Metabolic dysfunction-associated fatty liver disease,representing a spectrum of liver disorders from simple steatosis to metabolic dysfunction-associated steatohepatitis,fibrosis,and cirrhosis,has emerged as one of th...Metabolic dysfunction-associated fatty liver disease,representing a spectrum of liver disorders from simple steatosis to metabolic dysfunction-associated steatohepatitis,fibrosis,and cirrhosis,has emerged as one of the most prevalent chronic liver conditions globally,affecting an estimated approximately 30%of the world's population.Its pathogenesis is highly complex,involving intricate interactions between genetic predisposition,metabolic dysregulation,inflammation,and cellular stress responses.Within this complex landscape,orphan nuclear receptors(ONRs)have gained significant attention.Defined by the lack of identified endogenous ligands,ONRs function as master transcriptional regulators controlling diverse biological processes.Crucially,they play pivotal roles in the development and progression of numerous diseases,including metabolic disorders.This review specifically focuses on elucidating the critical contributions of various ONRs to the pathogenesis of metabolic dysfunctionassociated fatty liver disease.We examined how these receptors modulate key pathological drivers:lipid metabolism,inflammation,and autophagy.展开更多
基金supported by the National Key Research and Development Program of China(2023YFC2507405)the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(JCRCFZ-2022-017).
文摘Metabolic dysfunction-associated fatty liver disease,representing a spectrum of liver disorders from simple steatosis to metabolic dysfunction-associated steatohepatitis,fibrosis,and cirrhosis,has emerged as one of the most prevalent chronic liver conditions globally,affecting an estimated approximately 30%of the world's population.Its pathogenesis is highly complex,involving intricate interactions between genetic predisposition,metabolic dysregulation,inflammation,and cellular stress responses.Within this complex landscape,orphan nuclear receptors(ONRs)have gained significant attention.Defined by the lack of identified endogenous ligands,ONRs function as master transcriptional regulators controlling diverse biological processes.Crucially,they play pivotal roles in the development and progression of numerous diseases,including metabolic disorders.This review specifically focuses on elucidating the critical contributions of various ONRs to the pathogenesis of metabolic dysfunctionassociated fatty liver disease.We examined how these receptors modulate key pathological drivers:lipid metabolism,inflammation,and autophagy.
