noise,body mass index(BMI)and systemic inflammatory response on hypertension.Methods In January 2019,1124 male workers from an automobile factory in Wuhan were selected by cluster random sampling method.The study population was divided into normal body weight group(BMI<24 kg/m^(2))and overweight group(BMI≥24 kg/m^(2))according to BMI,and were followed up for 3 years.The occupational health examination of the workers was carried out every year,blood routine and blood biochemical indexes were collected,and the information of the workers'age,BMI,type of work and age of exposure to injury were collected through field questionnaires.The noise intensity of the workplace of theenterpriseewas measured for 3 consecutive years,and the equivalent sound level was calculated according to the working time.Normal and skewness measurements were described by Mean±SD and[M(Q_(1),Q_(3))],respectively.t-test or Wilcoxon rank sumtestwasusedfor inter-group comparisons.Categorical variables were expressed by frequency and percentage(%),and Chi-square test was used for intergroup comparisons.Mixed effects models and generalized estimationequations were fitted toanalyzethe relationshipbetween occupational noise,systemic inflammation,and their interactionterms with blood pressure and hypertensionrisk.Results Univariate analysis revealed that the white blood cell counts,neutrophil counts,lymphocyte counts and eosinophil counts were positively associated with systolic blood pressure and diastolic blood pressure in overweight group(n=467),respectively(P<0.05).The participants with white blood cell counts≥5.94×10^(9)/L,neutrophil counts≥3.31×10^(9)/L,lymphocyte counts≥2.03×10^(9)/L,and eosinophil counts≥0.12×10^(9)/L had increased risk of hypertension by 52%(RR=1.52,95%CI:1.11-2.05),37%(RR=1.37,95%CI:1.01-1.83),58%(RR=1.58,95%CI:1.18-2.09),and 52%(RR=1.52,95%CI:1.12-2.06),respectively(all P<0.05).Multivariate analysis found a positive association between BMI and the risk of hypertension in the overweight group(P<0.05),the participants with lymphocyte counts≥2.03×10^(9)/L and eosinophil counts≥0.12×10^(9)/L had increased risk of hypertension by 39%(RR=1.39,95%CI:1.01-1.89)and 46%(RR=1.46,95%CI:1.06-1.98),respectively(all P<0.05).There was no correlation between BMI and the risk of hypertension in normal weight group(P>0.05).The multiplicative interaction of occupational noise(≥80 dB)with white blood cell counts(≥5.94×10^(9)/L)and lymphocyte counts(≥2.03×10^(9)/L)increased the risk of hypertension by 100%(RR=2.00,95%CI:1.06-3.55)and 89%(RR=1.89,95%CI:1.01-3.32)(all P<0.05)in overweight group,respectively.Additionally,a significant additive interaction was observed between noise exposure(≥80 dB)and basophil counts(≥0.03×10^(9)/L)on hypertension risk in the overweight group(RERI=0.49,95%CI:0.02-0.96,P<0.05).Conclusion The combined exposure of occupational noise and systemic inflammation may increase the risk of hypertension in overweight workers in automobile manufacturing plants,and the two have additive and multiplicative interactions.
