The ruins of GugeKingdom arefound in Ngari,atthe westernmostpoint of the Tibet Plateau. Itabuts India in the west andsouth,Kashmir in the north-west and Xinjiang in the north.Screened by mountains onthree sides,it is ...The ruins of GugeKingdom arefound in Ngari,atthe westernmostpoint of the Tibet Plateau. Itabuts India in the west andsouth,Kashmir in the north-west and Xinjiang in the north.Screened by mountains onthree sides,it is tucked awayat an elevation of 4,000meters. This is a part of theworld which is very dry.TheZhangzhung Culture existedbefore the kingdom wasfounded.展开更多
作为国家“十四五”重点工程及中国石化天津基地的产业核心工程,中国石化天津南港乙烯工程生产工艺复杂、控制要求严格,传统的通用仿真培训系统无法满足激增的大批量员工岗前培训需求,也无法提升现场DCS调试效率和开车成功率。针对上述...作为国家“十四五”重点工程及中国石化天津基地的产业核心工程,中国石化天津南港乙烯工程生产工艺复杂、控制要求严格,传统的通用仿真培训系统无法满足激增的大批量员工岗前培训需求,也无法提升现场DCS调试效率和开车成功率。针对上述痛点,和利时创新推出BS架构的DCS直连仿真(Hard Link)解决方案—Hia Sim Web Online在线仿真培训管理系统。该系统采用B/S架构,支持多终端访问(办公区/宿舍/家庭),通过企业内网、互联网或云平台提供与现场DCS高度一致的仿真环境,覆盖操作培训、事故演练、工艺优化等场景,支持单机、协同及网络培训等多元培训模式,解决了大批量员工集中的岗前培训需求,同时在培训过程中同步验证控制逻辑及开停车方案,共计发现设计问题177条,逻辑及画面问题856条,缩短现场DCS调试周期30%,为项目顺利开车提供双重保障,为流程工业数字化交付提供新模式。展开更多
This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA f...This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA framework integrates security by design principles, micro-segmentation, and Island Mode Operation (IMO) to enhance cyber resilience and ensure continuous, secure operations. The methodology deploys a Forward-Thinking Architecture Strategy (FTAS) algorithm, which utilises an industrial Intrusion Detection System (IDS) implemented with Python’s Network Intrusion Detection System (NIDS) library. The FTAS algorithm successfully identified and responded to cyber-attacks, ensuring minimal system disruption. ISERA has been validated through comprehensive testing scenarios simulating Denial of Service (DoS) attacks and malware intrusions, at both the IT and OT layers where it successfully mitigates the impact of malicious activity. Results demonstrate ISERA’s efficacy in real-time threat detection, containment, and incident response, thus ensuring the integrity and reliability of critical infrastructure systems. ISERA’s decentralised approach contributes to global net zero goals by optimising resource use and minimising environmental impact. By adopting a decentralised control architecture and leveraging virtualisation, ISERA significantly enhances the cyber resilience and sustainability of critical infrastructure systems. This approach not only strengthens defences against evolving cyber threats but also optimises resource allocation, reducing the system’s carbon footprint. As a result, ISERA ensures the uninterrupted operation of essential services while contributing to broader net zero goals.展开更多
文摘The ruins of GugeKingdom arefound in Ngari,atthe westernmostpoint of the Tibet Plateau. Itabuts India in the west andsouth,Kashmir in the north-west and Xinjiang in the north.Screened by mountains onthree sides,it is tucked awayat an elevation of 4,000meters. This is a part of theworld which is very dry.TheZhangzhung Culture existedbefore the kingdom wasfounded.
文摘作为国家“十四五”重点工程及中国石化天津基地的产业核心工程,中国石化天津南港乙烯工程生产工艺复杂、控制要求严格,传统的通用仿真培训系统无法满足激增的大批量员工岗前培训需求,也无法提升现场DCS调试效率和开车成功率。针对上述痛点,和利时创新推出BS架构的DCS直连仿真(Hard Link)解决方案—Hia Sim Web Online在线仿真培训管理系统。该系统采用B/S架构,支持多终端访问(办公区/宿舍/家庭),通过企业内网、互联网或云平台提供与现场DCS高度一致的仿真环境,覆盖操作培训、事故演练、工艺优化等场景,支持单机、协同及网络培训等多元培训模式,解决了大批量员工集中的岗前培训需求,同时在培训过程中同步验证控制逻辑及开停车方案,共计发现设计问题177条,逻辑及画面问题856条,缩短现场DCS调试周期30%,为项目顺利开车提供双重保障,为流程工业数字化交付提供新模式。
基金funded by the Office of Gas and Electricity Markets(Ofgem)and supported by De Montfort University(DMU)and Nottingham Trent University(NTU),UK.
文摘This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA framework integrates security by design principles, micro-segmentation, and Island Mode Operation (IMO) to enhance cyber resilience and ensure continuous, secure operations. The methodology deploys a Forward-Thinking Architecture Strategy (FTAS) algorithm, which utilises an industrial Intrusion Detection System (IDS) implemented with Python’s Network Intrusion Detection System (NIDS) library. The FTAS algorithm successfully identified and responded to cyber-attacks, ensuring minimal system disruption. ISERA has been validated through comprehensive testing scenarios simulating Denial of Service (DoS) attacks and malware intrusions, at both the IT and OT layers where it successfully mitigates the impact of malicious activity. Results demonstrate ISERA’s efficacy in real-time threat detection, containment, and incident response, thus ensuring the integrity and reliability of critical infrastructure systems. ISERA’s decentralised approach contributes to global net zero goals by optimising resource use and minimising environmental impact. By adopting a decentralised control architecture and leveraging virtualisation, ISERA significantly enhances the cyber resilience and sustainability of critical infrastructure systems. This approach not only strengthens defences against evolving cyber threats but also optimises resource allocation, reducing the system’s carbon footprint. As a result, ISERA ensures the uninterrupted operation of essential services while contributing to broader net zero goals.
文摘长非编码RNA KCNQ1OT1对多种癌症的发生发展中起着重要的促进作用。然而,目前还没有研究在泛癌中对KCNQ1OT1进行系统的分析。本研究通过对KCNQ1OT1在泛癌组织中的表达水平以及对肿瘤患者的预后情况分析,阐明KCNQ1OT1在肿瘤诊断和预后中的价值,通过分析KCNQ1OT1在胃癌中的调控机制,为胃癌的诊疗提供新的分子靶点。使用Sangerbox 3.0、临床生信之家以及UALCAN数据库,发现KCNQ1OT1在7种肿瘤组织中表达增高(均P<0.05)。在Sangerbox 3.0数据库中发现KCNQ1OT1与多种肿瘤的预后不良相关。使用R软件分析胃癌患者中KCNQ1OT1高表达组和低表达组的差异基因(P<0.05,log2FoldChange>1),并使用基因本体(gene ontology,GO)和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)功能富集分析发现,KCNQ1OT1参与了胃癌谷氨酰胺的代谢过程。细胞计数和Western印迹检测发现,敲低KCNQ1OT1后胃癌细胞的活性、SLC1A5表达水平以及其介导的谷氨酰胺转运过程均显著下降(P<0.01)。生物信息学、RNA免疫沉淀和双荧光素酶分析验证了KCNQ1OT1竞争性结合miR-138-5p,并促进SLC1A5的表达。最后,染色质免疫沉淀测序数据检测KCNQ1OT1的基因位点具有高H3K27ac信号,并通过染色质免疫沉淀定量PCR验证了P300介导的增强子活性调控了胃癌中KCNQ1OT1的高表达。KCNQ1OT1在多种肿瘤中可以作为一种独立的诊断标志物和预后预测因子。靶向KCNQ1OT1/miR-138-5p/SLC1A5信号轴调控的谷氨酰胺代谢,为胃癌的治疗提供了新的策略和分子靶点。
