Human activities are closely related to geological environments or those influenced by geological factors,which can significantly impact human health.Previous studies have predominantly focused on isolated spheres or ...Human activities are closely related to geological environments or those influenced by geological factors,which can significantly impact human health.Previous studies have predominantly focused on isolated spheres or single environmental indicators,lacking research on the multifactorial influences affecting the overall geographic environment.From the“One Health”perspective,this paper synthesizes natural environmental factors across the lithosphere,hydrosphere,atmosphere,and pedosphere,encompassing the sources,forms,concentrations,and bioavailability of chemical elements,as well as pollutants and their associations with human health.Comprehensive natural environmental factors,based on GeoHealth,are intimately connected to human health.Under the pressures of future population growth and rapid industrial development,the relationship between the global geological environment and human health will become increasingly prominent.Therefore,it is crucial to pay close attention to health-based thresholds and promptly implement pollution prevention and control measures.展开更多
Background: Antimicrobial resistance (AMR) is a global health challenge that has escalated due to the inappropriate use of antimicrobials in humans, animals, and the environment. Developing and implementing strategies...Background: Antimicrobial resistance (AMR) is a global health challenge that has escalated due to the inappropriate use of antimicrobials in humans, animals, and the environment. Developing and implementing strategies to reduce and combat AMR is critical. Purpose: This study aimed to highlight some global strategies that can be implemented to address AMR using a One Health approach. Methods: This study employed a narrative review design that included studies published from January 2002 to July 2023. The study searched for literature on AMR and antimicrobial stewardship (AMS) in PubMed and Google Scholar using the 2020 PRISMA guidelines. Results: This study reveals that AMR remains a significant global public health problem. Its severity has been markedly exacerbated by inappropriate use of antimicrobials in humans, animals, and the broader ecological environment. Several strategies have been developed to address AMR, including the Global Action Plan (GAP), National Action Plans (NAPs), AMS programs, and implementation of the AWaRe classification of antimicrobials. These strategies also involve strengthening surveillance of antimicrobial consumption and resistance, encouraging the development of new antimicrobials, and enhancing regulations around antimicrobial prescribing, dispensing, and usage. Additional measures include promoting global partnerships, combating substandard and falsified antimicrobials, advocating for vaccinations, sanitation, hygiene and biosecurity, as well as exploring alternatives to antimicrobials. However, the implementation of these strategies faces various challenges. These challenges include low awareness and knowledge of AMR, a shortage of human resources and capacity building for AMR and AMS, in adequate funding for AMR and AMS initiatives, limited laboratory capacities for surveillance, behavioural change issues, and ineffective leadership and multidisciplinary teams. Conclusion: In conclusion, this study established that AMR is prevalent among humans, animals, and the environment. Successfully addressing AMR calls for a collaborative, multifaceted One Health approach. Despite this, some gaps remain effectively implementing strategies currently recommended to combat AMR. As a result, it is essential to reinforce the strategies that are deployed to counter AMR across the human, animal, and environmental sectors.展开更多
Nanoscience and technology have shown promise in revitalizing the agricultural sector and industries.This tool has gained the interest of many researchers as it can be utilized to drive sustainable agriculture by sugg...Nanoscience and technology have shown promise in revitalizing the agricultural sector and industries.This tool has gained the interest of many researchers as it can be utilized to drive sustainable agriculture by suggesting long-lasting solutions to different problems in the agricultural space.However,there is a paucity of data on its health implications for the environment,plants,animals,and humans.This review evaluated the cost-effectiveness and productivity of nanoscience and technologies.The review highlighted the underlying health implications of nanoscience and technology from a One Health perspective.展开更多
The attention on microbiome research and its translation to application deployment is escalating along with diffused hype.There is real excitement in this new science,leveraging the growing potential of advances in mo...The attention on microbiome research and its translation to application deployment is escalating along with diffused hype.There is real excitement in this new science,leveraging the growing potential of advances in molecular biology and sequencing techniques.Yet,despite the substantial efforts provided by the scientific communities,the true significance of research achievements requires coordinated and constructive actions across interdisciplinary fields.Individual researchers,universities,small and large companies,venture capitalists,and governments play a fundamental role in fostering collaboration and promoting knowledge that will benefit each other and sustain global prosperity.Making meaningful connections across different fields and getting a new perspective on how technological developments interrelate are the main drivers for creativity and progress.To help the broader innovation community focus on potentially new cross-sectorial developments,the One Health-microbiome-centric approach,defined here as“Microbiome One Health”,is considered as the efficient,holistic approach to product and service exploitations meant to preserve human well-being within a healthy ecosystem.The model opposes the biomedical system and generalizes the“One World-One Health^(TM)”concept.The focus will be given to Nutrition as a driver of health and the food system for its commercial exploitation microbiome-centric,specifically at the interface of human-animal-agricultural.Remarkably,at the interface of human-animals,the interaction with pets,specifically dogs,has been recognized as a driving force of novel microbiome exploitation.展开更多
Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes tha...Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components.This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal.Recently, much work has been done describing antibiotic resistance genes in various environments;now quantitative, mechanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.展开更多
基金supported by the project of China Geological Survey(DD20243344,DD20230700702)Science and Technology Program of Chengde City(202304B047)National Research and Development Project(2022YFC3702301).
文摘Human activities are closely related to geological environments or those influenced by geological factors,which can significantly impact human health.Previous studies have predominantly focused on isolated spheres or single environmental indicators,lacking research on the multifactorial influences affecting the overall geographic environment.From the“One Health”perspective,this paper synthesizes natural environmental factors across the lithosphere,hydrosphere,atmosphere,and pedosphere,encompassing the sources,forms,concentrations,and bioavailability of chemical elements,as well as pollutants and their associations with human health.Comprehensive natural environmental factors,based on GeoHealth,are intimately connected to human health.Under the pressures of future population growth and rapid industrial development,the relationship between the global geological environment and human health will become increasingly prominent.Therefore,it is crucial to pay close attention to health-based thresholds and promptly implement pollution prevention and control measures.
文摘Background: Antimicrobial resistance (AMR) is a global health challenge that has escalated due to the inappropriate use of antimicrobials in humans, animals, and the environment. Developing and implementing strategies to reduce and combat AMR is critical. Purpose: This study aimed to highlight some global strategies that can be implemented to address AMR using a One Health approach. Methods: This study employed a narrative review design that included studies published from January 2002 to July 2023. The study searched for literature on AMR and antimicrobial stewardship (AMS) in PubMed and Google Scholar using the 2020 PRISMA guidelines. Results: This study reveals that AMR remains a significant global public health problem. Its severity has been markedly exacerbated by inappropriate use of antimicrobials in humans, animals, and the broader ecological environment. Several strategies have been developed to address AMR, including the Global Action Plan (GAP), National Action Plans (NAPs), AMS programs, and implementation of the AWaRe classification of antimicrobials. These strategies also involve strengthening surveillance of antimicrobial consumption and resistance, encouraging the development of new antimicrobials, and enhancing regulations around antimicrobial prescribing, dispensing, and usage. Additional measures include promoting global partnerships, combating substandard and falsified antimicrobials, advocating for vaccinations, sanitation, hygiene and biosecurity, as well as exploring alternatives to antimicrobials. However, the implementation of these strategies faces various challenges. These challenges include low awareness and knowledge of AMR, a shortage of human resources and capacity building for AMR and AMS, in adequate funding for AMR and AMS initiatives, limited laboratory capacities for surveillance, behavioural change issues, and ineffective leadership and multidisciplinary teams. Conclusion: In conclusion, this study established that AMR is prevalent among humans, animals, and the environment. Successfully addressing AMR calls for a collaborative, multifaceted One Health approach. Despite this, some gaps remain effectively implementing strategies currently recommended to combat AMR. As a result, it is essential to reinforce the strategies that are deployed to counter AMR across the human, animal, and environmental sectors.
文摘Nanoscience and technology have shown promise in revitalizing the agricultural sector and industries.This tool has gained the interest of many researchers as it can be utilized to drive sustainable agriculture by suggesting long-lasting solutions to different problems in the agricultural space.However,there is a paucity of data on its health implications for the environment,plants,animals,and humans.This review evaluated the cost-effectiveness and productivity of nanoscience and technologies.The review highlighted the underlying health implications of nanoscience and technology from a One Health perspective.
基金国家自然科学基金面上项目“基于高压人群身心健康的工作环境绿色空间体系研究”(编号51978364)丰田跨学科专项2022“未来城市跨学科研究关键技术集成与示范”(Action Plan for Integrated Demonstration of Key Technologies for Interdisciplinary Research on Future Cities)共同资助。
文摘The attention on microbiome research and its translation to application deployment is escalating along with diffused hype.There is real excitement in this new science,leveraging the growing potential of advances in molecular biology and sequencing techniques.Yet,despite the substantial efforts provided by the scientific communities,the true significance of research achievements requires coordinated and constructive actions across interdisciplinary fields.Individual researchers,universities,small and large companies,venture capitalists,and governments play a fundamental role in fostering collaboration and promoting knowledge that will benefit each other and sustain global prosperity.Making meaningful connections across different fields and getting a new perspective on how technological developments interrelate are the main drivers for creativity and progress.To help the broader innovation community focus on potentially new cross-sectorial developments,the One Health-microbiome-centric approach,defined here as“Microbiome One Health”,is considered as the efficient,holistic approach to product and service exploitations meant to preserve human well-being within a healthy ecosystem.The model opposes the biomedical system and generalizes the“One World-One Health^(TM)”concept.The focus will be given to Nutrition as a driver of health and the food system for its commercial exploitation microbiome-centric,specifically at the interface of human-animal-agricultural.Remarkably,at the interface of human-animals,the interaction with pets,specifically dogs,has been recognized as a driving force of novel microbiome exploitation.
基金funded by the National Natural Science Foundation of China (No. 21677149)the Outstanding Youth Fund of the Natural Science Foundation of Jiangsu Province, China (No. BK20150050)+6 种基金the Innovative Project of Chinese Academy of Sciences (No. ISSASIP1616)funded by the Center for Health Impacts of Agriculture (CHIA) of Michigan State University, USAfunded by Agriculture and AgriFood Canada, the Canadian Genomics Research Development Initiative (GRDI-AMR)the Canadian Institute for Health Research (CIHR) through the Joint Programming Initiative on Antimicrobial Resistance (JPIAMR)the National Funds from FCT—Fundacao para a Ciência e a Tecnologia, Portugal (No. UID/Multi/ 50016/2013)funded by Academy of Finland and the Joint Programming Initiative “Water Challenges for a Changing World” (Water JPI)funded by the Collaborative Research Fund of Hong Kong (CRF), China (No. C6033-14G)
文摘Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components.This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal.Recently, much work has been done describing antibiotic resistance genes in various environments;now quantitative, mechanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains.
