目的评估数字化作业治疗(数字OT训练)联合有氧运动对慢性精神分裂症患者认知功能及自我效能感的影响。方法选取2023年1月~2024年12月在苏州市广济医院接受住院治疗的100例慢性精神分裂症患者,依据随机数字表法将其分为对照组和研究组。...目的评估数字化作业治疗(数字OT训练)联合有氧运动对慢性精神分裂症患者认知功能及自我效能感的影响。方法选取2023年1月~2024年12月在苏州市广济医院接受住院治疗的100例慢性精神分裂症患者,依据随机数字表法将其分为对照组和研究组。对照组接受常规药物治疗及基础精神科护理,研究组在此基础上增加为期12周的数字OT训练与有氧运动联合干预。比较两组患者可重复性神经心理状态评定量表(Repeatable Battery for the Assessment of Neuropsychological Status,RBANS)、一般自我效能感量表(General Self-Efficacy Scale,GSES)、阳性与阴性症状量表(Positive and Negative Syndrome Scale,PANSS)、工具性日常生活活动能力量表(Instrumental Activities of Daily Living Scale,IADL)和个人与社会功能量表(Personal and Social Performance Scale,PSP)评分差异。结果干预12周后,研究组的RBANS、GSES评分均显著高于对照组,且两组患者干预后的评分均较干预前有所提高(P<0.05);临床症状方面,研究组的PANSS评分低于对照组(P<0.05);功能恢复方面,研究组的IADL和PSP评分均高于对照组(P<0.05)。结论数字OT训练联合有氧运动能够显著改善慢性精神分裂症患者的认知功能、自我效能感及临床症状,并促进功能恢复。展开更多
This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA f...This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA framework integrates security by design principles, micro-segmentation, and Island Mode Operation (IMO) to enhance cyber resilience and ensure continuous, secure operations. The methodology deploys a Forward-Thinking Architecture Strategy (FTAS) algorithm, which utilises an industrial Intrusion Detection System (IDS) implemented with Python’s Network Intrusion Detection System (NIDS) library. The FTAS algorithm successfully identified and responded to cyber-attacks, ensuring minimal system disruption. ISERA has been validated through comprehensive testing scenarios simulating Denial of Service (DoS) attacks and malware intrusions, at both the IT and OT layers where it successfully mitigates the impact of malicious activity. Results demonstrate ISERA’s efficacy in real-time threat detection, containment, and incident response, thus ensuring the integrity and reliability of critical infrastructure systems. ISERA’s decentralised approach contributes to global net zero goals by optimising resource use and minimising environmental impact. By adopting a decentralised control architecture and leveraging virtualisation, ISERA significantly enhances the cyber resilience and sustainability of critical infrastructure systems. This approach not only strengthens defences against evolving cyber threats but also optimises resource allocation, reducing the system’s carbon footprint. As a result, ISERA ensures the uninterrupted operation of essential services while contributing to broader net zero goals.展开更多
文摘目的评估数字化作业治疗(数字OT训练)联合有氧运动对慢性精神分裂症患者认知功能及自我效能感的影响。方法选取2023年1月~2024年12月在苏州市广济医院接受住院治疗的100例慢性精神分裂症患者,依据随机数字表法将其分为对照组和研究组。对照组接受常规药物治疗及基础精神科护理,研究组在此基础上增加为期12周的数字OT训练与有氧运动联合干预。比较两组患者可重复性神经心理状态评定量表(Repeatable Battery for the Assessment of Neuropsychological Status,RBANS)、一般自我效能感量表(General Self-Efficacy Scale,GSES)、阳性与阴性症状量表(Positive and Negative Syndrome Scale,PANSS)、工具性日常生活活动能力量表(Instrumental Activities of Daily Living Scale,IADL)和个人与社会功能量表(Personal and Social Performance Scale,PSP)评分差异。结果干预12周后,研究组的RBANS、GSES评分均显著高于对照组,且两组患者干预后的评分均较干预前有所提高(P<0.05);临床症状方面,研究组的PANSS评分低于对照组(P<0.05);功能恢复方面,研究组的IADL和PSP评分均高于对照组(P<0.05)。结论数字OT训练联合有氧运动能够显著改善慢性精神分裂症患者的认知功能、自我效能感及临床症状,并促进功能恢复。
基金funded by the Office of Gas and Electricity Markets(Ofgem)and supported by De Montfort University(DMU)and Nottingham Trent University(NTU),UK.
文摘This paper introduces the Integrated Security Embedded Resilience Architecture (ISERA) as an advanced resilience mechanism for Industrial Control Systems (ICS) and Operational Technology (OT) environments. The ISERA framework integrates security by design principles, micro-segmentation, and Island Mode Operation (IMO) to enhance cyber resilience and ensure continuous, secure operations. The methodology deploys a Forward-Thinking Architecture Strategy (FTAS) algorithm, which utilises an industrial Intrusion Detection System (IDS) implemented with Python’s Network Intrusion Detection System (NIDS) library. The FTAS algorithm successfully identified and responded to cyber-attacks, ensuring minimal system disruption. ISERA has been validated through comprehensive testing scenarios simulating Denial of Service (DoS) attacks and malware intrusions, at both the IT and OT layers where it successfully mitigates the impact of malicious activity. Results demonstrate ISERA’s efficacy in real-time threat detection, containment, and incident response, thus ensuring the integrity and reliability of critical infrastructure systems. ISERA’s decentralised approach contributes to global net zero goals by optimising resource use and minimising environmental impact. By adopting a decentralised control architecture and leveraging virtualisation, ISERA significantly enhances the cyber resilience and sustainability of critical infrastructure systems. This approach not only strengthens defences against evolving cyber threats but also optimises resource allocation, reducing the system’s carbon footprint. As a result, ISERA ensures the uninterrupted operation of essential services while contributing to broader net zero goals.
文摘长非编码RNA KCNQ1OT1对多种癌症的发生发展中起着重要的促进作用。然而,目前还没有研究在泛癌中对KCNQ1OT1进行系统的分析。本研究通过对KCNQ1OT1在泛癌组织中的表达水平以及对肿瘤患者的预后情况分析,阐明KCNQ1OT1在肿瘤诊断和预后中的价值,通过分析KCNQ1OT1在胃癌中的调控机制,为胃癌的诊疗提供新的分子靶点。使用Sangerbox 3.0、临床生信之家以及UALCAN数据库,发现KCNQ1OT1在7种肿瘤组织中表达增高(均P<0.05)。在Sangerbox 3.0数据库中发现KCNQ1OT1与多种肿瘤的预后不良相关。使用R软件分析胃癌患者中KCNQ1OT1高表达组和低表达组的差异基因(P<0.05,log2FoldChange>1),并使用基因本体(gene ontology,GO)和京都基因与基因组百科全书(kyoto encyclopedia of genes and genomes,KEGG)功能富集分析发现,KCNQ1OT1参与了胃癌谷氨酰胺的代谢过程。细胞计数和Western印迹检测发现,敲低KCNQ1OT1后胃癌细胞的活性、SLC1A5表达水平以及其介导的谷氨酰胺转运过程均显著下降(P<0.01)。生物信息学、RNA免疫沉淀和双荧光素酶分析验证了KCNQ1OT1竞争性结合miR-138-5p,并促进SLC1A5的表达。最后,染色质免疫沉淀测序数据检测KCNQ1OT1的基因位点具有高H3K27ac信号,并通过染色质免疫沉淀定量PCR验证了P300介导的增强子活性调控了胃癌中KCNQ1OT1的高表达。KCNQ1OT1在多种肿瘤中可以作为一种独立的诊断标志物和预后预测因子。靶向KCNQ1OT1/miR-138-5p/SLC1A5信号轴调控的谷氨酰胺代谢,为胃癌的治疗提供了新的策略和分子靶点。
