A method for stereoselective construction of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem‑difluoroalkenes in mild conditions was described.The combination of lithium organoborate and ZnBr_(2)...A method for stereoselective construction of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem‑difluoroalkenes in mild conditions was described.The combination of lithium organoborate and ZnBr_(2) generated in situ lithium aryl zincates,which facilitates the transmetalation step of the nickel-catalyzed cross coupling reaction.展开更多
The insertion of dichlorocarbene generated from chloroform by Phase Transfer Catalysis(PTC)into carbon-boron bond of dialkylborate anions 3,obtained by method A and B,resulted in the formation of the inter- mediates 5...The insertion of dichlorocarbene generated from chloroform by Phase Transfer Catalysis(PTC)into carbon-boron bond of dialkylborate anions 3,obtained by method A and B,resulted in the formation of the inter- mediates 5,which were oxidized with alkaline hydrogen peroxide to give the corresponding dialkylketones in 36-77.9% yields.展开更多
The reactions of trialkylalkynylborate with many electrophiles, as the effective method, appear to have a broader and broader prospect in organic synthesis. In the presence of palladium complex, trialkylalkynylborate ...The reactions of trialkylalkynylborate with many electrophiles, as the effective method, appear to have a broader and broader prospect in organic synthesis. In the presence of palladium complex, trialkylalkynylborate can be allylated by allyl acetate, after protonation, giving 1, 4-alkadienes with high stereoselectivity. Similarly, the reaction between展开更多
基金the National Natural Science Foundation of China(Nos.21625206.21632009,21421002,22061160465)for financial support.
文摘A method for stereoselective construction of Z-monofluoroalkenes by nickel-catalyzed defluorinative coupling of gem‑difluoroalkenes in mild conditions was described.The combination of lithium organoborate and ZnBr_(2) generated in situ lithium aryl zincates,which facilitates the transmetalation step of the nickel-catalyzed cross coupling reaction.
文摘The insertion of dichlorocarbene generated from chloroform by Phase Transfer Catalysis(PTC)into carbon-boron bond of dialkylborate anions 3,obtained by method A and B,resulted in the formation of the inter- mediates 5,which were oxidized with alkaline hydrogen peroxide to give the corresponding dialkylketones in 36-77.9% yields.
基金Project supported by the National Natural Science Foundation of China.
文摘The reactions of trialkylalkynylborate with many electrophiles, as the effective method, appear to have a broader and broader prospect in organic synthesis. In the presence of palladium complex, trialkylalkynylborate can be allylated by allyl acetate, after protonation, giving 1, 4-alkadienes with high stereoselectivity. Similarly, the reaction between
