Residual ridge resorption(RRR)is the decrease in the jaw structure that follows tooth extraction.It is a multifactorial disorder,but reports on the associated genetic factors are scarce,particularly amongst the Saudis...Residual ridge resorption(RRR)is the decrease in the jaw structure that follows tooth extraction.It is a multifactorial disorder,but reports on the associated genetic factors are scarce,particularly amongst the Saudis.This study aimed to investigate the role of single nucleotide polymorphisms(SNPs)in fibroblast growth factor receptor 1 oncogene partner 2(FGFR1OP2)in RRR development in Saudis.The study included 192 individuals(RRR=96;controls=96)attending outpatient clinics at the College of Dentistry,King Saud University.Demographic and clinical data were collected,the digital panoramic dental radiograph was obtained,and mandibular residual ridge height was measured.DNA was extracted from saliva and genotyping was conducted on“Sequenom MassARRAY iPLEX”.Genotype and allele frequencies of three SNPs were calculated and compared.The age at first diagnosis and bone height were compared in the three genotypes of each SNP.The age of the patients,age at first edentulism,and bone height ranged 21-80 years,12-70 years,and 13-34.6 mm,respectively.All three genotypes of the studied SNPs(rs2279351,rs78054962 and rs2306852)were identified.SNP rs2279351 associated significantly with RRR,and the mutant C allele was highly predisposing.No association was observed for the other two SNPs.The genotypes of all SNPs had an influence on age at first edentulism and bone height,but the results were not statistically different.Since FGFR1OP2 plays a role in the process of rapid wound healing in the oral cavity,it may be playing a role in the development of RRR by influencing the rate of resorption of the jawbone.SNP rs2279351 may alter its expression and hence RRR development.This study is limited due to small a sample size,and further large-scale studies are required to confirm this association and to consider rs2279351 as a possible marker of RRR development.展开更多
Current HPC hardware presents the characteristics of heterogeneity and diversity.Portable parallel programming technologies are attractive for application developers.OP2 is a domain specific programming framework for ...Current HPC hardware presents the characteristics of heterogeneity and diversity.Portable parallel programming technologies are attractive for application developers.OP2 is a domain specific programming framework for unstructured applications.It supports unified programming and automatic code generation for multiple hardware platforms.However,current OP2 implementation is faced with some difficulties in programming application with complex data structures and function calls.To address this issue,we improve the implementation of OP2 framework in this paper.We modified the source-to-source translator and the runtime library of OP2,making it possible to automatically support applications with complex data structures and function calls during the generation of serial,OpenMP,CUDA,and MPI versions of codes.This avoids tedious manual code rewriting process for the OP2 application developers.HOUR2D,a high order and complex unstructured CFD application,is used as an example to verify the applicability of our extension to the OP2 framework.The results show that our extension enables OP2 to support portable programming for complex unstructured applications without changing its programming mode,ensures the correctness of the results,and achieves comparable or even better performance than manual parallelizations on Intel Xeon Gold CPU,HUAWEI Kunpeng CPU and NVIDIA V100 GPU.展开更多
文摘OP2S发动机(Opposed-Piston Two-Stroke,OP2S,对置活塞二冲程发动机)相较于传统四冲程发动机,具有功率密度高、热负荷高的特点,需在活塞内部设计内冷油腔对其进行强制振荡冷却,以确保活塞在严苛环境下安全可靠地工作。以某OP2S发动机活塞内冷油腔为设计对象,应用三维建模软件和流体传热计算软件Fluent,建立了卵形、椭圆形和水滴形三种截面形状的油腔模型作为研究对象,采用VOF(volume of fluid)多相流模型、动网格技术等,对活塞内冷油腔强制振荡冷却过程进行了流动和换热分析。经过分析得知,活塞内冷油腔的截面形状、喷油速度等影响因素对其振荡冷却的流动和换热特性影响较大。在2800 r/min额定转速下,卵形油腔的壁面平均换热系数分别高于水滴形和椭圆形油腔7%和4%。通过对不同喷油速度条件下的内冷油腔流动和换热特性分析得出了OP2S发动机活塞内冷油腔的流动和换热规律,同时确定了该发动机的冷却喷嘴机油流速,对同类型活塞内冷油腔的设计具有参考意义。
文摘Residual ridge resorption(RRR)is the decrease in the jaw structure that follows tooth extraction.It is a multifactorial disorder,but reports on the associated genetic factors are scarce,particularly amongst the Saudis.This study aimed to investigate the role of single nucleotide polymorphisms(SNPs)in fibroblast growth factor receptor 1 oncogene partner 2(FGFR1OP2)in RRR development in Saudis.The study included 192 individuals(RRR=96;controls=96)attending outpatient clinics at the College of Dentistry,King Saud University.Demographic and clinical data were collected,the digital panoramic dental radiograph was obtained,and mandibular residual ridge height was measured.DNA was extracted from saliva and genotyping was conducted on“Sequenom MassARRAY iPLEX”.Genotype and allele frequencies of three SNPs were calculated and compared.The age at first diagnosis and bone height were compared in the three genotypes of each SNP.The age of the patients,age at first edentulism,and bone height ranged 21-80 years,12-70 years,and 13-34.6 mm,respectively.All three genotypes of the studied SNPs(rs2279351,rs78054962 and rs2306852)were identified.SNP rs2279351 associated significantly with RRR,and the mutant C allele was highly predisposing.No association was observed for the other two SNPs.The genotypes of all SNPs had an influence on age at first edentulism and bone height,but the results were not statistically different.Since FGFR1OP2 plays a role in the process of rapid wound healing in the oral cavity,it may be playing a role in the development of RRR by influencing the rate of resorption of the jawbone.SNP rs2279351 may alter its expression and hence RRR development.This study is limited due to small a sample size,and further large-scale studies are required to confirm this association and to consider rs2279351 as a possible marker of RRR development.
基金supported by the National Natural Science Foundation of China under Grant Nos.62272474 and 61561146395.
文摘Current HPC hardware presents the characteristics of heterogeneity and diversity.Portable parallel programming technologies are attractive for application developers.OP2 is a domain specific programming framework for unstructured applications.It supports unified programming and automatic code generation for multiple hardware platforms.However,current OP2 implementation is faced with some difficulties in programming application with complex data structures and function calls.To address this issue,we improve the implementation of OP2 framework in this paper.We modified the source-to-source translator and the runtime library of OP2,making it possible to automatically support applications with complex data structures and function calls during the generation of serial,OpenMP,CUDA,and MPI versions of codes.This avoids tedious manual code rewriting process for the OP2 application developers.HOUR2D,a high order and complex unstructured CFD application,is used as an example to verify the applicability of our extension to the OP2 framework.The results show that our extension enables OP2 to support portable programming for complex unstructured applications without changing its programming mode,ensures the correctness of the results,and achieves comparable or even better performance than manual parallelizations on Intel Xeon Gold CPU,HUAWEI Kunpeng CPU and NVIDIA V100 GPU.
