Background: Surgical treatment of lumbar disc herniation is a widely debated topic, with several techniques available. Percutaneous endoscopic discectomy (PELD) has gained popularity due to its lower invasiveness comp...Background: Surgical treatment of lumbar disc herniation is a widely debated topic, with several techniques available. Percutaneous endoscopic discectomy (PELD) has gained popularity due to its lower invasiveness compared to conventional techniques such as microdiscectomy/open lumbar microdiscectomy (OLMD)/tubular microdiscectomy (TMD). However, evidence on the effectiveness, recovery time and complications of these techniques is not yet clearly established. This systematic review aims to compare the preoperative and postoperative outcomes of both techniques. Methods: A comprehensive search was performed in databases including PubMed and Cochrane, following strict inclusion and exclusion criteria. Comparative studies and narrative reviews on PELD and OLMD/TMD published between 2019 and 2024 were included. Key outcomes considered were pre- and postoperative Visual Analogue Scale (VAS), hospitalization time, time to return to work, and postoperative complications. Results: The reviewed studies indicated that PELD is associated with a greater reduction in postoperative pain compared to OLMD/TMD, with a significant decrease in VAS, according to the study by Priola et al. (2019). The hospital stay was also shorter for patients undergoing PELD, averaging 2 days compared to OLMD/TMD. Furthermore, PELD favored a faster return to work and had a lower rate of postoperative complications, such as dural tears and reoperations, compared to OLMD/TMD. Conclusions: PELD demonstrates clear advantages over OLMD/TMD in terms of pain reduction, shorter hospital stay, faster return to work, and fewer postoperative complications. However, the implementation of this technique requires a significant learning curve, suggesting that its effectiveness may vary depending on the surgeon’s experience. PELD should be considered a preferred option in the resection of lumbar disc herniations, especially in patients seeking a quick and less invasive recovery.展开更多
This paper covers the preparation of a sol gel derived macrocyclic dioxopolyamine(1,4,7,10 tetraazaclotridecane 11,13 dione) stationary phase for open tubular capillary electrochromatography(OTCEC). The sol gel derive...This paper covers the preparation of a sol gel derived macrocyclic dioxopolyamine(1,4,7,10 tetraazaclotridecane 11,13 dione) stationary phase for open tubular capillary electrochromatography(OTCEC). The sol gel derived macrocyclic dioxopolyamine capillary columns have shown improved separations of neurotransmitters, isomeric nitrophenols, isomeric dihydroxybenzenes, isomeric aminophenols, isomeric diaminobenzenes and three ortho halogen anilines, in comparison with those of untreated capillaries. The characteristics of the sol gel derived macrocyclic dioxopolyamine capillary columns are compared with the capillary column modified with the macrocyclic dioxopolyamine by chemically bonded method after etching. The sol gel method provided a porous silica material with stationary phase in place within the same experimental procedure. This provided speedy fabrications of high efficiency columns with high surface area and improved phase ratio. We achieved high efficiencies of 60 000-340 000 plates/m for the various isomeric compounds. The reproducibility migration time and the plate number were pretty good.展开更多
The macrocyclic dioxopolyamine compounds, 1,4,7,10-tetraazacyclotridecane-11,13-diones were used as stationary phases with the aid of 3-(2-cyclooxypropoxyl)propyl-trimethoxy silane as a bridge in open-tubular capillar...The macrocyclic dioxopolyamine compounds, 1,4,7,10-tetraazacyclotridecane-11,13-diones were used as stationary phases with the aid of 3-(2-cyclooxypropoxyl)propyl-trimethoxy silane as a bridge in open-tubular capillary electrochromatography(OTCEC). The capillaries were etched by aqueous sodium before being coated. These modified capillaries had shown improved separations of neurotransmitters, isomeric dihydrobenzenes, isomeric nitrophenols and isomeric aminophenols in comparison with untreated capillaries.展开更多
Poly(amidoamine)(PAMAM) dendrimer has a large number of terminal groups which can be functionalized by different kinds of ligands.A novel open-tubular CEC(OT-CEC) column in which BSA was bonded to inner wall of capill...Poly(amidoamine)(PAMAM) dendrimer has a large number of terminal groups which can be functionalized by different kinds of ligands.A novel open-tubular CEC(OT-CEC) column in which BSA was bonded to inner wall of capillary as stationary phase through different generations of PAMAM dendrimer was developed.The obtained columns were characterized via labelling BSA with fluorescein isothiocyanate(FITC).Under the optimized condition,the resolution of D,L-Trp was gradually improved with the increase of PAMAM generation.By OT-CEC column modified with BSA-G3.0-PAMAM,the baseline separation of D,L-Trp can be obtained.展开更多
采用溶胶-凝胶法制备对硝基苯氨基甲酸酯化β-环糊精毛细管开管柱（NCDP）,建立了分别拆分钙离子阻滞剂盐酸马尼地平和盐酸尼卡地平对映体的毛细管电色谱方法。采用红外光谱、扫描电子显微镜对其进行了必要的结构及形态表征。在极性有...采用溶胶-凝胶法制备对硝基苯氨基甲酸酯化β-环糊精毛细管开管柱（NCDP）,建立了分别拆分钙离子阻滞剂盐酸马尼地平和盐酸尼卡地平对映体的毛细管电色谱方法。采用红外光谱、扫描电子显微镜对其进行了必要的结构及形态表征。在极性有机模式下,考察了有机溶剂的组成及含量、三乙胺和冰醋酸的含量、运行电压、温度对手性分离的影响。优化的条件为：温度20℃,检测波长236 nm,压力进样（3.448 k Pa×3 s）,盐酸马尼地平在乙腈-甲醇-三乙胺-冰醋酸（体积比57∶43∶0.05∶0.07）流动相中,运行电压25 k V时,分离度（RS）为1.39;盐酸尼卡地平在乙腈-甲醇-三乙胺-冰醋酸（体积比55∶45∶0.05∶0.08）流动相中,运行电压20 k V时,分离度为1.30。上述两种地平对映体保留时间和峰面积的RSD分别小于1.2%和5.6%（n=5）,表明所制备的电色谱柱有良好的稳定性。盐酸马尼地平的拆分时间〈5 min,盐酸尼卡地平的拆分时间〈7 min,有利于建立快速测定其对映体含量的方法。盐酸马尼地平和盐酸尼卡地平在5.2~125 mg/L范围内线性关系良好（r≥0.9969）,检测限分别为1.8和2.3 mg/L（S/N=3）。初步将NCDP柱用于盐酸马尼地平片和盐酸尼卡地平缓释胶囊中对映体含量的测定。展开更多
文摘Background: Surgical treatment of lumbar disc herniation is a widely debated topic, with several techniques available. Percutaneous endoscopic discectomy (PELD) has gained popularity due to its lower invasiveness compared to conventional techniques such as microdiscectomy/open lumbar microdiscectomy (OLMD)/tubular microdiscectomy (TMD). However, evidence on the effectiveness, recovery time and complications of these techniques is not yet clearly established. This systematic review aims to compare the preoperative and postoperative outcomes of both techniques. Methods: A comprehensive search was performed in databases including PubMed and Cochrane, following strict inclusion and exclusion criteria. Comparative studies and narrative reviews on PELD and OLMD/TMD published between 2019 and 2024 were included. Key outcomes considered were pre- and postoperative Visual Analogue Scale (VAS), hospitalization time, time to return to work, and postoperative complications. Results: The reviewed studies indicated that PELD is associated with a greater reduction in postoperative pain compared to OLMD/TMD, with a significant decrease in VAS, according to the study by Priola et al. (2019). The hospital stay was also shorter for patients undergoing PELD, averaging 2 days compared to OLMD/TMD. Furthermore, PELD favored a faster return to work and had a lower rate of postoperative complications, such as dural tears and reoperations, compared to OLMD/TMD. Conclusions: PELD demonstrates clear advantages over OLMD/TMD in terms of pain reduction, shorter hospital stay, faster return to work, and fewer postoperative complications. However, the implementation of this technique requires a significant learning curve, suggesting that its effectiveness may vary depending on the surgeon’s experience. PELD should be considered a preferred option in the resection of lumbar disc herniations, especially in patients seeking a quick and less invasive recovery.
文摘This paper covers the preparation of a sol gel derived macrocyclic dioxopolyamine(1,4,7,10 tetraazaclotridecane 11,13 dione) stationary phase for open tubular capillary electrochromatography(OTCEC). The sol gel derived macrocyclic dioxopolyamine capillary columns have shown improved separations of neurotransmitters, isomeric nitrophenols, isomeric dihydroxybenzenes, isomeric aminophenols, isomeric diaminobenzenes and three ortho halogen anilines, in comparison with those of untreated capillaries. The characteristics of the sol gel derived macrocyclic dioxopolyamine capillary columns are compared with the capillary column modified with the macrocyclic dioxopolyamine by chemically bonded method after etching. The sol gel method provided a porous silica material with stationary phase in place within the same experimental procedure. This provided speedy fabrications of high efficiency columns with high surface area and improved phase ratio. We achieved high efficiencies of 60 000-340 000 plates/m for the various isomeric compounds. The reproducibility migration time and the plate number were pretty good.
文摘The macrocyclic dioxopolyamine compounds, 1,4,7,10-tetraazacyclotridecane-11,13-diones were used as stationary phases with the aid of 3-(2-cyclooxypropoxyl)propyl-trimethoxy silane as a bridge in open-tubular capillary electrochromatography(OTCEC). The capillaries were etched by aqueous sodium before being coated. These modified capillaries had shown improved separations of neurotransmitters, isomeric dihydrobenzenes, isomeric nitrophenols and isomeric aminophenols in comparison with untreated capillaries.
文摘Poly(amidoamine)(PAMAM) dendrimer has a large number of terminal groups which can be functionalized by different kinds of ligands.A novel open-tubular CEC(OT-CEC) column in which BSA was bonded to inner wall of capillary as stationary phase through different generations of PAMAM dendrimer was developed.The obtained columns were characterized via labelling BSA with fluorescein isothiocyanate(FITC).Under the optimized condition,the resolution of D,L-Trp was gradually improved with the increase of PAMAM generation.By OT-CEC column modified with BSA-G3.0-PAMAM,the baseline separation of D,L-Trp can be obtained.
文摘采用溶胶-凝胶法制备对硝基苯氨基甲酸酯化β-环糊精毛细管开管柱（NCDP）,建立了分别拆分钙离子阻滞剂盐酸马尼地平和盐酸尼卡地平对映体的毛细管电色谱方法。采用红外光谱、扫描电子显微镜对其进行了必要的结构及形态表征。在极性有机模式下,考察了有机溶剂的组成及含量、三乙胺和冰醋酸的含量、运行电压、温度对手性分离的影响。优化的条件为：温度20℃,检测波长236 nm,压力进样（3.448 k Pa×3 s）,盐酸马尼地平在乙腈-甲醇-三乙胺-冰醋酸（体积比57∶43∶0.05∶0.07）流动相中,运行电压25 k V时,分离度（RS）为1.39;盐酸尼卡地平在乙腈-甲醇-三乙胺-冰醋酸（体积比55∶45∶0.05∶0.08）流动相中,运行电压20 k V时,分离度为1.30。上述两种地平对映体保留时间和峰面积的RSD分别小于1.2%和5.6%（n=5）,表明所制备的电色谱柱有良好的稳定性。盐酸马尼地平的拆分时间〈5 min,盐酸尼卡地平的拆分时间〈7 min,有利于建立快速测定其对映体含量的方法。盐酸马尼地平和盐酸尼卡地平在5.2~125 mg/L范围内线性关系良好（r≥0.9969）,检测限分别为1.8和2.3 mg/L（S/N=3）。初步将NCDP柱用于盐酸马尼地平片和盐酸尼卡地平缓释胶囊中对映体含量的测定。
