Submergence can induce anaerobic stress on germinating seedlings in direct seeded rice paddy fields,limiting the practice of direct seeding.Longer coleoptiles improves the anaerobic tolerance of rice seedlings under s...Submergence can induce anaerobic stress on germinating seedlings in direct seeded rice paddy fields,limiting the practice of direct seeding.Longer coleoptiles improves the anaerobic tolerance of rice seedlings under submerged conditions.In a search for genes that could be beneficial for developing submergence-tolerant varieties 148 non-repetitive SNP loci were detected in on a genome-wide association study(GWAS)of coleoptile length(CL),coleoptile surface area(CSA),coleoptile volume(CV),and coleoptile diameter(CD)of 591 rice accessions subjected to 4 d of anaerobic conditions.Integration of GWAS results and gene expression data identified OsEE1,an early embryogenesis-specific enolase 1 gene associated with coleoptile length(CL)in rice grown in anaerobic conditions.Disruption of OsEE1 caused reduced CL in plants seeded under anaerobic conditions,whereas CL of OE-OsEE1 overexpression lines was significantly increased compared with the wild type.Functional analysis revealed that OsEE1 affects coleoptile length by modulating the glycolysis and tricarboxylic acid cycle pathways.Transcriptome sequencing of ko-osee1-1 knock out mutants highlighted enrichment in energy and carbohydrate metabolism,glycolysis,amino acid metabolism,and hormone signal transduction.Metabolite analysis indicated decreased levels of key metabolites in the tricarboxylic acid cycle and glycolysis pathways in koosee1-1 mutants compared to the wild type under anaerobic conditions.Overall,these findings shed light on the role of OsEE1 in determination coleoptile length of rice seedlings under anaerobic conditions.展开更多
OSEK/VDX(open systems and the corresponding interfaces for automobile electronic/vehicle distributed execu-tive)OS规范描述了一个嵌入式实时操作系统,对系统服务调用的上下文做了严格的限制。违反系统服务调用规范是一种很隐...OSEK/VDX(open systems and the corresponding interfaces for automobile electronic/vehicle distributed execu-tive)OS规范描述了一个嵌入式实时操作系统,对系统服务调用的上下文做了严格的限制。违反系统服务调用规范是一种很隐蔽的错误,不会被编译器发现。提出一种OSEK/VDX OS系统服务调用规范一致性的检测方法,利用森林图描述用户自定义代码中的函数及其调用关系,采用矩阵描述OSEK/VDX OS系统服务调用的规则,遍历该森林图的函数调用路径,对于每条路径,结合该规则矩阵判断其规范一致性。实验和分析表明该方法能有效地检测用户自定义代码中隐藏的违反OSEK/VDX OS系统服务调用规范的错误。展开更多
In this study,we selected 18 SG（superconducting gravimeter）records from 15 GGP stations with 99 vertical and 69 horizontal components of IRIS broad-band seismograms during 2004 Sumatra Earthquake to detect the split...In this study,we selected 18 SG（superconducting gravimeter）records from 15 GGP stations with 99 vertical and 69 horizontal components of IRIS broad-band seismograms during 2004 Sumatra Earthquake to detect the splitting of higher-degree Earth’s free oscillations modes（0S4,0S7〈sub〉0S10,2S4,1S5,2S5,1S6）and 12 inner-core sensitive modes（25S2,27S2,6S3,9S3,13S3,15S3,11S4,18S4,8S5,11S5,23S5,16S6）by using OSE（optimal sequence estimation）method which only considers self-coupling.Results indicate that OSE can completely isolate singlets of high-degree modes in time-domain,effectively resolve the coupled multiplets independently,and reduce the possibility of mode mixing and end effect,showing that OSE could improve some signals’signal-to-noise ratio.Comparing the results of SG records with seismic data sets suggests that the number of SG records is inadequate to detect all singlets of higher modes.Hence we mainly selected plentiful seismograms of IRIS to observe the multiplets of higher modes.We estimate frequencies of the singlets using AR method and evaluate the measurement error using bootstrap method.Besides,we compared the observations with the predictions of PREM-tidal model.This study demonstrates that OSE is effective in isolating singlets of Earth’s free oscillations with higher modes.The experimental results may provide constraints to the construction of 3D Earth model.展开更多
马兰士的产品中经常会出现OSE版本，发烧友通常称其为“原音特别版”，因为OSE这三个字母就代表着Original Special Edition。通常OSE版本的器材都是在以往备受欢迎的某些型号上，采用马兰士的独特技术将其进一步优化，例如在关键部分...马兰士的产品中经常会出现OSE版本，发烧友通常称其为“原音特别版”，因为OSE这三个字母就代表着Original Special Edition。通常OSE版本的器材都是在以往备受欢迎的某些型号上，采用马兰士的独特技术将其进一步优化，例如在关键部分采用更高级别的元器件、加强电源供应、强化机箱结构等等，以求获得更佳音质表现。PM6010过去就曾是一款很受欧洲发烧友青睐的合并式功放，如今也推出了PM6010 OSE版本，机器面板布局相当简洁，展开更多
马兰士的产品中经常会出现OSE版本，发烧友通常称其为“原音特别版”，因为OSE这三个字母就代表着Origlnal Special EditloN。通常OSE版本的器材都是在以往备受欢迎的某些型号上，采用马兰士的独特技术将其进一步优化．例如在关键部分...马兰士的产品中经常会出现OSE版本，发烧友通常称其为“原音特别版”，因为OSE这三个字母就代表着Origlnal Special EditloN。通常OSE版本的器材都是在以往备受欢迎的某些型号上，采用马兰士的独特技术将其进一步优化．例如在关键部分采用更高级别的元器件、加强电源供应、强化机箱结构等等，以求获得更佳音质表现。展开更多
BACKGROUND Posterior ankle impingement syndrome(PAIS)is a cause of ankle pain due to pinching of bony or soft tissue structures in the hindfoot.The diagnosis is primarily made based on detailed history and accurate cl...BACKGROUND Posterior ankle impingement syndrome(PAIS)is a cause of ankle pain due to pinching of bony or soft tissue structures in the hindfoot.The diagnosis is primarily made based on detailed history and accurate clinical examination.The delay in its diagnosis has not yet been described in the pediatric and adolescent population.AIM To identify and characterize misdiagnosed cases of PAIS in pediatric and adolescent patients.METHODS This descriptive prospective study at a tertiary children’s hospital included patients≤18 years who underwent posterior ankle arthroscopy after presenting with chronic posterior ankle pain after being diagnosed with PAIS.Collected data included:Demographics,prior diagnoses and treatments,providers seen,time to diagnosis from presentation,and prior imaging obtained.Visual Analogue Scale(VAS)for pain and American Orthopedic Foot Ankle Society(AOFAS)ankle-hindfoot scores were noted at initial presentation and follow-up.RESULTS 35 patients(46 ankles)with average age of 13 years had an average 19 mo(range 0-60 mo)delay in diagnosis from initial presentation.25(71%)patients had previously seen multiple medical providers and were given multiple other diagnoses.All 46(100%)ankles had tenderness to palpation over the posterior ankle joint.Radiographs were reported normal in 31/42(72%)exams.In 32 ankles who underwent MRI,the most common findings included os trigonum(47%)/Stieda process(47%).Conservative treatment had already been attempted in all patients.Ankle impingement pathology was confirmed during arthroscopy in 46(100%)ankles.At an average follow-up of 13.1 mo,there was an improvement of VAS(pre-op 7.0 to post-op 1.2)and AOFAS scores(pre-op 65.1 to post-op 94).CONCLUSION This is the first study which shows that PAIS is a clinically misdiagnosed cause of posterior ankle pain in pediatric and adolescent population;an increased awareness about this diagnosis is needed amongst providers treating young patients.展开更多
Cerebral Venous Sinus Thrombosis (CVST/CSVT) is occlusion of cerebral veins and venous sinuses of brain secondary to blood clot formation resulting in hindrance in the blood drainage system in brain, leading to distur...Cerebral Venous Sinus Thrombosis (CVST/CSVT) is occlusion of cerebral veins and venous sinuses of brain secondary to blood clot formation resulting in hindrance in the blood drainage system in brain, leading to disturbances the internal homeostasis of brain, raised intracranial pressure, cerebral edema, and 50% of cases will have venous infarction or venous hemorrhage (stroke). CVST although being a Rare disorder but may be more common in children than adults with greater risk in neonatal period i.e. first 28 days of life. Here we are discussing a case of Pediatric CVST in a 7-month-old baby boy who presented to Emergency Room (ER) with recurrent discrete episodes of vomiting, fever, seizures, drowsiness and respiratory distress. The fatal outcome in our child was attributed to delayed presentation in a tertiary care center, hence missed early diagnosis and treatment. In this child the CVST could be result of amalgamation of complex underlying ongoing multiple pathological processes: an acute systemic illness like sepsis, severe dehydration, undiagnosed and untreated complex congenital heart disease, tetralogy of fallot with osteum secondum atrial septal defect, worsening the coagulopathy. It takes this case even more unique. This discussion is to bring focus on the importance of knowledge about CVST amongst emergency physicians and primary care physicians, specially managing this rare disorder with flummox presentation mimicking other more common disorders, especially in pediatric and neonatal population where definitive history and chief complaints are often vague and difficult to obtain, making it more difficult to diagnose. We the authors hence reporting this case with intent to spread awareness of CVST, how to doubt it, detect it and then manage it, especially in places like Chhattisgarh, India, where CVST is not so uncommon. We believe early diagnosis, early presentation to tertiary care center with aggressive early treatment can significantly reduce the mortality. Should the parents brought the baby early to any tertiary care center owing to his complex deteriorating symptoms like high grade fever progressed to drowsiness and seizure episodes, could there be a different outcome for this child as well as his parents.展开更多
基金supported by the DUS Testing and Database Construction for Rice,Corn and Other Varieties(H20231012)the Analysis of Agronomic and Economic Traits of Superior Rice Varieties(2020KJ382-05).
文摘Submergence can induce anaerobic stress on germinating seedlings in direct seeded rice paddy fields,limiting the practice of direct seeding.Longer coleoptiles improves the anaerobic tolerance of rice seedlings under submerged conditions.In a search for genes that could be beneficial for developing submergence-tolerant varieties 148 non-repetitive SNP loci were detected in on a genome-wide association study(GWAS)of coleoptile length(CL),coleoptile surface area(CSA),coleoptile volume(CV),and coleoptile diameter(CD)of 591 rice accessions subjected to 4 d of anaerobic conditions.Integration of GWAS results and gene expression data identified OsEE1,an early embryogenesis-specific enolase 1 gene associated with coleoptile length(CL)in rice grown in anaerobic conditions.Disruption of OsEE1 caused reduced CL in plants seeded under anaerobic conditions,whereas CL of OE-OsEE1 overexpression lines was significantly increased compared with the wild type.Functional analysis revealed that OsEE1 affects coleoptile length by modulating the glycolysis and tricarboxylic acid cycle pathways.Transcriptome sequencing of ko-osee1-1 knock out mutants highlighted enrichment in energy and carbohydrate metabolism,glycolysis,amino acid metabolism,and hormone signal transduction.Metabolite analysis indicated decreased levels of key metabolites in the tricarboxylic acid cycle and glycolysis pathways in koosee1-1 mutants compared to the wild type under anaerobic conditions.Overall,these findings shed light on the role of OsEE1 in determination coleoptile length of rice seedlings under anaerobic conditions.
文摘OSEK/VDX(open systems and the corresponding interfaces for automobile electronic/vehicle distributed execu-tive)OS规范描述了一个嵌入式实时操作系统,对系统服务调用的上下文做了严格的限制。违反系统服务调用规范是一种很隐蔽的错误,不会被编译器发现。提出一种OSEK/VDX OS系统服务调用规范一致性的检测方法,利用森林图描述用户自定义代码中的函数及其调用关系,采用矩阵描述OSEK/VDX OS系统服务调用的规则,遍历该森林图的函数调用路径,对于每条路径,结合该规则矩阵判断其规范一致性。实验和分析表明该方法能有效地检测用户自定义代码中隐藏的违反OSEK/VDX OS系统服务调用规范的错误。
基金supported by the National 973 Project of China (No.2013CB733305)the NSFC (Nos.41174011,41429401,41574007,41210006,41128003,41021061)
文摘In this study,we selected 18 SG（superconducting gravimeter）records from 15 GGP stations with 99 vertical and 69 horizontal components of IRIS broad-band seismograms during 2004 Sumatra Earthquake to detect the splitting of higher-degree Earth’s free oscillations modes（0S4,0S7〈sub〉0S10,2S4,1S5,2S5,1S6）and 12 inner-core sensitive modes（25S2,27S2,6S3,9S3,13S3,15S3,11S4,18S4,8S5,11S5,23S5,16S6）by using OSE（optimal sequence estimation）method which only considers self-coupling.Results indicate that OSE can completely isolate singlets of high-degree modes in time-domain,effectively resolve the coupled multiplets independently,and reduce the possibility of mode mixing and end effect,showing that OSE could improve some signals’signal-to-noise ratio.Comparing the results of SG records with seismic data sets suggests that the number of SG records is inadequate to detect all singlets of higher modes.Hence we mainly selected plentiful seismograms of IRIS to observe the multiplets of higher modes.We estimate frequencies of the singlets using AR method and evaluate the measurement error using bootstrap method.Besides,we compared the observations with the predictions of PREM-tidal model.This study demonstrates that OSE is effective in isolating singlets of Earth’s free oscillations with higher modes.The experimental results may provide constraints to the construction of 3D Earth model.
文摘马兰士的产品中经常会出现OSE版本，发烧友通常称其为“原音特别版”，因为OSE这三个字母就代表着Original Special Edition。通常OSE版本的器材都是在以往备受欢迎的某些型号上，采用马兰士的独特技术将其进一步优化，例如在关键部分采用更高级别的元器件、加强电源供应、强化机箱结构等等，以求获得更佳音质表现。PM6010过去就曾是一款很受欧洲发烧友青睐的合并式功放，如今也推出了PM6010 OSE版本，机器面板布局相当简洁，
文摘马兰士的产品中经常会出现OSE版本，发烧友通常称其为“原音特别版”，因为OSE这三个字母就代表着Origlnal Special EditloN。通常OSE版本的器材都是在以往备受欢迎的某些型号上，采用马兰士的独特技术将其进一步优化．例如在关键部分采用更高级别的元器件、加强电源供应、强化机箱结构等等，以求获得更佳音质表现。
文摘BACKGROUND Posterior ankle impingement syndrome(PAIS)is a cause of ankle pain due to pinching of bony or soft tissue structures in the hindfoot.The diagnosis is primarily made based on detailed history and accurate clinical examination.The delay in its diagnosis has not yet been described in the pediatric and adolescent population.AIM To identify and characterize misdiagnosed cases of PAIS in pediatric and adolescent patients.METHODS This descriptive prospective study at a tertiary children’s hospital included patients≤18 years who underwent posterior ankle arthroscopy after presenting with chronic posterior ankle pain after being diagnosed with PAIS.Collected data included:Demographics,prior diagnoses and treatments,providers seen,time to diagnosis from presentation,and prior imaging obtained.Visual Analogue Scale(VAS)for pain and American Orthopedic Foot Ankle Society(AOFAS)ankle-hindfoot scores were noted at initial presentation and follow-up.RESULTS 35 patients(46 ankles)with average age of 13 years had an average 19 mo(range 0-60 mo)delay in diagnosis from initial presentation.25(71%)patients had previously seen multiple medical providers and were given multiple other diagnoses.All 46(100%)ankles had tenderness to palpation over the posterior ankle joint.Radiographs were reported normal in 31/42(72%)exams.In 32 ankles who underwent MRI,the most common findings included os trigonum(47%)/Stieda process(47%).Conservative treatment had already been attempted in all patients.Ankle impingement pathology was confirmed during arthroscopy in 46(100%)ankles.At an average follow-up of 13.1 mo,there was an improvement of VAS(pre-op 7.0 to post-op 1.2)and AOFAS scores(pre-op 65.1 to post-op 94).CONCLUSION This is the first study which shows that PAIS is a clinically misdiagnosed cause of posterior ankle pain in pediatric and adolescent population;an increased awareness about this diagnosis is needed amongst providers treating young patients.
文摘Cerebral Venous Sinus Thrombosis (CVST/CSVT) is occlusion of cerebral veins and venous sinuses of brain secondary to blood clot formation resulting in hindrance in the blood drainage system in brain, leading to disturbances the internal homeostasis of brain, raised intracranial pressure, cerebral edema, and 50% of cases will have venous infarction or venous hemorrhage (stroke). CVST although being a Rare disorder but may be more common in children than adults with greater risk in neonatal period i.e. first 28 days of life. Here we are discussing a case of Pediatric CVST in a 7-month-old baby boy who presented to Emergency Room (ER) with recurrent discrete episodes of vomiting, fever, seizures, drowsiness and respiratory distress. The fatal outcome in our child was attributed to delayed presentation in a tertiary care center, hence missed early diagnosis and treatment. In this child the CVST could be result of amalgamation of complex underlying ongoing multiple pathological processes: an acute systemic illness like sepsis, severe dehydration, undiagnosed and untreated complex congenital heart disease, tetralogy of fallot with osteum secondum atrial septal defect, worsening the coagulopathy. It takes this case even more unique. This discussion is to bring focus on the importance of knowledge about CVST amongst emergency physicians and primary care physicians, specially managing this rare disorder with flummox presentation mimicking other more common disorders, especially in pediatric and neonatal population where definitive history and chief complaints are often vague and difficult to obtain, making it more difficult to diagnose. We the authors hence reporting this case with intent to spread awareness of CVST, how to doubt it, detect it and then manage it, especially in places like Chhattisgarh, India, where CVST is not so uncommon. We believe early diagnosis, early presentation to tertiary care center with aggressive early treatment can significantly reduce the mortality. Should the parents brought the baby early to any tertiary care center owing to his complex deteriorating symptoms like high grade fever progressed to drowsiness and seizure episodes, could there be a different outcome for this child as well as his parents.
