Olfactory receptors(ORs)play a key role in the prime sensorial perception,being highly relevant for intra/interspecific interactions.ORs are a subgroup of G-protein coupled receptors that exhibit highly complex subgen...Olfactory receptors(ORs)play a key role in the prime sensorial perception,being highly relevant for intra/interspecific interactions.ORs are a subgroup of G-protein coupled receptors that exhibit highly complex subgenomes in vertebrates.However,OR repertoires remain poorly studied in fish lineages,precluding finely retracing their origin,evolution,and diversification,especially in the most basal groups.Here,we conduct an exhaustive gene screening upon 43 high-quality fish genomes exhibiting varied gene repertoires(2e583 genes).While the early vertebrates performed gas exchange through gills,we hypothesize that the emergence of new breathing structures(swim bladder and paired lungs)in early osteichthyans may be associated with expansions in the ORs gene families sensitive to airborne molecules.Additionally,we verify that the OR repertoire of moderns actinopterygians has not increased as expected following a whole genome duplication,likely due to regulatory mechanisms compensating the gene load excess.Finally,we identify 25 distinct OR families,allowing us to propose an updated universal nomenclature for the fish ORs.展开更多
基金was supported by a PhD grant from "Fundagao para a Ciencia e a Tecnologia"(FCT)(L.S.:SFRH/BD/134565/2017,COVID/BD/151995/2021,T.M.:SFRH/BD/112458/2015supported by a PhD grant from“Fundação para a CiêL.R.:SFRH/BD/142322/2018)+3 种基金A.A.was partially supported by the Strategic Funding UIDB/04423/2020 and UIDP/04423/2020 through national funds provided by FCT and the European Regional Development Fund(ERDF)in the framework of the program PT 2020the European Structural and Investment Funds(ESIF)through the Competitiveness and Internationalization Operational Program e COMPETE 2020 through the FCT project PTDC/CTA-AMB/31774/2017(POCI-01-0145-FEDER/031774/2017)the projects Ocean3R(NORTE-01-0145-FEDER-000064)Atlantida(NORTE-01-0145-FEDER-000040).
文摘Olfactory receptors(ORs)play a key role in the prime sensorial perception,being highly relevant for intra/interspecific interactions.ORs are a subgroup of G-protein coupled receptors that exhibit highly complex subgenomes in vertebrates.However,OR repertoires remain poorly studied in fish lineages,precluding finely retracing their origin,evolution,and diversification,especially in the most basal groups.Here,we conduct an exhaustive gene screening upon 43 high-quality fish genomes exhibiting varied gene repertoires(2e583 genes).While the early vertebrates performed gas exchange through gills,we hypothesize that the emergence of new breathing structures(swim bladder and paired lungs)in early osteichthyans may be associated with expansions in the ORs gene families sensitive to airborne molecules.Additionally,we verify that the OR repertoire of moderns actinopterygians has not increased as expected following a whole genome duplication,likely due to regulatory mechanisms compensating the gene load excess.Finally,we identify 25 distinct OR families,allowing us to propose an updated universal nomenclature for the fish ORs.
