Optical frequency combs(OFCs)and supercontinuum generation(SCG)facilitate a plethora of important applications in metrology,spectroscopy,optical clocks,etc.Recent advances in integrated photonics offer an attractive a...Optical frequency combs(OFCs)and supercontinuum generation(SCG)facilitate a plethora of important applications in metrology,spectroscopy,optical clocks,etc.Recent advances in integrated photonics offer an attractive avenue to implement compact or chip-integrated comb sources.However,the prevalent method based on nano-waveguides usually exhibits low output power and large coupling losses during the SCG process.展开更多
Human orofacial clefts (OFCs) are congenital anomalies that result from the breakdown of normal mechanisms that regulate the formation of the human face. They could be syndromic or non-syndromic, with a global inciden...Human orofacial clefts (OFCs) are congenital anomalies that result from the breakdown of normal mechanisms that regulate the formation of the human face. They could be syndromic or non-syndromic, with a global incidence of 1:700 per live births. Environmental and genetic factors are thought to play various roles in the aetiology of OFCs. This study seeks to establish the diversity, distribution and pattern of inheritance of OFCs as well as environmental and other risk factors associated with OFCs in a Ghanaian population. A family-based, descriptive cross-sectional study that employed an interview-based survey questionnaire was used to obtain information from 467 families with history of OFCs. We employed chi-square statistics to analyse the data and used graphs to interpret the data. All previously reported subphenotypes of OFCs were observed by the present study. Clinically, about 12% of clefts in the study population were syndromic. The most common syndromic forms observed were Pierre Robin Sequence, cleft-with-club foot abnormalities and Van der Woude Syndrome. Only about 5% of clefts in the study cohort were familial. The study also established that lower level of education of parents, poverty, late antenatal care and dietary folate deficiency are major environmental factors associated with clefts in the Ghanaian population. In conclusion, OFCs are non-randomly distributed in Ghana and folate deficiency could likely be a source of genetic mutations and “epimutations” that cause OFCs, since folate is essential for DNA methylation, replication and repair as well as histone modification.展开更多
基金National Key Research and Development Program of China(2022YFA1205100,2023YFA1407200)National Natural Science Foundation of China(12192252,12074252)+3 种基金Science and Technology Commission of Shanghai Municipality(24JD1401700)Shanghai Municipal Science and Technology Major Project(2019SHZDZX01-ZX06)Innovation Program for Quantum Science and Technology(2021ZD0300802)Yangyang Development Fund。
文摘Optical frequency combs(OFCs)and supercontinuum generation(SCG)facilitate a plethora of important applications in metrology,spectroscopy,optical clocks,etc.Recent advances in integrated photonics offer an attractive avenue to implement compact or chip-integrated comb sources.However,the prevalent method based on nano-waveguides usually exhibits low output power and large coupling losses during the SCG process.
文摘Human orofacial clefts (OFCs) are congenital anomalies that result from the breakdown of normal mechanisms that regulate the formation of the human face. They could be syndromic or non-syndromic, with a global incidence of 1:700 per live births. Environmental and genetic factors are thought to play various roles in the aetiology of OFCs. This study seeks to establish the diversity, distribution and pattern of inheritance of OFCs as well as environmental and other risk factors associated with OFCs in a Ghanaian population. A family-based, descriptive cross-sectional study that employed an interview-based survey questionnaire was used to obtain information from 467 families with history of OFCs. We employed chi-square statistics to analyse the data and used graphs to interpret the data. All previously reported subphenotypes of OFCs were observed by the present study. Clinically, about 12% of clefts in the study population were syndromic. The most common syndromic forms observed were Pierre Robin Sequence, cleft-with-club foot abnormalities and Van der Woude Syndrome. Only about 5% of clefts in the study cohort were familial. The study also established that lower level of education of parents, poverty, late antenatal care and dietary folate deficiency are major environmental factors associated with clefts in the Ghanaian population. In conclusion, OFCs are non-randomly distributed in Ghana and folate deficiency could likely be a source of genetic mutations and “epimutations” that cause OFCs, since folate is essential for DNA methylation, replication and repair as well as histone modification.
