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Absolute blood flow velocity measurement using microsphere tracking in optical coherence tomography
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作者 Huanhuan Yu Mingjie Ni +2 位作者 Dongqing Shang Teng Ma Cuixia Dai 《Journal of Innovative Optical Health Sciences》 2025年第6期43-54,共12页
Visualizing blood flow velocity distribution is essential for comprehending the pathogenesis of various diseases and facilitating early diagnosis and treatment.Current hemodynamic studies utilizing optical coherence t... Visualizing blood flow velocity distribution is essential for comprehending the pathogenesis of various diseases and facilitating early diagnosis and treatment.Current hemodynamic studies utilizing optical coherence tomography(OCT)primarily rely on Doppler OCT(D-OCT)and OCT Angiography(OCTA),which measure axial blood vessel velocity or visualize the vascular architecture,respectively.However,these techniques have limitations in accurately quantifying the absolute velocity of red blood cells(RBCs).This study presents a novel method based on microsphere tracking,which enables precise quantification of absolute blood flow velocity along a blood vessel.In phantom experiments,freshly harvested blood mixed with microspheres was infused into a cellulose tube to simulate a single blood vessel.Experimental results,demon-strating an error margin of less than 10%,validated the effectiveness of this method.Blood flow velocities ranging from 0.472 mm/s to 18.9 mm/s were accurately measured.A preliminary in vivo examination of rabbit ear vessels was conducted,further validating the reliability of this method.This study presents a potential method for specific disease diagnosis by detecting tar-geted vessel flow velocity variations using swept-source optical coherence tomography(SS-OCT)combined with microsphere tracking. 展开更多
关键词 Absolute blood flow velocity microsphere tracking swept-source optical coherence tomography
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Deep Learning-Based Natural Language Processing Model and Optical Character Recognition for Detection of Online Grooming on Social Networking Services
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作者 Sangmin Kim Byeongcheon Lee +2 位作者 Muazzam Maqsood Jihoon Moon Seungmin Rho 《Computer Modeling in Engineering & Sciences》 2025年第5期2079-2108,共30页
The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children a... The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children and adolescents who are increasingly exposed to online grooming crimes.Early and accurate identification of grooming conversations is crucial in preventing long-term harm to victims.However,research on grooming detection in South Korea remains limited,as existing models trained primarily on English text and fail to reflect the unique linguistic features of SNS conversations,leading to inaccurate classifications.To address these issues,this study proposes a novel framework that integrates optical character recognition(OCR)technology with KcELECTRA,a deep learning-based natural language processing(NLP)model that shows excellent performance in processing the colloquial Korean language.In the proposed framework,the KcELECTRA model is fine-tuned by an extensive dataset,including Korean social media conversations,Korean ethical verification data from AI-Hub,and Korean hate speech data from Hug-gingFace,to enable more accurate classification of text extracted from social media conversation images.Experimental results show that the proposed framework achieves an accuracy of 0.953,outperforming existing transformer-based models.Furthermore,OCR technology shows high accuracy in extracting text from images,demonstrating that the proposed framework is effective for online grooming detection.The proposed framework is expected to contribute to the more accurate detection of grooming text and the prevention of grooming-related crimes. 展开更多
关键词 Online grooming KcELECTRA natural language processing optical character recognition social networking service text classification
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Agreement between swept-source OCT-based and Scheimpflug-based optical biometers in myopic children
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作者 Ying-Yan Qin Zhao-Tian Zhang +4 位作者 Shu-Wen Xing Shi-Ya Lin Bai-Zhou Chen Liang-Ping Liu Yao Ni 《International Journal of Ophthalmology(English edition)》 2026年第2期339-345,共7页
AIM:To evaluate the agreement of axial length(AL),anterior chamber parameters,and total cornea power obtained by swept-source optical coherence tomography(SS-OCT)-based and Scheimpflug-based optical biometers in myopi... AIM:To evaluate the agreement of axial length(AL),anterior chamber parameters,and total cornea power obtained by swept-source optical coherence tomography(SS-OCT)-based and Scheimpflug-based optical biometers in myopic children.METHODS:AL,steep keratometry(K),flat K,posterior corneal keratometry(PK),total keratometry(TK),anterior chamber depth(ACD),horizontal corneal diameter(CD),and central corneal thickness(CCT)were obtained using IOL Master 700 and Pentacam AXL.The agreement between the devices was evaluated using intraclass correlation coefficients(ICC),Bland-Altman plots,and astigmatism vector analysis.RESULTS:Totally 175 myopic children(48.5%male)with a mean age of 10.29±2.14y were enrolled.The ICC and Bland-Altman plots indicated a satisfactory agreement for AL,ACD,and CCT.The mean difference in CD of-0.31±0.30 mm was considered clinically significant(>0.2 mm).Additionally,measurements of K and TK obtained from the IOL Master 700 showed good agreement.Nevertheless,there were clinically significant differences observed in PK,simulated keratometry(simK),total cornea power,and astigmatism(at least 10%of the cases with a difference of>10 degrees in meridian)between the two devices.CONCLUSION:The study findings demonstrate a significant difference in K,PK,astigmatism,and CD,indicating that the two optical biometers cannot be considered interchangeable.Therefore,it is recommended to utilize one kind device for follow-up examinations in myopic children. 展开更多
关键词 MYOPIA axial length total cornea power optical biometers swept-source optical coherence tomography
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Direct Generation of an Array with 78400 Optical Tweezers Using a Single Metasurface
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作者 Yuqing Wang Yuxuan Liao +9 位作者 Tao Zhang Ye Tian Yujia Wu Wenjun Zhang Wei Zhang Yidong Huang Hui Zhai Wenlan Chen Xue Feng Zhongchi Zhang 《Chinese Physics Letters》 2026年第1期129-133,共5页
Scalability remains a major challenge in building practical fault-tolerant quantum computers.Currently,the largest number of qubits achieved across leading quantum platforms ranges from hundreds to thousands.In atom a... Scalability remains a major challenge in building practical fault-tolerant quantum computers.Currently,the largest number of qubits achieved across leading quantum platforms ranges from hundreds to thousands.In atom arrays,scalability is primarily constrained by the capacity to generate large numbers of optical tweezers,and conventional techniques using acousto-optic deflectors or spatial light modulators struggle to produce arrays much beyond∼10,000 tweezers.Moreover,these methods require additional microscope objectives to focus the light into micrometer-sized spots,which further complicates system integration and scalability.Here,we demonstrate the experimental generation of an optical tweezer array containing 280×280 spots using a metasurface,nearly an order of magnitude more than most existing systems.The metasurface leverages a large number of subwavelength phase-control pixels to engineer the wavefront of the incident light,enabling both large-scale tweezer generation and direct focusing into micron-scale spots without the need for a microscope.This result shifts the scalability bottleneck for atom arrays from the tweezer generation hardware to the available laser power.Furthermore,the array shows excellent intensity uniformity exceeding 90%,making it suitable for homogeneous single-atom loading and paving the way for trapping arrays of more than 10,000 atoms in the near future. 展开更多
关键词 quantum computing optical tweezersand quantum platforms optical tweezers atom arraysscalability atom arrays SCALABILITY spatial light modulators
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Tunable Optical Metamaterial Enables Steganography,Rewriting,and Multilevel Information Storage
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作者 Jianchen Zheng Yuzhao Zhang +7 位作者 Haibo Yu Jingang Wang Hongji Guo Ye Qiu Xiaoduo Wang Yu Feng Lianqing Liu Wen Jung Li 《Nano-Micro Letters》 2026年第2期553-568,共16页
In the realm of secure information storage,optical encryption has emerged as a vital technique,particularly with the miniaturization of encryption devices.However,many existing systems lack the necessary reconfigurabi... In the realm of secure information storage,optical encryption has emerged as a vital technique,particularly with the miniaturization of encryption devices.However,many existing systems lack the necessary reconfigurability and dynamic functionality.This study presents a novel approach through the development of dynamic optical-to-chemical energy conversion metamaterials,which enable enhanced steganography and multilevel information storage.We introduce a micro-dynamic multiple encryption device that leverages programmable optical properties in coumarin-based metamaterials,achieved through a direct laser writing grayscale gradient strategy.This methodology allows for the dynamic regulation of photoluminescent characteristics and cross-linking networks,facilitating innovative steganographic techniques under varying light conditions.The integration of a multi-optical field control system enables real-time adjustments to the material’s properties,enhancing the device’s reconfigurability and storage capabilities.Our findings underscore the potential of these metamaterials in advancing the field of microscale optical encryption,paving the way for future applications in dynamic storage and information security. 展开更多
关键词 Micro/nano-device optical encryption METAMATERIALS Photoluminescence 4D printing
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Optical design of wide-field and broadband light field camera for high-precision optical surface defect detection
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作者 Chengchen Zhou Yukun Wang +7 位作者 Yue Ding Dacheng Wang Jiucheng Nie Jialong Li Zhixi Li Zheng Zhou Shuangshuang Zhang Xiaokun Wang 《Astronomical Techniques and Instruments》 2026年第1期64-74,共11页
To address the challenges of high-precision optical surface defect detection,we propose a novel design for a wide-field and broadband light field camera in this work.The proposed system can achieve a 50°field of ... To address the challenges of high-precision optical surface defect detection,we propose a novel design for a wide-field and broadband light field camera in this work.The proposed system can achieve a 50°field of view and operates at both visible and near-infrared wavelengths.Using the principles of light field imaging,the proposed design enables 3D reconstruction of optical surfaces,thus enabling vertical surface height measurements with enhanced accuracy.Using Zemax-based simulations,we evaluate the system’s modulation transfer function,its optical aberrations,and its tolerance to shape variations through Zernike coefficient adjustments.The results demonstrate that this camera can achieve the required spatial resolution while also maintaining high imaging quality and thus offers a promising solution for advanced optical surface defect inspection. 展开更多
关键词 optical design Defect detection Wide-field camera Broadband light field camera
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Chronic alcohol consumption on retinal microcirculation in healthy subjects:an optic coherence tomography angiography study
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作者 Dilan Yildiz Tahsin Uzundede +2 位作者 Akin Cakir Gamze Karatas Busra Coban 《International Journal of Ophthalmology(English edition)》 2026年第2期326-332,共7页
AIM:To investigate the effects of chronic alcohol consumption on retinal microcirculation by comparing different alcohol-consuming groups using optical coherence tomography(OCT)and OCT angiography(OCTA).METHODS:This o... AIM:To investigate the effects of chronic alcohol consumption on retinal microcirculation by comparing different alcohol-consuming groups using optical coherence tomography(OCT)and OCT angiography(OCTA).METHODS:This observational clinical study utilized a cross-sectional and prospective design,focusing on chronic alcohol consumers alongside a non-consuming control group.OCT/OCTA imaging parameters including central retinal subfield thickness(CST),subfoveal choroidal thickness(SCT),foveal avascular zone(FAZ)and vessel density(VD)in the superficial and deep capillary plexuses in both the macular and optic disc(OD)regions were recorded.Data were analyzed using SPSS 15.0;descriptive statistics were reported,group comparisons were performed with Chisquare,Kruskal–Wallis,and Bonferroni-corrected Mann–Whitney U tests,and relationships were assessed using Spearman correlation,with statistical significance set at P<0.05.RESULTS:A total of 160 eyes of 160 participants(110 females and 50 males with mean age 38.7±9.9y)who don’t smoke were divided into five groups:never,occasional,monthly,weekly and daily drinkers.The mean CST was 216.6±14.2μm and the mean SCT was 358.9±84.5μm.There was no statistically significantly difference in CST and SCT among the groups(P=0.890,0.799).Foveal superficial capillary plexuses(SCPs)VD was higher in monthly drinkers compared to occasional drinkers(P=0.015).Foveal VD in deep capillary plexus was also higher in monthly drinkers than in never and occasional drinkers(P=0.004,0.006).Nasal SCPs VD at the OD was higher in monthly drinkers compared to never drinkers(P=0.005).There was no significant difference FAZ area among the groups(P=0.071).CONCLUSION:Both superficial and deep microvascular structures in the inferior quadrants of macula are positively correlated with frequency of alcohol use.Also in our study results is that the monthly drinker group has uniquely higher VDs in both macula and OD.This leads us to consider moderate alcohol consumption may also have protective effects on retinal microcirculation. 展开更多
关键词 alcohol consumption foveal avascular zone retinal microcirculation optical coherence tomography angiography vessel density
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Investigation of natural and anthropogenic effects on aerosols optical properties over the Western Pacific ocean by the research vessel KEXUE
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作者 Jinyuan Xin Yining Ma +6 位作者 Xiangguang Zhang Yongjing Ma Xiaoyan Wu Fangkun Wu Quan Liu Yilong Lyu Jiawei Jiang 《Journal of Environmental Sciences》 2026年第1期596-605,共10页
In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural a... In winter 2018,an aerosol physicochemical experiment was conducted in the Western Pacific Ocean(WPO)aboard the Research Vessel KEXUE of Chinese Academy of Sciences.This study systematically investigated both natural and anthropogenic effects on marine aerosols optical properties,as well as the applicability of multi-satellite products and IMPROVE equation.The averaged aerosol optical depth(AOD500 nm)was 0.31±0.16 andÅngström exponent440–675 nm was 0.29±0.30.In offshore China,significant anthropogenic emissions affected the marine environment.In remote WPO,dust aerosols transported from northern China,Siberia,Central Asia,and those settling from the upper troposphere originating from north Africa,Arabian peninsula,and western India,were dominant.The spatial trends of AOD were opposite in the mid-latitude and southern seas of WPO.The highest AOD,0.32±0.23,appeared along the coast of South Asia at mid-latitude,decreasing from offshore seas to remote oceans.In low-latitude and equatorial seas,AOD significantly increased from coast to remote oceans.Ångström exponent dropped significantly from the coast to remote oceans as anthropogenic influence diminished across the entire WPO.Correlation analysis showed that both MODIS-C6 and Himawari AOD prod-ucts showed similar applicability in coastal urban areas,while Himawari AOD is highly recommended for coastal background and marine environment due to its finer resolution.The extinction coefficient derived from PM_(2.5) chemical compositions using IMPROVE algorithm exhibited a significant correlation(R^(2)=0.58)with the con-currently measured AOD in the absence of long-distance transport,suggesting that the IMPROVE is a reasonable proxy of the columnar average of marine aerosol extinctions free from transport influences. 展开更多
关键词 Aerosol optical properties Natural and anthropogenic effects Improve algorithm Ship-borne experiment Western Pacific Ocean
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Fundus autofluorescence in central serous chorioretinopathy: association with spectral-domain optical coherence tomography and fluorescein angiography 被引量:7
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作者 Peng Zhang Hai-Yan Wang +4 位作者 Zi-Feng Zhang Dong-Jie Sun Jin-Ting Zhu Juan Li Yu-Sheng Wang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2015年第5期1003-1007,共5页
and FA for identifying pathological abnormalities in CSC. The characteristics of IA AF in CSC were attributable to the modification of melanin in the RPE. IR- AIM: To evaluate the correlation among changes in fundus a... and FA for identifying pathological abnormalities in CSC. The characteristics of IA AF in CSC were attributable to the modification of melanin in the RPE. IR- AIM: To evaluate the correlation among changes in fundus autofluorescence (AF) measured using infrared fundus AF (IR -AF) and short-wave length fundus AF (SW -AF) with changes in spectral -domain optical coherence tomography (SD -OCT) and fluorescein angiography (FA) in central serous chorioretinopathy (CSC). METHODS: Two hundred and twenty consecutive patients with CSC were included. In addition to AF, patients were assessed by means of SD -OCT and FA. Abnormalities in images of IA -AF, SW -AF, FA were analyzed and correlated with the corresponding outer retinal alterations in SD-OCT findings. RESULTS: Eyes with abnormalities on either IR-AF or SW-AF were found in 256 eyes (58.18%), among them 256 eyes (100%) showed abnormal IR -AF, but SW-AF abnormalities were present only in 213 eyes (83.20%). The hypo-IR-AF corresponded to accumulation of subretinal liquid, collapse of retinal pigment epithelium (APE) or detachment of APE with or without RPE leakage point in the corresponding area. The hyper -IR -AF corresponded to the area with loss of the ellipsoid portion of the inner segments and sub -sensory retinal deposits or focal melanogenesis under sensory retina. The hypo-SW-AF corresponded to accumulation of subretinal liquid or atrophy of RPE. The hyper -SW -AF associated with sub -sensory retinal deposits, detachment of RPE and focal melanogenesis. CONCLUSION: IR-AF was more sensitive than SW-AF AF should be used as a common diagnostic tool for identifying pathological lesion in CSC. 展开更多
关键词 central serous chorioretinopathy fluorescein angiography fundus autofluorescence optical coherence tomography
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Association of macular pigment optical density with early stage of non-proliferative diabetic retinopathy in Chinese patients with type 2 diabetes mellitus 被引量:5
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作者 Chong-Yang She Hong Gu +3 位作者 Jun Xu Xiu-Fen Yang Xue-Tao Ren Ning-Pu Liu 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2016年第10期1433-1438,共6页
AIM:To detect the association between macular pigment optical density(MPOD),which reflects the antioxidant ability of retina,and diabetic retinopathy(DR)and to investigate the correlated factors of MPOD.METHODS:... AIM:To detect the association between macular pigment optical density(MPOD),which reflects the antioxidant ability of retina,and diabetic retinopathy(DR)and to investigate the correlated factors of MPOD.METHODS: Totally 435 subjects of urban Chinese were recruited to the study and divided into 3 groups: non-diabetes mellitus controls(NDM),diabetic patients without retinopathy(DWR),and patients with early stage of non-proliferative diabetic retinopathy(DR).Demographic and lifestyle characteristics were ascertained by questionnaire.A food-frequency questionnaire,general physical and ophthalmic examinations were completed for all participants.MPOD was measured by heterochromatic flicker photometry.Foveal thickness was measured by optical coherence tomography.The difference of MPOD among 3 groups was analyzed by analysis of covariance.The correlation analyses of MPOD with the candidate influence factors were assessed using the generalized estimating equations(GEE) model.RESULTS: Of the 435 participants,34 could not perform the MPOD measurements.Final analysis included 401 subjects,including 48 were in DR group,134 in DWR group,and 219 in NDM group.MPOD was not significantly different among DR(0.49 ±0.21),DWR(0.45 ±0.21),and NDM(0.49±0.17) groups(P=0.24) after adjustment for fasting plasma glycemia,central foveal thickness,green vegetables,Chinese wolfberry,carotene and vitamin E.For all the 401 participants included,MPOD was positively associated with central foveal thickness(E=0.0007,P=0.001),Chinese wolfberry(E=0.0345,P=0.01),and green vegetables(E=0.0596,P〈0.001) intake.CONCLUSION: The data suggest that MPOD level is not statistically significantly influenced by the onset of diabetes or early stage of DR in the studied population.MPOD level is positively associated with thicker central foveal thickness and higher intake of foods containing carotenoids. 展开更多
关键词 diabetic retinopathy DIET foveal thickness macular pigment optical density
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Perfect Optical Nonreciprocity with Mechanical Driving in a Three-Mode Optomechanical System 被引量:2
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作者 Li-Hua Zhao Xian-Li Li +1 位作者 He-Lin Lu Xue-Dong Tian 《Communications in Theoretical Physics》 SCIE CAS CSCD 2019年第8期1011-1016,共6页
Nonreciprocal devices are indispensable for building quantum networks and ubiquitous in modern communication technology.Here, we study perfect optical nonreciprocity in a three-mode optomechanical system with mechanic... Nonreciprocal devices are indispensable for building quantum networks and ubiquitous in modern communication technology.Here, we study perfect optical nonreciprocity in a three-mode optomechanical system with mechanical driving.The scheme relies on the interference between optomechanical interaction and mechanical driving.We find perfect optical nonreciprocity can be achieved even though nonreciprocal phase difference is zero if we drive the system by a mechanical driving with a nonzero phase.We obtain the essential conditions for perfect optical nonreciprocity and analyze properties of the optical nonreciprocal transmission.These results can be used to control optical transmission in quantum information processing. 展开更多
关键词 cavity OPTOMECHANICS optical NONRECIPRociTY nonreciprocal transmission MECHANICAL driving
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Interactions between optical bullets with different velocities in the three-dimensional cubic-quintic complex Ginzburg-Landau equation 被引量:2
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作者 郑浪 唐翌 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第4期298-303,共6页
By using the three-dimensional complex Ginzburg--Landau equation with cubic--quintic nonlinearity, this paper numerically investigates the interactions between optical bullets with different velocities in a dissipativ... By using the three-dimensional complex Ginzburg--Landau equation with cubic--quintic nonlinearity, this paper numerically investigates the interactions between optical bullets with different velocities in a dissipative system. The results reveal an abundance of interesting behaviours relating to the velocities of bullets: merging of the optical bullets into a single one at small velocities; periodic collisions at large velocities and disappearance of two bullets after several collisions in an intermediate region of velocity. Finally, it also reports that an extra bullet derives from the collision of optical bullets when optical bullets are at small velocities but with high energies. 展开更多
关键词 optical bullet dissipative soliton complex Ginzburg Landau equation
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Theoretical analysis of stack gas emission velocity measurement by optical scintillation 被引量:1
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作者 杨阳 董凤忠 +4 位作者 倪志波 庞涛 曾宗泳 吴边 张志荣 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第4期202-207,共6页
Theoretical analysis for an online measurement of the stack gas flow velocity based on the optical scintillation method with a structure of two parallel optical paths is performed. The causes of optical scintillation ... Theoretical analysis for an online measurement of the stack gas flow velocity based on the optical scintillation method with a structure of two parallel optical paths is performed. The causes of optical scintillation in a stack are first introduced. Then, the principle of flow velocity measurement and its mathematical expression based on cross correlation of the optical scintillation are presented. The field test results show that the flow velocity measured by the proposed technique in this article is consistent with the value tested by the Pitot tube. It verifies the effectiveness of this method. Finally, by use of the structure function of logarithmic light intensity fluctuations, the theoretical explanation of optical scintillation spec- tral characteristic in low frequency is given. The analysis of the optical scintillation spectrum provides the basis for the measurement of the stack gas flow velocity and particle concentration simultaneously. 展开更多
关键词 optical scintillation cross correlation flow velocity SPECTRUM
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Association of colorectal cancer with pathogenic Escherichia coli: Focus on mechanisms using optical imaging 被引量:11
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作者 Julie Veziant Johan Gagnière +6 位作者 Elodie Jouberton Virginie Bonnin Pierre Sauvanet Denis Pezet Nicolas Barnich Elisabeth Miot-Noirault Mathilde Bonnet 《World Journal of Clinical Oncology》 CAS 2016年第3期293-301,共9页
AIM: To investigate the molecular or cellular mechanisms related to the infection of epithelial colonic mucosa by pks-positive Escherichia coli(E. coli) using optical imaging.METHODS: We choose to evaluate the tumor m... AIM: To investigate the molecular or cellular mechanisms related to the infection of epithelial colonic mucosa by pks-positive Escherichia coli(E. coli) using optical imaging.METHODS: We choose to evaluate the tumor metabolic activity using a fluorodeoxyglucose analogue as 2-deoxyglucosone fluorescent probes and to correlate it with tumoral volume(mm^3). Inflammation measuring myeloperoxidase(MPO) activity and reactive oxygen species production was monitored by a bioluminescent(BLI) inflammation probe and related to histological examination and MPO levels by enzyme-linked immunosorbent assay(ELISA) on tumor specimens. The detection and quantitation of these two signals were validated on a xenograft model of human colon adenocarcinoma epithelial cells(HCT116) in nude mice infected with a pks-positive E. coli. The inflammatory BLI signal was validated intra-digestively in the colitisCEABAC10 DSS models, which mimicked Crohn's disease. RESULTS: Using a 2-deoxyglucosone fluorescent probe, we observed a high and specific HCT116 tumor uptake in correlation with tumoral volume(P = 0.0036). Using the inflammation probe targeting MPO, we detected a rapid systemic elimination and a significant increase of the BLI signal in the pks-positive E. coli-infected HCT116 xenograft group(P < 0.005). ELISA confirmed that MPO levels were significantly higher(1556 ± 313.6 vs 234.6 ± 121.6 ng/m L P = 0.001) in xenografts infected with the pathogenic E. coli strain. Moreover, histological examination of tumor samples confirmed massive infiltration of pks-positive E. coli-infected HCT116 tumors by inflammatory cells compared to the uninfected group. These data showed that infection with the pathogenic E. coli strain enhanced inflammation and ROS production in tumors before tumor growth. Moreover, we demonstrated that the intra-digestive monitoring of inflammation is feasible in a reference colitis murine model(CEABAC10/DSS).CONCLUSION: Using BLI and fluorescence optical imaging, we provided tools to better understand hostpathogen interactions at the early stage of disease, such as inflammatory bowel disease and colorectal cancer. 展开更多
关键词 Colorectal carcinoma Escherichia coli Colibactin MYELOPEROXIDASE In vivo optical imaging
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Subclinical hypothyroidism is associated with lipid-rich plaques in patients with coronary artery disease as assessed by optical coherence tomography 被引量:5
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作者 Xiao-Qing CAI Feng TIAN +6 位作者 Tian-Wen HAN Dong-Kai SHAN Yang LIU Wei-Jun YIN Jing Jing Qiang Xu Yun-Dai CHEN 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2018年第8期534-539,共6页
Background Subclinical hypothyroidism (SCH) has recently been acknowledged as an unconventional risk factor for coronary artery disease (CAD) and characterized by poor prognosis, which may be due to atheroscleroti... Background Subclinical hypothyroidism (SCH) has recently been acknowledged as an unconventional risk factor for coronary artery disease (CAD) and characterized by poor prognosis, which may be due to atherosclerotic plaque characteristics. We conducted this study to observe coronary plaque characteristics in coronary artery disease patients with concomitant SCH. Methods Patients with coronary artery disease were enrolled in the study and divided into an SCH group (patients, n = 26; plaques, n = 35) and a non-SCH group (patients, n = 52; plaques, n = 66). They were divided 1:2 according to propensity-matched analysis including age, diabetes mellitus, gender, CAD severity and culprit vessel. Optical coherence tomography (OCT) imaging was performed on all patients, and images were analyzed by two inde- pendent investigators. Lipid-rich plaques (LRP), the precursor of vulnerable plaques, were defined as having more than one quadrant occu- pied with lipid pool. Maximum lipid arcs were simultaneously recorded. Fibrotic plaques and calcific plaques were also identified. The pres- ence of coronary dissection, plaque erosion, thrombus, macrophage, calcific nodule, thin-cap fibroatheroma and micro channel were all noted. Results The ratio of LRP in SCH group was significantly higher than that in non-SCH group (54% vs. 30.3%, P = 0.037). That was the case as well for the maximum lipid arcs value (181.5°± 61.6° vs. 142.1° 4± 35.9°, p = 0.046). While thin-cap fibroatheroma (TCFA) was detected, no difference was identified between the two groups in either TCFA ratio (20% vs. 16.7%, P = 0.579) or fibrous cap thickness (57.5 4± 14.0 vs. 63.5 4±10.7 gin, P = 0.319). Other OCT characteristics such as dissection, plaque erosion, thrombus, macrophage shadow and calcific nodule were also similar. ConcLusion Higher ratio of LRP with greater lipid arc in SCH patients may be related to the plaque instability and poor prognosis in CAD patients with SCH. 展开更多
关键词 Coronary artery disease optical coherence tomography Plaque characteristics Subclinical hypothyroidism
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Spatio-Temporal Variations in the Associations between Hourly PM<sub>2.5</sub>and Aerosol Optical Depth (AOD) from MODIS Sensors on Terra and Aqua 被引量:1
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作者 Minho Kim Xingyou Zhang +1 位作者 James B. Holt Yang Liu 《Health》 2013年第10期8-13,共6页
Recent studies have explored the relationship between aerosol optical depth (AOD) measurements by satellite sensors and concentrations of particulate matter with aerodynamic diameters less than 2.5 μm (PM2.5). Howeve... Recent studies have explored the relationship between aerosol optical depth (AOD) measurements by satellite sensors and concentrations of particulate matter with aerodynamic diameters less than 2.5 μm (PM2.5). However, relatively little is known about spatial and temporal patterns in this relationship across the contiguous United States. In this study, we investigated the relationship between US Environmental Protection Agency estimates of PM2.5 concentrations and Moderate Resolution Imaging Spectroradiometer (MODIS) AOD measurements provided by two NASA satellites (Terra and Aqua) across the contiguous United States during 2005. We found that the combined use of both satellite sensors provided more AOD coverage than the use of either satellite sensor alone, that the correlation between AOD measurements and PM2.5 concentrations varied substantially by geographic location, and that this correlation was stronger in the summer and fall than that in the winter and spring. 展开更多
关键词 Aerosol optical Depth Moderate Resolution Imaging SPECTRORADIOMETER TERRA AQUA PM2.5 Contiguous UNITED States
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Anterior Segment Parameters Associated to Acute Glaucoma with Slit Lamp Optical Coherence Tomography 被引量:2
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作者 Liamet Fernández Argones Ibrain Piloto Díaz +1 位作者 Sirley Sibello Deustua Carmen María Padilla González 《Open Journal of Ophthalmology》 2014年第2期40-45,共6页
Purpose: To identify the anterior segment parameters associated to acute primary angle closure. Patients and Methods: Case-control study in 58 primary angle closure suspect eyes (PACS, control group) and in 19 acute p... Purpose: To identify the anterior segment parameters associated to acute primary angle closure. Patients and Methods: Case-control study in 58 primary angle closure suspect eyes (PACS, control group) and in 19 acute primary angle closure fellow eyes, case group. All subjects underwent SL OCT imaging in a dark room. Results: The SS, ACD and ACV measures were significantly smaller in case group than in control group (p = 0.011;p < 0.001;p = 0.007 respectively);while the IT was significantly greater (at 500 and 750 μm) (p = 0.038 and p = 0.050). The difference between quadrants were statistically significant only for control group (p = 0.001;p = 0.003;p = 0.009;p = 0.018;p = 0.002 and p 500, AOD500, AOD750, TISA500, and TISA750 respectively. Conclusion: Acute primary angle closure is associated to the smaller anterior segment dimensions and the thicker iris compared to PACS. 展开更多
关键词 ACUTE Primary ANGLE CLOSURE ACUTE GLAUCOMA ANGLE Opening Distance Trabecular-Iris Space Area IRIS Thickness optical Coherence Tomography
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Measurement of the O_2 Dissociation Fraction in RF Low Pressure O_2/Ar Plasma Using Optical Emission Spectrometry
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作者 刘忠伟 李森 +2 位作者 陈强 杨丽珍 王正铎 《Plasma Science and Technology》 SCIE EI CAS CSCD 2011年第4期458-461,共4页
Measurement of the oxygen dissociation fraction in RF low pressure oxygen/argon plasma using optical emission spectrometry is presented. The oxygen dissociation fraction and its evolutions as functions of operational ... Measurement of the oxygen dissociation fraction in RF low pressure oxygen/argon plasma using optical emission spectrometry is presented. The oxygen dissociation fraction and its evolutions as functions of operational parameters were determined using argon as the actinometer. At a pressure of 30 Pa, the oxygen dissociation fraction decreased from 13.4% to 9.5% as the input power increased from 10 W to 70 W. At an input power of 50 W, the oxygen dissociation fraction decreased from 12.3% to 7.7% when the gas pressure increased from 10 Pa to 40 Pa. The influences of operational parameters on the generation of atomic oxygen were also discussed. 展开更多
关键词 optical emission spectroscopy RF O2/Ar plasma ACTINOMETRY
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Optical nonreciprocity in a piezo-optomechanical system
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作者 Yu-Ming Xiao Jun-Hao Liu +2 位作者 Qin Wu Ya-Fei Yu Zhi-Ming Zhang 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第7期321-325,共5页
We theoretically study the optical nonreciprocity in a piezo-optomechanical microdisk resonator,in which the cavity modes and the mechanical mode are optically pumped and piezoelectrically driven,respectively.For asym... We theoretically study the optical nonreciprocity in a piezo-optomechanical microdisk resonator,in which the cavity modes and the mechanical mode are optically pumped and piezoelectrically driven,respectively.For asymmetric optical pumping and different piezoelectrical drivings,our system shows some nonreciprocal optical responses.We find that our system can function as an optical isolator,a nonreciprocal amplifier,or a nonreciprocal phase shifter. 展开更多
关键词 quantum optics cavity optomechanical system optical nonreciprocity piezoelectric force
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Research on Measurement Technology of Flue Gas Velocity Based on Optical Scintillation Induced by Fluctuation of Particulate Concentration
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作者 Zhibo Ni Tao Pang +1 位作者 Yang Yang Fengzhong Dong 《Journal of Environmental Protection》 2014年第10期905-913,共9页
Based on the theory of optical scintillation induced by fluctuation of particulate concentration, a Gas Flow Velocity Measurement System (GFVMS) is proposed to measure the gas flow velocity in stack. Verification expe... Based on the theory of optical scintillation induced by fluctuation of particulate concentration, a Gas Flow Velocity Measurement System (GFVMS) is proposed to measure the gas flow velocity in stack. Verification experiments on simulation flue indicate that, for the smoothing effect of transmitting and receiving apertures, optical scintillation induced by refractive index fluctuation is very weak. When particles are added into gas flow, the standard deviation of optical scintillation increased obviously. And when the particulate number concentration exceeds 4000/m3, the GFVMS can work normally, and the variation range of measured velocities is almost the same with that of Pitot tube. Sensitivity testing results show that, GFVMS is very sensitive to velocity change. Results of outfield experiment prove that, velocities measured by GFVMS are more stable and the average velocity (7.62/s) is very close to the statistical average (7.61 m/s) of velocities measured by Pitot tube at different points along optical path. 展开更多
关键词 optical Scintillation FLUE Gas VELociTY PARTICULATE CONCENTRATION Cross Correlation
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