Logistics service providers significantly contribute to environmental degradation through improper waste disposal,hazardous packaging materials,excessive fuel consumption,and emissions.This study examines the impact o...Logistics service providers significantly contribute to environmental degradation through improper waste disposal,hazardous packaging materials,excessive fuel consumption,and emissions.This study examines the impact of green in-bound logistics and green outbound logistics on environmental,economic,and social performance of logistics companies using survey data from 221 Vietnamese logistics firms.Statistical analysis using Structural Equation Modeling revealed that green inbound logistics positively influences environmental and social performance while moderately affecting eco-nomic outcomes.In contrast,green outbound logistics demonstrates stronger effects on economic and environmental performance but exhibits limited impact on social dimensions.The measurement model showed strong reliability and validity(Cronbach's Alpha>0.70,robust Composite Reliability and Average Variance Extracted values),with excellent fit indices(Chi-Square/df=1.681,GFI=0.898,TLI=0.945,CFI=0.956,RMSEA=0.056).These findings highlight important distinctions between inbound and outbound green logistics impacts,offering valuable insights for an industry with currently low adoption rates of sustainable practices.The research demonstrates that implementing green logistics enhances both environmental preservation and business performance,providing compelling evidence for companies to accelerate their sustainability transition.By understanding these differential impacts,logistics firms can develop more tar-geted and effective sustainability strategies that optimize triple bottom line outcomes.展开更多
目的探究赖氨酸特异性组蛋白去甲基化酶1(lysine specific demethylase 1,LSD1)特异性抑制剂OGL002与抗癌药物顺铂对宫颈癌CaSki细胞的影响。方法培养CaSki细胞并分为4组:对照组、OGL002组、顺铂组、OGL002+顺铂组,按照组别分别用OGL00...目的探究赖氨酸特异性组蛋白去甲基化酶1(lysine specific demethylase 1,LSD1)特异性抑制剂OGL002与抗癌药物顺铂对宫颈癌CaSki细胞的影响。方法培养CaSki细胞并分为4组:对照组、OGL002组、顺铂组、OGL002+顺铂组,按照组别分别用OGL002以及顺铂处理CaSki细胞48 h。MTT检测细胞增殖,集落形成实验检测细胞增殖,Transwell检测细胞侵袭,流式细胞仪检测细胞凋亡,实时荧光定量PCR检测LSD1的表达,Western blot检测LSD1以及下游组蛋白甲基化水平。结果OGL002与顺铂单独以及联合用药抑制CaSki细胞增殖和侵袭,促进细胞凋亡,降低LSD1的表达,促进H3K4me1、H3K4me2表达水平上调,联合使用效果更加明显。结论OGL002以及顺铂联合用药后降低了LSD1以及组蛋白的表达,并且对细胞功能的影响比单独用药更加明显,提示OGL002与顺铂联合用药对于宫颈癌的治疗具有重要意义。展开更多
文摘Logistics service providers significantly contribute to environmental degradation through improper waste disposal,hazardous packaging materials,excessive fuel consumption,and emissions.This study examines the impact of green in-bound logistics and green outbound logistics on environmental,economic,and social performance of logistics companies using survey data from 221 Vietnamese logistics firms.Statistical analysis using Structural Equation Modeling revealed that green inbound logistics positively influences environmental and social performance while moderately affecting eco-nomic outcomes.In contrast,green outbound logistics demonstrates stronger effects on economic and environmental performance but exhibits limited impact on social dimensions.The measurement model showed strong reliability and validity(Cronbach's Alpha>0.70,robust Composite Reliability and Average Variance Extracted values),with excellent fit indices(Chi-Square/df=1.681,GFI=0.898,TLI=0.945,CFI=0.956,RMSEA=0.056).These findings highlight important distinctions between inbound and outbound green logistics impacts,offering valuable insights for an industry with currently low adoption rates of sustainable practices.The research demonstrates that implementing green logistics enhances both environmental preservation and business performance,providing compelling evidence for companies to accelerate their sustainability transition.By understanding these differential impacts,logistics firms can develop more tar-geted and effective sustainability strategies that optimize triple bottom line outcomes.
