骨质疏松症由于其严重的致病后果同时较高的发病率已经成为我国老年人的头号健康潜在威胁,而OPG/RANK/RANKL信号通路主要通过影响破骨细胞分化成熟,从而在骨质疏松症的发病机制中占据了重要地位,是许多抗骨质疏松药品开发的重要研究靶...骨质疏松症由于其严重的致病后果同时较高的发病率已经成为我国老年人的头号健康潜在威胁,而OPG/RANK/RANKL信号通路主要通过影响破骨细胞分化成熟,从而在骨质疏松症的发病机制中占据了重要地位,是许多抗骨质疏松药品开发的重要研究靶点之一。为了探究OPG/RANK/RANKL信号通路在骨质疏松症中的作用机制及中医药干预现状和进展,通过CNKI、WANFANG DATE、中华医学期刊全文数据库、Web of Science、Pub Med数据库,以骨质疏松症、OPG/RANK/RANKL、中药和中药方剂为关键词检索近10年相关文献报道,结果显示许多中药及其有效成分和中药方剂都可通过调控OPG/RANK/RANKL信号通路抑制破骨细胞,改善骨质疏松症,增加骨强度,提示中药及其有效成分和中药方剂能有效防治骨质疏松症,同时在药物研发方面具有极大的潜力和应用前景。展开更多
Objectives:The purpose of this narrative review is to offer an updated perspective on the current research on the glycoprotein Osteoprotegerin(OPG),including its potential therapeutic impact and mechanisms of action,a...Objectives:The purpose of this narrative review is to offer an updated perspective on the current research on the glycoprotein Osteoprotegerin(OPG),including its potential therapeutic impact and mechanisms of action,and interaction with bone and muscle tissues.Content:As health and social care advances people are living longer,with projections suggesting that in 2050 there will be 2 billion people who are aged over 60 years.Yet musculoskeletal health still declines into older age and as a result there is an increase in the proportion of older populations that spend more time with persistent disabilities.Although physical exercise is repeatedly demonstrated to minimise detrimental effects of ageing,it is not always a feasible intervention,and other directions must be considered.Summary and outlook:OPG,a glycoprotein decoy receptor for the receptor activator of nuclear factor kappa-βligand(RANKL)is a key regulator of bone formation yet emerging evidence has presented its potential to offer positive outcomes in regard to the preservation of skeletal muscle mass and function.Animal models have shown that OPG levels increase during exercise,and independently acts to restore losses of muscle strength and reduce bone resorption.Interventions to increase circulating OPG alongside exercise may act as a therapeutic target to combat the decline in quality of life in older age in humans.Further research is needed on the mechanisms of its action and interaction in humans in combination with exercise.展开更多
文摘骨质疏松症由于其严重的致病后果同时较高的发病率已经成为我国老年人的头号健康潜在威胁,而OPG/RANK/RANKL信号通路主要通过影响破骨细胞分化成熟,从而在骨质疏松症的发病机制中占据了重要地位,是许多抗骨质疏松药品开发的重要研究靶点之一。为了探究OPG/RANK/RANKL信号通路在骨质疏松症中的作用机制及中医药干预现状和进展,通过CNKI、WANFANG DATE、中华医学期刊全文数据库、Web of Science、Pub Med数据库,以骨质疏松症、OPG/RANK/RANKL、中药和中药方剂为关键词检索近10年相关文献报道,结果显示许多中药及其有效成分和中药方剂都可通过调控OPG/RANK/RANKL信号通路抑制破骨细胞,改善骨质疏松症,增加骨强度,提示中药及其有效成分和中药方剂能有效防治骨质疏松症,同时在药物研发方面具有极大的潜力和应用前景。
文摘Objectives:The purpose of this narrative review is to offer an updated perspective on the current research on the glycoprotein Osteoprotegerin(OPG),including its potential therapeutic impact and mechanisms of action,and interaction with bone and muscle tissues.Content:As health and social care advances people are living longer,with projections suggesting that in 2050 there will be 2 billion people who are aged over 60 years.Yet musculoskeletal health still declines into older age and as a result there is an increase in the proportion of older populations that spend more time with persistent disabilities.Although physical exercise is repeatedly demonstrated to minimise detrimental effects of ageing,it is not always a feasible intervention,and other directions must be considered.Summary and outlook:OPG,a glycoprotein decoy receptor for the receptor activator of nuclear factor kappa-βligand(RANKL)is a key regulator of bone formation yet emerging evidence has presented its potential to offer positive outcomes in regard to the preservation of skeletal muscle mass and function.Animal models have shown that OPG levels increase during exercise,and independently acts to restore losses of muscle strength and reduce bone resorption.Interventions to increase circulating OPG alongside exercise may act as a therapeutic target to combat the decline in quality of life in older age in humans.Further research is needed on the mechanisms of its action and interaction in humans in combination with exercise.
