A highly efficient conformation from facile benzoylhydrazines was developed under electrochemical condition. A variety of oxadiazoles were obtained with good yields by virtue of this new method.
Fourteen new 2-acylhydrazino-5 -(2,4-dichlorophenyl)-1, 3,4 -oxadiazo les were prepared by nucleophilic displacement of acylhpeine at the 2-position of 2-methylsulfonyl-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole. Fourtee...Fourteen new 2-acylhydrazino-5 -(2,4-dichlorophenyl)-1, 3,4 -oxadiazo les were prepared by nucleophilic displacement of acylhpeine at the 2-position of 2-methylsulfonyl-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole. Fourteen new 3-substhad-6-(2,4-dichlorophenyl)-s-triazolo [3,4-b]-1,3,4-oxadiazoles were obtained by treating 2 -acylhydrazion- 5-(2,4-dichlorophenyl )- 1, 3,4-oxadiazoles with K2CO3 solution. All the new compounds showed significant antibacterial activity展开更多
Novel 1, 3, 4-thia(oxa)diazoles containing thienyl groups were synthesized. Analogous to the naturally-occurring compound, a-terthienyl, they can be photosensitized by ultraviolet light and showed phototoxicities agai...Novel 1, 3, 4-thia(oxa)diazoles containing thienyl groups were synthesized. Analogous to the naturally-occurring compound, a-terthienyl, they can be photosensitized by ultraviolet light and showed phototoxicities against the 2nd instar larvae of southern armyworm (Pseudaletia separata Walker), they also showed photocleavage action to pBR322 DNA.展开更多
Discovering potent drug candidates requires new antimalarial targets.For this reason,antimalarial drug researchers focus on developing new drug candidates on promising targets.In the identification of these targets,a ...Discovering potent drug candidates requires new antimalarial targets.For this reason,antimalarial drug researchers focus on developing new drug candidates on promising targets.In the identification of these targets,a basic understanding of the metabolism and biochemical processes of malaria parasites such as Plasmodium falciparum can prove invaluable.However,malarial resistant parasites are becoming more and more significant issues as antimalarial medications progress.Antimalarial drugs are becoming increasingly resistant,thus the search for new molecules is very important task.Artemisinin based combination therapies are becoming more popular for treating malaria.This will ultimately lead to the selection of resistance due to their extensive and indiscriminate deployment.Alternative artemisinin-based combination therapies are therefore required.There is an interest in finding suitable antimalarial compounds based on their potential effectiveness against malaria.The potential activity of 1,3,4 oxadiazole analogues against malarial infections is a major draw of the search for suitable antimalarial compounds.This review identifies existing antimalarial drugs that have own therapeutic effects and evaluating their feasibility for developing novel synthetic antimalarial derivatives.展开更多
To discover an efficient route for the shift from an antibacterial fluoroquinolone to an antitumor one based on the mechanistic similarities between targeting topoisomerases and the eukaryotic ones,two series of the t...To discover an efficient route for the shift from an antibacterial fluoroquinolone to an antitumor one based on the mechanistic similarities between targeting topoisomerases and the eukaryotic ones,two series of the title compounds,C3 bis-oxadiazole methylsulfides 6a―6h and corresponding dimethylpiperazinium iodides 7a―7h derived from levofloxacin 1 were designed and synthesized.Their in vitro antiproliferative activities against Chinese hamster ovary cell line（CHO）,murine leukemia cell line（L1210） and human leukocytoma cell line（HL60） were evaluated by MTT assay,and inhibitory effect on DNA topoisomerase IIα was also measured by means of densitometric assay.展开更多
A new cyclometalated platinum complex containing 2, 5-bis(naphthalene-1-yl)-1,3,4-oxadiazole ligand was synthesized and characterized. The UV-Vis absorptions and photoluminescent properties of the ligand and its plati...A new cyclometalated platinum complex containing 2, 5-bis(naphthalene-1-yl)-1,3,4-oxadiazole ligand was synthesized and characterized. The UV-Vis absorptions and photoluminescent properties of the ligand and its platinum complex were investigated. A characteristic metal-ligand charge transfer absorption peak at 439 nm in the UV spectrum and a strong emission peak at 625 nm in the photoluminescence spectrum were observed for this complex in dichloromethane. Cyclic voltammtry (CV) analysis shows that the EHOMO (energy level of the highest occupied molecular orbital) and ELUMO (energy level of the lowest unoccupied molecular orbital) of the platinum complex are about 、5.69 and 、3.25 eV, respectively, indicating that the oxadiazole-based platinum complex has a potential application in electrophosphorescent devices used as a red-emitting material.展开更多
A novel conjugated polymer containing azobenzene and oxadiazole units was synthesized through multi-step synthesis. The structures and properties of monomer and polymer were characterized and evaluated with IR, ^1H NM...A novel conjugated polymer containing azobenzene and oxadiazole units was synthesized through multi-step synthesis. The structures and properties of monomer and polymer were characterized and evaluated with IR, ^1H NMR, UV, TGA and GPC, respectively. Polymer with long side chain of alkoxy shows good solubility, thermal stability and photoisomerization property.展开更多
In the present study, a novel series of Mannich bases of 3-substituted 5-(pyridin-4-yl)-1,3, 4-oxadiazol-2-thione derivatives were synthesized. Docking study was performed to rationalize the possible interactions betw...In the present study, a novel series of Mannich bases of 3-substituted 5-(pyridin-4-yl)-1,3, 4-oxadiazol-2-thione derivatives were synthesized. Docking study was performed to rationalize the possible interactions between the synthesized com-pounds and active site of 14DM. The test compounds were screened for antimycobacterial activity using Middlebrook 7H9 medium against M. tuberculosis H37Rv (ATCC 27294) as well as Isoniazid (INH) resistant clinical strain. Among the series 5c and 5a are found to be most potent (susceptible) while the compound 5f did not show activity against M. tuberculosis H37Rv (resistant). The SAR study reveals the importance of substitutions at para position for good activity.展开更多
4-Amino-5-pyridin-4-yl-s-triazole-3-thiol （1） was sequentally reacted with 3-chloro-1- phenylpropan-1-one to afford 3-（4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl）-1-phenylpropan-1- one （2） followed by oximatio...4-Amino-5-pyridin-4-yl-s-triazole-3-thiol （1） was sequentally reacted with 3-chloro-1- phenylpropan-1-one to afford 3-（4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl）-1-phenylpropan-1- one （2） followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-[13,4]oxadiazole-2-cbloromethanes to the corresponding oxime （3） and oxime-ethers （4a-e）, respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds （5a-e）. The antibacterial activity in vitro against Gram-postive （G^＋） and Gram negative （G） bacteria was primarily evaluated.展开更多
5-（5＂-Substituted phenyl-[1＂,3＂,4＂]oxadiazol-2＂-yl methylsulfanyl）-3-pyridin-3′-yl- [1,2,4] triazol-4-yl amines la-j were quaternarized with methyl iodide to afford the corresponding methyl pyridinium salts 2a...5-（5＂-Substituted phenyl-[1＂,3＂,4＂]oxadiazol-2＂-yl methylsulfanyl）-3-pyridin-3′-yl- [1,2,4] triazol-4-yl amines la-j were quaternarized with methyl iodide to afford the corresponding methyl pyridinium salts 2a-j. The reduction of compounds 2 with NaBH4 in methanol gave the target compounds 5-（5＂-substituted phenyl-[1＂,3＂,4＂]oxadiazol-2＂-yl methylsulfanyl）-3-（1′-methyl-1＇,2＇,5＇,6＇-tetrahydropyridin-3＇-yl）-[1,2,4]triazol-4-ylamines 3a-j. The endothelium vascular relaxing activity of the target compounds were screened.展开更多
The effects of pressure on the fluorescence emission and Raman spectra of 1,4-bis[（4-methyloxyphenyl）-1,3,4-oxadiazolyl]- 2,5-bisheptyloxyphenylene （OXD-2） and on the fluorescence emission spectra of 1,4-bis[（4-m...The effects of pressure on the fluorescence emission and Raman spectra of 1,4-bis[（4-methyloxyphenyl）-1,3,4-oxadiazolyl]- 2,5-bisheptyloxyphenylene （OXD-2） and on the fluorescence emission spectra of 1,4-bis[（4-methylphenyl）- 1,3,4-oxadiazolyl]phenylene （OXD-1） are investigated using a diamond anvil cell. With the increase of pressure, the intensity of the fluorescence emission increases and reaches maxima at 13GPa for OXD-1 and at 9.6GPa for OXD-2. The effect of pressure on the peak position of the emission shows a similar trend, red shift with the increase of pressure. But at higher pressures, the intensity of emission drops down dramatically. The Raman spectra of OXD-2 indicate that there appears a structural change at ca 3GPa.展开更多
A novel POSS-based organic/inorganic hybrid covalently attached at molecular level, 2-（4-（allyloxy）phenyl）-5-（4-（octyloxy）phenyl）-1,3,4-oxadiazole-POSS （6） （abbreviated as oxadiazole-POSS） was synthesized ...A novel POSS-based organic/inorganic hybrid covalently attached at molecular level, 2-（4-（allyloxy）phenyl）-5-（4-（octyloxy）phenyl）-1,3,4-oxadiazole-POSS （6） （abbreviated as oxadiazole-POSS） was synthesized by Pt（dcp） catalyst. The hybrid was soluble in common organic solvents such as CHCl3, toluene, C2H4Cl2, and THF. Its structures and properties were characterized and evaluated with FTIR, 1^H NMR, 13^C NMR,29^Si NMR, EA, TGA, DSC, GPC, and CV, respectively. The results show that the novel hybrid possesses high thermal stability and good electron injection ability.展开更多
A new kind of polyfluorene containing oxadiazole as the side chain was synthesized. The introduction of oxadiazole moiety as more bulky group prevents the aggregation and reduces the crystallinity of the polymers. Eff...A new kind of polyfluorene containing oxadiazole as the side chain was synthesized. The introduction of oxadiazole moiety as more bulky group prevents the aggregation and reduces the crystallinity of the polymers. Efficient intramolecular energy transfer from oxadiazole moiety to the conjugated backbone has been realized, leading to 70% improvement of photoluminescence quantum efficiency of the designed polymers. Compared with PAF, the PFOXD exhibits significant improvement in electroluminescence properties, with luminous efficiency of 0.8 cd/A and maximum luminance of 1800 cd/m2.展开更多
The different oxidation states of sulphur atom play a significant role on functional materials.In this work,a aryl-thioether and its sulphone substituted benzo[c][1,2,5]oxadiazole dyes were synthesized and utilized to...The different oxidation states of sulphur atom play a significant role on functional materials.In this work,a aryl-thioether and its sulphone substituted benzo[c][1,2,5]oxadiazole dyes were synthesized and utilized to determine thiol-containing amino acids.The result of selectivity experiments showed they detected the cysteine and homocysteine under physiological condition with negligible interference from other amino acids.In comparison to the thioether dye,the sulphone-based dye exhibited much faster response time for Cys and Hcy.However,the sulphone restricted its thiol-reactivity and bioimaging performance in living cells.By reducing the oxidation state of sulphur atom,we amazedly found that the sulfoxide-based dye still maintained high selectivity ultrafast response time for Cys/Hcy under physiological condition.It was worth mentioning that it also had high reactivity and good bioimaging performance that sulfone compounds did not have.展开更多
The title compound 2-（（2-fluorobenzyl）thio）-5-（pyridin-4-yl）-1,3,4-oxadiazole（C_（14）H_（10）FN_3OS） was synthesized,and its structure was confirmed by ~1H NMR,MS,elemental analyses and X-ray diffraction. It ...The title compound 2-（（2-fluorobenzyl）thio）-5-（pyridin-4-yl）-1,3,4-oxadiazole（C_（14）H_（10）FN_3OS） was synthesized,and its structure was confirmed by ~1H NMR,MS,elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system,space group P21/n with a = 11.541（16）,b = 8.226（12）,c = 13.683（19） ？,β = 94.872（17）o,V = 1294（3） ？~3,Z = 4 and R = 0.0648 for 2198 observed reflections with I 〉 2σ（I）. The preliminary biological test shows that the title compound has good activity against Pythium ultimum with inhibitory to be 100%.展开更多
Viologens (<i>N,N'</i>-dimethyl-4,4-bipyridinium) are advanced functional materials, found important applications in electrochromic devices, molecular machines, organic batteries, and carbohydrate oxid...Viologens (<i>N,N'</i>-dimethyl-4,4-bipyridinium) are advanced functional materials, found important applications in electrochromic devices, molecular machines, organic batteries, and carbohydrate oxidation catalysts in alkaline fuel. In this article, we investigated the design, synthesis and photophysical properties of <i>N,N'</i>-dimethyl-2,5-Bis(pyridinium)oxadiazole <b>4</b> and its precursor 2,5- Bis(pyridine)oxadiazole<b> 2</b>. The crystal structure and photophysical properties of viologen <b>4</b> and precursor <b>2</b> have been determined. The viologen molecule <b>4</b> crystallized in monoclinic form, space group <i>P</i>2<sub>1</sub>/<i>n</i> with four molecules in unit cell. Precursor molecule <b>2</b> also crystalized in monoclinic form, space group <i>C</i>2/<i>c</i> with four molecules in unit cell. From X-rd data, we found three cations in the molecular structure of viologen molecule <b>4</b>, which is unusual in viologens. In the three-dimensional molecular packing diagram of molecule <b>4</b>, the three cations and iodate anions are stabilized by C···C, C···I, N···I, N···H, H···I, N—H···I and C—H···I. The dihedral angle between planes having oxadiazole and two benzene rings are 5°and 8°, suggesting the molecule <b>4</b> is a slightly strained one. The molecular structure of precursor molecule <b>2</b> stabilized by C···C and N···H short contacts between the molecules. The molecule <b>4</b> displayed strong absorbance at 315 nm and emissions between 390 - 410 nm.展开更多
The title copolymer(PDEBO) was synthesized. The thermal characteristics of the polymer were determined by means of DSC and TGA, revealing that the polymer has a good thermal stability. The X-ray diffraction measuremen...The title copolymer(PDEBO) was synthesized. The thermal characteristics of the polymer were determined by means of DSC and TGA, revealing that the polymer has a good thermal stability. The X-ray diffraction measurements of the thin films showed that the polymer is disorder. Electroluminescence(EL) in the green region of the spectrum with a maximum at 500 nm was observed from the polymer films sandwiched between indium-tin-oxide and an Al electrode.展开更多
Two new molecules containing oxadiazoles and triphenylamine-stilbene moiety were synthesized. Their luminescent properties were determined, which indicated that they had strong green fluorescent properties. All the tw...Two new molecules containing oxadiazoles and triphenylamine-stilbene moiety were synthesized. Their luminescent properties were determined, which indicated that they had strong green fluorescent properties. All the two molecules can be used as green organic electroluminescence materials.展开更多
A novel high molecular weight functional polyacetylene bearing oxadiazole group as a pendant, poly{4-[2-（4-octoxyphenyl）-1,3,4-oxadiazolyl]-benzenyloxypropynylene}, was synthesized by [Rh（nbd）Cl]2-Et3N catalyst. T...A novel high molecular weight functional polyacetylene bearing oxadiazole group as a pendant, poly{4-[2-（4-octoxyphenyl）-1,3,4-oxadiazolyl]-benzenyloxypropynylene}, was synthesized by [Rh（nbd）Cl]2-Et3N catalyst. The polymer was soluble in common organic solvents such as CHCl3 and THE The structures and properties of monomer and polymer were characterized and evaluated with FTIR, NMR, UV, TGA, GPC, and CV, respectively. The results show that the polymer possesses high thermal stability and well electron-injection property.展开更多
The highest efficiency thermally activated delayed fluorescence(TADF)emitters in OLEDs are mostly based on twisted donor/acceptor(D/A)type organic molecules.Herein,we report the rational molecular design on twisted al...The highest efficiency thermally activated delayed fluorescence(TADF)emitters in OLEDs are mostly based on twisted donor/acceptor(D/A)type organic molecules.Herein,we report the rational molecular design on twisted all ortho-linked carbazole/oxadiazole(Cz/OXD)hybrids with tunable D-A interactions by adjusting the numbers of donor/acceptor units and electron-donating abilities.Singlet-triplet energy bandgaps(ΔEST)are facilely tuned from^0.4,0.15 to^0 eV in D-A,D-A-D to A-D-A type compounds.This variation correlates well with triplet-excited-state frontier orbital spatial separation efficiency.NonTADF feature with solid state photoluminescence quantum yield(PLQY)<10%is observed in D-A type 2CzOXD and D-A-D type 4CzOXD.Owing to the extremely lowΔEST for efficient reverse intersystem crossing,strong TADF with PLQY of 71%-92%is achieved in A-D-A type 4CzDOXD and 4tCzDOXD.High external quantum efficiency from 19.4%to 22.6%is achieved in A-D-A typed 4CzDOXD and 4tCzDOXD.展开更多
基金the National Natural Science Foundation of China(Nos.91213303,21272222,20932002,21172205)for the financial support
文摘A highly efficient conformation from facile benzoylhydrazines was developed under electrochemical condition. A variety of oxadiazoles were obtained with good yields by virtue of this new method.
文摘Fourteen new 2-acylhydrazino-5 -(2,4-dichlorophenyl)-1, 3,4 -oxadiazo les were prepared by nucleophilic displacement of acylhpeine at the 2-position of 2-methylsulfonyl-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole. Fourteen new 3-substhad-6-(2,4-dichlorophenyl)-s-triazolo [3,4-b]-1,3,4-oxadiazoles were obtained by treating 2 -acylhydrazion- 5-(2,4-dichlorophenyl )- 1, 3,4-oxadiazoles with K2CO3 solution. All the new compounds showed significant antibacterial activity
文摘Novel 1, 3, 4-thia(oxa)diazoles containing thienyl groups were synthesized. Analogous to the naturally-occurring compound, a-terthienyl, they can be photosensitized by ultraviolet light and showed phototoxicities against the 2nd instar larvae of southern armyworm (Pseudaletia separata Walker), they also showed photocleavage action to pBR322 DNA.
文摘Discovering potent drug candidates requires new antimalarial targets.For this reason,antimalarial drug researchers focus on developing new drug candidates on promising targets.In the identification of these targets,a basic understanding of the metabolism and biochemical processes of malaria parasites such as Plasmodium falciparum can prove invaluable.However,malarial resistant parasites are becoming more and more significant issues as antimalarial medications progress.Antimalarial drugs are becoming increasingly resistant,thus the search for new molecules is very important task.Artemisinin based combination therapies are becoming more popular for treating malaria.This will ultimately lead to the selection of resistance due to their extensive and indiscriminate deployment.Alternative artemisinin-based combination therapies are therefore required.There is an interest in finding suitable antimalarial compounds based on their potential effectiveness against malaria.The potential activity of 1,3,4 oxadiazole analogues against malarial infections is a major draw of the search for suitable antimalarial compounds.This review identifies existing antimalarial drugs that have own therapeutic effects and evaluating their feasibility for developing novel synthetic antimalarial derivatives.
基金Supported by the National Natural Science Foundation of China(Nos.20872028,21072045)
文摘To discover an efficient route for the shift from an antibacterial fluoroquinolone to an antitumor one based on the mechanistic similarities between targeting topoisomerases and the eukaryotic ones,two series of the title compounds,C3 bis-oxadiazole methylsulfides 6a―6h and corresponding dimethylpiperazinium iodides 7a―7h derived from levofloxacin 1 were designed and synthesized.Their in vitro antiproliferative activities against Chinese hamster ovary cell line（CHO）,murine leukemia cell line（L1210） and human leukocytoma cell line（HL60） were evaluated by MTT assay,and inhibitory effect on DNA topoisomerase IIα was also measured by means of densitometric assay.
基金Project(50473046) supported by the National Natural Science Foundation of ChinaProject(204097) supported by the Science Foundation of the Ministry of Education of China+1 种基金Project(04JJ1002) supported by the Outstanding Youth Foundation of Hunan Province,ChinaProject(06JJ2008) supported by the Natural Science Foundation of Hunan Province,China
文摘A new cyclometalated platinum complex containing 2, 5-bis(naphthalene-1-yl)-1,3,4-oxadiazole ligand was synthesized and characterized. The UV-Vis absorptions and photoluminescent properties of the ligand and its platinum complex were investigated. A characteristic metal-ligand charge transfer absorption peak at 439 nm in the UV spectrum and a strong emission peak at 625 nm in the photoluminescence spectrum were observed for this complex in dichloromethane. Cyclic voltammtry (CV) analysis shows that the EHOMO (energy level of the highest occupied molecular orbital) and ELUMO (energy level of the lowest unoccupied molecular orbital) of the platinum complex are about 、5.69 and 、3.25 eV, respectively, indicating that the oxadiazole-based platinum complex has a potential application in electrophosphorescent devices used as a red-emitting material.
基金supported by the National Natural Science Foundation of China(No.20573049).
文摘A novel conjugated polymer containing azobenzene and oxadiazole units was synthesized through multi-step synthesis. The structures and properties of monomer and polymer were characterized and evaluated with IR, ^1H NMR, UV, TGA and GPC, respectively. Polymer with long side chain of alkoxy shows good solubility, thermal stability and photoisomerization property.
文摘In the present study, a novel series of Mannich bases of 3-substituted 5-(pyridin-4-yl)-1,3, 4-oxadiazol-2-thione derivatives were synthesized. Docking study was performed to rationalize the possible interactions between the synthesized com-pounds and active site of 14DM. The test compounds were screened for antimycobacterial activity using Middlebrook 7H9 medium against M. tuberculosis H37Rv (ATCC 27294) as well as Isoniazid (INH) resistant clinical strain. Among the series 5c and 5a are found to be most potent (susceptible) while the compound 5f did not show activity against M. tuberculosis H37Rv (resistant). The SAR study reveals the importance of substitutions at para position for good activity.
基金the State Basic Research and Development Project （No. G 1998051112） the Science Foundation of Henan University （04ZDZR009）.
文摘4-Amino-5-pyridin-4-yl-s-triazole-3-thiol （1） was sequentally reacted with 3-chloro-1- phenylpropan-1-one to afford 3-（4-amino-5-pyridin-4-yl-s-triazole-3-sulfanyl）-1-phenylpropan-1- one （2） followed by oximation with hydroxylamine hydrochloride and etherification with 5-aryl-[13,4]oxadiazole-2-cbloromethanes to the corresponding oxime （3） and oxime-ethers （4a-e）, respectively. The condensation of compounds 4 with salicylaldehyde gave the title compounds （5a-e）. The antibacterial activity in vitro against Gram-postive （G^＋） and Gram negative （G） bacteria was primarily evaluated.
基金supported by the State Basic Research and Development Project(No.G 1998051112)the Science Foundation of Henan University(04ZDZR009).
文摘5-（5＂-Substituted phenyl-[1＂,3＂,4＂]oxadiazol-2＂-yl methylsulfanyl）-3-pyridin-3′-yl- [1,2,4] triazol-4-yl amines la-j were quaternarized with methyl iodide to afford the corresponding methyl pyridinium salts 2a-j. The reduction of compounds 2 with NaBH4 in methanol gave the target compounds 5-（5＂-substituted phenyl-[1＂,3＂,4＂]oxadiazol-2＂-yl methylsulfanyl）-3-（1′-methyl-1＇,2＇,5＇,6＇-tetrahydropyridin-3＇-yl）-[1,2,4]triazol-4-ylamines 3a-j. The endothelium vascular relaxing activity of the target compounds were screened.
基金Project supported by the National Natural Science Foundation of China （Grant Nos 10104008, 29974013, 50373016 ）, the International Science and Technology Cooperation Project of China （Grant No 2001CB711201） and the State Education Commission Foundation for Excellent Young Teachers of China.
文摘The effects of pressure on the fluorescence emission and Raman spectra of 1,4-bis[（4-methyloxyphenyl）-1,3,4-oxadiazolyl]- 2,5-bisheptyloxyphenylene （OXD-2） and on the fluorescence emission spectra of 1,4-bis[（4-methylphenyl）- 1,3,4-oxadiazolyl]phenylene （OXD-1） are investigated using a diamond anvil cell. With the increase of pressure, the intensity of the fluorescence emission increases and reaches maxima at 13GPa for OXD-1 and at 9.6GPa for OXD-2. The effect of pressure on the peak position of the emission shows a similar trend, red shift with the increase of pressure. But at higher pressures, the intensity of emission drops down dramatically. The Raman spectra of OXD-2 indicate that there appears a structural change at ca 3GPa.
文摘A novel POSS-based organic/inorganic hybrid covalently attached at molecular level, 2-（4-（allyloxy）phenyl）-5-（4-（octyloxy）phenyl）-1,3,4-oxadiazole-POSS （6） （abbreviated as oxadiazole-POSS） was synthesized by Pt（dcp） catalyst. The hybrid was soluble in common organic solvents such as CHCl3, toluene, C2H4Cl2, and THF. Its structures and properties were characterized and evaluated with FTIR, 1^H NMR, 13^C NMR,29^Si NMR, EA, TGA, DSC, GPC, and CV, respectively. The results show that the novel hybrid possesses high thermal stability and good electron injection ability.
基金The work was supported by the National Natural Science Foundation of China (No. 29725410 and 29992530) and the 973Project (No. 2002CB613402).
文摘A new kind of polyfluorene containing oxadiazole as the side chain was synthesized. The introduction of oxadiazole moiety as more bulky group prevents the aggregation and reduces the crystallinity of the polymers. Efficient intramolecular energy transfer from oxadiazole moiety to the conjugated backbone has been realized, leading to 70% improvement of photoluminescence quantum efficiency of the designed polymers. Compared with PAF, the PFOXD exhibits significant improvement in electroluminescence properties, with luminous efficiency of 0.8 cd/A and maximum luminance of 1800 cd/m2.
基金the National Natural Science Foundation of China(Nos.21676113,21402057,21772054,21472059)Distinguished Young Scholar of Hubei Province(No.2018CFA079)+5 种基金Youth Chen-Guang Project of Wuhan(No.2016070204010098)the 111 Project B17019the Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology(Shenzhen),the State Key Laboratory of Materials-Oriented Chemical Engineering(No.KL17-10)Open Project Fund of Key Laboratory of Natural Resources of Changbai Mountain&Functional Molecules(Yanbian University),Ministry of Education(No.NRFM201701)the Foundation of Key Laboratory of Synthetic and Biological Colloids,Ministry of Education,Jiangnan University(No.JDSJ2017-07)the Self-determined Research Funds of CCNU from the Colleges’Basic Research and Operation of MOE(No.CCNU18TS012)。
文摘The different oxidation states of sulphur atom play a significant role on functional materials.In this work,a aryl-thioether and its sulphone substituted benzo[c][1,2,5]oxadiazole dyes were synthesized and utilized to determine thiol-containing amino acids.The result of selectivity experiments showed they detected the cysteine and homocysteine under physiological condition with negligible interference from other amino acids.In comparison to the thioether dye,the sulphone-based dye exhibited much faster response time for Cys and Hcy.However,the sulphone restricted its thiol-reactivity and bioimaging performance in living cells.By reducing the oxidation state of sulphur atom,we amazedly found that the sulfoxide-based dye still maintained high selectivity ultrafast response time for Cys/Hcy under physiological condition.It was worth mentioning that it also had high reactivity and good bioimaging performance that sulfone compounds did not have.
基金funded by the Natural Science Foundation of Zhejiang Province(No.LY16C140007)the program of Science and Technology of Jiangsu Province(BY2014108-14)
文摘The title compound 2-（（2-fluorobenzyl）thio）-5-（pyridin-4-yl）-1,3,4-oxadiazole（C_（14）H_（10）FN_3OS） was synthesized,and its structure was confirmed by ~1H NMR,MS,elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system,space group P21/n with a = 11.541（16）,b = 8.226（12）,c = 13.683（19） ？,β = 94.872（17）o,V = 1294（3） ？~3,Z = 4 and R = 0.0648 for 2198 observed reflections with I 〉 2σ（I）. The preliminary biological test shows that the title compound has good activity against Pythium ultimum with inhibitory to be 100%.
文摘Viologens (<i>N,N'</i>-dimethyl-4,4-bipyridinium) are advanced functional materials, found important applications in electrochromic devices, molecular machines, organic batteries, and carbohydrate oxidation catalysts in alkaline fuel. In this article, we investigated the design, synthesis and photophysical properties of <i>N,N'</i>-dimethyl-2,5-Bis(pyridinium)oxadiazole <b>4</b> and its precursor 2,5- Bis(pyridine)oxadiazole<b> 2</b>. The crystal structure and photophysical properties of viologen <b>4</b> and precursor <b>2</b> have been determined. The viologen molecule <b>4</b> crystallized in monoclinic form, space group <i>P</i>2<sub>1</sub>/<i>n</i> with four molecules in unit cell. Precursor molecule <b>2</b> also crystalized in monoclinic form, space group <i>C</i>2/<i>c</i> with four molecules in unit cell. From X-rd data, we found three cations in the molecular structure of viologen molecule <b>4</b>, which is unusual in viologens. In the three-dimensional molecular packing diagram of molecule <b>4</b>, the three cations and iodate anions are stabilized by C···C, C···I, N···I, N···H, H···I, N—H···I and C—H···I. The dihedral angle between planes having oxadiazole and two benzene rings are 5°and 8°, suggesting the molecule <b>4</b> is a slightly strained one. The molecular structure of precursor molecule <b>2</b> stabilized by C···C and N···H short contacts between the molecules. The molecule <b>4</b> displayed strong absorbance at 315 nm and emissions between 390 - 410 nm.
基金Supported by the National Natural Science Foundation of China(No.2 99740 2 5 ) and Zhejiang Provincial Nature Science Foundation(No.5 9910 0 ) State Key L aboratory of Silicon MaterialsL aboratory of Organnic Solids,Institute of Chemistry,Chinese Acade
文摘The title copolymer(PDEBO) was synthesized. The thermal characteristics of the polymer were determined by means of DSC and TGA, revealing that the polymer has a good thermal stability. The X-ray diffraction measurements of the thin films showed that the polymer is disorder. Electroluminescence(EL) in the green region of the spectrum with a maximum at 500 nm was observed from the polymer films sandwiched between indium-tin-oxide and an Al electrode.
基金the National Natural Science Foundation of China(No.20072018.29832030)for the financial support.
文摘Two new molecules containing oxadiazoles and triphenylamine-stilbene moiety were synthesized. Their luminescent properties were determined, which indicated that they had strong green fluorescent properties. All the two molecules can be used as green organic electroluminescence materials.
文摘A novel high molecular weight functional polyacetylene bearing oxadiazole group as a pendant, poly{4-[2-（4-octoxyphenyl）-1,3,4-oxadiazolyl]-benzenyloxypropynylene}, was synthesized by [Rh（nbd）Cl]2-Et3N catalyst. The polymer was soluble in common organic solvents such as CHCl3 and THE The structures and properties of monomer and polymer were characterized and evaluated with FTIR, NMR, UV, TGA, GPC, and CV, respectively. The results show that the polymer possesses high thermal stability and well electron-injection property.
基金National Natural Science Foundation of China(Nos.91833304,61805211)National Key Research and Development Program of China for the Joint Research Program between China and European Union(No.2016YFE0112000)+1 种基金the Natural Science Foundation of Jiangsu Province(Nos.BK20160042 and XYDXX-026)the Foundation for the Author of National Excellent Doctoral Dissertation of China FANEDD(No.201436)
文摘The highest efficiency thermally activated delayed fluorescence(TADF)emitters in OLEDs are mostly based on twisted donor/acceptor(D/A)type organic molecules.Herein,we report the rational molecular design on twisted all ortho-linked carbazole/oxadiazole(Cz/OXD)hybrids with tunable D-A interactions by adjusting the numbers of donor/acceptor units and electron-donating abilities.Singlet-triplet energy bandgaps(ΔEST)are facilely tuned from^0.4,0.15 to^0 eV in D-A,D-A-D to A-D-A type compounds.This variation correlates well with triplet-excited-state frontier orbital spatial separation efficiency.NonTADF feature with solid state photoluminescence quantum yield(PLQY)<10%is observed in D-A type 2CzOXD and D-A-D type 4CzOXD.Owing to the extremely lowΔEST for efficient reverse intersystem crossing,strong TADF with PLQY of 71%-92%is achieved in A-D-A type 4CzDOXD and 4tCzDOXD.High external quantum efficiency from 19.4%to 22.6%is achieved in A-D-A typed 4CzDOXD and 4tCzDOXD.
