Han-Ping Shi,M.D.,Ph.D.,FACS,Professor of Surgery,Oncology and Nutrition.He is the current Director of the Faculty of Clinical Nutrition,Capital Medical University.Dr.Shi received his M.D.degree at the School of Medic...Han-Ping Shi,M.D.,Ph.D.,FACS,Professor of Surgery,Oncology and Nutrition.He is the current Director of the Faculty of Clinical Nutrition,Capital Medical University.Dr.Shi received his M.D.degree at the School of Medicine,Wuhan University,Wuhan,and his Ph.D.degree at the Second Military Medical University,Shanghai,China.From 1999 to 2002,Dr.Shi was a postdoc fellow in School of Medicine,Johns Hopkins University,under the supervision of Adrian Barbul,M.D.,FACS,and then in New Jersey Medical School,Rutgers University,under the supervision of Edwin A.Deitch,M.D.,FACS.Dr.Han-Ping Shi was the Chairman of the Chinese Society for Parenteral&Enteral Nutrition(CSPEN)between 2018-2021.He is the founder Chairman of the Chinese Society of Nutritional Oncology(2012-2024),and the director of the Department of Academic,China Anti-Cancer Association(CACA)since 2017.Dr.Han-Ping Shi is currently the founder Editor-in-Chief of Electronic Journal of Metabolism and Nutrition of Cancer(Chinese),founder Editor-in-Chief of Journal of Nutritional Oncology(English)and founder Editor-in-Chief of Precision Nutrition(English).展开更多
Han-Ping Shi,M.D.,Ph.D.,FACS,Professor of Surgery,Oncology and Nutrition.He is the current Chairman of the Department of GI Surgery/Clinical Nutrition at Beijing Shijitan Hospital,Capital Medical University,Beijing,Ch...Han-Ping Shi,M.D.,Ph.D.,FACS,Professor of Surgery,Oncology and Nutrition.He is the current Chairman of the Department of GI Surgery/Clinical Nutrition at Beijing Shijitan Hospital,Capital Medical University,Beijing,China.Dr.Shi received his M.D.degree at the School of Medicine,Wuhan University,Wuhan,and his Ph.D.degree at the Second Military Medical University,Shanghai,China.展开更多
Organoids are three-dimensional stem cell-derived models that offer a more physiologically relevant representation of tumor biology compared to traditional two-dimensional cell cultures or animal models.Organoids pres...Organoids are three-dimensional stem cell-derived models that offer a more physiologically relevant representation of tumor biology compared to traditional two-dimensional cell cultures or animal models.Organoids preserve the complex tissue architecture and cellular diversity of human cancers,enabling more accurate predictions of tumor growth,metastasis,and drug responses.Integration with microfluidic platforms,such as organ-on-a-chip systems,further enhances the ability to model tumor-environment interactions in real-time.Organoids facilitate in-depth exploration of tumor heterogeneity,molecular mechanisms,and the development of personalized treatment strategies when coupled with multi-omics technologies.Organoids provide a platform for investigating tumor-immune cell interactions,which aid in the design and testing of immune-based therapies and vaccines.Taken together,these features position organoids as a transformative tool in advancing cancer research and precision medicine.展开更多
In this article,artificial intelligence(AI)usage and its benefits in medicine are reviewed in the oncology,radiology,and cardiology fields.The relevant literature was searched in PubMed and Google Scholar using the wo...In this article,artificial intelligence(AI)usage and its benefits in medicine are reviewed in the oncology,radiology,and cardiology fields.The relevant literature was searched in PubMed and Google Scholar using the words“Artificial Intelligence”,“Artificial Intelligence in Medicine”,“Artificial Intelligence in Cardiology”,“Artificial Intelligence in Oncology”,and“Artificial Intelligence in Radiology”for the last 10 years.This article covers the AI’s current implications in daily practice,discussing its advantages and disadvantages based on the findings.AI’s effect in medicine for reducing workload,diagnosis,time management,and drug dosing is going to be reviewed especially in radiology,oncology,and cardiology fields as well as general usage of AI in addition to important highlights.Lastly,this minireview evaluates the current challenges of AI technology in medicine and how clinicians should work with this emerging technology.展开更多
This article discusses the innovative use of computed tomography radiomics combined with clinical factors to predict treatment response to first-line transarterial chemoembolization in hepatocellular carcinoma.Zhao et...This article discusses the innovative use of computed tomography radiomics combined with clinical factors to predict treatment response to first-line transarterial chemoembolization in hepatocellular carcinoma.Zhao et al developed a robust predictive model demonstrating high accuracy(area under the curve 0.92 in the training cohort)by integrating venous phase radiomic features with alphafetoprotein levels.This noninvasive approach enables early identification of patients unlikely to benefit from transarterial chemoembolization,allowing a timely transition to alternative therapies such as targeted agents or immunotherapy.Such precision strategies may improve clinical outcomes,optimize resource utilization,and increase survival in advanced hepatocellular carcinoma management.Future studies should emphasize external validation and broader clinical adoption.展开更多
Objectives:The study aimed to survey the current situation and explore the factors that influence the ability of palliative care practice among oncology nurses.Methods:A multicenter cross-sectional study was conducted...Objectives:The study aimed to survey the current situation and explore the factors that influence the ability of palliative care practice among oncology nurses.Methods:A multicenter cross-sectional study was conducted using stratified random sampling to select 26 tertiary hospitals’oncology departments in Hubei Province,China.A total of 1,198 nurses were included and finished the questionnaire consisting of social demographic characteristics,Palliative Care Self-Report Practice Scale(PCPS),End-of-life Professional Caregiver Survey(EPCS),and Self-Perceived Pain Assessment Knowledge and Confidence Scale(Self-PAC)through the online platform.Data were analyzed using t-test,one-way ANOVA,Pearson correlation analysis,and multiple linear regression analysis in SPSS 26.0.Results:The total score for PCPS was 67.17±12.57,the three dimensions’scores were:physical symptom care(32.50±6.10),spiritual and psychological care(23.35±4.97),communication(11.58±2.48).There are significant positive correlations between the palliative care practice ability and core competence(r=0.77,P<0.01),as well as pain assessment ability(r=0.56,P<0.01).Multiple regression analysis identified female,with high education background(bachelor’s degree and master’s degree or above),interest in palliative care,pain assessment ability,and core competence were positive predictors of palliative care practice ability(Adjusted R^(2)=0.668,P<0.05).Conclusions:The overall ability of the oncology nurses to practice palliative care was relatively high,but the palliative nurses reported suboptimal performance in the communication dimension of palliative nursing practice ability.To comprehensively improve oncology nurses’palliative care practice ability,managers must consider the gender structure,educational background,enthusiasm for palliative care work,core competence,and pain assessment ability.展开更多
Oncology covers a wide range of knowledge and is more difficult compared to other clinical disciplines.Therefore,it is crucial to seek an efficient teaching method for oncology education.In recent years,China’s inter...Oncology covers a wide range of knowledge and is more difficult compared to other clinical disciplines.Therefore,it is crucial to seek an efficient teaching method for oncology education.In recent years,China’s internet technology has achieved rapid development.Massive Open Online Course(MOOC),a blended learning approach based on internet technology,has strong applicability to medical education.It can not only improve teaching quality but also promote further reform of the discipline.Based on this,our study searched for relevant research at home and abroad and reviewed the implementation path of integrating MOOC and blended learning in oncology education.This provides a theoretical foundation for the innovation of oncology teaching models,improves the level of oncology teaching,and lays a solid foundation for talent reserves in oncology departments.展开更多
BACKGROUND Global tumor incidence rises and therapies advance,driving oncology nursing specialization.Granting nurses prescriptive authority optimizes care but polarizes nurses'attitudes due to factors like risk a...BACKGROUND Global tumor incidence rises and therapies advance,driving oncology nursing specialization.Granting nurses prescriptive authority optimizes care but polarizes nurses'attitudes due to factors like risk and competence,hindering policy implementation.AIM To investigate the current status of the attitudes of oncology specialist nurses toward having prescribing authority,specifically concerning symptom management and supportive care in oncology practice,and we conducted a path analysis of their influencing factors.METHODS As participants in the survey,oncology specialist nurses working in hospitals of different grades in Jiangsu Province were selected from March 2025 to May 2025 using a stratified sampling method.The questionnaires were administered using the general information questionnaire,the beliefs and attitudes about nurses'prescriptive authority scale,the nurses'professional identity scale,and the selfefficacy scale.Pearson’s method was used to analyze the correlation between beliefs and attitudes about the prescriptive authority,professional identity,and self-efficacy of nurses.Multiple linear regression was performed to analyze the factors influencing the beliefs and attitudes of nurses’prescriptive authority.The Amos plug-in was used to construct structural equation models to analyze the influencing pathways.RESULTS A total of 329 questionnaires were distributed,and 328 valid questionnaires were returned(effective recovery rate:99.70%).The total score of the 328 oncology nurses on the beliefs and attitudes about nurses'prescriptive authority scale was 101.88±15.13,indicating a moderately high level.Univariate analysis revealed that gender and hospital grade were associated with this score(P<0.05).The Pearson correlation analysis revealed that self-efficacy was positively correlated with the scores of the beliefs and attitudes about nurses’prescriptive authority scale and the nurses’professional identity scale(r=0.4999,P<0.0001 and r=0.7048,P<0.05,respectively),whereas occupational identity was positively correlated only with the former(r=0.6209,P<0.05).Multiple linear regression analysis revealed occupational identity and self-efficacy as the factors influencing the scores of the beliefs and attitudes about nurses’prescriptive authority scale(P<0.05).The results of the path analysis revealed that selfefficacy significantly positively affected nurses’occupational identity and their beliefs and attitudes about having prescriptive authority;occupational identity played a mediating role between the two,with a mediating effect accounting for 54.46% of the total effect,and the structural equation model was well-fitted.CONCLUSION Oncology nurses have more positive attitudes toward prescriptive authority.In addition,self-efficacy positively and indirectly affects nurses’attitudes toward prescriptive authority through the mediating effect of occupational identity.This can be used as a basis for clinical practice to take targeted measures to improve nurses’self-efficacy and occupational identity,thus creating favorable conditions for effectively implementing the policy of prescriptive authority.展开更多
The consumption of ultra-processed foods(UPFs)is continuously increasing,and there is growing evidence that these foods contribute to the development and progression of cancer.For oncology patients alone,maintaining n...The consumption of ultra-processed foods(UPFs)is continuously increasing,and there is growing evidence that these foods contribute to the development and progression of cancer.For oncology patients alone,maintaining nutritional status is crucial for tolerating treatments and improving survival.The aim of this paper is to review the role of UPFs in the diet of oncology patients,highlighting their potential health-damaging effects(e.g.,increased inflammation,microbiome disruption,nutrient deficiencies)and potential benefits(e.g.,easy accessibility,high energy content,specially formulated nutritional supplements)particularly in the context of addressing the energy and nutrient needs and nutritional challenges of patients experiencing cancer-related cachexia or anorexia.Using a literature review,we examine how the UPFs can impact oncology patients’health,supporting the quality of life and clinical outcomes of oncology patients.展开更多
Nanomedicine has evolved significantly over the last decades and expanded its applications in pediatric oncology,which represents a special domain with unique patients and distinct requirements.The need for early canc...Nanomedicine has evolved significantly over the last decades and expanded its applications in pediatric oncology,which represents a special domain with unique patients and distinct requirements.The need for early cancer diagnosis andmore effective and targeted therapies aiming to increase the pediatric patients’survival rates andminimize the treatment-related side effects to survivors is profound.Nanoparticles(NPs)come as a beacon of hope to provide sensitive cancer diagnostic tools and assist contrast agents’transport to the malignant tumors.Besides,NPs could be designed to deliver targeted drugs and genes to tumors,minimizing the medicine-related toxicities.Metal and metal oxide NPs could be exploited as sensitizers to enhance chemotherapy and radiotherapy effects.Future research should emphasize pediatric models to gain secure results about NPs’safety and efficiency for pediatric cancer patients.This review presents the recent studies on the use of NPs in pediatric cancer management and highlights their impact on diagnosis,treatment outcomes,and the quality of life of the survivors.The purpose of this study is to investigate the benefits that may arise from the use of NPs in pediatric oncology,address the potential limitations and challenges,and discuss the needs for future research efforts.展开更多
BACKGROUND Death anxiety(DA)is a prevalent psychological challenge among oncology nurses that affects their emotional well-being and professional competence in coping with death-related situations.Death-related attitu...BACKGROUND Death anxiety(DA)is a prevalent psychological challenge among oncology nurses that affects their emotional well-being and professional competence in coping with death-related situations.Death-related attitudes and resilience are critical factors that may mediate the relationship between DA and coping with death competence(CDC).However,few studies have examined the chain-mediating effect of these factors among Chinese oncology nurses.This study aimed to investigate the association between DA and CDC among Chinese oncology nurses,with a focus on the mediating roles of death attitude and resilience.AIM To investigate the association between DA and CDC among Chinese oncology nurses.using an electronic questionnaire distributed in Wenjuanxing,China.In total,615 valid responses were obtained.The participants completed the Templer death anxiety scale,death attitude profile-revised,Connor-Davidson resilience scale,and coping with death scale.A chain mediation analysis was performed using the PROCESS macro in SPSS to examine the relationships between these variables.RESULTS The findings indicated that DA had a significant direct effect on CDC[effect=0.201,95%confidence interval(CI):0.112-0.322].In addition to this direct effect,three significant indirect pathways were observed:(1)Death attitude(effect=0.118,95%CI:0.056-0.163);(2)Resilience(effect=0.108,95%CI:0.032-0.176);and(3)A sequential mediation pathway involving both death attitude and resilience(effect=0.071,95%CI:0.042-0.123).The total indirect effects of the three mediation paths accounted for 29.7%of the relationship between DA and CDC.CONCLUSION Using a chain mediation model,this study explored the mechanisms linking DA,death attitude,resilience,and CDC among Chinese oncology nurses.These findings highlighted the crucial role of death attitude and resilience in mediating the relationship between DA and CDC.Interventions aimed at fostering adaptive attitudes toward death and enhancing resilience may improve nurses’ability to cope with death-related stressors,ultimately benefiting their psychological well-being and professional competence.展开更多
With the global population aging,the care of elderly cancer patients has become increasingly complex and significant.Comprehensive geriatric assessment(CGA),a multidimensional evaluation tool,has been widely implement...With the global population aging,the care of elderly cancer patients has become increasingly complex and significant.Comprehensive geriatric assessment(CGA),a multidimensional evaluation tool,has been widely implemented in oncology nursing to enhance the precision of treatment decisions and improve patient outcomes.This review examines the application of CGA in oncology nursing,drawing on literature published between 2010 and 2024 in major databases using keywords such as“Comprehensive Geriatric Assessment”and“Oncology Nursing”.It highlights how CGA contributes to optimizing treatment selection,monitoring the treatment process,and improving patients’quality of life and long-term outcomes.CGA provides a comprehensive evaluation of elderly cancer patients,including physical,psychological,and social aspects,enabling the identification of high-risk patients and reducing treatment-related side effects and complications.It also offers a critical foundation for developing personalized care plans.The article discusses various practical examples of CGA implementation across different countries and regions,including multidisciplinary collaborative models in France,the United States,and Australia,demonstrating CGA’s flexible application in diverse healthcare settings.Although significant progress has been made in applying CGA in oncology nursing,numerous challenges remain in its implementation,such as resource limitations and insufficient personnel training.Future research will focus on integrating CGA with emerging technologies,such as artificial intelligence and precision medicine,to further improve the quality of care and treatment outcomes for elderly cancer patients.By summarizing the current status and challenges of CGA in oncology nursing,this review provides guidance for future research and clinical practice,emphasizing the importance of advancing CGA application to meet the growing demands of elderly oncology care.展开更多
Objective:To systematically evaluate the effectiveness of research-oriented integrated nursing interventions on cancer pain management in hospitalized oncology patients in China.Methods:A computerized search of Chines...Objective:To systematically evaluate the effectiveness of research-oriented integrated nursing interventions on cancer pain management in hospitalized oncology patients in China.Methods:A computerized search of Chinese and English databases was conducted to identify relevant studies.Two researchers independently assessed the quality of included literature using the Newcastle-Ottawa Scale(NOS).Data were extracted and analyzed via Stata 14.A random-effects model was applied due to significant heterogeneity(I²>50%).Sensitivity analysis and Egger’s test were performed to assess bias.Results:12 eligible studies(2014-2024)were included.Meta-analysis demonstrated that integrated nursing interventions significantly reduced cancer pain scores compared to routine care(SMD=-1.51,95%CI:-1.90 to-1.12;I²=84.8%),with superior efficacy.Subgroup-analyses revealed enhanced effects for“Nursing modes”(SMD=-2.11)and“cancer pain education”(SMD=-2.30).Conclusion:Research-oriented integrated nursing interventions significantly improve cancer pain management in Chinese hospitalized oncology patients,particularly through synergistic effects of“Nursing modes”and“can-cer pain education.”However,implementation bias from“additive interventions”in teaching hospitals and high heterogeneity warrant attention.Future studies should optimize designs to enhance clinical applicability.展开更多
The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published s...The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published separate guidelines for NSCLC and small cell lung cancer(SCLC)for the first time to improve clinical usability.展开更多
Background:Precision medicine is an emerging approach for treating pediatric cancer due to its ability to target tumor-specific genetic drivers rather than provide broad and aggressive treatments.The study aimed to ou...Background:Precision medicine is an emerging approach for treating pediatric cancer due to its ability to target tumor-specific genetic drivers rather than provide broad and aggressive treatments.The study aimed to outline the establishment and impact of a Precision Medicine Clinic(PMC)in the setting of pediatric oncology,with the objective of offering targeted treatment options within the institution and creating a scalable model for adoption by other healthcare systems to achieve a wider impact.Methods:Recognizing this need for an individualized approach to treating patients,Cook Children’s Medical Center(CCMC)established a multidisciplinary molecular tumor board in 2019,followed by the launch of an official PMC in 2021.Before this,there was no dedicated place to discuss and evaluate genetic sequencing results.Results:In 2022 and 2023,the PMC discussed 69 patients with a wide variety of oncologic diagnoses.Through the clinic’s efforts,133 genetic variants across 101 genes have been identified,spanning oncogenic pathways related to cell cycling,DNA processing,and cell signaling.Of the sequenced patients,four have received targeted therapy according to recommendations from the PMC.Conclusion:While the PMC continues to evaluate patients and their long-term outcomes,the continually growing PMC at CCMC represents the beginning of the advancement of treating pediatric oncology patients through the interpretation of genetic sequencing results,making actionable targeted treatment recommendations,and continuing to follow the patient’s course of care over time.This additionally provides a framework for starting a PMC that can be adapted for specific clinical needs and implemented broadly.展开更多
Objective:To analyze the effect of perioperative comprehensive nursing intervention on patients undergoing breast surgery in oncology surgery.Methods:A total of 100 patients undergoing breast surgery were selected as ...Objective:To analyze the effect of perioperative comprehensive nursing intervention on patients undergoing breast surgery in oncology surgery.Methods:A total of 100 patients undergoing breast surgery were selected as the study subjects and divided into a control group and a study group.The control group received routine nursing,while the study group received perioperative comprehensive nursing.The effects were observed.Results:The study group had lower negative emotion scores and complication rates than the control group,and higher range of motion of the affected shoulder joint and quality of life than the control group(P<0.05).Conclusion:Oncology breast surgery is often accompanied by adverse psychological emotions during the perioperative period.To ensure surgical efficacy and postoperative recovery,comprehensive perioperative nursing measures can effectively prevent and develop complications,improve shoulder joint range of motion,and promote recovery.展开更多
Although the whole world has been suffering under the Coronavirus Disease 2019 epidemic,the World Journal of Clinical Oncology(WJCO)was able to productively direct our efforts in the field through 2020.This was only a...Although the whole world has been suffering under the Coronavirus Disease 2019 epidemic,the World Journal of Clinical Oncology(WJCO)was able to productively direct our efforts in the field through 2020.This was only accomplished through the collective efforts and support of our Editorial Board members,peer reviewers,authors,readers and editorial office staff.In 2020,the WJCO published 12 issues encompassing 84 papers,a 115.4%increase over 2019(39 papers).In December of 2020,we strategized a plan to solicit even more high-quality contributions for WJCO in 2021.So far,we have registered and accepted 188 manuscript titles,including 132 reviews and 56 original articles.In the New Year,we will work with our internal and external colleagues who care about and support the development of WJCO with the express aim of improving the academic rank of WJCO in the field of oncology.Ultimately,our goal is to merit and gain inclusion in the Science Citation Index Expanded,with the first impact factor being awarded as soon as possible.展开更多
BACKGROUND Reactivation of hepatitis B virus(HBV)infection is a well-known risk that can occur spontaneously or following immunosuppressive therapies,including cancer chemotherapy.HBV reactivation can cause significan...BACKGROUND Reactivation of hepatitis B virus(HBV)infection is a well-known risk that can occur spontaneously or following immunosuppressive therapies,including cancer chemotherapy.HBV reactivation can cause significant morbidity and even mortality,which are preventable if at-risk individuals are identified through screening and started on antiviral prophylaxis.AIM To determine the prevalence of chronic HBV(CHB)and occult HBV infection(OBI)among oncology and hematology-oncology patients undergoing chemo-therapy.METHODS In this observational study,the prevalence of CHB and OBI was assessed among patients receiving chemotherapy.Serological markers of HBV infection[hepatitis B surface antigen(HBsAg)/anti-hepatitis B core antigen(HBc)]were evaluated for all patients.HBV DNA levels were assessed in those who tested negative for HBsAg but positive for total anti-HBc.RESULTS The prevalence of CHB in the study cohort was determined to be 2.3%[95%confidence interval(95%CI):1.0-4.2].Additionally,the prevalence of OBI among the study participants was found to be 0.8%(95%CI:0.2-2.3).CONCLUSION The findings of this study highlight the importance of screening for hepatitis B infection in oncology and hematology-oncology patients undergoing chemotherapy.Identifying individuals with CHB and OBI is crucial for implementing appropriate antiviral prophylaxis to prevent the reactivation of HBV infection,which can lead to increased morbidity and mortality.展开更多
There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S. Food and Drug Administration for advanced melanoma and non-sma...There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S. Food and Drug Administration for advanced melanoma and non-small cell lung cancer,immune checkpoint inhibitors also appears to have significant antitumor activity in multiple other tumor types. An exciting component of immunotherapy is the durability of antitumor responses observed, with some patients achieving disease control for many years. Nevertheless, not all patients benefit, and efforts should thus now focus on improving the efficacy of immunotherapy through the use of combination approaches and predictive biomarkers of response and resistance. There are multiple potential rational combinations using an immunotherapy backbone, including existing treatments such as radiotherapy, chemotherapy or molecularly targeted agents, as well as other immunotherapeutics. The aim of such antitumor strategies will be to raise the tail on the survival curve by increasing the number of long term survivors, while managing any additive or synergistic toxicities that may arise with immunotherapy combinations. Rational trial designs based on a clear understanding of tumor biology and drug pharmacology remain paramount. This article reviews the biology underpinning immuno-oncology, discusses existing and novel immunotherapeutic combinations currently in development, the challenges of predictive biomarkers of response and resistance and the impact of immuno-oncology on early phase clinical trial design.展开更多
文摘Han-Ping Shi,M.D.,Ph.D.,FACS,Professor of Surgery,Oncology and Nutrition.He is the current Director of the Faculty of Clinical Nutrition,Capital Medical University.Dr.Shi received his M.D.degree at the School of Medicine,Wuhan University,Wuhan,and his Ph.D.degree at the Second Military Medical University,Shanghai,China.From 1999 to 2002,Dr.Shi was a postdoc fellow in School of Medicine,Johns Hopkins University,under the supervision of Adrian Barbul,M.D.,FACS,and then in New Jersey Medical School,Rutgers University,under the supervision of Edwin A.Deitch,M.D.,FACS.Dr.Han-Ping Shi was the Chairman of the Chinese Society for Parenteral&Enteral Nutrition(CSPEN)between 2018-2021.He is the founder Chairman of the Chinese Society of Nutritional Oncology(2012-2024),and the director of the Department of Academic,China Anti-Cancer Association(CACA)since 2017.Dr.Han-Ping Shi is currently the founder Editor-in-Chief of Electronic Journal of Metabolism and Nutrition of Cancer(Chinese),founder Editor-in-Chief of Journal of Nutritional Oncology(English)and founder Editor-in-Chief of Precision Nutrition(English).
文摘Han-Ping Shi,M.D.,Ph.D.,FACS,Professor of Surgery,Oncology and Nutrition.He is the current Chairman of the Department of GI Surgery/Clinical Nutrition at Beijing Shijitan Hospital,Capital Medical University,Beijing,China.Dr.Shi received his M.D.degree at the School of Medicine,Wuhan University,Wuhan,and his Ph.D.degree at the Second Military Medical University,Shanghai,China.
基金supported by the Chinese Academy of Medical Sciences(Grant No.2021RU002)Beijing Natural Science Foundation(Grant No.Z240013)+2 种基金National Natural Science Foundation of China(Grant Nos.82450111,82388102,82373416,and 92259303)Beijing Research Ward Excellence Program(Grant Nos.BRWEP2024W034080200 and BRWEP2024W034080204)Peking University People’s Hospital Research and Development Funds(Grant No.RZG2024-02).
文摘Organoids are three-dimensional stem cell-derived models that offer a more physiologically relevant representation of tumor biology compared to traditional two-dimensional cell cultures or animal models.Organoids preserve the complex tissue architecture and cellular diversity of human cancers,enabling more accurate predictions of tumor growth,metastasis,and drug responses.Integration with microfluidic platforms,such as organ-on-a-chip systems,further enhances the ability to model tumor-environment interactions in real-time.Organoids facilitate in-depth exploration of tumor heterogeneity,molecular mechanisms,and the development of personalized treatment strategies when coupled with multi-omics technologies.Organoids provide a platform for investigating tumor-immune cell interactions,which aid in the design and testing of immune-based therapies and vaccines.Taken together,these features position organoids as a transformative tool in advancing cancer research and precision medicine.
文摘In this article,artificial intelligence(AI)usage and its benefits in medicine are reviewed in the oncology,radiology,and cardiology fields.The relevant literature was searched in PubMed and Google Scholar using the words“Artificial Intelligence”,“Artificial Intelligence in Medicine”,“Artificial Intelligence in Cardiology”,“Artificial Intelligence in Oncology”,and“Artificial Intelligence in Radiology”for the last 10 years.This article covers the AI’s current implications in daily practice,discussing its advantages and disadvantages based on the findings.AI’s effect in medicine for reducing workload,diagnosis,time management,and drug dosing is going to be reviewed especially in radiology,oncology,and cardiology fields as well as general usage of AI in addition to important highlights.Lastly,this minireview evaluates the current challenges of AI technology in medicine and how clinicians should work with this emerging technology.
文摘This article discusses the innovative use of computed tomography radiomics combined with clinical factors to predict treatment response to first-line transarterial chemoembolization in hepatocellular carcinoma.Zhao et al developed a robust predictive model demonstrating high accuracy(area under the curve 0.92 in the training cohort)by integrating venous phase radiomic features with alphafetoprotein levels.This noninvasive approach enables early identification of patients unlikely to benefit from transarterial chemoembolization,allowing a timely transition to alternative therapies such as targeted agents or immunotherapy.Such precision strategies may improve clinical outcomes,optimize resource utilization,and increase survival in advanced hepatocellular carcinoma management.Future studies should emphasize external validation and broader clinical adoption.
基金supported by the Philosophy and Social Science Research Youth Project of the Hubei Department of Education in 2022(22Q148).
文摘Objectives:The study aimed to survey the current situation and explore the factors that influence the ability of palliative care practice among oncology nurses.Methods:A multicenter cross-sectional study was conducted using stratified random sampling to select 26 tertiary hospitals’oncology departments in Hubei Province,China.A total of 1,198 nurses were included and finished the questionnaire consisting of social demographic characteristics,Palliative Care Self-Report Practice Scale(PCPS),End-of-life Professional Caregiver Survey(EPCS),and Self-Perceived Pain Assessment Knowledge and Confidence Scale(Self-PAC)through the online platform.Data were analyzed using t-test,one-way ANOVA,Pearson correlation analysis,and multiple linear regression analysis in SPSS 26.0.Results:The total score for PCPS was 67.17±12.57,the three dimensions’scores were:physical symptom care(32.50±6.10),spiritual and psychological care(23.35±4.97),communication(11.58±2.48).There are significant positive correlations between the palliative care practice ability and core competence(r=0.77,P<0.01),as well as pain assessment ability(r=0.56,P<0.01).Multiple regression analysis identified female,with high education background(bachelor’s degree and master’s degree or above),interest in palliative care,pain assessment ability,and core competence were positive predictors of palliative care practice ability(Adjusted R^(2)=0.668,P<0.05).Conclusions:The overall ability of the oncology nurses to practice palliative care was relatively high,but the palliative nurses reported suboptimal performance in the communication dimension of palliative nursing practice ability.To comprehensively improve oncology nurses’palliative care practice ability,managers must consider the gender structure,educational background,enthusiasm for palliative care work,core competence,and pain assessment ability.
基金Mechanism of Nanotechnology-driven Polyphyllin I in Sensitizing PD-1 Monoclonal Antibody in Breast Cancer(82204922)Nanotechnology-driven Polyphyllin I Affects Mitochondrial Homeostasis via Cuproptosis and Its Mechanism in Breast Cancer Treatment(ZZ18-YQ-022)。
文摘Oncology covers a wide range of knowledge and is more difficult compared to other clinical disciplines.Therefore,it is crucial to seek an efficient teaching method for oncology education.In recent years,China’s internet technology has achieved rapid development.Massive Open Online Course(MOOC),a blended learning approach based on internet technology,has strong applicability to medical education.It can not only improve teaching quality but also promote further reform of the discipline.Based on this,our study searched for relevant research at home and abroad and reviewed the implementation path of integrating MOOC and blended learning in oncology education.This provides a theoretical foundation for the innovation of oncology teaching models,improves the level of oncology teaching,and lays a solid foundation for talent reserves in oncology departments.
文摘BACKGROUND Global tumor incidence rises and therapies advance,driving oncology nursing specialization.Granting nurses prescriptive authority optimizes care but polarizes nurses'attitudes due to factors like risk and competence,hindering policy implementation.AIM To investigate the current status of the attitudes of oncology specialist nurses toward having prescribing authority,specifically concerning symptom management and supportive care in oncology practice,and we conducted a path analysis of their influencing factors.METHODS As participants in the survey,oncology specialist nurses working in hospitals of different grades in Jiangsu Province were selected from March 2025 to May 2025 using a stratified sampling method.The questionnaires were administered using the general information questionnaire,the beliefs and attitudes about nurses'prescriptive authority scale,the nurses'professional identity scale,and the selfefficacy scale.Pearson’s method was used to analyze the correlation between beliefs and attitudes about the prescriptive authority,professional identity,and self-efficacy of nurses.Multiple linear regression was performed to analyze the factors influencing the beliefs and attitudes of nurses’prescriptive authority.The Amos plug-in was used to construct structural equation models to analyze the influencing pathways.RESULTS A total of 329 questionnaires were distributed,and 328 valid questionnaires were returned(effective recovery rate:99.70%).The total score of the 328 oncology nurses on the beliefs and attitudes about nurses'prescriptive authority scale was 101.88±15.13,indicating a moderately high level.Univariate analysis revealed that gender and hospital grade were associated with this score(P<0.05).The Pearson correlation analysis revealed that self-efficacy was positively correlated with the scores of the beliefs and attitudes about nurses’prescriptive authority scale and the nurses’professional identity scale(r=0.4999,P<0.0001 and r=0.7048,P<0.05,respectively),whereas occupational identity was positively correlated only with the former(r=0.6209,P<0.05).Multiple linear regression analysis revealed occupational identity and self-efficacy as the factors influencing the scores of the beliefs and attitudes about nurses’prescriptive authority scale(P<0.05).The results of the path analysis revealed that selfefficacy significantly positively affected nurses’occupational identity and their beliefs and attitudes about having prescriptive authority;occupational identity played a mediating role between the two,with a mediating effect accounting for 54.46% of the total effect,and the structural equation model was well-fitted.CONCLUSION Oncology nurses have more positive attitudes toward prescriptive authority.In addition,self-efficacy positively and indirectly affects nurses’attitudes toward prescriptive authority through the mediating effect of occupational identity.This can be used as a basis for clinical practice to take targeted measures to improve nurses’self-efficacy and occupational identity,thus creating favorable conditions for effectively implementing the policy of prescriptive authority.
文摘The consumption of ultra-processed foods(UPFs)is continuously increasing,and there is growing evidence that these foods contribute to the development and progression of cancer.For oncology patients alone,maintaining nutritional status is crucial for tolerating treatments and improving survival.The aim of this paper is to review the role of UPFs in the diet of oncology patients,highlighting their potential health-damaging effects(e.g.,increased inflammation,microbiome disruption,nutrient deficiencies)and potential benefits(e.g.,easy accessibility,high energy content,specially formulated nutritional supplements)particularly in the context of addressing the energy and nutrient needs and nutritional challenges of patients experiencing cancer-related cachexia or anorexia.Using a literature review,we examine how the UPFs can impact oncology patients’health,supporting the quality of life and clinical outcomes of oncology patients.
文摘Nanomedicine has evolved significantly over the last decades and expanded its applications in pediatric oncology,which represents a special domain with unique patients and distinct requirements.The need for early cancer diagnosis andmore effective and targeted therapies aiming to increase the pediatric patients’survival rates andminimize the treatment-related side effects to survivors is profound.Nanoparticles(NPs)come as a beacon of hope to provide sensitive cancer diagnostic tools and assist contrast agents’transport to the malignant tumors.Besides,NPs could be designed to deliver targeted drugs and genes to tumors,minimizing the medicine-related toxicities.Metal and metal oxide NPs could be exploited as sensitizers to enhance chemotherapy and radiotherapy effects.Future research should emphasize pediatric models to gain secure results about NPs’safety and efficiency for pediatric cancer patients.This review presents the recent studies on the use of NPs in pediatric cancer management and highlights their impact on diagnosis,treatment outcomes,and the quality of life of the survivors.The purpose of this study is to investigate the benefits that may arise from the use of NPs in pediatric oncology,address the potential limitations and challenges,and discuss the needs for future research efforts.
基金Supported by the Hunan Provincial Natural Science Foundation of China,No.2025JJ80410.
文摘BACKGROUND Death anxiety(DA)is a prevalent psychological challenge among oncology nurses that affects their emotional well-being and professional competence in coping with death-related situations.Death-related attitudes and resilience are critical factors that may mediate the relationship between DA and coping with death competence(CDC).However,few studies have examined the chain-mediating effect of these factors among Chinese oncology nurses.This study aimed to investigate the association between DA and CDC among Chinese oncology nurses,with a focus on the mediating roles of death attitude and resilience.AIM To investigate the association between DA and CDC among Chinese oncology nurses.using an electronic questionnaire distributed in Wenjuanxing,China.In total,615 valid responses were obtained.The participants completed the Templer death anxiety scale,death attitude profile-revised,Connor-Davidson resilience scale,and coping with death scale.A chain mediation analysis was performed using the PROCESS macro in SPSS to examine the relationships between these variables.RESULTS The findings indicated that DA had a significant direct effect on CDC[effect=0.201,95%confidence interval(CI):0.112-0.322].In addition to this direct effect,three significant indirect pathways were observed:(1)Death attitude(effect=0.118,95%CI:0.056-0.163);(2)Resilience(effect=0.108,95%CI:0.032-0.176);and(3)A sequential mediation pathway involving both death attitude and resilience(effect=0.071,95%CI:0.042-0.123).The total indirect effects of the three mediation paths accounted for 29.7%of the relationship between DA and CDC.CONCLUSION Using a chain mediation model,this study explored the mechanisms linking DA,death attitude,resilience,and CDC among Chinese oncology nurses.These findings highlighted the crucial role of death attitude and resilience in mediating the relationship between DA and CDC.Interventions aimed at fostering adaptive attitudes toward death and enhancing resilience may improve nurses’ability to cope with death-related stressors,ultimately benefiting their psychological well-being and professional competence.
基金Supported by Henan Province Key Research and Development Program,No.231111311000Henan Provincial Science and Technology Research Project,No.232102310411+2 种基金Henan Province Medical Science and Technology Key Project,No.LHGJ20220566 and No.LHGJ20240365Henan Province Medical Education Research Project,No.WJLX2023079Zhengzhou Medical and Health Technology Innovation Guidance Program,No.2024YLZDJH022.
文摘With the global population aging,the care of elderly cancer patients has become increasingly complex and significant.Comprehensive geriatric assessment(CGA),a multidimensional evaluation tool,has been widely implemented in oncology nursing to enhance the precision of treatment decisions and improve patient outcomes.This review examines the application of CGA in oncology nursing,drawing on literature published between 2010 and 2024 in major databases using keywords such as“Comprehensive Geriatric Assessment”and“Oncology Nursing”.It highlights how CGA contributes to optimizing treatment selection,monitoring the treatment process,and improving patients’quality of life and long-term outcomes.CGA provides a comprehensive evaluation of elderly cancer patients,including physical,psychological,and social aspects,enabling the identification of high-risk patients and reducing treatment-related side effects and complications.It also offers a critical foundation for developing personalized care plans.The article discusses various practical examples of CGA implementation across different countries and regions,including multidisciplinary collaborative models in France,the United States,and Australia,demonstrating CGA’s flexible application in diverse healthcare settings.Although significant progress has been made in applying CGA in oncology nursing,numerous challenges remain in its implementation,such as resource limitations and insufficient personnel training.Future research will focus on integrating CGA with emerging technologies,such as artificial intelligence and precision medicine,to further improve the quality of care and treatment outcomes for elderly cancer patients.By summarizing the current status and challenges of CGA in oncology nursing,this review provides guidance for future research and clinical practice,emphasizing the importance of advancing CGA application to meet the growing demands of elderly oncology care.
文摘Objective:To systematically evaluate the effectiveness of research-oriented integrated nursing interventions on cancer pain management in hospitalized oncology patients in China.Methods:A computerized search of Chinese and English databases was conducted to identify relevant studies.Two researchers independently assessed the quality of included literature using the Newcastle-Ottawa Scale(NOS).Data were extracted and analyzed via Stata 14.A random-effects model was applied due to significant heterogeneity(I²>50%).Sensitivity analysis and Egger’s test were performed to assess bias.Results:12 eligible studies(2014-2024)were included.Meta-analysis demonstrated that integrated nursing interventions significantly reduced cancer pain scores compared to routine care(SMD=-1.51,95%CI:-1.90 to-1.12;I²=84.8%),with superior efficacy.Subgroup-analyses revealed enhanced effects for“Nursing modes”(SMD=-2.11)and“cancer pain education”(SMD=-2.30).Conclusion:Research-oriented integrated nursing interventions significantly improve cancer pain management in Chinese hospitalized oncology patients,particularly through synergistic effects of“Nursing modes”and“can-cer pain education.”However,implementation bias from“additive interventions”in teaching hospitals and high heterogeneity warrant attention.Future studies should optimize designs to enhance clinical applicability.
文摘The Chinese Society of Clinical Oncology Non-small Cell Lung Cancer(CSCO NSCLC)guidelines were first published in 2016,ranking among the earliest-released guidelines within the CSCO series.In 2020 the CSCO published separate guidelines for NSCLC and small cell lung cancer(SCLC)for the first time to improve clinical usability.
文摘Background:Precision medicine is an emerging approach for treating pediatric cancer due to its ability to target tumor-specific genetic drivers rather than provide broad and aggressive treatments.The study aimed to outline the establishment and impact of a Precision Medicine Clinic(PMC)in the setting of pediatric oncology,with the objective of offering targeted treatment options within the institution and creating a scalable model for adoption by other healthcare systems to achieve a wider impact.Methods:Recognizing this need for an individualized approach to treating patients,Cook Children’s Medical Center(CCMC)established a multidisciplinary molecular tumor board in 2019,followed by the launch of an official PMC in 2021.Before this,there was no dedicated place to discuss and evaluate genetic sequencing results.Results:In 2022 and 2023,the PMC discussed 69 patients with a wide variety of oncologic diagnoses.Through the clinic’s efforts,133 genetic variants across 101 genes have been identified,spanning oncogenic pathways related to cell cycling,DNA processing,and cell signaling.Of the sequenced patients,four have received targeted therapy according to recommendations from the PMC.Conclusion:While the PMC continues to evaluate patients and their long-term outcomes,the continually growing PMC at CCMC represents the beginning of the advancement of treating pediatric oncology patients through the interpretation of genetic sequencing results,making actionable targeted treatment recommendations,and continuing to follow the patient’s course of care over time.This additionally provides a framework for starting a PMC that can be adapted for specific clinical needs and implemented broadly.
文摘Objective:To analyze the effect of perioperative comprehensive nursing intervention on patients undergoing breast surgery in oncology surgery.Methods:A total of 100 patients undergoing breast surgery were selected as the study subjects and divided into a control group and a study group.The control group received routine nursing,while the study group received perioperative comprehensive nursing.The effects were observed.Results:The study group had lower negative emotion scores and complication rates than the control group,and higher range of motion of the affected shoulder joint and quality of life than the control group(P<0.05).Conclusion:Oncology breast surgery is often accompanied by adverse psychological emotions during the perioperative period.To ensure surgical efficacy and postoperative recovery,comprehensive perioperative nursing measures can effectively prevent and develop complications,improve shoulder joint range of motion,and promote recovery.
文摘Although the whole world has been suffering under the Coronavirus Disease 2019 epidemic,the World Journal of Clinical Oncology(WJCO)was able to productively direct our efforts in the field through 2020.This was only accomplished through the collective efforts and support of our Editorial Board members,peer reviewers,authors,readers and editorial office staff.In 2020,the WJCO published 12 issues encompassing 84 papers,a 115.4%increase over 2019(39 papers).In December of 2020,we strategized a plan to solicit even more high-quality contributions for WJCO in 2021.So far,we have registered and accepted 188 manuscript titles,including 132 reviews and 56 original articles.In the New Year,we will work with our internal and external colleagues who care about and support the development of WJCO with the express aim of improving the academic rank of WJCO in the field of oncology.Ultimately,our goal is to merit and gain inclusion in the Science Citation Index Expanded,with the first impact factor being awarded as soon as possible.
文摘BACKGROUND Reactivation of hepatitis B virus(HBV)infection is a well-known risk that can occur spontaneously or following immunosuppressive therapies,including cancer chemotherapy.HBV reactivation can cause significant morbidity and even mortality,which are preventable if at-risk individuals are identified through screening and started on antiviral prophylaxis.AIM To determine the prevalence of chronic HBV(CHB)and occult HBV infection(OBI)among oncology and hematology-oncology patients undergoing chemo-therapy.METHODS In this observational study,the prevalence of CHB and OBI was assessed among patients receiving chemotherapy.Serological markers of HBV infection[hepatitis B surface antigen(HBsAg)/anti-hepatitis B core antigen(HBc)]were evaluated for all patients.HBV DNA levels were assessed in those who tested negative for HBsAg but positive for total anti-HBc.RESULTS The prevalence of CHB in the study cohort was determined to be 2.3%[95%confidence interval(95%CI):1.0-4.2].Additionally,the prevalence of OBI among the study participants was found to be 0.8%(95%CI:0.2-2.3).CONCLUSION The findings of this study highlight the importance of screening for hepatitis B infection in oncology and hematology-oncology patients undergoing chemotherapy.Identifying individuals with CHB and OBI is crucial for implementing appropriate antiviral prophylaxis to prevent the reactivation of HBV infection,which can lead to increased morbidity and mortality.
文摘There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S. Food and Drug Administration for advanced melanoma and non-small cell lung cancer,immune checkpoint inhibitors also appears to have significant antitumor activity in multiple other tumor types. An exciting component of immunotherapy is the durability of antitumor responses observed, with some patients achieving disease control for many years. Nevertheless, not all patients benefit, and efforts should thus now focus on improving the efficacy of immunotherapy through the use of combination approaches and predictive biomarkers of response and resistance. There are multiple potential rational combinations using an immunotherapy backbone, including existing treatments such as radiotherapy, chemotherapy or molecularly targeted agents, as well as other immunotherapeutics. The aim of such antitumor strategies will be to raise the tail on the survival curve by increasing the number of long term survivors, while managing any additive or synergistic toxicities that may arise with immunotherapy combinations. Rational trial designs based on a clear understanding of tumor biology and drug pharmacology remain paramount. This article reviews the biology underpinning immuno-oncology, discusses existing and novel immunotherapeutic combinations currently in development, the challenges of predictive biomarkers of response and resistance and the impact of immuno-oncology on early phase clinical trial design.
