This study evaluates the effects of a fall experience caused by tripping during the repetitive stepping movements over an obstacle [obstacle-single leg forward step (OSFS) test]. The study included 147 participants wh...This study evaluates the effects of a fall experience caused by tripping during the repetitive stepping movements over an obstacle [obstacle-single leg forward step (OSFS) test]. The study included 147 participants who were divided into 2 groups: 25 fallers caused by tripping and 122 nonfallers. The subjects were asked to step forward over a 10-cm-high obstacle with 1 leg and then return to their original position, as quickly as possible, and this test was repeated for 5 times. The OSFS test was evaluated in 2 phases: the OSFS-F phase, wherein the participants stepped forward on one leg, and the OSFS-R phase, wherein they returned to their original position. Significant differences were observed in both phases of the OSFS test between the two groups, and the fallers by tripping were significantly inferior to the nonfallers. The area under the curve [AUC;area under the receiver operating characteristic (ROC) curve] was more than 0.63 for all the parameters, which was statistically significant. In conclusion, the fallers by tripping were inferior to the nonfallers in the obstacle step movement.展开更多
Oral submucous fibrosis(OSF),characterized by excessive deposition of extracellular matrix(ECM)that causes oral mucosal tissue sclerosis,and even cancer transformation,is a chronic,progressive fibrosis disease.However...Oral submucous fibrosis(OSF),characterized by excessive deposition of extracellular matrix(ECM)that causes oral mucosal tissue sclerosis,and even cancer transformation,is a chronic,progressive fibrosis disease.However,despite some advancements in recent years,no targeted antifibrotic strategies for OSF have been approved;likely because the complicated mechanisms that initiate and drive fibrosis remain to be determined.In this review,we briefly introduce the epidemiology and etiology of OSF.Then,we highlight how cell-intrinsic changes in significant structural cells can drive fibrotic response by regulating biological behaviors,secretion function,and activation of ECM-producing myofibroblasts.In addition,we also discuss the role of innate and adaptive immune cells and how they contribute to the pathogenesis of OSF.Finally,we summarize strategies to interrupt key mechanisms that cause OSF,including modulation of the ECM,inhibition of inflammation,improvement of vascular disturbance.This review will provide potential routes for developing novel anti-OSF therapeutics.展开更多
文摘This study evaluates the effects of a fall experience caused by tripping during the repetitive stepping movements over an obstacle [obstacle-single leg forward step (OSFS) test]. The study included 147 participants who were divided into 2 groups: 25 fallers caused by tripping and 122 nonfallers. The subjects were asked to step forward over a 10-cm-high obstacle with 1 leg and then return to their original position, as quickly as possible, and this test was repeated for 5 times. The OSFS test was evaluated in 2 phases: the OSFS-F phase, wherein the participants stepped forward on one leg, and the OSFS-R phase, wherein they returned to their original position. Significant differences were observed in both phases of the OSFS test between the two groups, and the fallers by tripping were significantly inferior to the nonfallers. The area under the curve [AUC;area under the receiver operating characteristic (ROC) curve] was more than 0.63 for all the parameters, which was statistically significant. In conclusion, the fallers by tripping were inferior to the nonfallers in the obstacle step movement.
基金study was supported by the National Key Research and Development Program of China(2022YFC2402900)National Natural Science Foundation of China(82470989,52103327)+3 种基金The Joint Funds of the Hunan Provincial Natural Science Foundation(2023JJ60509)The Science and Technology Talent Support Project of the Hunan Provincial Science Popularization Special Project(2023TJ-Z08)Hunan Provincial Innovation Foundation for Postgraduate(2023ZZTS0218)The Postgraduate Inde-pendent Exploration Innovation Fund of the Central South University(2023ZZTS0987)。
文摘Oral submucous fibrosis(OSF),characterized by excessive deposition of extracellular matrix(ECM)that causes oral mucosal tissue sclerosis,and even cancer transformation,is a chronic,progressive fibrosis disease.However,despite some advancements in recent years,no targeted antifibrotic strategies for OSF have been approved;likely because the complicated mechanisms that initiate and drive fibrosis remain to be determined.In this review,we briefly introduce the epidemiology and etiology of OSF.Then,we highlight how cell-intrinsic changes in significant structural cells can drive fibrotic response by regulating biological behaviors,secretion function,and activation of ECM-producing myofibroblasts.In addition,we also discuss the role of innate and adaptive immune cells and how they contribute to the pathogenesis of OSF.Finally,we summarize strategies to interrupt key mechanisms that cause OSF,including modulation of the ECM,inhibition of inflammation,improvement of vascular disturbance.This review will provide potential routes for developing novel anti-OSF therapeutics.
