Objective Short-chain fatty acids(SCFAs)produced by intestinal microbiota influence the pathogenesis and development of several intestinal diseases.OR51E2 is a newly discovered SCFA receptor.At present,research on the...Objective Short-chain fatty acids(SCFAs)produced by intestinal microbiota influence the pathogenesis and development of several intestinal diseases.OR51E2 is a newly discovered SCFA receptor.At present,research on the link between OR51E2 and intestinal cancer is limited.This study aimed to analyze the relationship between OR51E2 and colorectal cancer.Methods Bioinformatic analysis revealed the OR51E2 protein expression pattern in different parts of the intestine,regulation of related proteins,and immune cell infiltration.The expression pattern and prognostic value of OR51E2 in colon and rectal cancer was determined,and the miRNAs targeting OR51E2 were predicted.Results The expression level of OR51E2 was relatively high in the colon,small intestine,and duodenum.In addition,OR51E2 expression level was significantly reduced in colon and rectal cancer.A positive correlation between OR51E2 and immune cells was observed,which was associated with the survival of patients with colon and rectal cancer(hazard ratio:1.5).Further,miR-96-5p and miR-1271-5-p were predicted to target OR51E2.Conclusion OR51E2 plays an important positive role in the survival of patients with colon cancer and rectal adenocarcinoma.展开更多
The expression of ectopic olfactory receptors （ORs） in melanized cells, such as the human brain nigrostri- atal dopaminergic neurons and skin melanocytes, is here pointed out. ORs are recognized to regulate skin mel...The expression of ectopic olfactory receptors （ORs） in melanized cells, such as the human brain nigrostri- atal dopaminergic neurons and skin melanocytes, is here pointed out. ORs are recognized to regulate skin melanogenesis, whereas OR expression in the dopaminergic neurons, characterized by accumulation of pigment neuromelanin, is downregulated in Parkinson＇s disease. Furthermore, the correlation between the pigmentation process and the dopamine pathway through ct-synuclein expression is also highlighted. Purposely, these ORs are suggested as therapeutic target for neurodegenerative diseases related to the pig- mentation disorders. Based on this evidence, a possible way of turning odorants into drugs, acting on three specific olfactory receptors, OR51E2, OR2AT4 and VN1R1, is thus introduced. Various odorous molecules are shown to interact with these ORs and their therapeutic potential against melanogenic and neurodegen- erative dysfunctions, including melanoma and Parkinson＇s disease, is suggested. Finally, a direct functional link between olfactory and endocrine systems in human brain through VNIR1 is proposed, helping to counteract female susceptibility to Parkinson＇s disease in quiescent life.展开更多
文摘Objective Short-chain fatty acids(SCFAs)produced by intestinal microbiota influence the pathogenesis and development of several intestinal diseases.OR51E2 is a newly discovered SCFA receptor.At present,research on the link between OR51E2 and intestinal cancer is limited.This study aimed to analyze the relationship between OR51E2 and colorectal cancer.Methods Bioinformatic analysis revealed the OR51E2 protein expression pattern in different parts of the intestine,regulation of related proteins,and immune cell infiltration.The expression pattern and prognostic value of OR51E2 in colon and rectal cancer was determined,and the miRNAs targeting OR51E2 were predicted.Results The expression level of OR51E2 was relatively high in the colon,small intestine,and duodenum.In addition,OR51E2 expression level was significantly reduced in colon and rectal cancer.A positive correlation between OR51E2 and immune cells was observed,which was associated with the survival of patients with colon and rectal cancer(hazard ratio:1.5).Further,miR-96-5p and miR-1271-5-p were predicted to target OR51E2.Conclusion OR51E2 plays an important positive role in the survival of patients with colon cancer and rectal adenocarcinoma.
基金supported by the University of Ferrara(F72I15000470005)in the frame of the project FAR2014
文摘The expression of ectopic olfactory receptors （ORs） in melanized cells, such as the human brain nigrostri- atal dopaminergic neurons and skin melanocytes, is here pointed out. ORs are recognized to regulate skin melanogenesis, whereas OR expression in the dopaminergic neurons, characterized by accumulation of pigment neuromelanin, is downregulated in Parkinson＇s disease. Furthermore, the correlation between the pigmentation process and the dopamine pathway through ct-synuclein expression is also highlighted. Purposely, these ORs are suggested as therapeutic target for neurodegenerative diseases related to the pig- mentation disorders. Based on this evidence, a possible way of turning odorants into drugs, acting on three specific olfactory receptors, OR51E2, OR2AT4 and VN1R1, is thus introduced. Various odorous molecules are shown to interact with these ORs and their therapeutic potential against melanogenic and neurodegen- erative dysfunctions, including melanoma and Parkinson＇s disease, is suggested. Finally, a direct functional link between olfactory and endocrine systems in human brain through VNIR1 is proposed, helping to counteract female susceptibility to Parkinson＇s disease in quiescent life.
