Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
A supported Mn-porphyrin catalyst was prepared by adsorption of Mn-porphyrin on active carbon, and found to be efficient for the hydroxylation of hexane with hydrogen peroxide.
Life expectancy of the elderly is a significant problem in China, and it changes not only the health care, but also the pension. This study used tracking data from the Chinese Urban and Rural Elderly Population Survey...Life expectancy of the elderly is a significant problem in China, and it changes not only the health care, but also the pension. This study used tracking data from the Chinese Urban and Rural Elderly Population Survey to calculate the age-specific Active Life Expectancy (ALE) of the Chinese elderly population aged 60 years and over. For analysis, this population was divided into different sub-populations according to gender, census register and region. The main conclusions of our study are as follows: 1) The quality of life for elderly males may be greater than that for elderly females;2) There were significant differences in Active Life Expectancy (ALE) and Inactive Life Expectancy (ILE) between urban and rural elderly;3) The differences in ALE between the eastern, central and western regions of China were not significant;and 4) The increased remaining life expectancy of the elderly was mainly attributed to the extended ALE in the lower age group and the expanded ILE in the higher age group. This study expands the knowledge of Chinese elderly’s life expectancy in different health status.展开更多
Today, most people know that physical activity(PA) is beneficial for their health ^(1,2)and aspire to engage in regular PA.^(3,4)However, despite their awareness of the importance of PA, it is evident that the transit...Today, most people know that physical activity(PA) is beneficial for their health ^(1,2)and aspire to engage in regular PA.^(3,4)However, despite their awareness of the importance of PA, it is evident that the transition from intention to action is challenging-a situation that has important public health implications. According to the World Health Organization,^(5)1 person dies every 6 s worldwide from causes related to physical inactivity, which underscores the urgency of addressing this situation.展开更多
BACKGROUND This report describes a rare case of a small gastric cancer lesion with widespread bone metastases and markedly elevated alkaline phosphatase levels that was initially misdiagnosed as rheumatoid arthritis,a...BACKGROUND This report describes a rare case of a small gastric cancer lesion with widespread bone metastases and markedly elevated alkaline phosphatase levels that was initially misdiagnosed as rheumatoid arthritis,as the patient’s sole clinical manifestation was chronic bone pain persisting for 1 year.CASE SUMMARY An 83-year-old man was admitted due to worsening generalized joint pain over 1 year.Serum alkaline phosphatase levels were markedly elevated,and technetium-99m methylene diphosphonate single-photon emission computed tomography(CT)and fluorine-18 sodium fluoride positron emission tomography(PET)/CT images showed symmetrical diffuse uptake of the radiotracers throughout the skeleton.Initially,Paget’s disease was suspected,but abnormal hematologic tumor markers and bone biopsy confirmed metastatic adenocarcinoma.Fluorine-18-fluorodeoxyglucose PET/CT did not reveal a primary tumor.The patient had a history of colon polypectomy and tubulovillous adenoma with atypical hy-perplasia on pathological examination 10 years prior.Further investigation using gallium-68-labeled fibroblast-activation protein inhibitor PET/CT images showed increased punctate uptake in the gastric antrum.Gastroscopy demonstrated a 1.0 cm ulcerated mass in the prepyloric region,and histopathological evaluation of the biopsy specimen revealed poorly differentiated adenocarcinoma.The incidence of bone metastases from gastric cancer is very low,especially with such extensive involvement.CONCLUSION Occult gastric carcinomas with bone metastases necessitate proactive high-risk surveillance and multidisciplinary integration to improve diagnostic accuracy and clinical outcomes.展开更多
Background:The social environment might play an important role in explaining people’s physical activity(PA)behavior.However,little is known regarding whether personal networks differ between physically active and phy...Background:The social environment might play an important role in explaining people’s physical activity(PA)behavior.However,little is known regarding whether personal networks differ between physically active and physically inactive people.This study aimed to examine the relationship between personal network characteristics and adults’physical(in)activity.Methods:An egocentric social network study was conducted in a random sample in Switzerland(n=529,mean age of 53 years,54%females).Individual and personal network measures were compared between regular exercisers and non-exercisers.The extent of these factors’association with PA levels was also examined.Results:Non-exercisers(n=183)had 70%non-exercising individuals in their personal networks,indicating homogeneity,whereas regular exercisers(n=346)had 57%regularly exercising individuals in their networks,meaning more heterogeneous personal networks.Additionally,having more regular exercisers in personal networks was associated with higher PA levels,over and above individual factors.Respondents with an entirely active personal network reported,on average,1 day of PA more per week than respondents who had a completely inactive personal network.Other personal network characteristics,such as network size or gender composition,were not associated with PA.Conclusion:Non-exercisers seem to be clustered in inactive networks that provide fewer opportunities and resources,as well as less social support,for PA.To effectively promote PA,both individuals and personal networks need to be addressed,particularly the networks of inactive people(e.g.,by promoting group activities).展开更多
Non-atrophic active chronic gastritis (ACG) is characterized by the presence of H. pylori in the gastric epithelium, known to be one of the first steps that precede progression to gastric adenocarcinoma. Inactive chro...Non-atrophic active chronic gastritis (ACG) is characterized by the presence of H. pylori in the gastric epithelium, known to be one of the first steps that precede progression to gastric adenocarcinoma. Inactive chronic gastritis (ICG) suggests that the patient has H. pylori gastritis, but this diagnosis is rarely made in routine histopathology. Clinical manifestations associated with H. pylori infection are potentially due to differences in virulence between strains;however, it is unclear if the progression of ACG to ICG depends on the H. pylori strain. The aim of this study was to compare the prevalence of the virulence factors of H. pylori found in patients with ACG and ICG, and its influence on the development of ICG. A significant association was observed between H. pylori detection by histological examination and the activity of gastritis (p 1 year) was reported by 28.6% of the ACG group and 42.5% of the ICG, while no evidence of association between long-term use of PPI and decreased inflammation was found in the patients studied. The genes cagA, cagE and virB11 were statistically associated with ACG (p = 0.01, p vacAs1 allele groups, ACG was associated with the most virulent group (p = 0.0015), while ICG was associated with the less virulent group (p < 0.001). The rate of co-infection was significantly higher in ICG than in ACG cases (p = 0.02). In conclusion, this study points to the role of virulent strains of H. pylori in the non-resolution of gastritis.展开更多
Objective: To assess the patterns and intensities of physical activity among pregnant women in southwestern China, which help us create a fitness regimen based on the 2002 American College of Obstetricians and Gynecol...Objective: To assess the patterns and intensities of physical activity among pregnant women in southwestern China, which help us create a fitness regimen based on the 2002 American College of Obstetricians and Gynecologists (ACOG) guidelines for exercise during pregnancy. Methods: A cross-sectional study was performed to recruit pregnant women at a prenatal checking visit clinic with the self-administered Chinese version of Pregnancy Physical Activity Questionnaire (PPAQ). Results: A total of 1179 Chinese pregnant women were enrolled, of whom 92.60% were classified as not meeting the ACOG guidelines. By intensity, 47.36% of the score was attributed to light-intensity activities (1.5 to <3.0 metabolic equivalent [MET]) in the first trimester;the other 2 trimesters were similar. By patterns, about 45.15% of the score was attributed to inactivity. More than 82.35% of enrolled pregnant women regarded slowly walking as the most common type of exercise during pregnancy. Conclusions: This study represents a group of Chinese women who maintained an inactive lifestyle, including low-intensity activities and unitary type of exercises during their pregnancy. Health-care providers are advised to provide appropriate physical activity guidelines to pregnant women. Development of MET-hours/week recommendations is warranted to promote greater physical activity during pregnancy.展开更多
Physical activity represents a fundamental pillar of healthy living and serves as a critical determinant of population health outcomes.The World Health Organization(WHO)identifies physical inactivity as the fourth lea...Physical activity represents a fundamental pillar of healthy living and serves as a critical determinant of population health outcomes.The World Health Organization(WHO)identifies physical inactivity as the fourth leading risk factor for global mortality,accounting for approximately 3.2 million deaths annually(1).Recognizing this significant public health challenge,nations worldwide have implemented comprehensive strategies to promote physical fitness among their populations.China formally established“National Fitness Day”in 2009,designating August 8 as an annual nationwide initiative dedicated to encouraging physical activity participation.This landmark decision not only commemorates the legacy of the 2008 Beijing Olympics but also signifies a strategic shift from prioritizing elite athletic performance toward fostering widespread community engagement in sports and fitness activities.展开更多
Hepatitis B virus(HBV)reactivation(HBVr)in patients undergoing immunosuppressive therapy is still a hot topic worldwide.Its prevention and management still represents a challenge for specialists dealing with immunosup...Hepatitis B virus(HBV)reactivation(HBVr)in patients undergoing immunosuppressive therapy is still a hot topic worldwide.Its prevention and management still represents a challenge for specialists dealing with immunosuppressed patients.Aim of this paper is to provide a critical review of the relevant information emerged in the recent literature regarding HBV reactivation following immunosuppressive treatments for oncohematological tumors.A computerized literature search in MEDLINE was performed using appropriate terms arrangement,including English-written literature only or additional relevant articles.Articles published only in abstract form and case reports not giving considerable news were excluded.Clinical manifestation of HBVr can be manifold,ranging from asymptomatic self-limiting anicteric hepatitis to life-threatening fulminant liver failure.In clusters of patients adverse outcomes are potentially predictable.Clinicians should be aware of the inherent risk of HBVr among the different virological categories(active carriers,occult HBV carriers and inactive carriers,the most intriguing category),and classes of immunosuppressive drugs.We recommend that patients undergoing immunosuppressive treatments for hematological malignancies should undergo HBV screening.In case of serological sign(s)of current or past infection with the virus,appropriate therapeutic or preventive strategies are suggested,according to both virological categories,risk of HBVr by immunosuppressive drugsand liver status.Either antiviral drug management and surveillance and pre-emptive approach are examined,commenting the current international recommendations about this debated issue.展开更多
基于1959～2013年的观测和再分析资料以及10.7 cm （2800MHz）太阳射电通量资料,本文分析了太阳活动变化与东亚冬季气候的相关关系,分析结果表明：太阳活动变化与东亚冬季大气环流有较好的相关性,且在太阳活动的强、弱时期该相关关系存...基于1959～2013年的观测和再分析资料以及10.7 cm （2800MHz）太阳射电通量资料,本文分析了太阳活动变化与东亚冬季气候的相关关系,分析结果表明：太阳活动变化与东亚冬季大气环流有较好的相关性,且在太阳活动的强、弱时期该相关关系存在很大差异,在强太阳活动时期太阳活动变化与东亚冬季气候的联系更为显著,而在弱太阳活动时期二者之间的直接联系微弱,这表明太阳活动变化对东亚冬季气候的影响具有非对称性特征.在太阳活动较强的时期,随着太阳活动的增强,东亚中高纬对流层中层的大气环流倾向纬向型,东亚大槽减弱,850 hPa出现异常偏南风,地面上西伯利亚高压以及冬季风减弱,东亚大部分地区气温显著偏高;而在太阳活动较弱的时期,太阳活动的年际差异与东亚冬季大气环流之间几乎不存在显著联系.分析太阳活动较强和较弱时期纬向平均纬向风的差异发现,其间平流层行星波活动、热带西北太平洋海表温度的差异可能是造成这种非对称影响的重要原因.在强太阳活动时期,平流层行星波在太阳活动的异常增强年有异常的从极地向赤道的水平传播,高纬地区E-P通量（Eliassen-Palm flux）异常辐散,导致中高纬西风及北极涛动（AO）增强,同时热带西北太平洋海温异常偏冷,海陆热力差异缩小,大气环流经向度减弱,东亚冬季风偏弱.展开更多
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
文摘A supported Mn-porphyrin catalyst was prepared by adsorption of Mn-porphyrin on active carbon, and found to be efficient for the hydroxylation of hexane with hydrogen peroxide.
文摘Life expectancy of the elderly is a significant problem in China, and it changes not only the health care, but also the pension. This study used tracking data from the Chinese Urban and Rural Elderly Population Survey to calculate the age-specific Active Life Expectancy (ALE) of the Chinese elderly population aged 60 years and over. For analysis, this population was divided into different sub-populations according to gender, census register and region. The main conclusions of our study are as follows: 1) The quality of life for elderly males may be greater than that for elderly females;2) There were significant differences in Active Life Expectancy (ALE) and Inactive Life Expectancy (ILE) between urban and rural elderly;3) The differences in ALE between the eastern, central and western regions of China were not significant;and 4) The increased remaining life expectancy of the elderly was mainly attributed to the extended ALE in the lower age group and the expanded ILE in the higher age group. This study expands the knowledge of Chinese elderly’s life expectancy in different health status.
基金supported by The Shenzhen Educational Research Funding(zdzb2014)The Shenzhen Science and Technology Innovation Commission(202307313000096)+4 种基金The Social Science Foundation from the China's Ministry of Education(23YJA880093)The Post-Doctoral Fellowship(2022M711174)The National Center for Mental Health(Z014)BC is supported by the Chaires de recherche Rennes Métropole(23C 0909)SM is supported by the National Insti-tutes of Health(R01AG72445).
文摘Today, most people know that physical activity(PA) is beneficial for their health ^(1,2)and aspire to engage in regular PA.^(3,4)However, despite their awareness of the importance of PA, it is evident that the transition from intention to action is challenging-a situation that has important public health implications. According to the World Health Organization,^(5)1 person dies every 6 s worldwide from causes related to physical inactivity, which underscores the urgency of addressing this situation.
文摘BACKGROUND This report describes a rare case of a small gastric cancer lesion with widespread bone metastases and markedly elevated alkaline phosphatase levels that was initially misdiagnosed as rheumatoid arthritis,as the patient’s sole clinical manifestation was chronic bone pain persisting for 1 year.CASE SUMMARY An 83-year-old man was admitted due to worsening generalized joint pain over 1 year.Serum alkaline phosphatase levels were markedly elevated,and technetium-99m methylene diphosphonate single-photon emission computed tomography(CT)and fluorine-18 sodium fluoride positron emission tomography(PET)/CT images showed symmetrical diffuse uptake of the radiotracers throughout the skeleton.Initially,Paget’s disease was suspected,but abnormal hematologic tumor markers and bone biopsy confirmed metastatic adenocarcinoma.Fluorine-18-fluorodeoxyglucose PET/CT did not reveal a primary tumor.The patient had a history of colon polypectomy and tubulovillous adenoma with atypical hy-perplasia on pathological examination 10 years prior.Further investigation using gallium-68-labeled fibroblast-activation protein inhibitor PET/CT images showed increased punctate uptake in the gastric antrum.Gastroscopy demonstrated a 1.0 cm ulcerated mass in the prepyloric region,and histopathological evaluation of the biopsy specimen revealed poorly differentiated adenocarcinoma.The incidence of bone metastases from gastric cancer is very low,especially with such extensive involvement.CONCLUSION Occult gastric carcinomas with bone metastases necessitate proactive high-risk surveillance and multidisciplinary integration to improve diagnostic accuracy and clinical outcomes.
文摘Background:The social environment might play an important role in explaining people’s physical activity(PA)behavior.However,little is known regarding whether personal networks differ between physically active and physically inactive people.This study aimed to examine the relationship between personal network characteristics and adults’physical(in)activity.Methods:An egocentric social network study was conducted in a random sample in Switzerland(n=529,mean age of 53 years,54%females).Individual and personal network measures were compared between regular exercisers and non-exercisers.The extent of these factors’association with PA levels was also examined.Results:Non-exercisers(n=183)had 70%non-exercising individuals in their personal networks,indicating homogeneity,whereas regular exercisers(n=346)had 57%regularly exercising individuals in their networks,meaning more heterogeneous personal networks.Additionally,having more regular exercisers in personal networks was associated with higher PA levels,over and above individual factors.Respondents with an entirely active personal network reported,on average,1 day of PA more per week than respondents who had a completely inactive personal network.Other personal network characteristics,such as network size or gender composition,were not associated with PA.Conclusion:Non-exercisers seem to be clustered in inactive networks that provide fewer opportunities and resources,as well as less social support,for PA.To effectively promote PA,both individuals and personal networks need to be addressed,particularly the networks of inactive people(e.g.,by promoting group activities).
文摘Non-atrophic active chronic gastritis (ACG) is characterized by the presence of H. pylori in the gastric epithelium, known to be one of the first steps that precede progression to gastric adenocarcinoma. Inactive chronic gastritis (ICG) suggests that the patient has H. pylori gastritis, but this diagnosis is rarely made in routine histopathology. Clinical manifestations associated with H. pylori infection are potentially due to differences in virulence between strains;however, it is unclear if the progression of ACG to ICG depends on the H. pylori strain. The aim of this study was to compare the prevalence of the virulence factors of H. pylori found in patients with ACG and ICG, and its influence on the development of ICG. A significant association was observed between H. pylori detection by histological examination and the activity of gastritis (p 1 year) was reported by 28.6% of the ACG group and 42.5% of the ICG, while no evidence of association between long-term use of PPI and decreased inflammation was found in the patients studied. The genes cagA, cagE and virB11 were statistically associated with ACG (p = 0.01, p vacAs1 allele groups, ACG was associated with the most virulent group (p = 0.0015), while ICG was associated with the less virulent group (p < 0.001). The rate of co-infection was significantly higher in ICG than in ACG cases (p = 0.02). In conclusion, this study points to the role of virulent strains of H. pylori in the non-resolution of gastritis.
文摘Objective: To assess the patterns and intensities of physical activity among pregnant women in southwestern China, which help us create a fitness regimen based on the 2002 American College of Obstetricians and Gynecologists (ACOG) guidelines for exercise during pregnancy. Methods: A cross-sectional study was performed to recruit pregnant women at a prenatal checking visit clinic with the self-administered Chinese version of Pregnancy Physical Activity Questionnaire (PPAQ). Results: A total of 1179 Chinese pregnant women were enrolled, of whom 92.60% were classified as not meeting the ACOG guidelines. By intensity, 47.36% of the score was attributed to light-intensity activities (1.5 to <3.0 metabolic equivalent [MET]) in the first trimester;the other 2 trimesters were similar. By patterns, about 45.15% of the score was attributed to inactivity. More than 82.35% of enrolled pregnant women regarded slowly walking as the most common type of exercise during pregnancy. Conclusions: This study represents a group of Chinese women who maintained an inactive lifestyle, including low-intensity activities and unitary type of exercises during their pregnancy. Health-care providers are advised to provide appropriate physical activity guidelines to pregnant women. Development of MET-hours/week recommendations is warranted to promote greater physical activity during pregnancy.
文摘Physical activity represents a fundamental pillar of healthy living and serves as a critical determinant of population health outcomes.The World Health Organization(WHO)identifies physical inactivity as the fourth leading risk factor for global mortality,accounting for approximately 3.2 million deaths annually(1).Recognizing this significant public health challenge,nations worldwide have implemented comprehensive strategies to promote physical fitness among their populations.China formally established“National Fitness Day”in 2009,designating August 8 as an annual nationwide initiative dedicated to encouraging physical activity participation.This landmark decision not only commemorates the legacy of the 2008 Beijing Olympics but also signifies a strategic shift from prioritizing elite athletic performance toward fostering widespread community engagement in sports and fitness activities.
文摘Hepatitis B virus(HBV)reactivation(HBVr)in patients undergoing immunosuppressive therapy is still a hot topic worldwide.Its prevention and management still represents a challenge for specialists dealing with immunosuppressed patients.Aim of this paper is to provide a critical review of the relevant information emerged in the recent literature regarding HBV reactivation following immunosuppressive treatments for oncohematological tumors.A computerized literature search in MEDLINE was performed using appropriate terms arrangement,including English-written literature only or additional relevant articles.Articles published only in abstract form and case reports not giving considerable news were excluded.Clinical manifestation of HBVr can be manifold,ranging from asymptomatic self-limiting anicteric hepatitis to life-threatening fulminant liver failure.In clusters of patients adverse outcomes are potentially predictable.Clinicians should be aware of the inherent risk of HBVr among the different virological categories(active carriers,occult HBV carriers and inactive carriers,the most intriguing category),and classes of immunosuppressive drugs.We recommend that patients undergoing immunosuppressive treatments for hematological malignancies should undergo HBV screening.In case of serological sign(s)of current or past infection with the virus,appropriate therapeutic or preventive strategies are suggested,according to both virological categories,risk of HBVr by immunosuppressive drugsand liver status.Either antiviral drug management and surveillance and pre-emptive approach are examined,commenting the current international recommendations about this debated issue.
文摘基于1959～2013年的观测和再分析资料以及10.7 cm （2800MHz）太阳射电通量资料,本文分析了太阳活动变化与东亚冬季气候的相关关系,分析结果表明：太阳活动变化与东亚冬季大气环流有较好的相关性,且在太阳活动的强、弱时期该相关关系存在很大差异,在强太阳活动时期太阳活动变化与东亚冬季气候的联系更为显著,而在弱太阳活动时期二者之间的直接联系微弱,这表明太阳活动变化对东亚冬季气候的影响具有非对称性特征.在太阳活动较强的时期,随着太阳活动的增强,东亚中高纬对流层中层的大气环流倾向纬向型,东亚大槽减弱,850 hPa出现异常偏南风,地面上西伯利亚高压以及冬季风减弱,东亚大部分地区气温显著偏高;而在太阳活动较弱的时期,太阳活动的年际差异与东亚冬季大气环流之间几乎不存在显著联系.分析太阳活动较强和较弱时期纬向平均纬向风的差异发现,其间平流层行星波活动、热带西北太平洋海表温度的差异可能是造成这种非对称影响的重要原因.在强太阳活动时期,平流层行星波在太阳活动的异常增强年有异常的从极地向赤道的水平传播,高纬地区E-P通量（Eliassen-Palm flux）异常辐散,导致中高纬西风及北极涛动（AO）增强,同时热带西北太平洋海温异常偏冷,海陆热力差异缩小,大气环流经向度减弱,东亚冬季风偏弱.
