Recent discoveries have revealed a groundbreaking phenomenon where light alone, without any thermal input, can induce water evaporation, termed the “photomolecular effect”. This study explores a novel hypothesis tha...Recent discoveries have revealed a groundbreaking phenomenon where light alone, without any thermal input, can induce water evaporation, termed the “photomolecular effect”. This study explores a novel hypothesis that this effect can be explained by ortho-para magnetic spin interactions in water molecules within the water-air interface layer. Water molecules, consisting of hydrogen and oxygen, exhibit different nuclear spin states: ortho-(triplet) and para-(singlet). The interaction of polarized light with these spin states may induce transitions between the rotational levels of ortho- and para-forms due to catalysts like triplet oxygen (O2) in its inhomogeneous magnetic field. Resonance pumping at 532 nm (~18,797 cm−1) due to the transition v1-v2-v3 ~ 0-8-2 (~18,796 cm−1) results in an increase in molecular energy sufficient to overcome intermolecular forces at the water surface, thereby causing evaporation. The proposed ortho-para conversion mechanism involves spin-orbit coupling and specific resonance conditions. This theory provides a quantum mechanical perspective on the photomolecular effect, potentially offering insights into natural processes such as cloud formation and climate modeling, as well as practical applications in solar desalination and industrial drying. Further experimental validation is required to confirm the role of spin interactions in light-induced water evaporation.展开更多
目的本研究目的在于评估Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性,检验其是否具备解决术前半月板手术方式预测困难的能力。方法纳入本院2019年3月至2019年12月因半月板损伤而接受关节镜下手术者55膝58侧半月板。本研...目的本研究目的在于评估Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性,检验其是否具备解决术前半月板手术方式预测困难的能力。方法纳入本院2019年3月至2019年12月因半月板损伤而接受关节镜下手术者55膝58侧半月板。本研究分为两个部分。第一部分:评分过程由两位医生按Ortho One PROMT评分细则分别对半月板损伤者进行独立评分,并根据得分预测半月板手术术式。第二部分:将两位评分医生预测的半月板手术术式分别与手术医生的实际手术术式进行一致性比较,最终评价Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性、敏感度及特异度。结果评分医生预测半月板修复的平均正确率为86.9%,平均敏感度为86.9%,平均特异度为87.5%,平均阳性预测值92.9%,平均阴性预测值为77.9%;预测半月板切除的平均正确率为87.5%,平均敏感度为87.5%,平均特异度为86.9%,平均阳性预测值为77.9%,平均阴性预测值为92.9%。两位评分医生的预测结果与手术医生的实际术式高度一致(k=0.78,k=0.67)。结论Ortho One PROMT评分预测半月板撕裂可修复性不仅简便、可操作性强,而且具有良好的准确性、敏感度和特异度,能够有效解决当前术前半月板手术方式预测困难的问题,具有一定的临床应用推广价值。展开更多
The present study was designed to determine the chemical constituents of the stems and hooks of Uncaria rhynchophylla. The chemical constituents were isolated and purified from CH_2Cl_2 fraction by chromatography. The...The present study was designed to determine the chemical constituents of the stems and hooks of Uncaria rhynchophylla. The chemical constituents were isolated and purified from CH_2Cl_2 fraction by chromatography. Their structures were elucidated by spectroscopic analyses. Their cytotoxicity was tested using MTT method. Two new ortho benzoquinones, 3-diethylamino-5-methoxy-1, 2-benzoquinone(1) and 3-ethylamino-5-methoxy-1, 2-benzoquinone(2), together with a known compound isorhynchophyllic acid(3) were isolated from U. rhynchophylla. These compounds were evaluated for their cytotoxicity against cancer cells A549, Hep G2 and A2780. Compounds 1 and 2 were new ortho benzoquinones and showed weak antiproliferative activities on A549, Hep G2 and A2780 cells. Compound 3 significantly inhibited the proliferation of A549, Hep G2 and A2780 cells with IC_(50) values being 5.8, 12.8 and 11.8 μmol·L^(–1), respectively.展开更多
In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely unknown.Here,we used an orthodontic i...In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely unknown.Here,we used an orthodontic intrusion tooth movement model with an L-loop in rats to demonstrate that mechanical stress-induced senescent cells aggravate apical root resorption,which was prevented by administering senolytics(a dasatinib and quercetin cocktail).展开更多
Neimadian-point is a newly-found acupointwith a good analgesic effect. 306 orthopedic op-erations on extremities were underNeimadian-point acupuncture anesthesia withgood results. 198 cases with complete clinicalmate...Neimadian-point is a newly-found acupointwith a good analgesic effect. 306 orthopedic op-erations on extremities were underNeimadian-point acupuncture anesthesia withgood results. 198 cases with complete clinicalmaterials were selected and analyzed in the pa-per.展开更多
The Ortho-SUV frame,a novel external fixator,can effectively treat limb deformities and fractures.Its kinematics is used when it is necessary to achieve bone movements with high precision.In this work,the kinematics m...The Ortho-SUV frame,a novel external fixator,can effectively treat limb deformities and fractures.Its kinematics is used when it is necessary to achieve bone movements with high precision.In this work,the kinematics model of the Ortho-SUV frame is established by six pose parameters,and its forward and inverse solutions are given.There is no need to solve nonlinear high-coupling equations with trigonometric functions in this solution method due to its special structure.By numerical examples and simulated orthopedic experiment of tibial fracture,the correctness and accuracy of the kinematics model and its solutions are verified.Besides,on the basis of kinematics analysis,the position workspace and orientation workspace of the Ortho-SUV frame are simulated in Matlab,which can help surgeons choose suitable device dimensions.The kinematics analysis provides a theoretical basis for the Ortho-SUV frame to be used in orthopedic treatment.展开更多
TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance(MDR)and as an anticancer agent for synergistic antitumor effects.However,the comparatively high critical micelle concen...TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance(MDR)and as an anticancer agent for synergistic antitumor effects.However,the comparatively high critical micelle concentration(CMC),low drug loading(DL)and poor tumor target limit its further clinical application.To overcome these drawbacks,the pH-sensitive star-shaped TPGS copolymers were successfully constructed via using pentaerythritol as the initial materials,ortho esters as the pH-triggered linkages and TPGS active-ester as the terminated MDR material.The amphiphilic star-shaped TPGS copolymers could self-assemble into free and doxorubicin(DOX)-loaded micelles at neutral aqueous solutions.The micelles exhibited the lower CMC(8.2×10^(−5) mg/ml),higher DL(10.8%)and long-term storage and circulation stability,and showed enhanced cellular uptake,apoptosis,cytotoxicity,and growth inhibition for in vitro MCF-7/ADR and/or MCF-7/ADR multicellular spheroids and in vivo MCF-7/ADR tumors via efficiently targeted drug release at tumoral intracellular pH(5.0),MDR reversal of TPGS,and synergistic effect of DOX and TPGS.Therefore,the pH-sensitive micelles self-assembled from star-shaped TPGS copolymers with ortho ester linkages are potentially useful to clinically transform for enhanced MDR cancer treatment.展开更多
The mesomorphie properties of title complexes are investigated by means of DSC and polarizing microscopy. The mesophase temperature ranges of complexes are wider than that of corresponding organic ligands. The bridgin...The mesomorphie properties of title complexes are investigated by means of DSC and polarizing microscopy. The mesophase temperature ranges of complexes are wider than that of corresponding organic ligands. The bridging groups of the complexes have profoand effects on the mesomorphic behavior, When the bridging groups are opticallhy active. the compleve show chiral smectic展开更多
The degradation of ortho-chlorophenol using Fenton＇s reagent was studied by chemiluminescence （CL）. Without a special CL reagent, a weak CL emission from the mixture of ferrous ion and hydrogen peroxide was observe...The degradation of ortho-chlorophenol using Fenton＇s reagent was studied by chemiluminescence （CL）. Without a special CL reagent, a weak CL emission from the mixture of ferrous ion and hydrogen peroxide was observed at room temperature. The CL intensity was increased by the addition of ortho-chlorophenol into the mixed solution. When the temperature was raised to 65°C, the CL intensity was enhanced strongly. The CL mechanisms for the system H2O2-Fe2＋ with and without ortho-chlorophenol were studied by examining the CL spectrum, gas chromatography-mass spectrometry and electron spin resonance spectrum. The effects of various free radical scavengers, surfactants and fluorescence compounds on the CL intensity were also investigated. A self-catalytic oxidation mechanism was proposed. The results showed that singlet oxygen was the main emitter for the system H2O2-Fe2＋. The strong CL from the system H2O2-Fe2＋-ortho-chlorophenol was due to singlet oxygen and electronically excited quinone. The benzenediol-like intermediate product formed during the phenol oxidation process greatly promoted the Fenton＇s reaction and led to higher CL intensity. Chemiluninescence is a novel approach for the investigation of the oxidation of some organic pollutants by Fenton＇s reagent.展开更多
The sol-gel transition of methylcellulose （MC） solutions in the presence of ortho-methoxycinnamic acid （OMCA） or cetyltrimethylammonium bromide （CTAB） and in the coexistence of OMCA and CTAB was determined by th...The sol-gel transition of methylcellulose （MC） solutions in the presence of ortho-methoxycinnamic acid （OMCA） or cetyltrimethylammonium bromide （CTAB） and in the coexistence of OMCA and CTAB was determined by the rheological measurement. It has been found that the sol-gel transition temperature of MC solutions increases linearly with the concentration of either OMCA or CTAB in solution, respectively. However, in the coexistence of OMCA and CTAB, the sol-gel transition temperature of MC solutions remains invariable, independent of the concentration of CTAB in solution. The experimental results show that OMCA has priority to adsorb on the methyl group of MC chains to form polymer-bound aggregates. In particular, these aggregates inhibit the hydrophobic interaction between CTAB and the methyl group of MC chains completely. Taking into account the fact that OMCA is almost insoluble in MC-free solutions but dissolves very well in aqueous MC solutions, we propose the formation of the core-shell architecture prompted by OMCA and the methyl group of MC chains, with the methyl group of MC chains serving as the core and the self-assembly of OMCA molecules serving as the shell. Obviously, the formation of the core-shell structure increases the solubility of OMCA, improves the stability of methyl groups of MC chains at high temperatures and inhibits the hydrophobic interaction between CTAB and the methyl group of MC chains in solution. The abnormal behavior relating to the sol-gel transition of MC solutions in the presence of OMCA or in the coexistence of OMCA and CTAB is therefore explained. Upon UV irradiation, the sol-gel transition temperature of MC solutions in the presence of OMCA, or in the coexistence of OMCA and CTAB, decreases notably. However, the dependence of the sol-gel transition temperature of MC solutions as a function of OMCA concentration, or CTAB concentration in the presence of OMCA, does not change after UV irradiation.展开更多
The SnCl2 reduction of 2-nitrocyclododecanone or 2-bromo-12-nitrocyclododecanone gave a colorless compound 2,3,5,6-bis（ortho-1,10-decylidene）dihydropyrazine 1a characterized by IR, NMR and X-ray diffraction analysis...The SnCl2 reduction of 2-nitrocyclododecanone or 2-bromo-12-nitrocyclododecanone gave a colorless compound 2,3,5,6-bis（ortho-1,10-decylidene）dihydropyrazine 1a characterized by IR, NMR and X-ray diffraction analysis. Crystal data for 1a： Mr = 358.60, monoclinic, space group P2 1/n, α = 0.48028（3）, b = 2.8646（4）, c = 0.77097（6） nm, β = 98.432（12）°, V = 1.04924（19） nm^3, Dc = 1.135 g/cm^3, Z = 2, F（000） = 400 and μ（MoKa） = 0.065 mm^-1. All ^1H- and ^13C-NMR resonance lines of 1a were assigned by DEPT, COSY, HMQC and HMBC technology. In the crystal, the dihydropyrazine ring has a planar structure, two twelve-membered tings adopt [lene2333] conformation, their double bonds have cis-configuration, and the whole molecule has a center of symmetry. In solution, the symmetric ^1H- and ^13C-NMR signals suggest that two twelve-membered rings of 1a may adopt enantiomorphous [ lene2333] conformation existing in a dynamic equilibrium.展开更多
Ointment-like poly(ortho esters) were synthesized from the reaction of 3,9-bis (methylene)-2,4,8,10-tetraoxaspiro[5.5]undecane with PEG-400,N,N-bis(2-hydroxyethyl)-n-hexadecylamine and N,N-bis(2-hydroxyethyl) palmitam...Ointment-like poly(ortho esters) were synthesized from the reaction of 3,9-bis (methylene)-2,4,8,10-tetraoxaspiro[5.5]undecane with PEG-400,N,N-bis(2-hydroxyethyl)-n-hexadecylamine and N,N-bis(2-hydroxyethyl) palmitamide respectively. The influence of the catalyst on the intrinsic viscosity of polymers was also studied.展开更多
文摘Recent discoveries have revealed a groundbreaking phenomenon where light alone, without any thermal input, can induce water evaporation, termed the “photomolecular effect”. This study explores a novel hypothesis that this effect can be explained by ortho-para magnetic spin interactions in water molecules within the water-air interface layer. Water molecules, consisting of hydrogen and oxygen, exhibit different nuclear spin states: ortho-(triplet) and para-(singlet). The interaction of polarized light with these spin states may induce transitions between the rotational levels of ortho- and para-forms due to catalysts like triplet oxygen (O2) in its inhomogeneous magnetic field. Resonance pumping at 532 nm (~18,797 cm−1) due to the transition v1-v2-v3 ~ 0-8-2 (~18,796 cm−1) results in an increase in molecular energy sufficient to overcome intermolecular forces at the water surface, thereby causing evaporation. The proposed ortho-para conversion mechanism involves spin-orbit coupling and specific resonance conditions. This theory provides a quantum mechanical perspective on the photomolecular effect, potentially offering insights into natural processes such as cloud formation and climate modeling, as well as practical applications in solar desalination and industrial drying. Further experimental validation is required to confirm the role of spin interactions in light-induced water evaporation.
文摘目的本研究目的在于评估Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性,检验其是否具备解决术前半月板手术方式预测困难的能力。方法纳入本院2019年3月至2019年12月因半月板损伤而接受关节镜下手术者55膝58侧半月板。本研究分为两个部分。第一部分:评分过程由两位医生按Ortho One PROMT评分细则分别对半月板损伤者进行独立评分,并根据得分预测半月板手术术式。第二部分:将两位评分医生预测的半月板手术术式分别与手术医生的实际手术术式进行一致性比较,最终评价Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性、敏感度及特异度。结果评分医生预测半月板修复的平均正确率为86.9%,平均敏感度为86.9%,平均特异度为87.5%,平均阳性预测值92.9%,平均阴性预测值为77.9%;预测半月板切除的平均正确率为87.5%,平均敏感度为87.5%,平均特异度为86.9%,平均阳性预测值为77.9%,平均阴性预测值为92.9%。两位评分医生的预测结果与手术医生的实际术式高度一致(k=0.78,k=0.67)。结论Ortho One PROMT评分预测半月板撕裂可修复性不仅简便、可操作性强,而且具有良好的准确性、敏感度和特异度,能够有效解决当前术前半月板手术方式预测困难的问题,具有一定的临床应用推广价值。
基金financially supported by the National Natural Science Foundation of China(Nos.81373956 and 81274064)the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘The present study was designed to determine the chemical constituents of the stems and hooks of Uncaria rhynchophylla. The chemical constituents were isolated and purified from CH_2Cl_2 fraction by chromatography. Their structures were elucidated by spectroscopic analyses. Their cytotoxicity was tested using MTT method. Two new ortho benzoquinones, 3-diethylamino-5-methoxy-1, 2-benzoquinone(1) and 3-ethylamino-5-methoxy-1, 2-benzoquinone(2), together with a known compound isorhynchophyllic acid(3) were isolated from U. rhynchophylla. These compounds were evaluated for their cytotoxicity against cancer cells A549, Hep G2 and A2780. Compounds 1 and 2 were new ortho benzoquinones and showed weak antiproliferative activities on A549, Hep G2 and A2780 cells. Compound 3 significantly inhibited the proliferation of A549, Hep G2 and A2780 cells with IC_(50) values being 5.8, 12.8 and 11.8 μmol·L^(–1), respectively.
基金supported by JST,CREST Grant Number JPMJCR22L5,Japan。
文摘In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely unknown.Here,we used an orthodontic intrusion tooth movement model with an L-loop in rats to demonstrate that mechanical stress-induced senescent cells aggravate apical root resorption,which was prevented by administering senolytics(a dasatinib and quercetin cocktail).
文摘Neimadian-point is a newly-found acupointwith a good analgesic effect. 306 orthopedic op-erations on extremities were underNeimadian-point acupuncture anesthesia withgood results. 198 cases with complete clinicalmaterials were selected and analyzed in the pa-per.
基金National Key Research & Development Program of China(No.2017YFB1302901)
文摘The Ortho-SUV frame,a novel external fixator,can effectively treat limb deformities and fractures.Its kinematics is used when it is necessary to achieve bone movements with high precision.In this work,the kinematics model of the Ortho-SUV frame is established by six pose parameters,and its forward and inverse solutions are given.There is no need to solve nonlinear high-coupling equations with trigonometric functions in this solution method due to its special structure.By numerical examples and simulated orthopedic experiment of tibial fracture,the correctness and accuracy of the kinematics model and its solutions are verified.Besides,on the basis of kinematics analysis,the position workspace and orientation workspace of the Ortho-SUV frame are simulated in Matlab,which can help surgeons choose suitable device dimensions.The kinematics analysis provides a theoretical basis for the Ortho-SUV frame to be used in orthopedic treatment.
基金This work is financially supported by the National Natural Science Foundation of China(No.51803001)the Research Foundation of Education Department of Anhui Province of China(No.KJ2018ZD003 and KJ2018A0006)the Academic and Technology Introduction Project of Anhui University(AU02303203).
文摘TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance(MDR)and as an anticancer agent for synergistic antitumor effects.However,the comparatively high critical micelle concentration(CMC),low drug loading(DL)and poor tumor target limit its further clinical application.To overcome these drawbacks,the pH-sensitive star-shaped TPGS copolymers were successfully constructed via using pentaerythritol as the initial materials,ortho esters as the pH-triggered linkages and TPGS active-ester as the terminated MDR material.The amphiphilic star-shaped TPGS copolymers could self-assemble into free and doxorubicin(DOX)-loaded micelles at neutral aqueous solutions.The micelles exhibited the lower CMC(8.2×10^(−5) mg/ml),higher DL(10.8%)and long-term storage and circulation stability,and showed enhanced cellular uptake,apoptosis,cytotoxicity,and growth inhibition for in vitro MCF-7/ADR and/or MCF-7/ADR multicellular spheroids and in vivo MCF-7/ADR tumors via efficiently targeted drug release at tumoral intracellular pH(5.0),MDR reversal of TPGS,and synergistic effect of DOX and TPGS.Therefore,the pH-sensitive micelles self-assembled from star-shaped TPGS copolymers with ortho ester linkages are potentially useful to clinically transform for enhanced MDR cancer treatment.
文摘The mesomorphie properties of title complexes are investigated by means of DSC and polarizing microscopy. The mesophase temperature ranges of complexes are wider than that of corresponding organic ligands. The bridging groups of the complexes have profoand effects on the mesomorphic behavior, When the bridging groups are opticallhy active. the compleve show chiral smectic
基金supported by the National Key Technology R & D Program of China (No. 2007AA09210107)
文摘The degradation of ortho-chlorophenol using Fenton＇s reagent was studied by chemiluminescence （CL）. Without a special CL reagent, a weak CL emission from the mixture of ferrous ion and hydrogen peroxide was observed at room temperature. The CL intensity was increased by the addition of ortho-chlorophenol into the mixed solution. When the temperature was raised to 65°C, the CL intensity was enhanced strongly. The CL mechanisms for the system H2O2-Fe2＋ with and without ortho-chlorophenol were studied by examining the CL spectrum, gas chromatography-mass spectrometry and electron spin resonance spectrum. The effects of various free radical scavengers, surfactants and fluorescence compounds on the CL intensity were also investigated. A self-catalytic oxidation mechanism was proposed. The results showed that singlet oxygen was the main emitter for the system H2O2-Fe2＋. The strong CL from the system H2O2-Fe2＋-ortho-chlorophenol was due to singlet oxygen and electronically excited quinone. The benzenediol-like intermediate product formed during the phenol oxidation process greatly promoted the Fenton＇s reaction and led to higher CL intensity. Chemiluninescence is a novel approach for the investigation of the oxidation of some organic pollutants by Fenton＇s reagent.
文摘The sol-gel transition of methylcellulose （MC） solutions in the presence of ortho-methoxycinnamic acid （OMCA） or cetyltrimethylammonium bromide （CTAB） and in the coexistence of OMCA and CTAB was determined by the rheological measurement. It has been found that the sol-gel transition temperature of MC solutions increases linearly with the concentration of either OMCA or CTAB in solution, respectively. However, in the coexistence of OMCA and CTAB, the sol-gel transition temperature of MC solutions remains invariable, independent of the concentration of CTAB in solution. The experimental results show that OMCA has priority to adsorb on the methyl group of MC chains to form polymer-bound aggregates. In particular, these aggregates inhibit the hydrophobic interaction between CTAB and the methyl group of MC chains completely. Taking into account the fact that OMCA is almost insoluble in MC-free solutions but dissolves very well in aqueous MC solutions, we propose the formation of the core-shell architecture prompted by OMCA and the methyl group of MC chains, with the methyl group of MC chains serving as the core and the self-assembly of OMCA molecules serving as the shell. Obviously, the formation of the core-shell structure increases the solubility of OMCA, improves the stability of methyl groups of MC chains at high temperatures and inhibits the hydrophobic interaction between CTAB and the methyl group of MC chains in solution. The abnormal behavior relating to the sol-gel transition of MC solutions in the presence of OMCA or in the coexistence of OMCA and CTAB is therefore explained. Upon UV irradiation, the sol-gel transition temperature of MC solutions in the presence of OMCA, or in the coexistence of OMCA and CTAB, decreases notably. However, the dependence of the sol-gel transition temperature of MC solutions as a function of OMCA concentration, or CTAB concentration in the presence of OMCA, does not change after UV irradiation.
基金This project was supported by the National Natural Science Foundation of China (No. 20072053)
文摘The SnCl2 reduction of 2-nitrocyclododecanone or 2-bromo-12-nitrocyclododecanone gave a colorless compound 2,3,5,6-bis（ortho-1,10-decylidene）dihydropyrazine 1a characterized by IR, NMR and X-ray diffraction analysis. Crystal data for 1a： Mr = 358.60, monoclinic, space group P2 1/n, α = 0.48028（3）, b = 2.8646（4）, c = 0.77097（6） nm, β = 98.432（12）°, V = 1.04924（19） nm^3, Dc = 1.135 g/cm^3, Z = 2, F（000） = 400 and μ（MoKa） = 0.065 mm^-1. All ^1H- and ^13C-NMR resonance lines of 1a were assigned by DEPT, COSY, HMQC and HMBC technology. In the crystal, the dihydropyrazine ring has a planar structure, two twelve-membered tings adopt [lene2333] conformation, their double bonds have cis-configuration, and the whole molecule has a center of symmetry. In solution, the symmetric ^1H- and ^13C-NMR signals suggest that two twelve-membered rings of 1a may adopt enantiomorphous [ lene2333] conformation existing in a dynamic equilibrium.
文摘Ointment-like poly(ortho esters) were synthesized from the reaction of 3,9-bis (methylene)-2,4,8,10-tetraoxaspiro[5.5]undecane with PEG-400,N,N-bis(2-hydroxyethyl)-n-hexadecylamine and N,N-bis(2-hydroxyethyl) palmitamide respectively. The influence of the catalyst on the intrinsic viscosity of polymers was also studied.
