目的观察帕金森病(Parkinson’s disease,PD)患者与非PD患者丙泊酚诱导意识消失所需的效应室浓度(effect-site concentration,Ce)。方法纳入2022年10月16日至2023年10月14日于首都医科大学附属北京天坛医院就诊的患者,筛选年龄50~80岁,...目的观察帕金森病(Parkinson’s disease,PD)患者与非PD患者丙泊酚诱导意识消失所需的效应室浓度(effect-site concentration,Ce)。方法纳入2022年10月16日至2023年10月14日于首都医科大学附属北京天坛医院就诊的患者,筛选年龄50~80岁,美国麻醉医师协会(American Society of Anesthesiologists,ASA)分级Ⅱ-Ⅲ级,行双侧脑深部电刺激手术的PD患者(PD组),并按照年龄和性别匹配选取同期行非神经外科非心脏手术的非PD患者(Non-PD组)各37例为研究对象。采用Schnider模型靶控泵注丙泊酚,警觉/镇静观察(Observer’s Assessment of Alertness/Sedation,OAA/S)评分达1分后20 s评估意识状态,采集5 min临床试验数据后停药,记录给药后OAA/S评分1分时、停药后OAA/S评分3分时丙泊酚的Ce、患者状态指数(patient state index,PSI)。结果PD患者组诱导至无意识状态所需丙泊酚剂量明显少于Non-PD患者组[(2.2±0.4)mg/L vs(3.1±0.4)mg/L,P<0.05];与Non-PD患者比较,PD患者意识消失和意识恢复时的PSI值更高(P<0.05),意识恢复时间明显延长(P<0.05),意识恢复时丙泊酚Ce更低(P<0.05)。结论PD患者诱导意识消失所需的丙泊酚剂量降低,且需要在更低的Ce下苏醒,苏醒时间明显长于非PD患者,在意识消失和苏醒时的PSI均高于非PD患者,麻醉管理中应予以重视。展开更多
A novel equivalent circuit model for a GaAs PIN diode is presented based on physical analysis. The diode is divided into three parts： the p^＋ n^- junction, the i-layer, and the n^- n^＋ junction, which are modeled s...A novel equivalent circuit model for a GaAs PIN diode is presented based on physical analysis. The diode is divided into three parts： the p^＋ n^- junction, the i-layer, and the n^- n^＋ junction, which are modeled separately. The entire model is then formed by combining the three sub-models. In this way, the model＇s accuracy is greatly enhanced. Furthermore, the corresponding parameter extraction method is easy, requiring no rigorous experiment or measurement. To validate this newly proposed model,fifteen groups of diodes are fabricated. Measurement shows that the model exactly represents behavior of GaAs PIN diodes under both forward and reversely biased conditions.展开更多
阐述了作战云的内涵,分析了作战云的特点和发展需求.构建了一个网络、二类服务、三种应用的作战云系统体系结构,特别提出了组织即服务(Organization as a service,Oaas)的概念,以此为基础,构造了5层构架的作战云技术体系结构.结合军事应...阐述了作战云的内涵,分析了作战云的特点和发展需求.构建了一个网络、二类服务、三种应用的作战云系统体系结构,特别提出了组织即服务(Organization as a service,Oaas)的概念,以此为基础,构造了5层构架的作战云技术体系结构.结合军事应用,提出了包含4种运用模式的作战云作战体系结构.展开更多
A monolithic single pole single throw （SPST） switch is developed with GaAs PIN diode technology from IMECAS. A novel small signal model of a GaAs PIN diode is developed for circuit simulation. The switch features an...A monolithic single pole single throw （SPST） switch is developed with GaAs PIN diode technology from IMECAS. A novel small signal model of a GaAs PIN diode is developed for circuit simulation. The switch features an on-state insertion loss of less than 1.6dB and a return loss of greater than 10dB while maintaining an off-state isolation of greater than 23dB from 5.5 to 7. 5GHz. The measured 1dB power gain compression point is about 20dBm.展开更多
文摘目的观察帕金森病(Parkinson’s disease,PD)患者与非PD患者丙泊酚诱导意识消失所需的效应室浓度(effect-site concentration,Ce)。方法纳入2022年10月16日至2023年10月14日于首都医科大学附属北京天坛医院就诊的患者,筛选年龄50~80岁,美国麻醉医师协会(American Society of Anesthesiologists,ASA)分级Ⅱ-Ⅲ级,行双侧脑深部电刺激手术的PD患者(PD组),并按照年龄和性别匹配选取同期行非神经外科非心脏手术的非PD患者(Non-PD组)各37例为研究对象。采用Schnider模型靶控泵注丙泊酚,警觉/镇静观察(Observer’s Assessment of Alertness/Sedation,OAA/S)评分达1分后20 s评估意识状态,采集5 min临床试验数据后停药,记录给药后OAA/S评分1分时、停药后OAA/S评分3分时丙泊酚的Ce、患者状态指数(patient state index,PSI)。结果PD患者组诱导至无意识状态所需丙泊酚剂量明显少于Non-PD患者组[(2.2±0.4)mg/L vs(3.1±0.4)mg/L,P<0.05];与Non-PD患者比较,PD患者意识消失和意识恢复时的PSI值更高(P<0.05),意识恢复时间明显延长(P<0.05),意识恢复时丙泊酚Ce更低(P<0.05)。结论PD患者诱导意识消失所需的丙泊酚剂量降低,且需要在更低的Ce下苏醒,苏醒时间明显长于非PD患者,在意识消失和苏醒时的PSI均高于非PD患者,麻醉管理中应予以重视。
文摘A novel equivalent circuit model for a GaAs PIN diode is presented based on physical analysis. The diode is divided into three parts： the p^＋ n^- junction, the i-layer, and the n^- n^＋ junction, which are modeled separately. The entire model is then formed by combining the three sub-models. In this way, the model＇s accuracy is greatly enhanced. Furthermore, the corresponding parameter extraction method is easy, requiring no rigorous experiment or measurement. To validate this newly proposed model,fifteen groups of diodes are fabricated. Measurement shows that the model exactly represents behavior of GaAs PIN diodes under both forward and reversely biased conditions.
文摘阐述了作战云的内涵,分析了作战云的特点和发展需求.构建了一个网络、二类服务、三种应用的作战云系统体系结构,特别提出了组织即服务(Organization as a service,Oaas)的概念,以此为基础,构造了5层构架的作战云技术体系结构.结合军事应用,提出了包含4种运用模式的作战云作战体系结构.
文摘A monolithic single pole single throw （SPST） switch is developed with GaAs PIN diode technology from IMECAS. A novel small signal model of a GaAs PIN diode is developed for circuit simulation. The switch features an on-state insertion loss of less than 1.6dB and a return loss of greater than 10dB while maintaining an off-state isolation of greater than 23dB from 5.5 to 7. 5GHz. The measured 1dB power gain compression point is about 20dBm.
