Introduction: Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a sleep-related breathing disorder characterized by repeated episodes of partial obstruction of the upper airways (hypopnea) and/or intermittent compl...Introduction: Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a sleep-related breathing disorder characterized by repeated episodes of partial obstruction of the upper airways (hypopnea) and/or intermittent complete obstruction (apnea). Our aim is to study the role of adeno-tonsillectomy in the management of OSAHS in children. Methodology: This was a prospective descriptive study conducted in the ENT-Head and Neck Surgery department of Ignace Deen National Hospital over a six-month period. We included in our study all patients aged 0 to 15 years, presenting with OSAHS of ENT etiology and who had undergone tonsillectomy/adenoidectomy. Results: The frequency of OSAHS was 13%. The mean age of our patients was 5.1 ± 3.8 years. There was a predominance of males (69.6%) with a sex ratio of 2.28. Snoring (98.6%), nasal obstruction (97.1%), and mouth breathing (96.6%) were the main reasons for consultation. Adeno-tonsillectomy (45.4%) was the primary surgical intervention. Almost all children (99.0%) had a simple postoperative course. Conclusion: OSAHS is a condition with a multifactorial etiology. Adeno-tonsillectomy remains the first-line surgical treatment to prevent severe complications and relieve the patient. Multidisciplinary collaboration is essential in the management of OSAHS.展开更多
目的:探讨机械通气脱机困难合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的综合护理策略。方法:回顾性分析1例脑出血后机械通气脱机困难合并OSAHS患者的临床资料,总结集束化肺康复护理与创新工具的应用效果。结果:通过个体化肺康复方...目的:探讨机械通气脱机困难合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的综合护理策略。方法:回顾性分析1例脑出血后机械通气脱机困难合并OSAHS患者的临床资料,总结集束化肺康复护理与创新工具的应用效果。结果:通过个体化肺康复方案(膈肌起搏、腹式抗阻训练等)联合自制下颌固定工具改善呼吸形态,患者成功脱机,序贯普通氧疗后康复出院。结论:集束化肺康复措施结合呼吸形态矫正工具有效提升脱机成功率,为同类患者的护理提供实践参考。Objective: To explore the comprehensive nursing strategy for patients with mechanical ventilation weaning difficulty and obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: A retrospective analysis of the clinical data of a patient with mechanical ventilation weaning difficulty and OSAHS after cerebral hemorrhage was conducted, and the application effects of bundled pulmonary rehabilitation nursing and innovative tools were summarized. Results: Through an individualized pulmonary rehabilitation program (diaphragm pacing, abdominal resistance training, etc.) combined with homemade mandibular fixation tools to improve respiratory morphology, the patient was successfully weaned and discharged after sequential ordinary oxygen therapy. Conclusion: Bundled pulmonary rehabilitation measures combined with respiratory morphology correction tools can effectively improve the success rate of weaning, and provide a practical reference for the nursing of similar patients.展开更多
目的阐明肝X受体(liver X receptor,LXR)及其靶基因环氧化酶-2(cyclooxygenase-2,COX-2)、胆固醇酯转移蛋白(cholesteryl ester transfer protein,CETP)的高表达是肥胖幼鼠阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea-hypopnea s...目的阐明肝X受体(liver X receptor,LXR)及其靶基因环氧化酶-2(cyclooxygenase-2,COX-2)、胆固醇酯转移蛋白(cholesteryl ester transfer protein,CETP)的高表达是肥胖幼鼠阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)发病过程中的保护性因素,为肥胖儿童OSAHS的发病机制提供基础研究资料。方法24只3~4周龄雄性Wistar幼鼠分为正常对照组(control组)、单纯肥胖组(obesity组)、单纯OSAHS组(OSAHS组)、肥胖+OSAHS组(obesity+OSAHS组)。HE染色观察幼鼠肝组织病理变化;蛋白免疫印迹法(Western blotting)检测幼鼠肝组织中LXRα、COX-2、CETP的表达水平;运用免疫组化方法检测幼鼠肝组织中LXRα、COX-2、CETP的表达水平及分布情况。结果单纯肥胖组和肥胖+OSAHS组幼鼠体质量、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)含量与正常对照组相比均明显增加(P<0.05),单纯OSAHS组和肥胖+OSAHS组幼鼠血氧饱和度与正常对照组相比均明显降低(P<0.05)。单纯肥胖组、单纯OSAHS组及肥胖+OSAHS组肝组织与正常对照组肝组织相比均有明显损伤,肥胖+OSAHS组肝组织损伤较单纯肥胖组、单纯OSAHS组肝组织损伤程度明显升高。单纯OSAHS组和单纯肥胖组幼鼠肝组织中LXRα、COX-2、CETP表达水平较正常对照组均明显升高(P<0.05)。肥胖+OSAHS组幼鼠肝组织中LXRα、COX-2、CETP表达水平较其余各组均明显升高(P<0.05)。结论LXR及其靶基因COX-2、CETP在肥胖OSAHS幼鼠肝脏中高表达,是发病过程中的可能保护性因素。展开更多
目的探讨高血压合并阻塞性睡眠呼吸暂停综合征(OSAHS)患者动态动脉硬化指数(AASI)与呼吸暂停低通气指数(AHI)的关系。方法选择高血压患者153例,根据AHI值分为实验组(OSAHS组,79例)和对照组(非OSAHS组,74例),收集所有患者年龄、性别、身...目的探讨高血压合并阻塞性睡眠呼吸暂停综合征(OSAHS)患者动态动脉硬化指数(AASI)与呼吸暂停低通气指数(AHI)的关系。方法选择高血压患者153例,根据AHI值分为实验组(OSAHS组,79例)和对照组(非OSAHS组,74例),收集所有患者年龄、性别、身高、体重、24 h动态血压监测数据、AHI值以及冠心病、高脂血症、2型糖尿病患病情况,计算出AASI值,比较两组AASI值的差别,分析AASI值与AHI值的相关性。结果实验组AASI值高于对照组(0.599±0.118 vs 0.381±0.098),差异有统计学意义(P<0.05),实验组AASI值与AHI值呈正相关(r=0.617,P<0.01),对照组AASI值与AHI值无相关性。结论高血压合并OSAHS患者动脉硬化程度较单纯高血压患者严重且与OSAHS严重程度呈正相关。展开更多
文摘Introduction: Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a sleep-related breathing disorder characterized by repeated episodes of partial obstruction of the upper airways (hypopnea) and/or intermittent complete obstruction (apnea). Our aim is to study the role of adeno-tonsillectomy in the management of OSAHS in children. Methodology: This was a prospective descriptive study conducted in the ENT-Head and Neck Surgery department of Ignace Deen National Hospital over a six-month period. We included in our study all patients aged 0 to 15 years, presenting with OSAHS of ENT etiology and who had undergone tonsillectomy/adenoidectomy. Results: The frequency of OSAHS was 13%. The mean age of our patients was 5.1 ± 3.8 years. There was a predominance of males (69.6%) with a sex ratio of 2.28. Snoring (98.6%), nasal obstruction (97.1%), and mouth breathing (96.6%) were the main reasons for consultation. Adeno-tonsillectomy (45.4%) was the primary surgical intervention. Almost all children (99.0%) had a simple postoperative course. Conclusion: OSAHS is a condition with a multifactorial etiology. Adeno-tonsillectomy remains the first-line surgical treatment to prevent severe complications and relieve the patient. Multidisciplinary collaboration is essential in the management of OSAHS.
文摘目的:探讨机械通气脱机困难合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的综合护理策略。方法:回顾性分析1例脑出血后机械通气脱机困难合并OSAHS患者的临床资料,总结集束化肺康复护理与创新工具的应用效果。结果:通过个体化肺康复方案(膈肌起搏、腹式抗阻训练等)联合自制下颌固定工具改善呼吸形态,患者成功脱机,序贯普通氧疗后康复出院。结论:集束化肺康复措施结合呼吸形态矫正工具有效提升脱机成功率,为同类患者的护理提供实践参考。Objective: To explore the comprehensive nursing strategy for patients with mechanical ventilation weaning difficulty and obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: A retrospective analysis of the clinical data of a patient with mechanical ventilation weaning difficulty and OSAHS after cerebral hemorrhage was conducted, and the application effects of bundled pulmonary rehabilitation nursing and innovative tools were summarized. Results: Through an individualized pulmonary rehabilitation program (diaphragm pacing, abdominal resistance training, etc.) combined with homemade mandibular fixation tools to improve respiratory morphology, the patient was successfully weaned and discharged after sequential ordinary oxygen therapy. Conclusion: Bundled pulmonary rehabilitation measures combined with respiratory morphology correction tools can effectively improve the success rate of weaning, and provide a practical reference for the nursing of similar patients.
文摘目的探讨高血压合并阻塞性睡眠呼吸暂停综合征(OSAHS)患者动态动脉硬化指数(AASI)与呼吸暂停低通气指数(AHI)的关系。方法选择高血压患者153例,根据AHI值分为实验组(OSAHS组,79例)和对照组(非OSAHS组,74例),收集所有患者年龄、性别、身高、体重、24 h动态血压监测数据、AHI值以及冠心病、高脂血症、2型糖尿病患病情况,计算出AASI值,比较两组AASI值的差别,分析AASI值与AHI值的相关性。结果实验组AASI值高于对照组(0.599±0.118 vs 0.381±0.098),差异有统计学意义(P<0.05),实验组AASI值与AHI值呈正相关(r=0.617,P<0.01),对照组AASI值与AHI值无相关性。结论高血压合并OSAHS患者动脉硬化程度较单纯高血压患者严重且与OSAHS严重程度呈正相关。
