National and international research on regional development has matured from the use of single elements and indicators to the application of comprehensive multi-element and multi-indicator measures. We selected 12 ind...National and international research on regional development has matured from the use of single elements and indicators to the application of comprehensive multi-element and multi-indicator measures. We selected 12 indicators from six dimensions for analysis in this study, including income, consumption, education, population urbanization, traffic, and indoor living facilities. We then proposed the polyhedron method to comprehensively measure levels of regional multidimensional development. We also enhanced the polygon and vector sum methods to render them more suitable for studying the status of regional multidimensional development. Finally, we measured levels of regional multidimensional development at county, city, and provincial scales across China and analyzed spatial differences using the three methods above and the weighted sum method applied widely. The results of this study reveal the presence of remarkable regional differences at the county scale across China in terms of single and multidimensional levels of regional development. Analyses show that values of the regional multidimensional development index （RMDI） are high in eastern coastal areas, intermediate in the midlands and in northern border regions, and low in the southwest and in western border regions. Districts characterized by enhanced and the highest levels of this index are distributed in eastern coastal areas, including cities in central and western regions, as well as areas characterized by the development of energy and mineral resources. The regional distribution of reduced and the lowest levels of this index is consistent with concentrations of areas that have always been impoverished. Correlation analyses of the results generated by the four methods at provincial, city, and county scales show that all are equivalent in practical application and can be used to generate satisfactory measures for regional multidimensional development. Additiona~ correlation analyses between RMDI values calculated using the polyhedron method and per capita gross domestic product （GDP） demonstrate that the latter is not a meaningful proxy for the level of regional multidimensional development.展开更多
Purpose–As an important part of the management of railway passenger transport,the rationality and effectiveness of the clearing method of railway passenger transport are directly related to the operating efficiency a...Purpose–As an important part of the management of railway passenger transport,the rationality and effectiveness of the clearing method of railway passenger transport are directly related to the operating efficiency and service quality of railway passenger transport enterprises.This paper aims to comprehensively and deeply discuss the evolution and development process of China’s railway passenger transport clearing method,analyze its characteristics and influences in each stage,identify the main factors affecting its evolution and development and then put forward thoughts on improving the future development of the clearing method.Design/methodology/approach–Through a detailed review of the railway passenger transport clearing methods from the planned economy period to the reform and opening up period and into the new century,the basis,mode,subject and object of clearing in different development stages are systematically compared.Findings–It comprehensively reveals the evolution of the clearing method,sorted out the characteristics and changes of the clearing method at each stage and the adaptability to the development of railway passenger transport at that time.The characteristics of the development of clearing measures for railway passenger transport in different stages and their far-reaching influence on railway passenger transport business are deeply analyzed.Originality/value–This paper summarized the factors influencing the development of China’s railway passenger transportation clearing approach evolution,including the simplified rules of clearing,enhanced the market adaptability,establishing and perfecting the incentive mechanism,strengthening the construction of informatization,etc.This paper puts forward the ways to improve the railway passenger transportation clearing future development thinking.展开更多
Carbonate reservoirs worldwide are complex in structure,diverse in form,and highly heterogeneous.Based on these characteristics,the reservoir stimulation technologies and fluid flow characteristics of carbonate reserv...Carbonate reservoirs worldwide are complex in structure,diverse in form,and highly heterogeneous.Based on these characteristics,the reservoir stimulation technologies and fluid flow characteristics of carbonate reservoirs are briefly described in this study.The development methods and EOR technologies of carbonate reservoirs are systematically summarized,the relevant mechanisms are analyzed,and the application status of oil fields is catalogued.The challenges in the development of carbonate reservoirs are discussed,and future research directions are explored.In the current development processes of carbonate reservoirs,water flooding and gas flooding remain the primary means but are often prone to channeling problems.Chemical flooding is an effective method of tertiary oil recovery,but the harsh formation conditions require high-performance chemical agents.The application of emerging technologies can enhance the oil recovery efficiency and environmental friendliness to a certain extent,which is welcome in hard-to-recover areas such as heavy oil reservoirs,but the economic cost is often high.In future research on EOR technologies,flow field control and flow channel plugging will be the potential directions of traditional development methods,and the application of nanoparticles will revolutionize the chemical EOR methods.On the basis of diversified reservoir stimulation,combined with a variety of modern data processing schemes,multichannel EOR technologies are being developed to realize the systematic,intelligent,and cost-effective development of carbonate reservoirs.展开更多
Brucellosis is a global public health issue that severely affects human health,Brucella melitensis is currently the predominant species in China.Brucella spondylitis is the primary cause of the debilitating and disabl...Brucellosis is a global public health issue that severely affects human health,Brucella melitensis is currently the predominant species in China.Brucella spondylitis is the primary cause of the debilitating and disabling complications[1].The lumbar vertebra was the most commonly affected site,followed by the thoracic,cervical,thoracolumbar,and lumbosacral segments,and back pain,fever,sweating,and fatigue were the most common symptoms[2].However,the diagnosis of Brucella spondylitis is challenging owing to its wide spectrum of clinical presentations,cross-reactions with other bacteria,and low strain isolation rate.Therefore,a timely and accurate diagnosis of spinal brucellosis is crucial for implementing an effective therapeutic plan and improving treatment outcomes.Droplet digital polymerase chain reaction(ddPCR)is widely used for low-abundance nucleic acid detection and is useful for diagnosing infectious diseases[3].Therefore,this study aimed to evaluate the ddPCR approach for the diagnosis of brucellosis with spondylitis to improve its clinical diagnostic capacity.展开更多
Microsatellite markers have become one kind of the most important molecular tools used in various researches. A large number of microsatellite markers are required for the whole genome survey in the fields of molecula...Microsatellite markers have become one kind of the most important molecular tools used in various researches. A large number of microsatellite markers are required for the whole genome survey in the fields of molecular ecology,quantitative genetics and genomics. Therefore,it is extremely necessary to select several versatile,low-cost,efficient and time-and labor-saving methods to develop a large panel of microsatellite markers. In this study,we used Zhikong scallop(Chlamys farreri) as the target species to compare the efficiency of the five methods derived from three strategies for microsatellite marker development. The results showed that the strategy of constructing small insert genomic DNA library resulted in poor efficiency,while the microsatellite-enriched strategy highly improved the isolation efficiency. Although the mining public database strategy is time-and cost-saving,it is difficult to obtain a large number of microsatellite markers,mainly due to the limited sequence data of non-model species deposited in public databases. Based on the results in this study,we recommend two methods,microsatellite-enriched library construction method and FIASCO-colony hybridization method,for large-scale microsatellite marker development. Both methods were derived from the microsatellite-enriched strategy. The experimental results obtained from Zhikong scallop also provide the reference for microsatellite marker development in other species with large genomes.展开更多
To investigate the effect of planting date, spacing and seeding methods on disease development and yield components ofrice, a factorial experiment in randomized complete block design （RCBD） with four replications wa...To investigate the effect of planting date, spacing and seeding methods on disease development and yield components ofrice, a factorial experiment in randomized complete block design （RCBD） with four replications was conducted during 2011 plantingseason at Izzi Local Government Area （LGA） of Ebonyi State, Nigeria. This experiment was carried out with four levels of plantingdates （early June, late June, early July and late July）, three levels of spacing （15, 20 and 25 cm） and two levels of seeding method（direct seeding and seedling transplanting）. The studied traits included plant height （PH）, number of tillers （NT）, leaf area （LA）, rootlength （RL）, panicle length （PL）, 1,000 seed weight （SW）, disease incidence and severity. The result showed that all the factors hadsignificant effect on the parameters measured. Sowing in early July had the highest LA of 65.38 cm^2, PH of 122.00 cm, RL of 29.04cm and TN of 10.54, and the second largest PL of 25.08 cm and SW of 25.12 g. Also sowing in early July had the highest diseaseseverity of 3.21, followed by 3.14 which occurred in late July, while the least 2.17 occurred in early June. The direct seeding methodhad the highest disease incidence of 70.83%, followed by plant spacing of 15 cm × 15 cm which had the disease incidence of 69.72%,while sowing in early June had the least disease incidence of 57.50%. In conclusion, planting of rice in Southeastern Nigeria shouldbe done in early July, as the yield components were significantly better than in other dates though with the highest disease severity.展开更多
The research work was carried out for establishing a new Ultra Violet (UV)— Visible spectroscopy and Reverse phase-Ultra Fast Liquid Chromatography (RP-UFLC) method for the analysis and quantification of a biosimilar...The research work was carried out for establishing a new Ultra Violet (UV)— Visible spectroscopy and Reverse phase-Ultra Fast Liquid Chromatography (RP-UFLC) method for the analysis and quantification of a biosimilar drug, Filgrastim. Filgrastim or recombinant methionyl granulocyte colony stimulating factor (rGCSF) is a glycoprotein. It has a biological action essential for proliferation and differentiation of hematopoetic and progenitor cells. The UV and RP-UFLC work was carried on a Shimadzu UV1800 Spectrophotometer and Shimadzu Prominence LC-20AD UFLC systems, respectively. The <i>λ</i><sub>max</sub> of filgrastim was found to be 215 nm. The correlation coefficient by UV spectroscopy was found to be 0.9994 for the concentration range of 1 to 3 μg/ml in double distilled water. The Reverse phase UFLC was done by using Phenomenex C4 (25 cm × 0.46 cm internal diameter) 15 μ, 300 A° analytical column. The optimized mobile phase for binary elution was Acetonitrile and double distilled water (80:20) with a flow rate of 1 ml/min. The retention time of drug was at 3.2 min. It was observed that the response of the detector was linear in the range of 5 - 15 μg/ml with correlation coefficient value of 0.999. After developing the methods, it was assured for the intended use by validation of the analytical parameters like linearity, accuracy, precision, limit of detection, limit of quantitation, ruggedness and robustness. The results of all the parameters for both the methods were found to be within the acceptance criteria as per the International Council for Harmonisation (ICH) guidelines.展开更多
The oil oxidation characteristics of the whole temperature regions from 30 ℃ to 600 ℃ during oil reservoir air injection were revealed by experiments. The whole oil oxidation temperature regions were divided into fo...The oil oxidation characteristics of the whole temperature regions from 30 ℃ to 600 ℃ during oil reservoir air injection were revealed by experiments. The whole oil oxidation temperature regions were divided into four different parts: dissolving and inflation region, low temperature oxidation region, medium temperature oxidation region and high temperature oxidation region. The reaction mechanisms of different regions were explained. Based on the oil oxidation characteristics and filed tests results, light oil reservoirs air injection development methods were divided into two types: oxygen-reducing air flooding and air flooding;heavy oil reservoirs air injection in-situ combustion development methods were divided into two types: medium temperature in-situ combustion and high temperature in-situ combustion. When the reservoir temperature is lower than 120 ℃, oxygen-reducing air flooding should be used for light oil reservoir development. When the reservoir temperature is higher than 120 ℃, air flooding method should be used for light oil reservoir development. For a normal heavy oil reservoir, when the combustion front temperature is lower than 400 ℃, the development method is medium temperature in-situ combustion. For a heavy oil reservoir with high oil resin and asphalting contents, when the combustion front temperature is higher than 450 ℃, the development method at this condition is high temperature in-situ combustion. Ten years field tests of air injection carried out by PetroChina proved that air has advantages in technical, economical and gas source aspects compared with other gas agents for oilfield gas injection development. Air injection development can be used in low/super-low permeability light oil reservoirs, medium and high permeability light oil reservoirs and heavy oil reservoirs. Air is a very promising gas flooding agent.展开更多
Dispersed and peripheral spaces in the urban core are influenced both by the trend towards constant growth as well as social ways of life which are constantly evolving. Following a connotation, these two factors there...Dispersed and peripheral spaces in the urban core are influenced both by the trend towards constant growth as well as social ways of life which are constantly evolving. Following a connotation, these two factors therefore play a crucial role in defining the alternation of urban space--in particular, that of the centers. The main focus of this research article is on the methodology used in the survey and evaluation of ＂centralities＂ as well as their developments over the past four decades （1974-2014） in approaches to urban development that has been developed in Graz.~ The analysis has drawn on the four editions （＂evolution＂） of approaches to urban development as conceived by the city of Graz in order to examine their verbal characteristics in regard to centralities. At the same time, the analysis does not examine presentations of plans which exist in supplementary forms （e.g., explanatory reports and supplemented plans）--it restricts itself solely to the various plans set out in the STEKs.2 The highest degree of accuracy has been applied to the notion of ＂centralis＂ in approaches to urban development. The goal of the research project was to depict the modulation of the notion of ＂centrality＂ in the urban context as a space-forming dimension. Furthermore, it clearly shows the extent to which the notion of the ＂centre＂ （in the widest sense of the word） has become distanced from qualitative, spatial development and at the current time of urban development is experiencing a sort of Renaissance. In the field of ＂urban development＂, architectural references in the context of＂centrality＂ have scarcely been researched. This has led to the opening-up of a complex interdisciplinary research field. In order to make the complex architectural determinants of ＂centrality＂ more accessible to the participating disciplines, approaches to urban development have been explored in the form of a social and spatial analysis.展开更多
Three main problems in system development and the plight of the system development are analyzed and discussed. Finally a practical and formalized method-object-oriented method is proposed to extncate the system develo...Three main problems in system development and the plight of the system development are analyzed and discussed. Finally a practical and formalized method-object-oriented method is proposed to extncate the system development from the predicament.展开更多
Since the 1990s, with the in-depth study and understanding of sustainable development, quantitative study of regional sustainable development (RSD) was increasingly hot in China. Based on quantitative study of RSD fro...Since the 1990s, with the in-depth study and understanding of sustainable development, quantitative study of regional sustainable development (RSD) was increasingly hot in China. Based on quantitative study of RSD from Core Periodical in China National Knowledge Infrastructure (1992–2008), statistical analysis on the annual distribution, periodicals distribution and changes of the distribution were made. And from perspectives of social–economic, ecological, systematic and emerging methods, the course, problems and trends of the quantitative study methods on RSD were examined and analyzed to get a clear summary. By the review, the context on the quantitative study of RSD was to be clarified. The study also showed that, primarily, fields involving quantitative study are expanding; second, big progresses and constant development have been made on the systematic method gradually sophisticated, the flourishing ecological method and emerging new methods in the context of cross and integration which has made complex integrated systems a more satisfactory solution; third, the method system has been more multi-angled, and the clues of independent innovation have been observed despite the fact that the introduction of imported method is the main trend. Although many problems exist, multi-scale study, dynamic timeseries study and inter-regional comparative study will be further exploited and increasingly carried out with the progress of spatial information technology, which would boost the development and application of new methods in RSD study.展开更多
Despite the obvious frauds published in [1] [2] and the involvement of Editors and Editors in Chief of the journals in the publication of these fraudulent papers, the Editors in Chief of publishers have not taken any ...Despite the obvious frauds published in [1] [2] and the involvement of Editors and Editors in Chief of the journals in the publication of these fraudulent papers, the Editors in Chief of publishers have not taken any action to retract the fraudulent papers or to dismiss the corrupt editors. By this passivity, these Editors in Chief are supporting plagiarism, dissemination of fraudulent data, lies and making published information unreliable. In the present paper, we evaluate examples of bold, fraudulent publications and give the names of some Editors directly participating in concealing fraudulent publications, together with the names of Editors in Chief who also concealed and covered the facts of fraud and were reluctant to remove the fraudulent papers from circulation or to remove cheaters from editorial positions. The truth is universal and international;in contrast, the lie is individual and partisan, social, political, confessional, cultural and dirty. Knowledge is a truth that is part of the Universe. Lies are a tool of manipulation and can exist only in distinct environments that produce and support them. In this paper, we will show how artificial prefabricated analytical procedures were used to disseminate false data with the aim of substituting the truth with fraud.展开更多
The ageing population in developed countries brings many benefits but also many challenges, particularly in terms of the development of appropriate technology to support their ability to remain in their own home envir...The ageing population in developed countries brings many benefits but also many challenges, particularly in terms of the development of appropriate technology to support their ability to remain in their own home environment. One particular challenge reported for such Home Care Systems (HCS) is the identification of an appropriate requirements development technique for dealing with the typical diverse stakeholders involved. Agile Methods (AMs) recognize this challenge and propose techniques that could be useful. This paper examines the desirable characteristics identified for requirements development in HCS and investigates the extent to which agile practices conform to these. It also sets out future work to improve the situation for the non compliant points found.展开更多
The increasing use of digital video everyday in a multitude of electronic devices, including mobile phones, tablets and laptops, poses the need for quick development of cross-platform video software. However current a...The increasing use of digital video everyday in a multitude of electronic devices, including mobile phones, tablets and laptops, poses the need for quick development of cross-platform video software. However current approaches to this direction usually require a long learning curve, and their development lacks standardization. This results in software components that are difficult to reuse, and hard to maintain or extend. In order to overcome such issues, we propose a novel object-oriented framework for efficient development of software systems for video analysis. It consists of a set of four abstract components, suitable for the implementation of independent plug-in modules for video acquisition, preprocessing, analysis and output handling. The extensibility of each module can be facilitated by sub-modules specifying additional functionalities. This architecture enables quick responses to changes and re-configurability;thus conforming to the requirements of agile software development practices. Considering the need for platform independency, the proposed Java Video Analysis (JVA) framework is implemented in Java. It is publicly available through the web as open-access software, supported by a growing collection of implemented modules. Its efficiency is empirically validated for the development of a representative video analysis system.展开更多
Eleven recently completed toxicological studies were critically reviewed to identify toxicologically significant endpoints and dose-response information. Dose-response data were compiled and entered into the USEPA＇s ...Eleven recently completed toxicological studies were critically reviewed to identify toxicologically significant endpoints and dose-response information. Dose-response data were compiled and entered into the USEPA＇s benchmark dose software （BMDS） for calculation of a benchmark dose （BMD） and a benchmark dose low （BMDL）. After assessing 91 endpoints across the nine studies, a total of 23 of these endpoints were identified for BMD modeling, and BMDL estimates corresponding to various dose-response models were compiled for these separate endpoints. Thyroid, neurobehavior and reproductive endpoints for BDE-47, -99, -209 were quantitatively evaluated. According to methods and feature of each study, different uncertainty factor （UF） value was decided and subsequently reference doses （RfDs） were proposed. Consistent with USEPA, the lowest BMDLs of 2.10, 81.77, and 1698 I^g/kg were used to develop RfDs for BDE-47, -99, and -209, respectively. RfDs for BDE-99 and BDE-209 were comparable to EPA results, and however, RfD of BDE-47 was much lower than that of EPA, which may result from that reproductive/developmental proves to be more sensitive than neurobehavior for BDE-47 and the principal study uses very-low-dose exposure.展开更多
This article describes the geographical indication characteristics of Zhuanbu strawberry,a special product of Yinan County,Shandong Province,a national geographical indication agricultural product,including specific p...This article describes the geographical indication characteristics of Zhuanbu strawberry,a special product of Yinan County,Shandong Province,a national geographical indication agricultural product,including specific production area,unique production environment,rich human history and unique product quality,summarizes the unique production method of Zhuanbu strawberry from selection of production area and varieties,production management,timely harvesting and other aspects,and puts forward corresponding industrial development measures,in order to maintain the brand of Zhuanbu strawberry to the greatest extent and further improve the brand awareness and market competitiveness of Zhuanbu strawberry.展开更多
Purpose–This method will become a new development trend in subgrade structure design for high speed railways.Design/methodology/approach–This paper summarizes the structural types and design methods of subgrade bed ...Purpose–This method will become a new development trend in subgrade structure design for high speed railways.Design/methodology/approach–This paper summarizes the structural types and design methods of subgrade bed for high speed railways in China,Japan,France,Germany,the United States and other countries based on the study and analysis of existing literature and combined with the research results and practices of high speed railway subgrade engineering at home and abroad.Findings–It is found that in foreign countries,the layered reinforced structure is generally adopted for the subgrade bed of high speed railways,and the unified double-layer or multi-layer structure is adopted for the surface layer of subgrade bed,while the simple structure is adopted in China;in foreign countries,different inspection parameters are adopted to evaluate the compaction state of fillers according to their respective understanding and practice,while in China,compaction coefficient,subsoil coefficient and dynamic deformation modulus are adopted for such evaluation;in foreign countries,the subgrade top deformation control method,the subgrade bottom deformation control method,the subsurface fill strength control method are mainly adopted in subgrade bed structure design of high speed railways,while in China,dynamic deformation control of subgrade surface and dynamic strain control of subgrade bed bottom layer is adopted in the design.However,the cumulative deformation of subgrade caused by train cyclic vibration load is not considered in the existing design methods.Originality/value–This paper introduces a new subgrade structure design method based on whole-process dynamics analysis that meets subgrade functional requirements and is established on the basis of the existing research at home and abroad on prediction methods for cumulative deformation of subgrade soil.展开更多
Structural development defects essentially refer to code structure that violates object-oriented design principles. They make program maintenance challenging and deteriorate software quality over time. Various detecti...Structural development defects essentially refer to code structure that violates object-oriented design principles. They make program maintenance challenging and deteriorate software quality over time. Various detection approaches, ranging from traditional heuristic algorithms to machine learning methods, are used to identify these defects. Ensemble learning methods have strengthened the detection of these defects. However, existing approaches do not simultaneously exploit the capabilities of extracting relevant features from pre-trained models and the performance of neural networks for the classification task. Therefore, our goal has been to design a model that combines a pre-trained model to extract relevant features from code excerpts through transfer learning and a bagging method with a base estimator, a dense neural network, for defect classification. To achieve this, we composed multiple samples of the same size with replacements from the imbalanced dataset MLCQ1. For all the samples, we used the CodeT5-small variant to extract features and trained a bagging method with the neural network Roberta Classification Head to classify defects based on these features. We then compared this model to RandomForest, one of the ensemble methods that yields good results. Our experiments showed that the number of base estimators to use for bagging depends on the defect to be detected. Next, we observed that it was not necessary to use a data balancing technique with our model when the imbalance rate was 23%. Finally, for blob detection, RandomForest had a median MCC value of 0.36 compared to 0.12 for our method. However, our method was predominant in Long Method detection with a median MCC value of 0.53 compared to 0.42 for RandomForest. These results suggest that the performance of ensemble methods in detecting structural development defects is dependent on specific defects.展开更多
With the gradual arrival of an aging society, the research on anti-aging beauty technology has become the focus of international beauty and medical circles. Skin aging is the result of the interaction of various facto...With the gradual arrival of an aging society, the research on anti-aging beauty technology has become the focus of international beauty and medical circles. Skin aging is the result of the interaction of various factors, which is mainly divided into two types: one is endogenous aging, also known as natural aging, which is determined by genetic factors in the body and is a natural slow aging process;The other is exogenous aging induced by the external environment, such as ultraviolet radiation, smoking, gravity, chemicals, etc. More than 80% of facial skin aging is caused by ultraviolet radiation, so it is also called light aging. The characteristics of this skin aging are rough skin texture, dark skin color, pigmentation and missing skin elasticity. As we all know, skin aging is an irreversible situation. If assisted by new beauty technology, the aging process can be prolonged. The current research focuses on stem cells and cytokines for treatment and anti-aging beauty, and the new development direction will be reviewed one by one.展开更多
基金National Natural Science Foundation of China,No.41171449Knowledge Innovation Project of the Chinese Academy of Sciences,No.KZZD-EW-06
文摘National and international research on regional development has matured from the use of single elements and indicators to the application of comprehensive multi-element and multi-indicator measures. We selected 12 indicators from six dimensions for analysis in this study, including income, consumption, education, population urbanization, traffic, and indoor living facilities. We then proposed the polyhedron method to comprehensively measure levels of regional multidimensional development. We also enhanced the polygon and vector sum methods to render them more suitable for studying the status of regional multidimensional development. Finally, we measured levels of regional multidimensional development at county, city, and provincial scales across China and analyzed spatial differences using the three methods above and the weighted sum method applied widely. The results of this study reveal the presence of remarkable regional differences at the county scale across China in terms of single and multidimensional levels of regional development. Analyses show that values of the regional multidimensional development index （RMDI） are high in eastern coastal areas, intermediate in the midlands and in northern border regions, and low in the southwest and in western border regions. Districts characterized by enhanced and the highest levels of this index are distributed in eastern coastal areas, including cities in central and western regions, as well as areas characterized by the development of energy and mineral resources. The regional distribution of reduced and the lowest levels of this index is consistent with concentrations of areas that have always been impoverished. Correlation analyses of the results generated by the four methods at provincial, city, and county scales show that all are equivalent in practical application and can be used to generate satisfactory measures for regional multidimensional development. Additiona~ correlation analyses between RMDI values calculated using the polyhedron method and per capita gross domestic product （GDP） demonstrate that the latter is not a meaningful proxy for the level of regional multidimensional development.
基金supported by the Research and Development Plan Project of China State Railway Group Co.,Ltd.(Project No.P2023X029).
文摘Purpose–As an important part of the management of railway passenger transport,the rationality and effectiveness of the clearing method of railway passenger transport are directly related to the operating efficiency and service quality of railway passenger transport enterprises.This paper aims to comprehensively and deeply discuss the evolution and development process of China’s railway passenger transport clearing method,analyze its characteristics and influences in each stage,identify the main factors affecting its evolution and development and then put forward thoughts on improving the future development of the clearing method.Design/methodology/approach–Through a detailed review of the railway passenger transport clearing methods from the planned economy period to the reform and opening up period and into the new century,the basis,mode,subject and object of clearing in different development stages are systematically compared.Findings–It comprehensively reveals the evolution of the clearing method,sorted out the characteristics and changes of the clearing method at each stage and the adaptability to the development of railway passenger transport at that time.The characteristics of the development of clearing measures for railway passenger transport in different stages and their far-reaching influence on railway passenger transport business are deeply analyzed.Originality/value–This paper summarized the factors influencing the development of China’s railway passenger transportation clearing approach evolution,including the simplified rules of clearing,enhanced the market adaptability,establishing and perfecting the incentive mechanism,strengthening the construction of informatization,etc.This paper puts forward the ways to improve the railway passenger transportation clearing future development thinking.
基金supported by the Innovation Project for Graduates in UPC(Grant YCX2019016)the National Natural Science Foundation of China(Nos.51774306 and 51974346)+1 种基金the Science and Technology Support Plan for Youth Innovation of University in Shandong Province under Grant 2019KJH002the Major Scientific and Technological Projects of CNPC under Grant ZD2019-183-008。
文摘Carbonate reservoirs worldwide are complex in structure,diverse in form,and highly heterogeneous.Based on these characteristics,the reservoir stimulation technologies and fluid flow characteristics of carbonate reservoirs are briefly described in this study.The development methods and EOR technologies of carbonate reservoirs are systematically summarized,the relevant mechanisms are analyzed,and the application status of oil fields is catalogued.The challenges in the development of carbonate reservoirs are discussed,and future research directions are explored.In the current development processes of carbonate reservoirs,water flooding and gas flooding remain the primary means but are often prone to channeling problems.Chemical flooding is an effective method of tertiary oil recovery,but the harsh formation conditions require high-performance chemical agents.The application of emerging technologies can enhance the oil recovery efficiency and environmental friendliness to a certain extent,which is welcome in hard-to-recover areas such as heavy oil reservoirs,but the economic cost is often high.In future research on EOR technologies,flow field control and flow channel plugging will be the potential directions of traditional development methods,and the application of nanoparticles will revolutionize the chemical EOR methods.On the basis of diversified reservoir stimulation,combined with a variety of modern data processing schemes,multichannel EOR technologies are being developed to realize the systematic,intelligent,and cost-effective development of carbonate reservoirs.
基金supported by the Key Research and Development Projects of the Ningxia Hui Autonomous Region(Grant no.2022BEG03161)。
文摘Brucellosis is a global public health issue that severely affects human health,Brucella melitensis is currently the predominant species in China.Brucella spondylitis is the primary cause of the debilitating and disabling complications[1].The lumbar vertebra was the most commonly affected site,followed by the thoracic,cervical,thoracolumbar,and lumbosacral segments,and back pain,fever,sweating,and fatigue were the most common symptoms[2].However,the diagnosis of Brucella spondylitis is challenging owing to its wide spectrum of clinical presentations,cross-reactions with other bacteria,and low strain isolation rate.Therefore,a timely and accurate diagnosis of spinal brucellosis is crucial for implementing an effective therapeutic plan and improving treatment outcomes.Droplet digital polymerase chain reaction(ddPCR)is widely used for low-abundance nucleic acid detection and is useful for diagnosing infectious diseases[3].Therefore,this study aimed to evaluate the ddPCR approach for the diagnosis of brucellosis with spondylitis to improve its clinical diagnostic capacity.
基金supported by ‘863’ Program (2006AA10A408 and 2006AA10A411), NSFC30571417, NYHYZX07-047, 2005DKA30470, 2006BAD09A10 and NCET-06-0594.
文摘Microsatellite markers have become one kind of the most important molecular tools used in various researches. A large number of microsatellite markers are required for the whole genome survey in the fields of molecular ecology,quantitative genetics and genomics. Therefore,it is extremely necessary to select several versatile,low-cost,efficient and time-and labor-saving methods to develop a large panel of microsatellite markers. In this study,we used Zhikong scallop(Chlamys farreri) as the target species to compare the efficiency of the five methods derived from three strategies for microsatellite marker development. The results showed that the strategy of constructing small insert genomic DNA library resulted in poor efficiency,while the microsatellite-enriched strategy highly improved the isolation efficiency. Although the mining public database strategy is time-and cost-saving,it is difficult to obtain a large number of microsatellite markers,mainly due to the limited sequence data of non-model species deposited in public databases. Based on the results in this study,we recommend two methods,microsatellite-enriched library construction method and FIASCO-colony hybridization method,for large-scale microsatellite marker development. Both methods were derived from the microsatellite-enriched strategy. The experimental results obtained from Zhikong scallop also provide the reference for microsatellite marker development in other species with large genomes.
文摘To investigate the effect of planting date, spacing and seeding methods on disease development and yield components ofrice, a factorial experiment in randomized complete block design （RCBD） with four replications was conducted during 2011 plantingseason at Izzi Local Government Area （LGA） of Ebonyi State, Nigeria. This experiment was carried out with four levels of plantingdates （early June, late June, early July and late July）, three levels of spacing （15, 20 and 25 cm） and two levels of seeding method（direct seeding and seedling transplanting）. The studied traits included plant height （PH）, number of tillers （NT）, leaf area （LA）, rootlength （RL）, panicle length （PL）, 1,000 seed weight （SW）, disease incidence and severity. The result showed that all the factors hadsignificant effect on the parameters measured. Sowing in early July had the highest LA of 65.38 cm^2, PH of 122.00 cm, RL of 29.04cm and TN of 10.54, and the second largest PL of 25.08 cm and SW of 25.12 g. Also sowing in early July had the highest diseaseseverity of 3.21, followed by 3.14 which occurred in late July, while the least 2.17 occurred in early June. The direct seeding methodhad the highest disease incidence of 70.83%, followed by plant spacing of 15 cm × 15 cm which had the disease incidence of 69.72%,while sowing in early June had the least disease incidence of 57.50%. In conclusion, planting of rice in Southeastern Nigeria shouldbe done in early July, as the yield components were significantly better than in other dates though with the highest disease severity.
文摘The research work was carried out for establishing a new Ultra Violet (UV)— Visible spectroscopy and Reverse phase-Ultra Fast Liquid Chromatography (RP-UFLC) method for the analysis and quantification of a biosimilar drug, Filgrastim. Filgrastim or recombinant methionyl granulocyte colony stimulating factor (rGCSF) is a glycoprotein. It has a biological action essential for proliferation and differentiation of hematopoetic and progenitor cells. The UV and RP-UFLC work was carried on a Shimadzu UV1800 Spectrophotometer and Shimadzu Prominence LC-20AD UFLC systems, respectively. The <i>λ</i><sub>max</sub> of filgrastim was found to be 215 nm. The correlation coefficient by UV spectroscopy was found to be 0.9994 for the concentration range of 1 to 3 μg/ml in double distilled water. The Reverse phase UFLC was done by using Phenomenex C4 (25 cm × 0.46 cm internal diameter) 15 μ, 300 A° analytical column. The optimized mobile phase for binary elution was Acetonitrile and double distilled water (80:20) with a flow rate of 1 ml/min. The retention time of drug was at 3.2 min. It was observed that the response of the detector was linear in the range of 5 - 15 μg/ml with correlation coefficient value of 0.999. After developing the methods, it was assured for the intended use by validation of the analytical parameters like linearity, accuracy, precision, limit of detection, limit of quantitation, ruggedness and robustness. The results of all the parameters for both the methods were found to be within the acceptance criteria as per the International Council for Harmonisation (ICH) guidelines.
文摘The oil oxidation characteristics of the whole temperature regions from 30 ℃ to 600 ℃ during oil reservoir air injection were revealed by experiments. The whole oil oxidation temperature regions were divided into four different parts: dissolving and inflation region, low temperature oxidation region, medium temperature oxidation region and high temperature oxidation region. The reaction mechanisms of different regions were explained. Based on the oil oxidation characteristics and filed tests results, light oil reservoirs air injection development methods were divided into two types: oxygen-reducing air flooding and air flooding;heavy oil reservoirs air injection in-situ combustion development methods were divided into two types: medium temperature in-situ combustion and high temperature in-situ combustion. When the reservoir temperature is lower than 120 ℃, oxygen-reducing air flooding should be used for light oil reservoir development. When the reservoir temperature is higher than 120 ℃, air flooding method should be used for light oil reservoir development. For a normal heavy oil reservoir, when the combustion front temperature is lower than 400 ℃, the development method is medium temperature in-situ combustion. For a heavy oil reservoir with high oil resin and asphalting contents, when the combustion front temperature is higher than 450 ℃, the development method at this condition is high temperature in-situ combustion. Ten years field tests of air injection carried out by PetroChina proved that air has advantages in technical, economical and gas source aspects compared with other gas agents for oilfield gas injection development. Air injection development can be used in low/super-low permeability light oil reservoirs, medium and high permeability light oil reservoirs and heavy oil reservoirs. Air is a very promising gas flooding agent.
文摘Dispersed and peripheral spaces in the urban core are influenced both by the trend towards constant growth as well as social ways of life which are constantly evolving. Following a connotation, these two factors therefore play a crucial role in defining the alternation of urban space--in particular, that of the centers. The main focus of this research article is on the methodology used in the survey and evaluation of ＂centralities＂ as well as their developments over the past four decades （1974-2014） in approaches to urban development that has been developed in Graz.~ The analysis has drawn on the four editions （＂evolution＂） of approaches to urban development as conceived by the city of Graz in order to examine their verbal characteristics in regard to centralities. At the same time, the analysis does not examine presentations of plans which exist in supplementary forms （e.g., explanatory reports and supplemented plans）--it restricts itself solely to the various plans set out in the STEKs.2 The highest degree of accuracy has been applied to the notion of ＂centralis＂ in approaches to urban development. The goal of the research project was to depict the modulation of the notion of ＂centrality＂ in the urban context as a space-forming dimension. Furthermore, it clearly shows the extent to which the notion of the ＂centre＂ （in the widest sense of the word） has become distanced from qualitative, spatial development and at the current time of urban development is experiencing a sort of Renaissance. In the field of ＂urban development＂, architectural references in the context of＂centrality＂ have scarcely been researched. This has led to the opening-up of a complex interdisciplinary research field. In order to make the complex architectural determinants of ＂centrality＂ more accessible to the participating disciplines, approaches to urban development have been explored in the form of a social and spatial analysis.
文摘Three main problems in system development and the plight of the system development are analyzed and discussed. Finally a practical and formalized method-object-oriented method is proposed to extncate the system development from the predicament.
基金supported by Research Projects of Province-ministry Co-constructing Henan University (Grant no. SBGJ090111)Research Projects of Social Science Plan in Shandong Province (Grant no. 08DJGJ16)Humanities and Social Science Research Projects Authorized by Education Department of Shandong Province (Grant no. J08WE14)
文摘Since the 1990s, with the in-depth study and understanding of sustainable development, quantitative study of regional sustainable development (RSD) was increasingly hot in China. Based on quantitative study of RSD from Core Periodical in China National Knowledge Infrastructure (1992–2008), statistical analysis on the annual distribution, periodicals distribution and changes of the distribution were made. And from perspectives of social–economic, ecological, systematic and emerging methods, the course, problems and trends of the quantitative study methods on RSD were examined and analyzed to get a clear summary. By the review, the context on the quantitative study of RSD was to be clarified. The study also showed that, primarily, fields involving quantitative study are expanding; second, big progresses and constant development have been made on the systematic method gradually sophisticated, the flourishing ecological method and emerging new methods in the context of cross and integration which has made complex integrated systems a more satisfactory solution; third, the method system has been more multi-angled, and the clues of independent innovation have been observed despite the fact that the introduction of imported method is the main trend. Although many problems exist, multi-scale study, dynamic timeseries study and inter-regional comparative study will be further exploited and increasingly carried out with the progress of spatial information technology, which would boost the development and application of new methods in RSD study.
文摘Despite the obvious frauds published in [1] [2] and the involvement of Editors and Editors in Chief of the journals in the publication of these fraudulent papers, the Editors in Chief of publishers have not taken any action to retract the fraudulent papers or to dismiss the corrupt editors. By this passivity, these Editors in Chief are supporting plagiarism, dissemination of fraudulent data, lies and making published information unreliable. In the present paper, we evaluate examples of bold, fraudulent publications and give the names of some Editors directly participating in concealing fraudulent publications, together with the names of Editors in Chief who also concealed and covered the facts of fraud and were reluctant to remove the fraudulent papers from circulation or to remove cheaters from editorial positions. The truth is universal and international;in contrast, the lie is individual and partisan, social, political, confessional, cultural and dirty. Knowledge is a truth that is part of the Universe. Lies are a tool of manipulation and can exist only in distinct environments that produce and support them. In this paper, we will show how artificial prefabricated analytical procedures were used to disseminate false data with the aim of substituting the truth with fraud.
文摘The ageing population in developed countries brings many benefits but also many challenges, particularly in terms of the development of appropriate technology to support their ability to remain in their own home environment. One particular challenge reported for such Home Care Systems (HCS) is the identification of an appropriate requirements development technique for dealing with the typical diverse stakeholders involved. Agile Methods (AMs) recognize this challenge and propose techniques that could be useful. This paper examines the desirable characteristics identified for requirements development in HCS and investigates the extent to which agile practices conform to these. It also sets out future work to improve the situation for the non compliant points found.
文摘The increasing use of digital video everyday in a multitude of electronic devices, including mobile phones, tablets and laptops, poses the need for quick development of cross-platform video software. However current approaches to this direction usually require a long learning curve, and their development lacks standardization. This results in software components that are difficult to reuse, and hard to maintain or extend. In order to overcome such issues, we propose a novel object-oriented framework for efficient development of software systems for video analysis. It consists of a set of four abstract components, suitable for the implementation of independent plug-in modules for video acquisition, preprocessing, analysis and output handling. The extensibility of each module can be facilitated by sub-modules specifying additional functionalities. This architecture enables quick responses to changes and re-configurability;thus conforming to the requirements of agile software development practices. Considering the need for platform independency, the proposed Java Video Analysis (JVA) framework is implemented in Java. It is publicly available through the web as open-access software, supported by a growing collection of implemented modules. Its efficiency is empirically validated for the development of a representative video analysis system.
基金financially supported by the Natural Science Foundation of China(Grant 81072263,to Y.Z.)Chun Tsung Scholarship of Fudan University(to D.C.)
文摘Eleven recently completed toxicological studies were critically reviewed to identify toxicologically significant endpoints and dose-response information. Dose-response data were compiled and entered into the USEPA＇s benchmark dose software （BMDS） for calculation of a benchmark dose （BMD） and a benchmark dose low （BMDL）. After assessing 91 endpoints across the nine studies, a total of 23 of these endpoints were identified for BMD modeling, and BMDL estimates corresponding to various dose-response models were compiled for these separate endpoints. Thyroid, neurobehavior and reproductive endpoints for BDE-47, -99, -209 were quantitatively evaluated. According to methods and feature of each study, different uncertainty factor （UF） value was decided and subsequently reference doses （RfDs） were proposed. Consistent with USEPA, the lowest BMDLs of 2.10, 81.77, and 1698 I^g/kg were used to develop RfDs for BDE-47, -99, and -209, respectively. RfDs for BDE-99 and BDE-209 were comparable to EPA results, and however, RfD of BDE-47 was much lower than that of EPA, which may result from that reproductive/developmental proves to be more sensitive than neurobehavior for BDE-47 and the principal study uses very-low-dose exposure.
基金Shandong Provincial Modern Agricultural Industrial Technology System:Project for Construction of Vegetation Innovative Team(SDAIT-05-18).
文摘This article describes the geographical indication characteristics of Zhuanbu strawberry,a special product of Yinan County,Shandong Province,a national geographical indication agricultural product,including specific production area,unique production environment,rich human history and unique product quality,summarizes the unique production method of Zhuanbu strawberry from selection of production area and varieties,production management,timely harvesting and other aspects,and puts forward corresponding industrial development measures,in order to maintain the brand of Zhuanbu strawberry to the greatest extent and further improve the brand awareness and market competitiveness of Zhuanbu strawberry.
基金The research was supported by the National Natural Science Foundation of China(Grant Nos.41731288 and 41972299)the Science and Technology Research and Development Program of China Railway(Grant No.P2018G050)+1 种基金the Young Top-Notch Talent Project of National“Ten Thousands Talent Program”(Grant No.2019YJ300)the Major Scientific Research and Development Project of China Academy of Railway Sciences Corporation Limited(Grant No.2019YJ026).
文摘Purpose–This method will become a new development trend in subgrade structure design for high speed railways.Design/methodology/approach–This paper summarizes the structural types and design methods of subgrade bed for high speed railways in China,Japan,France,Germany,the United States and other countries based on the study and analysis of existing literature and combined with the research results and practices of high speed railway subgrade engineering at home and abroad.Findings–It is found that in foreign countries,the layered reinforced structure is generally adopted for the subgrade bed of high speed railways,and the unified double-layer or multi-layer structure is adopted for the surface layer of subgrade bed,while the simple structure is adopted in China;in foreign countries,different inspection parameters are adopted to evaluate the compaction state of fillers according to their respective understanding and practice,while in China,compaction coefficient,subsoil coefficient and dynamic deformation modulus are adopted for such evaluation;in foreign countries,the subgrade top deformation control method,the subgrade bottom deformation control method,the subsurface fill strength control method are mainly adopted in subgrade bed structure design of high speed railways,while in China,dynamic deformation control of subgrade surface and dynamic strain control of subgrade bed bottom layer is adopted in the design.However,the cumulative deformation of subgrade caused by train cyclic vibration load is not considered in the existing design methods.Originality/value–This paper introduces a new subgrade structure design method based on whole-process dynamics analysis that meets subgrade functional requirements and is established on the basis of the existing research at home and abroad on prediction methods for cumulative deformation of subgrade soil.
文摘Structural development defects essentially refer to code structure that violates object-oriented design principles. They make program maintenance challenging and deteriorate software quality over time. Various detection approaches, ranging from traditional heuristic algorithms to machine learning methods, are used to identify these defects. Ensemble learning methods have strengthened the detection of these defects. However, existing approaches do not simultaneously exploit the capabilities of extracting relevant features from pre-trained models and the performance of neural networks for the classification task. Therefore, our goal has been to design a model that combines a pre-trained model to extract relevant features from code excerpts through transfer learning and a bagging method with a base estimator, a dense neural network, for defect classification. To achieve this, we composed multiple samples of the same size with replacements from the imbalanced dataset MLCQ1. For all the samples, we used the CodeT5-small variant to extract features and trained a bagging method with the neural network Roberta Classification Head to classify defects based on these features. We then compared this model to RandomForest, one of the ensemble methods that yields good results. Our experiments showed that the number of base estimators to use for bagging depends on the defect to be detected. Next, we observed that it was not necessary to use a data balancing technique with our model when the imbalance rate was 23%. Finally, for blob detection, RandomForest had a median MCC value of 0.36 compared to 0.12 for our method. However, our method was predominant in Long Method detection with a median MCC value of 0.53 compared to 0.42 for RandomForest. These results suggest that the performance of ensemble methods in detecting structural development defects is dependent on specific defects.
文摘With the gradual arrival of an aging society, the research on anti-aging beauty technology has become the focus of international beauty and medical circles. Skin aging is the result of the interaction of various factors, which is mainly divided into two types: one is endogenous aging, also known as natural aging, which is determined by genetic factors in the body and is a natural slow aging process;The other is exogenous aging induced by the external environment, such as ultraviolet radiation, smoking, gravity, chemicals, etc. More than 80% of facial skin aging is caused by ultraviolet radiation, so it is also called light aging. The characteristics of this skin aging are rough skin texture, dark skin color, pigmentation and missing skin elasticity. As we all know, skin aging is an irreversible situation. If assisted by new beauty technology, the aging process can be prolonged. The current research focuses on stem cells and cytokines for treatment and anti-aging beauty, and the new development direction will be reviewed one by one.
