目的:探讨儿童OSAHS特异性生活质量调查(Disease specific quality of for children with obstructive sleep apnea 18 items survey,OSA-18)量表评估儿童阻塞性睡眠呼吸暂停低通气综合征(Structive sleep apnea hypopnea syndrome,OSA...目的:探讨儿童OSAHS特异性生活质量调查(Disease specific quality of for children with obstructive sleep apnea 18 items survey,OSA-18)量表评估儿童阻塞性睡眠呼吸暂停低通气综合征(Structive sleep apnea hypopnea syndrome,OSAHS)疗效的可行性分析。方法:选取2015年5月-2016年12月于本院诊治的轻度OSAHS患儿60例为研究对象,按照随机数字表法将其分为药物治疗组和未用药物组,各30例,药物治疗组给予局部内固醇喷鼻剂治疗,未用药物组不给予药物治疗,随访观察3个月。治疗前后均行多道睡眠描记术(Polysomnography,PSG)及采用OSA-18量表评估患儿的治疗效果,分析轻度OSAHS儿童的呼吸暂停低通气指数(Pnea hypopnea index,AHI)和最低血氧饱和度(Lowest oxygen saturation,LSa O2)与OSA-18评分的相关性。结果:治疗后,药物治疗组AHI低于治疗前及同期未用药物组(P<0.05),药物治疗组LSa O2高于治疗前及同期未用药物组(P<0.05),未用药物组AHI、LSa O2与治疗前比较,差异均无统计学意义(P>0.05);治疗后,药物治疗组睡眠障碍、身体症状、对监护人影响及总分均低于治疗前及同期未用药物组,比较差异均有统计学意义(P<0.05),未用药物组OSA-18各项指标评分和总分与治疗前比较,差异均无统计学意义(P>0.05);OSA-18各项指标评分及总分与AHI均呈正相关(P<0.05),除对监护人影响外,OSA-18其余各项指标评分及总分与LSa O2均呈负相关(P<0.05)。结论:OSA-18评分与PSG存在相关关系,可作为临床评价儿童OSAHS的疗效指标。展开更多
Background:To investigate the effect of adenotonsillec tomy (AT) on bone development,quality of life and polysomnography evaluation in children with obstructive sleep apnea syndrome (OSA).Methods:Preoperative and post...Background:To investigate the effect of adenotonsillec tomy (AT) on bone development,quality of life and polysomnography evaluation in children with obstructive sleep apnea syndrome (OSA).Methods:Preoperative and postoperative (6 months) physical examination,PSG,bone age (BA) and osteocalcin (OC) evaluation were performed on the selected OSA children (n=92) and the healthy children (n=87).The OSA children were also scored based on the OSA 18-item questionnaire.A two-year follow-up was conducted to evaluate BA and OC changes.Results:After AT,81 (88.04%) OSA children recovered completely,eight (8.70%) achieved remarkable improvements,and three (3.26%) achieved moderate improvements.In the OSA children,postoperative OSA 18-item score and the scores of the five domains were significantly higher than preoperative ones.Compared with the preoperative,body mass index (BMI),weight for age Z-sores,height for age Z-sores,weight for height Z-sores and BMI Z-score in the OSA group 6 months after the operation were significantly increased,but no significant difference was detected between the OSA and the control group.The changes of BA and chronological age in the OSA group were significantly different from those in the control group.Two years after AT,BA between the two groups was no longer significantly different.Preoperative serum OC in the OSA group was lower than that in the control group,but increased to normal levels 6 months after AT.Correlation analysis showed serum OC levels were negatively correlated with apnea hyponea index,obstructive apnea index,arousal index,and lowest oxygen saturation.Conclusions:After AT,bone growth and development in children with OSA recovered gradually,and the serum OC levels decreased to the normal level.Therefore,preventive measures and positive treatments should be applied to minimize the negative effects of OSA in children.展开更多
文摘目的:探讨儿童OSAHS特异性生活质量调查(Disease specific quality of for children with obstructive sleep apnea 18 items survey,OSA-18)量表评估儿童阻塞性睡眠呼吸暂停低通气综合征(Structive sleep apnea hypopnea syndrome,OSAHS)疗效的可行性分析。方法:选取2015年5月-2016年12月于本院诊治的轻度OSAHS患儿60例为研究对象,按照随机数字表法将其分为药物治疗组和未用药物组,各30例,药物治疗组给予局部内固醇喷鼻剂治疗,未用药物组不给予药物治疗,随访观察3个月。治疗前后均行多道睡眠描记术(Polysomnography,PSG)及采用OSA-18量表评估患儿的治疗效果,分析轻度OSAHS儿童的呼吸暂停低通气指数(Pnea hypopnea index,AHI)和最低血氧饱和度(Lowest oxygen saturation,LSa O2)与OSA-18评分的相关性。结果:治疗后,药物治疗组AHI低于治疗前及同期未用药物组(P<0.05),药物治疗组LSa O2高于治疗前及同期未用药物组(P<0.05),未用药物组AHI、LSa O2与治疗前比较,差异均无统计学意义(P>0.05);治疗后,药物治疗组睡眠障碍、身体症状、对监护人影响及总分均低于治疗前及同期未用药物组,比较差异均有统计学意义(P<0.05),未用药物组OSA-18各项指标评分和总分与治疗前比较,差异均无统计学意义(P>0.05);OSA-18各项指标评分及总分与AHI均呈正相关(P<0.05),除对监护人影响外,OSA-18其余各项指标评分及总分与LSa O2均呈负相关(P<0.05)。结论:OSA-18评分与PSG存在相关关系,可作为临床评价儿童OSAHS的疗效指标。
文摘Background:To investigate the effect of adenotonsillec tomy (AT) on bone development,quality of life and polysomnography evaluation in children with obstructive sleep apnea syndrome (OSA).Methods:Preoperative and postoperative (6 months) physical examination,PSG,bone age (BA) and osteocalcin (OC) evaluation were performed on the selected OSA children (n=92) and the healthy children (n=87).The OSA children were also scored based on the OSA 18-item questionnaire.A two-year follow-up was conducted to evaluate BA and OC changes.Results:After AT,81 (88.04%) OSA children recovered completely,eight (8.70%) achieved remarkable improvements,and three (3.26%) achieved moderate improvements.In the OSA children,postoperative OSA 18-item score and the scores of the five domains were significantly higher than preoperative ones.Compared with the preoperative,body mass index (BMI),weight for age Z-sores,height for age Z-sores,weight for height Z-sores and BMI Z-score in the OSA group 6 months after the operation were significantly increased,but no significant difference was detected between the OSA and the control group.The changes of BA and chronological age in the OSA group were significantly different from those in the control group.Two years after AT,BA between the two groups was no longer significantly different.Preoperative serum OC in the OSA group was lower than that in the control group,but increased to normal levels 6 months after AT.Correlation analysis showed serum OC levels were negatively correlated with apnea hyponea index,obstructive apnea index,arousal index,and lowest oxygen saturation.Conclusions:After AT,bone growth and development in children with OSA recovered gradually,and the serum OC levels decreased to the normal level.Therefore,preventive measures and positive treatments should be applied to minimize the negative effects of OSA in children.
