In the current transformative era of biomedicine,hydrogels have established their presence in biomaterials due to their superior biocompatibility,tuneability and resemblance with native tissue.However,hydrogels typica...In the current transformative era of biomedicine,hydrogels have established their presence in biomaterials due to their superior biocompatibility,tuneability and resemblance with native tissue.However,hydrogels typically exhibit poor conductivity due to their hydrophilic polymer structure.Electrical conductivity provides an important enhancement to the properties of hydrogel-based systems in various biomedical applications such as drug delivery and tissue engineering.Consequently,researchers are developing combinatorial strategies to develop electrically responsive“SMART”systems to improve the therapeutic efficacy of biomolecules.Electrically conductive hydrogels have been explored for various drug delivery applications,enabling higher loading of therapeutic cargo with on-demand delivery.This review emphasizes the properties,mechanisms,fabrication techniques and recent advancements of electrically responsive“SMART”systems aiding on-site drug delivery applications.Additionally,it covers prospects for the successful translation of these systems into clinical research.展开更多
Diabetic wounds(DWs)are a major complication of diabetes mellitus,characterized by a complex patho-physiological microenvironment that is associated with elevated morbidity and mortality.Conventional management strate...Diabetic wounds(DWs)are a major complication of diabetes mellitus,characterized by a complex patho-physiological microenvironment that is associated with elevated morbidity and mortality.Conventional management strategies often fail to address the multifaceted nature of these wounds effectively.Recent advancements in understanding the mechanisms of DW healing have spurred the development of a plethora of bioactive dressings designed to interact with and modulate the DW microenvironment.These innovations have culminated in the introduction of the“microenvironment-sensitive with on-demand management”paradigm aimed at delivering precision therapy responsive to dynamic changes within DW.Despite these advancements,the current literature lacks a comprehensive review that cate-gorizes and evaluates active,passive,and on-demand approaches that address the DW microenviron-ment.Herein,we describe the unique pathogenic mechanisms and microenvironmental characteristics that distinguish DW from normal acute wounds.This review provides an extensive overview of contem-porary active and passive management strategies incorporating on-demand management principles designed for DW microenvironments.Furthermore,it addresses the principal challenges faced in this therapeutic domain and outlines the potential innovations that can enhance the efficacy and specificity of bioactive dressings.The insights presented here aim to guide further research and development in the on-demand management of DW to improve patient outcomes by aligning personalized therapy modali-ties with the pathophysiological realities of DW.展开更多
With the acceleration of global aging,the population aged 60 and above in China has exceeded 280 million,and the contradiction between the digital skills demands of the elderly and the supply of static and universal e...With the acceleration of global aging,the population aged 60 and above in China has exceeded 280 million,and the contradiction between the digital skills demands of the elderly and the supply of static and universal educational resources has become prominent.This article conducts an in-depth study on the“on-demand creation”model of elderly education resource services driven by generative AI.This study proposes an“on-demand creation”service paradigm based on generative AI,providing suitable resources for elderly intelligent life skills training through demand perception,content generation,and dynamic optimization mechanisms.From the perspective of technological philosophy and service science,deconstruct the core element logic of the paradigm to demonstrate its dual value in reconstructing the theoretical framework of elderly education and promoting practical transformation.This research indicates that this paradigm provides systematic theoretical support for the innovation of elderly education services through a balance between technological empowerment and humanistic care,helping the elderly master modern information technology and life skills,enhancing their self-care ability and social participation,and better adapting to life in the digital age.展开更多
On-demand droplet sorting is extensively applied for the efficient manipulation and genome-wide analysis of individual cells.However,state-of-the-art microfluidic chips for droplet sorting still suffer from low sortin...On-demand droplet sorting is extensively applied for the efficient manipulation and genome-wide analysis of individual cells.However,state-of-the-art microfluidic chips for droplet sorting still suffer from low sorting speeds,sample loss,and labor-intensive preparation procedures.Here,we demonstrate the development of a novel microfluidic chip that integrates droplet generation,on-demand electrostatic droplet charging,and high-throughput sorting.The charging electrode is a copper wire buried above the nozzle of the microchannel,and the deflecting electrode is the phosphate buffered saline in the microchannel,which greatly simplifies the structure and fabrication process of the chip.Moreover,this chip is capable of high-frequency droplet generation and sorting,with a frequency of 11.757 kHz in the drop state.The chip completes the selective charging process via electrostatic induction during droplet generation.On-demand charged microdroplets can arbitrarilymove to specific exit channels in a three-dimensional(3D)-deflected electric field,which can be controlled according to user requirements,and the flux of droplet deflection is thereby significantly enhanced.Furthermore,a lossless modification strategy is presented to improve the accuracy of droplet deflection or harvest rate from 97.49% to 99.38% by monitoring the frequency of droplet generation in real time and feeding it back to the charging signal.This chip has great potential for quantitative processing and analysis of single cells for elucidating cell-to-cell variations.展开更多
To improve the efficiency and fairness of the spectrum allocation for ground communication assisted by unmanned aerial vehicles(UAVs),a joint optimization method for on-demand deployment and spectrum allocation of UAV...To improve the efficiency and fairness of the spectrum allocation for ground communication assisted by unmanned aerial vehicles(UAVs),a joint optimization method for on-demand deployment and spectrum allocation of UAVs is proposed,which is modeled as a mixed-integer non-convex optimization problem(MINCOP).An algorithm to estimate the minimum number of required UAVs is firstly proposed based on the pre-estimation and simulated annealing.The MINCOP is then decomposed into three sub-problems based on the block coordinate descent method,including the spectrum allocation of UAVs,the association between UAVs and ground users,and the deployment of UAVs.Specifically,the optimal spectrum allocation is derived based on the interference mitigation and channel reuse.The association between UAVs and ground users is optimized based on local iterated optimization.A particle-based optimization algorithm is proposed to resolve the subproblem of the UAVs deployment.Simulation results show that the proposed method could effectively improve the minimum transmission rate of UAVs as well as user fairness of spectrum allocation.展开更多
The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer treatment.Herein,a smart hydrogel with self-adaptable size and dual responsive cargos release was fabricated to ...The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer treatment.Herein,a smart hydrogel with self-adaptable size and dual responsive cargos release was fabricated to treat breast cancer via accurate tumor elimination,on-demand adipose tissue regeneration and effective infection inhibition.The hydrogel consisted of thiol groups ended polyethylene glycol(SH-PEG-SH)and doxorubicin encapsulated mesoporous silica nanocarriers(DOX@MSNs)double crosslinked hyaluronic acid(HA)after loading of antibacterial peptides(AP)and adipose-derived stem cells(ADSCs).A pH-cleavable unsaturated amide bond was pre-introduced between MSNs and HA frame to perform the tumor-specific acidic environment dependent DOX@MSNs release,meanwhile an esterase degradable glyceryl dimethacrylate cap was grafted on MSNs,which contributed to the selective chemotherapy in tumor cells with over-expressed esterase.The bond cleavage between MSNs and HA would also cause the swelling of the hydrogel,which not only provide sufficient space for the growth of ADSCs,but allows the hydrogel to fully fill the irregular defects generated by surgery and residual tumor atrophy,resulting in the on-demand regeneration of adipose tissue.Moreover,the sustained release of AP could be simultaneously triggered along with the size change of hydrogel,which further avoided bacterial infection to promote tissue regeneration.展开更多
To meet the bandwidth requirement for the multicasting data flow in ad hoc networks, a distributed on- demand bandwidth-constrained multicast routing （BCMR） protocol for wireless ad hoc networks is proposed. With th...To meet the bandwidth requirement for the multicasting data flow in ad hoc networks, a distributed on- demand bandwidth-constrained multicast routing （BCMR） protocol for wireless ad hoc networks is proposed. With this protocol, the resource reservation table of each node will record the bandwidth requirements of data flows, which access itself, its neighbor nodes and hidden nodes, and every node calculates the remaining available bandwidth by deducting the bandwidth reserved in the resource reservation table from the total available bandwidth of the node. Moreover, the BCMR searches in a distributed manner for the paths with the shortest delay conditioned by the bandwidth constraint. Simulation results demonstrate the good performance of BCMR in terms of packet delivery reliability and the delay. BCMR can meet the requirements of real time communication and can be used in the multicast applications with low mobility in wireless ad hoc networks.展开更多
Objective:The intravaginal ejaculatory latency time(IELT)may increase less in on-demand compared to daily intake,but may fulfill a suitable treatment for specific patients.We decided to compare the efficacy and safety...Objective:The intravaginal ejaculatory latency time(IELT)may increase less in on-demand compared to daily intake,but may fulfill a suitable treatment for specific patients.We decided to compare the efficacy and safety of on-demand and daily use of sertraline in order to find the most effective and least complicated method in treatment of premature ejaculation(PE).Methods:This study was parallel or concurrent control randomized clinical trial.Two hundred and forty patients with PE diagnosed by urologist in the two groups of 120 from July 2017 to February 2019 enrolled in the study.In the first group,it is prescribed 50 mg sertraline each 12 h daily and the second group received 50 mg 4 h before coitus for 4 and 8 weeks.The IELT before treatment and during all coitus after treatment were recorded by the patient’s wife with a stopwatch.Results:Mean IELT before,4 and 8 weeks after treatment in two groups were:On-demand group 101.62±65.44 s,208.75±128.02 s and 265.87±145.70 s;daily use group 102.50-81.22 s,276.87±181.08 s and 353.75±176.45 s,respectively.The ejaculation time increased significantly in both groups(p<0.05).However,increase in ejaculation time in daily use group was significantly higher than the on-demand group in 4 weeks(p=0.036),especially in 8 weeks(p=0.009).The percent of side effects in daily use group(26.7%)was higher than on-demand group(20%)(p<0.05).Drowsiness,diarrhea and vertigo were significantly higher in the daily use than on-demand(p<0.05).Conclusions:On-demand and daily use of sertraline are effective and usually have no serious complications,but the on-demand method is considerably more tolerable.In patients who did not tolerate to daily use of this drug,on-demand could be used as a salvage therapy.展开更多
Injectable hydrogels have been considered as promising materials for bone regeneration,but their osteoinduction and mechanical performance are yet to be improved.In this study,a novel biocompatible injectable and self...Injectable hydrogels have been considered as promising materials for bone regeneration,but their osteoinduction and mechanical performance are yet to be improved.In this study,a novel biocompatible injectable and self-healing nano hybrid hydrogel was on-demand prepared via a fast(within 30 s)and easy gelation approach by reversible Schiff base formed between-CH=O of oxidized sodium alginate(OSA)and-NH2 of glycol chitosan(GCS)mixed with calcium phosphate nanoparticles(CaP NPs).Its raw materials can be ready in large quantities by a simple synthesis process.The mechanical strength,degradation and swelling behavior of the hydrogel can be readily controlled by simply controlling the molar ratio of-CH=O and-NH2.This hydrogel exhibits pH responsiveness,good degradability and biocompatibility.The hydrogel used as the matrix for mesenchymal stem cells can significantly induce the proliferation,differentiation and osteoinduction in vitro.These results showed this novel hydrogel is an ideal candidate for applications in bone tissue regeneration and drug delivery.展开更多
An ants-based on-demand routing algorithm （AORA） specialized for mobile ad hoc networks is proposed. AORA measures the network＇s traffic information including delivery time, route energy etc. by the continuous deli...An ants-based on-demand routing algorithm （AORA） specialized for mobile ad hoc networks is proposed. AORA measures the network＇s traffic information including delivery time, route energy etc. by the continuous delivery of data packets, then calculates the compositive parameter for each route which can be seen as the stigmity and uses it to choose the comparatively optimal route in real time. To adjust the weight of each traffic information, the algorithm can meet the different demand of the network＇s user. Multipath source self repair routing （MSSRR） algorithm and dynamic source routing （DSR） can be seen as the special samples of AORA. The routing overhead is not increased in this algorithm. By using simulation, it can be seen that the performance of AORA is better than that of DSR in all scenarios obviously, especially the delivery fraction is increased by more than 100 96.展开更多
Network coding has been proved to be an effective technique in improving the performance of data broadcast systems because clients requesting different data items can be served simultaneously in one broadcast. Previou...Network coding has been proved to be an effective technique in improving the performance of data broadcast systems because clients requesting different data items can be served simultaneously in one broadcast. Previous studies showed that its efficiency is highly related to the content of clients' cache. However, existing data broadcast systems do not take network coding information into account when making cache replacement decisions. In this paper, we propose two networks coding-aware cache replacement policies called DLRU and DLRU-CP to supplement network coding assisted data broadcast in on-demand broadcast environments. In DLRU, both data access and decoding contribution are taken into account to make replacement decisions. DLRU-CP is based on DLRU but allows clients to retrieve decodable data items that have not been requested yet. The performance gain of our proposed cache replacement policies over traditional cache replacement policy is shown in the simulation results, which demonstrate conclusively that the proposed policies can effectively reduce the overall response time.展开更多
Cloud computing provides a new paradigm for hardware and software infrastructure design as well as planning and usage of information systems. It offers flexible, efficient, inexpensive, and quality services. This pape...Cloud computing provides a new paradigm for hardware and software infrastructure design as well as planning and usage of information systems. It offers flexible, efficient, inexpensive, and quality services. This paper proposes an on-demand service system using the cloud computing architecture and analyzes important issues such as organization, management, and monitoring of distributed service resources; context-aware on-demand service modeling, on-demand automated service composition in large-scale networks, and service system analysis based on complex system theory. Continuous Operating Reference Station （CORS） of a geo-spatial information system is taken as an example, and its architecture is analyzed from the perspective of cloud computing. Some fundamental questions are raised about its service.展开更多
Routing on ad-hoc network has become a major research issue among the networking communities due to its increasing complexity and the surge of challenging problems. One major factor contributing to this tendency is th...Routing on ad-hoc network has become a major research issue among the networking communities due to its increasing complexity and the surge of challenging problems. One major factor contributing to this tendency is that every terminal of an ad-hoc network is also functioning as a network router. In this paper we provide a comprehensive review about the principles and mechanisms of routing protocols used in ad-hoc networks. For comparison purposes, we discuss some relevant technical issues of two well-known routing strategies, namely On-Demand (Proactive routing) and Table-Driven (Reactive routing). In particular, focus our attention on two major and well-known routing protocols: AODV (Ad-hoc On-Demand Distance Vector Protocol) and OLSR (Optimized Link State Routing Protocol). Our study has no intention to suggest any definite solution for any ad-hoc network, because it is the case depending on dictated by the nature and varying factors of networks. Instead, we demonstrate our major perception and describe general models that may assist us while modeling a given network.展开更多
In mobile ad hoc networks （MANETs）, if a mnltihop route breaks, route maintenance is typically performed to establish a new route which causes high control overhead and long packet delay. To decrease the time of rec...In mobile ad hoc networks （MANETs）, if a mnltihop route breaks, route maintenance is typically performed to establish a new route which causes high control overhead and long packet delay. To decrease the time of recovery and the overhead of maintenance, a new route maintenance mechanism in which the maintenance is confined to the vicinity of the broken link is proposed. This mechanism patches broken route through some other nodes in which only nodes near the broken link（s） may need to be substituted and the rest of nodes can be retained on the route. The broken link can be repaired without considering its relative position in the whole path, so the abihty of dealing with hnk failure is improved obviously. Simulation results show that the proposed strategy improves network performance significantly, such as in merits of control overhead and packet delay.展开更多
In post-disaster emergency shelter aid, various relief agencies and other actors with different backgrounds need to cooperate in a tremendously short amount of time and under very different circumstances. In this arti...In post-disaster emergency shelter aid, various relief agencies and other actors with different backgrounds need to cooperate in a tremendously short amount of time and under very different circumstances. In this article, we describe a research project that develops and tests a new approach in which the demands for shelters in a specific situation are methodically connected with available, innovative and sustainable shelter solutions, a DSS （decision support system）. The DSS is a digital tool that translates the gathered evidence on needs, solutions and location including long-term effects of shelter provision into advice for the provision of sustainable, integral broader shelter solutions and designs. The outcome is a set of characteristics for a DSS for the provision of on-demand emergency shelters. A DSS that meets these characteristics leads to the provision of sustainable shelters that meet the needs of the users and, therefore, have higher performance in long term.展开更多
With the acceleration of the pace of social life and the emergence of the convenience economy,the requirements for on-demand cooking services have increased due to the increasing demand for food quality and the health...With the acceleration of the pace of social life and the emergence of the convenience economy,the requirements for on-demand cooking services have increased due to the increasing demand for food quality and the health concerns associated with takeaway food,as well as the lack of cooking skills.This paper aims to analyze the business model of on-demand cooking service platforms in China with the theory of Business Model Canvas proposed by Alexander Osterwalder.By exploring the advantages and disadvantages of the business model of on-demand door-to-door cooking,the study seeks to provide relevant recommendations.展开更多
Multiple signaling molecules work together in mitochondria to mediate complex physiological processes.However,most current fluorescent probes lack of ability to clarify the function of these actives in mitochondria du...Multiple signaling molecules work together in mitochondria to mediate complex physiological processes.However,most current fluorescent probes lack of ability to clarify the function of these actives in mitochondria due to their non-specific binding with analytes outside mitochondria.In this study,we designed an on-demand light-activated mitochondria-targeted fluorescent probe to observe in situ fluctuations in mitochondrial esterase.The designed probe has a natural yellow fluorescence that monitors entry into the mitochondria and maintains nonfluorescent responsiveness to esterase during cellular delivery.Following the enrichment of the probe in mitochondria,on-demand photoactivation only at the required mitochondrial location resulted in a remarkable emission response to the esterase with red fluorescence at 700 nm.Precise spatiotemporal recognition of esterase in mitochondria is successfully achieved by activating the in situ fluorescence response of esterase by light irradiation.This work provides a new strategy for the study of esterase-related diseases.展开更多
On-demand food delivery(OFD)is gaining more and more popularity in modern society.As a kernel order assignment manner in OFD scenario,order recommendation directly influences the delivery efficiency of the platform an...On-demand food delivery(OFD)is gaining more and more popularity in modern society.As a kernel order assignment manner in OFD scenario,order recommendation directly influences the delivery efficiency of the platform and the delivery experience of riders.This paper addresses the dynamism of the order recommendation problem and proposes a reinforcement learning solution method.An actor-critic network based on long short term memory(LSTM)unit is designed to deal with the order-grabbing conflict between different riders.Besides,three rider sequencing rules are accordingly proposed to match different time steps of the LSTM unit with different riders.To test the performance of the proposed method,extensive experiments are conducted based on real data from Meituan delivery platform.The results demonstrate that the proposed reinforcement learning based order recommendation method can significantly increase the number of grabbed orders and reduce the number of order-grabbing conflicts,resulting in better delivery efficiency and experience for the platform and riders.展开更多
基金the Ministry of Human Resource and Development (MHRD) Government of India for funding
文摘In the current transformative era of biomedicine,hydrogels have established their presence in biomaterials due to their superior biocompatibility,tuneability and resemblance with native tissue.However,hydrogels typically exhibit poor conductivity due to their hydrophilic polymer structure.Electrical conductivity provides an important enhancement to the properties of hydrogel-based systems in various biomedical applications such as drug delivery and tissue engineering.Consequently,researchers are developing combinatorial strategies to develop electrically responsive“SMART”systems to improve the therapeutic efficacy of biomolecules.Electrically conductive hydrogels have been explored for various drug delivery applications,enabling higher loading of therapeutic cargo with on-demand delivery.This review emphasizes the properties,mechanisms,fabrication techniques and recent advancements of electrically responsive“SMART”systems aiding on-site drug delivery applications.Additionally,it covers prospects for the successful translation of these systems into clinical research.
基金supported by the National Natural Science Foundation of China(22408078,82401057,32101170)the Zhejiang Province Postdoctoral Excellence Funding Program-Special Support(ZJ2024004).
文摘Diabetic wounds(DWs)are a major complication of diabetes mellitus,characterized by a complex patho-physiological microenvironment that is associated with elevated morbidity and mortality.Conventional management strategies often fail to address the multifaceted nature of these wounds effectively.Recent advancements in understanding the mechanisms of DW healing have spurred the development of a plethora of bioactive dressings designed to interact with and modulate the DW microenvironment.These innovations have culminated in the introduction of the“microenvironment-sensitive with on-demand management”paradigm aimed at delivering precision therapy responsive to dynamic changes within DW.Despite these advancements,the current literature lacks a comprehensive review that cate-gorizes and evaluates active,passive,and on-demand approaches that address the DW microenviron-ment.Herein,we describe the unique pathogenic mechanisms and microenvironmental characteristics that distinguish DW from normal acute wounds.This review provides an extensive overview of contem-porary active and passive management strategies incorporating on-demand management principles designed for DW microenvironments.Furthermore,it addresses the principal challenges faced in this therapeutic domain and outlines the potential innovations that can enhance the efficacy and specificity of bioactive dressings.The insights presented here aim to guide further research and development in the on-demand management of DW to improve patient outcomes by aligning personalized therapy modali-ties with the pathophysiological realities of DW.
文摘With the acceleration of global aging,the population aged 60 and above in China has exceeded 280 million,and the contradiction between the digital skills demands of the elderly and the supply of static and universal educational resources has become prominent.This article conducts an in-depth study on the“on-demand creation”model of elderly education resource services driven by generative AI.This study proposes an“on-demand creation”service paradigm based on generative AI,providing suitable resources for elderly intelligent life skills training through demand perception,content generation,and dynamic optimization mechanisms.From the perspective of technological philosophy and service science,deconstruct the core element logic of the paradigm to demonstrate its dual value in reconstructing the theoretical framework of elderly education and promoting practical transformation.This research indicates that this paradigm provides systematic theoretical support for the innovation of elderly education services through a balance between technological empowerment and humanistic care,helping the elderly master modern information technology and life skills,enhancing their self-care ability and social participation,and better adapting to life in the digital age.
基金The authors acknowledge the financial support from the NationalNatural Science Foundation ofChina(No.52275562)the Technology Innovation Fund of Huazhong University of Science and Technology(No.2022JYCXJJ015).
文摘On-demand droplet sorting is extensively applied for the efficient manipulation and genome-wide analysis of individual cells.However,state-of-the-art microfluidic chips for droplet sorting still suffer from low sorting speeds,sample loss,and labor-intensive preparation procedures.Here,we demonstrate the development of a novel microfluidic chip that integrates droplet generation,on-demand electrostatic droplet charging,and high-throughput sorting.The charging electrode is a copper wire buried above the nozzle of the microchannel,and the deflecting electrode is the phosphate buffered saline in the microchannel,which greatly simplifies the structure and fabrication process of the chip.Moreover,this chip is capable of high-frequency droplet generation and sorting,with a frequency of 11.757 kHz in the drop state.The chip completes the selective charging process via electrostatic induction during droplet generation.On-demand charged microdroplets can arbitrarilymove to specific exit channels in a three-dimensional(3D)-deflected electric field,which can be controlled according to user requirements,and the flux of droplet deflection is thereby significantly enhanced.Furthermore,a lossless modification strategy is presented to improve the accuracy of droplet deflection or harvest rate from 97.49% to 99.38% by monitoring the frequency of droplet generation in real time and feeding it back to the charging signal.This chip has great potential for quantitative processing and analysis of single cells for elucidating cell-to-cell variations.
基金supported by Project funded by China Postdoctoral Science Foundation(No.2021MD703980)。
文摘To improve the efficiency and fairness of the spectrum allocation for ground communication assisted by unmanned aerial vehicles(UAVs),a joint optimization method for on-demand deployment and spectrum allocation of UAVs is proposed,which is modeled as a mixed-integer non-convex optimization problem(MINCOP).An algorithm to estimate the minimum number of required UAVs is firstly proposed based on the pre-estimation and simulated annealing.The MINCOP is then decomposed into three sub-problems based on the block coordinate descent method,including the spectrum allocation of UAVs,the association between UAVs and ground users,and the deployment of UAVs.Specifically,the optimal spectrum allocation is derived based on the interference mitigation and channel reuse.The association between UAVs and ground users is optimized based on local iterated optimization.A particle-based optimization algorithm is proposed to resolve the subproblem of the UAVs deployment.Simulation results show that the proposed method could effectively improve the minimum transmission rate of UAVs as well as user fairness of spectrum allocation.
基金the National High Level Talents Special Support Plan(X.C.)the“Young Talent Support Plan”of Xi'an Jiaotong University(X.C.)+2 种基金the Natural Science Foundation of Shaanxi Province(No.2022JZ-48 to X.C.)the National Natural Science Foundation of China(No.82272141 to X.C.)the Shaanxi Provincial Key Research and Development Plan Project(No.2023-JC-QN-0260 to X.Q.).
文摘The irregular defects and residual tumor tissue after surgery are challenges for effective breast cancer treatment.Herein,a smart hydrogel with self-adaptable size and dual responsive cargos release was fabricated to treat breast cancer via accurate tumor elimination,on-demand adipose tissue regeneration and effective infection inhibition.The hydrogel consisted of thiol groups ended polyethylene glycol(SH-PEG-SH)and doxorubicin encapsulated mesoporous silica nanocarriers(DOX@MSNs)double crosslinked hyaluronic acid(HA)after loading of antibacterial peptides(AP)and adipose-derived stem cells(ADSCs).A pH-cleavable unsaturated amide bond was pre-introduced between MSNs and HA frame to perform the tumor-specific acidic environment dependent DOX@MSNs release,meanwhile an esterase degradable glyceryl dimethacrylate cap was grafted on MSNs,which contributed to the selective chemotherapy in tumor cells with over-expressed esterase.The bond cleavage between MSNs and HA would also cause the swelling of the hydrogel,which not only provide sufficient space for the growth of ADSCs,but allows the hydrogel to fully fill the irregular defects generated by surgery and residual tumor atrophy,resulting in the on-demand regeneration of adipose tissue.Moreover,the sustained release of AP could be simultaneously triggered along with the size change of hydrogel,which further avoided bacterial infection to promote tissue regeneration.
基金The Natural Science Foundation of Zhejiang Province(No.Y1090232)
文摘To meet the bandwidth requirement for the multicasting data flow in ad hoc networks, a distributed on- demand bandwidth-constrained multicast routing （BCMR） protocol for wireless ad hoc networks is proposed. With this protocol, the resource reservation table of each node will record the bandwidth requirements of data flows, which access itself, its neighbor nodes and hidden nodes, and every node calculates the remaining available bandwidth by deducting the bandwidth reserved in the resource reservation table from the total available bandwidth of the node. Moreover, the BCMR searches in a distributed manner for the paths with the shortest delay conditioned by the bandwidth constraint. Simulation results demonstrate the good performance of BCMR in terms of packet delivery reliability and the delay. BCMR can meet the requirements of real time communication and can be used in the multicast applications with low mobility in wireless ad hoc networks.
文摘Objective:The intravaginal ejaculatory latency time(IELT)may increase less in on-demand compared to daily intake,but may fulfill a suitable treatment for specific patients.We decided to compare the efficacy and safety of on-demand and daily use of sertraline in order to find the most effective and least complicated method in treatment of premature ejaculation(PE).Methods:This study was parallel or concurrent control randomized clinical trial.Two hundred and forty patients with PE diagnosed by urologist in the two groups of 120 from July 2017 to February 2019 enrolled in the study.In the first group,it is prescribed 50 mg sertraline each 12 h daily and the second group received 50 mg 4 h before coitus for 4 and 8 weeks.The IELT before treatment and during all coitus after treatment were recorded by the patient’s wife with a stopwatch.Results:Mean IELT before,4 and 8 weeks after treatment in two groups were:On-demand group 101.62±65.44 s,208.75±128.02 s and 265.87±145.70 s;daily use group 102.50-81.22 s,276.87±181.08 s and 353.75±176.45 s,respectively.The ejaculation time increased significantly in both groups(p<0.05).However,increase in ejaculation time in daily use group was significantly higher than the on-demand group in 4 weeks(p=0.036),especially in 8 weeks(p=0.009).The percent of side effects in daily use group(26.7%)was higher than on-demand group(20%)(p<0.05).Drowsiness,diarrhea and vertigo were significantly higher in the daily use than on-demand(p<0.05).Conclusions:On-demand and daily use of sertraline are effective and usually have no serious complications,but the on-demand method is considerably more tolerable.In patients who did not tolerate to daily use of this drug,on-demand could be used as a salvage therapy.
基金supported by the National Key Research and Development Program of China(No.2017YFC1104102)National Natural Science Foundation of China(Nos.31370958,21875044)+1 种基金Key Program of Natural Science Foundation of Fujian Province(No.2018Y0056)the International Scientific Partnership Program ISPP at King Saud University for funding this research work through ISPP-17-94(2)。
文摘Injectable hydrogels have been considered as promising materials for bone regeneration,but their osteoinduction and mechanical performance are yet to be improved.In this study,a novel biocompatible injectable and self-healing nano hybrid hydrogel was on-demand prepared via a fast(within 30 s)and easy gelation approach by reversible Schiff base formed between-CH=O of oxidized sodium alginate(OSA)and-NH2 of glycol chitosan(GCS)mixed with calcium phosphate nanoparticles(CaP NPs).Its raw materials can be ready in large quantities by a simple synthesis process.The mechanical strength,degradation and swelling behavior of the hydrogel can be readily controlled by simply controlling the molar ratio of-CH=O and-NH2.This hydrogel exhibits pH responsiveness,good degradability and biocompatibility.The hydrogel used as the matrix for mesenchymal stem cells can significantly induce the proliferation,differentiation and osteoinduction in vitro.These results showed this novel hydrogel is an ideal candidate for applications in bone tissue regeneration and drug delivery.
文摘An ants-based on-demand routing algorithm （AORA） specialized for mobile ad hoc networks is proposed. AORA measures the network＇s traffic information including delivery time, route energy etc. by the continuous delivery of data packets, then calculates the compositive parameter for each route which can be seen as the stigmity and uses it to choose the comparatively optimal route in real time. To adjust the weight of each traffic information, the algorithm can meet the different demand of the network＇s user. Multipath source self repair routing （MSSRR） algorithm and dynamic source routing （DSR） can be seen as the special samples of AORA. The routing overhead is not increased in this algorithm. By using simulation, it can be seen that the performance of AORA is better than that of DSR in all scenarios obviously, especially the delivery fraction is increased by more than 100 96.
基金Sponsored by the Research Grants Council of the Hong Kong Special Administrative Region,China ( Grant No. CityU 7002702)the Social Science Foundation from the Ministry of Education,China ( Grant No. 10YJC630021 )the National Natural Science Foundation of China ( Grant No.71202120)
文摘Network coding has been proved to be an effective technique in improving the performance of data broadcast systems because clients requesting different data items can be served simultaneously in one broadcast. Previous studies showed that its efficiency is highly related to the content of clients' cache. However, existing data broadcast systems do not take network coding information into account when making cache replacement decisions. In this paper, we propose two networks coding-aware cache replacement policies called DLRU and DLRU-CP to supplement network coding assisted data broadcast in on-demand broadcast environments. In DLRU, both data access and decoding contribution are taken into account to make replacement decisions. DLRU-CP is based on DLRU but allows clients to retrieve decodable data items that have not been requested yet. The performance gain of our proposed cache replacement policies over traditional cache replacement policy is shown in the simulation results, which demonstrate conclusively that the proposed policies can effectively reduce the overall response time.
基金funded by the National Basic Research Program of China ("973" Program) under Grant No. 2007CB310805the National High Technology Research and Development Program of China ("863" Program) under Grant No. 2007AA12Z309
文摘Cloud computing provides a new paradigm for hardware and software infrastructure design as well as planning and usage of information systems. It offers flexible, efficient, inexpensive, and quality services. This paper proposes an on-demand service system using the cloud computing architecture and analyzes important issues such as organization, management, and monitoring of distributed service resources; context-aware on-demand service modeling, on-demand automated service composition in large-scale networks, and service system analysis based on complex system theory. Continuous Operating Reference Station （CORS） of a geo-spatial information system is taken as an example, and its architecture is analyzed from the perspective of cloud computing. Some fundamental questions are raised about its service.
文摘Routing on ad-hoc network has become a major research issue among the networking communities due to its increasing complexity and the surge of challenging problems. One major factor contributing to this tendency is that every terminal of an ad-hoc network is also functioning as a network router. In this paper we provide a comprehensive review about the principles and mechanisms of routing protocols used in ad-hoc networks. For comparison purposes, we discuss some relevant technical issues of two well-known routing strategies, namely On-Demand (Proactive routing) and Table-Driven (Reactive routing). In particular, focus our attention on two major and well-known routing protocols: AODV (Ad-hoc On-Demand Distance Vector Protocol) and OLSR (Optimized Link State Routing Protocol). Our study has no intention to suggest any definite solution for any ad-hoc network, because it is the case depending on dictated by the nature and varying factors of networks. Instead, we demonstrate our major perception and describe general models that may assist us while modeling a given network.
基金the National High Technology Research and Development Progamme of China(No2005AA123820)the National Natural Science Foundation of China(No60472052 and No10577007)
文摘In mobile ad hoc networks （MANETs）, if a mnltihop route breaks, route maintenance is typically performed to establish a new route which causes high control overhead and long packet delay. To decrease the time of recovery and the overhead of maintenance, a new route maintenance mechanism in which the maintenance is confined to the vicinity of the broken link is proposed. This mechanism patches broken route through some other nodes in which only nodes near the broken link（s） may need to be substituted and the rest of nodes can be retained on the route. The broken link can be repaired without considering its relative position in the whole path, so the abihty of dealing with hnk failure is improved obviously. Simulation results show that the proposed strategy improves network performance significantly, such as in merits of control overhead and packet delay.
文摘In post-disaster emergency shelter aid, various relief agencies and other actors with different backgrounds need to cooperate in a tremendously short amount of time and under very different circumstances. In this article, we describe a research project that develops and tests a new approach in which the demands for shelters in a specific situation are methodically connected with available, innovative and sustainable shelter solutions, a DSS （decision support system）. The DSS is a digital tool that translates the gathered evidence on needs, solutions and location including long-term effects of shelter provision into advice for the provision of sustainable, integral broader shelter solutions and designs. The outcome is a set of characteristics for a DSS for the provision of on-demand emergency shelters. A DSS that meets these characteristics leads to the provision of sustainable shelters that meet the needs of the users and, therefore, have higher performance in long term.
文摘With the acceleration of the pace of social life and the emergence of the convenience economy,the requirements for on-demand cooking services have increased due to the increasing demand for food quality and the health concerns associated with takeaway food,as well as the lack of cooking skills.This paper aims to analyze the business model of on-demand cooking service platforms in China with the theory of Business Model Canvas proposed by Alexander Osterwalder.By exploring the advantages and disadvantages of the business model of on-demand door-to-door cooking,the study seeks to provide relevant recommendations.
基金supported by the National Natural Science Foundation of China(82173657,22077030,22271092)the support from the Institute of Fudan University-Quzhou。
文摘Multiple signaling molecules work together in mitochondria to mediate complex physiological processes.However,most current fluorescent probes lack of ability to clarify the function of these actives in mitochondria due to their non-specific binding with analytes outside mitochondria.In this study,we designed an on-demand light-activated mitochondria-targeted fluorescent probe to observe in situ fluctuations in mitochondrial esterase.The designed probe has a natural yellow fluorescence that monitors entry into the mitochondria and maintains nonfluorescent responsiveness to esterase during cellular delivery.Following the enrichment of the probe in mitochondria,on-demand photoactivation only at the required mitochondrial location resulted in a remarkable emission response to the esterase with red fluorescence at 700 nm.Precise spatiotemporal recognition of esterase in mitochondria is successfully achieved by activating the in situ fluorescence response of esterase by light irradiation.This work provides a new strategy for the study of esterase-related diseases.
基金supported in part by the National Natural Science Foundation of China(No.62273193)Tsinghua University-Meituan Joint Institute for Digital Life,and the Research and Development Project of CRSC Research&Design Institute Group Co.,Ltd.
文摘On-demand food delivery(OFD)is gaining more and more popularity in modern society.As a kernel order assignment manner in OFD scenario,order recommendation directly influences the delivery efficiency of the platform and the delivery experience of riders.This paper addresses the dynamism of the order recommendation problem and proposes a reinforcement learning solution method.An actor-critic network based on long short term memory(LSTM)unit is designed to deal with the order-grabbing conflict between different riders.Besides,three rider sequencing rules are accordingly proposed to match different time steps of the LSTM unit with different riders.To test the performance of the proposed method,extensive experiments are conducted based on real data from Meituan delivery platform.The results demonstrate that the proposed reinforcement learning based order recommendation method can significantly increase the number of grabbed orders and reduce the number of order-grabbing conflicts,resulting in better delivery efficiency and experience for the platform and riders.
