The di-zhen (DZ) is an ancient type of acupuncture needle with a history dating back to more than 2000 years. Unlike modern acupuncture needles, the DZ is not inserted subcutaneously and is considered to be safe for c...The di-zhen (DZ) is an ancient type of acupuncture needle with a history dating back to more than 2000 years. Unlike modern acupuncture needles, the DZ is not inserted subcutaneously and is considered to be safe for common use, even at the bedside of terminally ill patients. In this case study, DZ application was selected and applied 14 times on a 92-year-old patient who had suffered severe oliguria along with administration of diuretics. Urine volume increased 12 out of 14 times following DZ treatment;however, the other two times it was ineffective. To investigate the reason and the differences in effective/ineffective DZ application, two internal conditions (effective vs ineffective) were compared by analyzing daily nursing reports (vital signs such as blood pressure, urine volume and body temperature) and weekly clinical data (including renal, liver and immune function, urea nitrogen, creatinine, ALT, AST, the ratio and number of leukocytes, erythrocytes). DZ application increased urine volume via a transient modification of the autonomic nervous system when internal homeostasis was maintained. Aging populations, who often have several diseases and medications, are rapidly increasing in developed countries. Therefore, the study and application of DZ may contribute to a reduction in medical costs, which have been rapidly and heavily expanding recently.展开更多
The potential association between medical resources and the proportion of oldest-old(90 years of age and above)in the Chinese population was examined,and we found that the higher proportion of oldest-old was associate...The potential association between medical resources and the proportion of oldest-old(90 years of age and above)in the Chinese population was examined,and we found that the higher proportion of oldest-old was associated with the higher number of beds in hospitals and health centers.展开更多
Background:Changes in thyroid hormone levels are commonly recognized characters among the elderly,which were reported to potentially influence incident frailty.Therefore,we examined the cross-sectional associations of...Background:Changes in thyroid hormone levels are commonly recognized characters among the elderly,which were reported to potentially influence incident frailty.Therefore,we examined the cross-sectional associations of thyroid hormones(THs)with frailty as well as the five components characterizing frailty(fatigue,resistance,ambulation,number ofillnesses,and loss of weight)among the oldest-old.Methods:Four hundred and eighty-seven community-dwelling oldest-old from a local community in Haidian District,Beijing,participated in our recruitment campaign between April 2019 and May 2020.The primary outcomes were a definitive diagnosis of frailty according to the FRAIL scale(Fatigue,Resistance,Ambulation,Illnesses,Loss of weight)and a positive score for each frailty subdomain.Demographic information(age,sex,marital status,and educational status),comorbidities,and details on the participants lifestyles were recorded.Serum THs including free triodothyronin(fT3),triiodothyronine(T3),free thyroxine(fT4),and thyroxine(T4)and thyroid stimulating hormone(TSH)levels were also measured at the beginning of our study.Logistic regressions were conducted to screen for potential risk factors for frailty and its subdomains.Results:Among the total 487 subjects at enrollment,60(12.23%)of them were diagnosed with subclinical hypothyroidism and 110(22.59%)of the total population scored positive for frailty.Logistic regression analyses adjusted for all potential confounders,showed that frailty was significantly associated with the serum TSH concentration(odds ratio[OR]:1.06),fT3 concentration(OR:0.54),and subclinical hypothyroidism score(OR:2.18).The association between fT4 and frailty was absent in our observational study.The fT3/fT4 ratio characterizing peripheral hormone conversion was also tested to be correlated with frailty.Conclusion:Subclinical hypothyroidism,higher TSH level,lower fT3 level,and decreased fT3/fT4 ratio were all associated with frailty assessed by the FRAIL scale among the community-dwelling oldest-old,suggesting a relevant role of thyroid function in aging.Future longitudinal studies are warranted to determine the casual relationship between thyroid dysfunction and frailty in the oldest-old.展开更多
Cohort evidence linking long-term survival of older adults with exposure to fine particulate matter(PM_(2.5))constituents remains scarce in China.By constructing a dynamic cohort based on the Chinese Longitudinal Heal...Cohort evidence linking long-term survival of older adults with exposure to fine particulate matter(PM_(2.5))constituents remains scarce in China.By constructing a dynamic cohort based on the Chinese Longitudinal Healthy Longevity Study,we aimed to assess the individual and joint associations of major PM_(2.5)constituents with all-cause death in Chinese oldest-old(≥80 years)adults.Time-dependent Cox proportional hazards models were adopted to estimate death risks of long-term exposure to PM_(2.5)constituents.Among 14,884 participants,totaling 56,342 person-years of follow-up,12,346 deaths were identified.The highest mortality risk associated with an interquartile range(IQR)increase in exposure was 1.081(95%confidence interval[CI]:1.055–1.108)for sulfate(IQR=4.1μg m^(-3)),followed by 1.078(95%CI:1.056–1.101)for black carbon(IQR=1.6μg m^(-3)),1.056(95%CI:1.028–1.084)for ammonium(IQR=3.2μg m^(-3)),1.050(95%CI:1.021–1.080)for nitrate(IQR=5.8μg m^(-3)),and 1.049(95%CI:1.024–1.074)for organic matter(IQR=10.3μg m^(-3)).In joint exposure,each IQRequivalent rise of all five PM_(2.5)constituents was associated with an 8.2%(95%CI:4.0%–12.6%)increase in mortality risk.The weight analysis indicated the predominant role of sulfate and black carbon in driving PM_(2.5)-related mortality.Octogenarians(aged 80–89 years)and rural dwellers were at significantly greater risk of mortality from individual and joint exposures to PM_(2.5)constituents.This study suggests that later-life exposure to PM_(2.5)constituents,particularly sulfate and black carbon,may curtail long-term survival of the oldest-old in China.展开更多
智慧养老通过智慧技术赋能传统养老服务模式,对其进行改造和升级,究其根本在于满足老年人多元化、差异化的具体需求。现有的智慧养老平台在提供服务时一般未进行人群细分,学术界对不同年龄段老年人需求差异性的研究也尚显匮乏,这导致智...智慧养老通过智慧技术赋能传统养老服务模式,对其进行改造和升级,究其根本在于满足老年人多元化、差异化的具体需求。现有的智慧养老平台在提供服务时一般未进行人群细分,学术界对不同年龄段老年人需求差异性的研究也尚显匮乏,这导致智慧养老服务的效果普遍不佳。通过将老年人分为低龄(60-69岁)、中龄(70-79岁)和高龄(80岁及以上)三个不同的年龄段,同时采用中国老年社会追踪调查(China Longitudinal Aging Social Survey,CLASS)的最新(2020年)数据,并从经典的马斯洛需求层次理论出发可构建不同年龄段老年群体的动态需求模型。研究发现,不同年龄段的老年人既存在共性需求又存在差异化需求。共性需求会因年龄而存在需求强度差异,差异化需求则体现不同年龄段老年群体的特定需求。在此基础上,安德森模型和Logistic回归分析探讨了倾向性因素(性别、婚姻状态等)、使能性因素(养老金水平、上网情况)以及需求性因素(慢性病情况、自评健康状况等)对老年群体关键养老服务需求的影响,并构建了不同类型需求的各年龄段老年人的特征画像。为此,智慧养老服务平台应针对不同年龄段的老年群体提供差异化服务内容,并根据老年人的个性化画像进行精准推荐;针对老年个体来说,平台也应具备动态调整能力,以满足老年人在不同年龄段的养老服务需求。展开更多
文摘The di-zhen (DZ) is an ancient type of acupuncture needle with a history dating back to more than 2000 years. Unlike modern acupuncture needles, the DZ is not inserted subcutaneously and is considered to be safe for common use, even at the bedside of terminally ill patients. In this case study, DZ application was selected and applied 14 times on a 92-year-old patient who had suffered severe oliguria along with administration of diuretics. Urine volume increased 12 out of 14 times following DZ treatment;however, the other two times it was ineffective. To investigate the reason and the differences in effective/ineffective DZ application, two internal conditions (effective vs ineffective) were compared by analyzing daily nursing reports (vital signs such as blood pressure, urine volume and body temperature) and weekly clinical data (including renal, liver and immune function, urea nitrogen, creatinine, ALT, AST, the ratio and number of leukocytes, erythrocytes). DZ application increased urine volume via a transient modification of the autonomic nervous system when internal homeostasis was maintained. Aging populations, who often have several diseases and medications, are rapidly increasing in developed countries. Therefore, the study and application of DZ may contribute to a reduction in medical costs, which have been rapidly and heavily expanding recently.
基金the National Natural Science Foundation of China(41877518)the Key Special Program of Logistic Scientific Research of PLA(BLJ18J005)the Key Support Objects of Excellent Talent Pool of Military Medical University。
文摘The potential association between medical resources and the proportion of oldest-old(90 years of age and above)in the Chinese population was examined,and we found that the higher proportion of oldest-old was associated with the higher number of beds in hospitals and health centers.
基金funded by grants from NCRCG-PLAGH-2022004the Military Healthcare Research Program(No.21BJZ26,18BJZ32).
文摘Background:Changes in thyroid hormone levels are commonly recognized characters among the elderly,which were reported to potentially influence incident frailty.Therefore,we examined the cross-sectional associations of thyroid hormones(THs)with frailty as well as the five components characterizing frailty(fatigue,resistance,ambulation,number ofillnesses,and loss of weight)among the oldest-old.Methods:Four hundred and eighty-seven community-dwelling oldest-old from a local community in Haidian District,Beijing,participated in our recruitment campaign between April 2019 and May 2020.The primary outcomes were a definitive diagnosis of frailty according to the FRAIL scale(Fatigue,Resistance,Ambulation,Illnesses,Loss of weight)and a positive score for each frailty subdomain.Demographic information(age,sex,marital status,and educational status),comorbidities,and details on the participants lifestyles were recorded.Serum THs including free triodothyronin(fT3),triiodothyronine(T3),free thyroxine(fT4),and thyroxine(T4)and thyroid stimulating hormone(TSH)levels were also measured at the beginning of our study.Logistic regressions were conducted to screen for potential risk factors for frailty and its subdomains.Results:Among the total 487 subjects at enrollment,60(12.23%)of them were diagnosed with subclinical hypothyroidism and 110(22.59%)of the total population scored positive for frailty.Logistic regression analyses adjusted for all potential confounders,showed that frailty was significantly associated with the serum TSH concentration(odds ratio[OR]:1.06),fT3 concentration(OR:0.54),and subclinical hypothyroidism score(OR:2.18).The association between fT4 and frailty was absent in our observational study.The fT3/fT4 ratio characterizing peripheral hormone conversion was also tested to be correlated with frailty.Conclusion:Subclinical hypothyroidism,higher TSH level,lower fT3 level,and decreased fT3/fT4 ratio were all associated with frailty assessed by the FRAIL scale among the community-dwelling oldest-old,suggesting a relevant role of thyroid function in aging.Future longitudinal studies are warranted to determine the casual relationship between thyroid dysfunction and frailty in the oldest-old.
基金supported by Youth Fund Project of Humanities and Social Sciences Research of the Ministry of Education (21YJCZH229)the Chunhui Program Collaborative Research Project of the Ministry of Education (HZKY20220336)“The 14th Five Year Plan”Hubei Provincial Advantaged Characteristic Disciplines (Groups)Project of Wuhan University of Science and Technology (2023C0102)。
文摘Cohort evidence linking long-term survival of older adults with exposure to fine particulate matter(PM_(2.5))constituents remains scarce in China.By constructing a dynamic cohort based on the Chinese Longitudinal Healthy Longevity Study,we aimed to assess the individual and joint associations of major PM_(2.5)constituents with all-cause death in Chinese oldest-old(≥80 years)adults.Time-dependent Cox proportional hazards models were adopted to estimate death risks of long-term exposure to PM_(2.5)constituents.Among 14,884 participants,totaling 56,342 person-years of follow-up,12,346 deaths were identified.The highest mortality risk associated with an interquartile range(IQR)increase in exposure was 1.081(95%confidence interval[CI]:1.055–1.108)for sulfate(IQR=4.1μg m^(-3)),followed by 1.078(95%CI:1.056–1.101)for black carbon(IQR=1.6μg m^(-3)),1.056(95%CI:1.028–1.084)for ammonium(IQR=3.2μg m^(-3)),1.050(95%CI:1.021–1.080)for nitrate(IQR=5.8μg m^(-3)),and 1.049(95%CI:1.024–1.074)for organic matter(IQR=10.3μg m^(-3)).In joint exposure,each IQRequivalent rise of all five PM_(2.5)constituents was associated with an 8.2%(95%CI:4.0%–12.6%)increase in mortality risk.The weight analysis indicated the predominant role of sulfate and black carbon in driving PM_(2.5)-related mortality.Octogenarians(aged 80–89 years)and rural dwellers were at significantly greater risk of mortality from individual and joint exposures to PM_(2.5)constituents.This study suggests that later-life exposure to PM_(2.5)constituents,particularly sulfate and black carbon,may curtail long-term survival of the oldest-old in China.
文摘智慧养老通过智慧技术赋能传统养老服务模式,对其进行改造和升级,究其根本在于满足老年人多元化、差异化的具体需求。现有的智慧养老平台在提供服务时一般未进行人群细分,学术界对不同年龄段老年人需求差异性的研究也尚显匮乏,这导致智慧养老服务的效果普遍不佳。通过将老年人分为低龄(60-69岁)、中龄(70-79岁)和高龄(80岁及以上)三个不同的年龄段,同时采用中国老年社会追踪调查(China Longitudinal Aging Social Survey,CLASS)的最新(2020年)数据,并从经典的马斯洛需求层次理论出发可构建不同年龄段老年群体的动态需求模型。研究发现,不同年龄段的老年人既存在共性需求又存在差异化需求。共性需求会因年龄而存在需求强度差异,差异化需求则体现不同年龄段老年群体的特定需求。在此基础上,安德森模型和Logistic回归分析探讨了倾向性因素(性别、婚姻状态等)、使能性因素(养老金水平、上网情况)以及需求性因素(慢性病情况、自评健康状况等)对老年群体关键养老服务需求的影响,并构建了不同类型需求的各年龄段老年人的特征画像。为此,智慧养老服务平台应针对不同年龄段的老年群体提供差异化服务内容,并根据老年人的个性化画像进行精准推荐;针对老年个体来说,平台也应具备动态调整能力,以满足老年人在不同年龄段的养老服务需求。
