Oates is regarded as one of the most prolific modern American writers.Wonderland is one of her most representative novels, which is regarded as a"family tragedy"novel.It is Willard Harte who begins the most ...Oates is regarded as one of the most prolific modern American writers.Wonderland is one of her most representative novels, which is regarded as a"family tragedy"novel.It is Willard Harte who begins the most horrible family tragedy. The author of the paper tries to analyze the desperate destroyer, Willard Harte, and his motive for the killing expecting to attract more Chinese scholars' attention.展开更多
Oates is reputed as a representative writer of"psychological realism".Wonderland is one of her most representative novels of in the 1970 s.The author of the thesis tentatively analyzes Oates' tragic arti...Oates is reputed as a representative writer of"psychological realism".Wonderland is one of her most representative novels of in the 1970 s.The author of the thesis tentatively analyzes Oates' tragic artistic point of view,hoping to contribute to the studies on Oates' artistic point of view and her works.展开更多
Joyce Carol Oates is one of the most productive writers in American literary circles,reputed as a representative writer of"psychological realism".For nearly 50 years,her works are various genres with profoun...Joyce Carol Oates is one of the most productive writers in American literary circles,reputed as a representative writer of"psychological realism".For nearly 50 years,her works are various genres with profound theme,which get a lot of attention by Chinese and foreign academic circles.The author of the paper introduces Oates to readers and analyzes her literary career in detail expecting to attract more Chinese scholars’attention.展开更多
Narrative ethics shows multiple representing methods in Oates' s novels,including not only a variety of characters' narrative construction processes of self-narrative,other-narrative and social narrative but a...Narrative ethics shows multiple representing methods in Oates' s novels,including not only a variety of characters' narrative construction processes of self-narrative,other-narrative and social narrative but also the meaninggenerating process of the characters' interpretation and reorganization of the external and internal world.In so doing,the characters are able to obtain personal identity,the ethical communication and existence transcendence by the way of narrative.展开更多
Joyce Carol Oates, one of America's most prestigious and prolific contemporary writers, favors depicting the dark side of America, especially poverty and violence. This paper studies Oates' s depiction of abje...Joyce Carol Oates, one of America's most prestigious and prolific contemporary writers, favors depicting the dark side of America, especially poverty and violence. This paper studies Oates' s depiction of abject poverty, of those most powerless and vulnerable and those who cannot attain the food, water, and shelter necessary for survival during the Great Depression. Then, relative poverty after the Depression is also discussed. Oates keenly observes "the invisible poor" in the affluent American society and gives voice to those relatively deprived and marginal. By analyzing the relationship between poverty and violence, this paper concludes that Oates tries to awaken readers to the social malaise and the real life of the downtrodden and at the same time calls for passion and life's energy. The obsession with the darkest sides of the society is not a sick fondness but reflects the social conscience of Oates as a serious writer.展开更多
Greenhouse gas(GHG)production during ensiling not only causes the nutrient losses of silage but also promotes climate warming.However,there is little information on the production of GHG and strategies for mitigating ...Greenhouse gas(GHG)production during ensiling not only causes the nutrient losses of silage but also promotes climate warming.However,there is little information on the production of GHG and strategies for mitigating GHG emissions during ensiling.This work aimed to study the gas production characteristics and techniques for reducing gas emissions during ensiling.Oats and triticale,with Lactiplantibacillus plantarum(LP)or corn meal(CM)addition,were ensiled.The cumulative gas volume rapidly increased and reached to the peak within the first 9 d of ensiling for both forage crops.The highest cumulative gas volume of triticale silage was twice as much as that of oats silage.Triticale silage produced lower carbon dioxide(CO_(2))concentration,higher methane(CH_(4))and nitrous oxide(N_(2)O)concentrations than oats silage within the 28 d of ensiling.Adding LP or CM significantly improved the fermentation quality and decreased the gas volume and GHG concentrations of 2 silages on d 56(except CH_(4)of triticale).At the early stage of ensiling,more Enterobacter,Lactococcus and Leuconostoc related to gas production were observed,and adding LP increased the abundance of Lactobacillus and decreased the abundance of bacteria like Kosakonia,Pantoea,Enterobacter and Lactococcus positively correlated with gas volume,CO_(2)and N_(2)O concentrations.These results suggest that gas formation during ensiling mainly occurs in the first 9 d.Adding LP or CM can significantly improve the fermentation quality and decrease the gas volume.This would benefit to reducing GHG emissions in silage production.展开更多
Objective:When the skin is exposed to external stimuli such as ultraviolet radiation,it can lead to dryness and sensitivity,highlighting the importance of skincare.Maintaining skin homeostasis for healthy complexion r...Objective:When the skin is exposed to external stimuli such as ultraviolet radiation,it can lead to dryness and sensitivity,highlighting the importance of skincare.Maintaining skin homeostasis for healthy complexion requires not only controlling the inflammatory response,but also protecting the skin barrier.The study aimed to explore the potential of fermented oats(FO)as an innovative ingredient in skin care products,focusing on its capacity to alleviate inflammation and repair the skin barrier.Methods:The present study aimed to characterize the active composition and skin care effects of FO,which underwent enzymatic hydrolysis followed by fermentation with Saccharomyces cerevisiae.To evaluate the antiinflammatory properties of FO,we performed experiments to inhibit TNF-α/TNFR1 binding,nitric oxide(NO)release in RAW264.7 macrophage cells and neutrophil aggregation in zebrafish embryos.Additionally,the study evaluated the secretion of inflammatory factors,skin barrier function and moisturizing effects using a UVBirradiated skin model as a surrogate for photodamaged skin.Results:This study reveals that the fermentation process involving Saccharomyces cerevisiae significantly enhances amino acids and their derivatives in FO.Specifically,β-glucan,total protein,and flavonoids in FO increased by 14.78%,39.13%,and 600%,respectively.FO achieved a 79.87%inhibition rate of TNF-α/TNFR1 binding.It also reduced lipopolysaccharide(LPS)-induced NO release in RAW264.7 cells and inhibited neutrophil recruitment in zebrafish embryos.In a capsaicin(CAP)-stimulated skin model,3.5%FO suppressed TRPV1 expression.In a UVB-irradiated 3D skin model,FO decreased the secretion of pro-inflammatory cytokines(IL-1α,IL-6,COX2,NF-κB)and significantly upregulated loricrin(128.57%),filaggrin(336.36%),transglutaminase 1(70.97%),and caspase-14(217.65%).Additionally,FO enhanced moisturizing efficacy by increasing skin moisture content and AQP3 levels.Conclusion:As a novel fermentation ingredient,FO inhibits the expression of inflammatory factors,improves skin tissue morphology,and enhances hydration,achieving multi-faceted soothing and repairing effects.These findings suggest that Saccharomyces cerevisiae-fermented oat extracts hold promise as an innovative ingredient with anti-inflammatory and skin-protective benefits.展开更多
Background:Testicular sperm aspiration(TESA)is a minimally invasive testicular sperm retrieval technique that has been utilized in the treatment of male factor infertility.We sought to evaluate sperm retrieval outcome...Background:Testicular sperm aspiration(TESA)is a minimally invasive testicular sperm retrieval technique that has been utilized in the treatment of male factor infertility.We sought to evaluate sperm retrieval outcomes of primary and redo TESA in men with severe oligoasthenoteratozoospermia(OAT)and obstructive azoospermia(OA).Methods:This is a retrospective analysis of consecutive TESAs(primary and redo)for men with severe OAT and OA performed between January 2011 and August 2022 at a high-volume infertility center.We compared TESA outcomes in men with severe OAT to those with OA and compared outcomes of men who underwent primary and redo TESA on the same testicular unit.Results:439 TESAs(366 primary and 73 redo)in men with severe OAT(n=133)and OA(n=306)were included.Men with OA had significantly higher sperm retrieval rate(SRR)and motile SRR compared to men with severe OAT(99%vs.95%and 98%vs.83%,respectively,p<0.05).The requirement for multiple biopsies and the total number of aspirates were significantly lower in men with OA compared to those with severe OAT(15%vs.32%and 1.2±0.5 vs.1.4±0.7,respectively,p<0.05).In both groups,SRR,motile SRR,the requirement for multiple biopsies,and the total number of aspirates were not significantly different in primary compared to redo cases.Conclusion:Our data demonstrate that TESA retrieval rates are significantly higher in men with OA compared to those with severe OAT.The data also demonstrate that a redo TESA in these men is as effective as a primary TESA,suggesting that areas of active spermatogenesis are preserved 6 months after TESA.展开更多
Oat husks,a byproduct of oat milling operations with limited economic value,present a promising feedstock for biorefinery processes due to their chemical composition.This study investigates the conversion of C5 carboh...Oat husks,a byproduct of oat milling operations with limited economic value,present a promising feedstock for biorefinery processes due to their chemical composition.This study investigates the conversion of C5 carbohydrates in oat husks into furfural through hydrothermal pretreatment using various phosphate-based catalysts,including H_(3)PO_(4),NH_(4)H_(2)PO_(4),NaH_(2)PO_(4),KH_(2)PO_(4),K_(2)HPO_(4) and K_(3)PO_(4) as catalyst.The catalysts’effectiveness in promoting furfural production was evaluated under identical hydrothermal conditions(treatment time for 60 min at a constant temperature of 170℃ and a catalyst amount).Continuous water steam was used to strip furfural from the reaction zone and minimize its degradation.Results indicated that H_(3)PO_(4) was the most effective catalyst,achieving a furfural yield of 13.99 wt.%,which corresponds to approximately 57%of the theoretical yield.NH4H2PO4 also showed moderate effectiveness,while sodium and potassium phosphate salts were significantly less effective.A scanning electron microscope analysis shows that catalysts with lower pH may disrupt the oat husks external layer thus providing a higher C5 carbohydrates conversion rate into furfural.The chemical complexity of oat husk contributes to side reactions between its carbohydrates and lignin during the hydrothermal treatment.This results in an increase in acid-insoluble lignin and inorganic matter in the oat husk lignocellulosic residue,which can reduce the effectiveness of further cellulose saccharification by enzymatic hydrolysis.展开更多
Digestive health is important for overall well-being,but gut health problems are common in the Chinese population.The objective of this study was to investigate the effects of oatβ-glucan-based prebiotic blended form...Digestive health is important for overall well-being,but gut health problems are common in the Chinese population.The objective of this study was to investigate the effects of oatβ-glucan-based prebiotic blended formulas in humans on digestive health by assessing defecation frequency,defecation symptoms,stool quality,self-reported digestive feelings,defecation satisfaction,and gut bacteria.A parallel,randomized,double-blind,controlled trial was conducted in 168 eligible adults randomized to 3 groups for 14 days:Intervention groups A and B received 2 different doses of oatβ-glucan-based prebiotic blended formulas and a Control group received oatβ-glucan mixed with hydroxypropylmethyl-cellulose and microcrystalline cellulose.Participants completed a defecation diary and Bristol stool chart daily and digestive system questionnaires weekly.Fecal samples were collected on day 0 and day 14 to evaluate gut bacteria using 16S rDNA analysis.Both formulas improved defecation frequency,stool quality,defecation symptoms,defecation satisfaction,and on digestive health of human,compared with baseline(P<0.05).Both formulas led to increased quantities of Bifidobacterium and Akkermansia bacteria,compared to control,on day 14.This study therefore demonstrated the beneficial effects of oatβ-glucan-based prebiotic blended formulas on gut health in generally healthy Chinese adults.These formulas are a feasible nutritional strategy for digestive health.展开更多
Whole-grain foods have attracted emerging attention due to their health benefits.Whole grains are rich in bound polyphenols(BPs)linked with dietary fibers,which is largely underestimated compared with free polyphenols...Whole-grain foods have attracted emerging attention due to their health benefits.Whole grains are rich in bound polyphenols(BPs)linked with dietary fibers,which is largely underestimated compared with free polyphenols.In this study,in vitro simulated gastrointestinal digestion and colonic fermentation models were used to study the release profile and metabolism of BPs of oat bran.Significantly higher level of BPs was released during in vitro colon fermentation(3.05 mg GAE/g)than in gastrointestinal digestion(0.54 mg GAE/g).Five polyphenols were detected via LC-MS and their possible conversion pathways were speculated.Released BPs exhibited chemical antioxidant capacity.16S rRNA sequencing further revealed that Clostridium butyricum,Enterococcus faecalis,Bacteroides acidifaciens were the key bacteria involved in the release of BPs,and this was verified by whole-cell transformation.Our results helped to explain the possible mechanism of the health benefits of BPs in whole grains.展开更多
BACKGROUND Antithrombotic strategies after percutaneous coronary interventions(PCI)in elderly patients on oral anticoagulant therapy(OAT)are debated due to the balance between ischemic and bleeding risks.Recent guidel...BACKGROUND Antithrombotic strategies after percutaneous coronary interventions(PCI)in elderly patients on oral anticoagulant therapy(OAT)are debated due to the balance between ischemic and bleeding risks.Recent guidelines recommend early transitioning from triple antithrombotic therapy to dual antithrombotic therapy,but there are limited data on elderly patients.METHODS We performed a post-hoc age-specific analysis of the PERSEO Registry population aimed to compare clinical features,therapeutic strategies,and outcomes of individuals aged≥80 years and<80 years who were on OAT and underwent PCI with stent.The primary endpoint was net adverse clinical events at 1-year follow-up.Secondary endpoints included major adverse cardiac and cerebral events(MACCE),major bleeding[Bleeding Academic Research Consortium(BARC)type 3–5],and clinically relevant bleeding(BARC type 2-5).RESULTS Among the 1234 patients enrolled,31%of patients were aged≥80 years(84±3 years,76% males).Compared to younger patients,elderly patients had higher rates of comorbidities such as hypertension,anaemia or chronic kidney disease,and atrial fibrillation was the leading indication for OAT.Elderly patients were more often discharged on dual antithrombotic therapy(23%)compared to younger patients(13%)(P<0.0001).They experienced higher net adverse clinical events(38%vs.21%,P<0.001),MACCE(24%vs.12%,P<0.001),as well as higher bleeding rates.Specifically,rates of major bleeding(9%vs.6%,P=0.026),and clinically relevant bleeding(21%vs.12%,P<0.001)were significantly higher in elderly patients.CONCLUSIONS Elderly patients on OAT undergoing PCI are a particular frail population with higher risk of MACCE and bleeding compared to younger patients despite a less aggressive antithrombotic therapy.展开更多
Thediagnosis of Dry EyeDisease(DED),however,usually depends on clinical information and complex,high-dimensional datasets.To improve the performance of classification models,this paper proposes a Computer Aided Design...Thediagnosis of Dry EyeDisease(DED),however,usually depends on clinical information and complex,high-dimensional datasets.To improve the performance of classification models,this paper proposes a Computer Aided Design(CAD)system that presents a new method for DED classification called(IAOO-PSO),which is a powerful Feature Selection technique(FS)that integrates with Opposition-Based Learning(OBL)and Particle Swarm Optimization(PSO).We improve the speed of convergence with the PSO algorithmand the exploration with the IAOO algorithm.The IAOO is demonstrated to possess superior global optimization capabilities,as validated on the IEEE Congress on Evolutionary Computation 2022(CEC’22)benchmark suite and compared with seven Metaheuristic(MH)algorithms.Additionally,an IAOO-PSO model based on Support Vector Machines(SVMs)classifier is proposed for FS and classification,where the IAOO-PSO is used to identify the most relevant features.This model was applied to the DED dataset comprising 20,000 cases and 26 features,achieving a high classification accuracy of 99.8%,which significantly outperforms other optimization algorithms.The experimental results demonstrate the reliability,success,and efficiency of the IAOO-PSO technique for both FS and classification in the detection of DED.展开更多
文摘Oates is regarded as one of the most prolific modern American writers.Wonderland is one of her most representative novels, which is regarded as a"family tragedy"novel.It is Willard Harte who begins the most horrible family tragedy. The author of the paper tries to analyze the desperate destroyer, Willard Harte, and his motive for the killing expecting to attract more Chinese scholars' attention.
文摘Oates is reputed as a representative writer of"psychological realism".Wonderland is one of her most representative novels of in the 1970 s.The author of the thesis tentatively analyzes Oates' tragic artistic point of view,hoping to contribute to the studies on Oates' artistic point of view and her works.
文摘Joyce Carol Oates is one of the most productive writers in American literary circles,reputed as a representative writer of"psychological realism".For nearly 50 years,her works are various genres with profound theme,which get a lot of attention by Chinese and foreign academic circles.The author of the paper introduces Oates to readers and analyzes her literary career in detail expecting to attract more Chinese scholars’attention.
文摘Narrative ethics shows multiple representing methods in Oates' s novels,including not only a variety of characters' narrative construction processes of self-narrative,other-narrative and social narrative but also the meaninggenerating process of the characters' interpretation and reorganization of the external and internal world.In so doing,the characters are able to obtain personal identity,the ethical communication and existence transcendence by the way of narrative.
基金part of the result of the research program the author hosts, “Body Study in Joyce Carol Oates’s Novels”, No. 2015SJB516
文摘Joyce Carol Oates, one of America's most prestigious and prolific contemporary writers, favors depicting the dark side of America, especially poverty and violence. This paper studies Oates' s depiction of abject poverty, of those most powerless and vulnerable and those who cannot attain the food, water, and shelter necessary for survival during the Great Depression. Then, relative poverty after the Depression is also discussed. Oates keenly observes "the invisible poor" in the affluent American society and gives voice to those relatively deprived and marginal. By analyzing the relationship between poverty and violence, this paper concludes that Oates tries to awaken readers to the social malaise and the real life of the downtrodden and at the same time calls for passion and life's energy. The obsession with the darkest sides of the society is not a sick fondness but reflects the social conscience of Oates as a serious writer.
基金supported by the National Key R&D Program of China(2022YFE0111000-2)。
文摘Greenhouse gas(GHG)production during ensiling not only causes the nutrient losses of silage but also promotes climate warming.However,there is little information on the production of GHG and strategies for mitigating GHG emissions during ensiling.This work aimed to study the gas production characteristics and techniques for reducing gas emissions during ensiling.Oats and triticale,with Lactiplantibacillus plantarum(LP)or corn meal(CM)addition,were ensiled.The cumulative gas volume rapidly increased and reached to the peak within the first 9 d of ensiling for both forage crops.The highest cumulative gas volume of triticale silage was twice as much as that of oats silage.Triticale silage produced lower carbon dioxide(CO_(2))concentration,higher methane(CH_(4))and nitrous oxide(N_(2)O)concentrations than oats silage within the 28 d of ensiling.Adding LP or CM significantly improved the fermentation quality and decreased the gas volume and GHG concentrations of 2 silages on d 56(except CH_(4)of triticale).At the early stage of ensiling,more Enterobacter,Lactococcus and Leuconostoc related to gas production were observed,and adding LP increased the abundance of Lactobacillus and decreased the abundance of bacteria like Kosakonia,Pantoea,Enterobacter and Lactococcus positively correlated with gas volume,CO_(2)and N_(2)O concentrations.These results suggest that gas formation during ensiling mainly occurs in the first 9 d.Adding LP or CM can significantly improve the fermentation quality and decrease the gas volume.This would benefit to reducing GHG emissions in silage production.
文摘Objective:When the skin is exposed to external stimuli such as ultraviolet radiation,it can lead to dryness and sensitivity,highlighting the importance of skincare.Maintaining skin homeostasis for healthy complexion requires not only controlling the inflammatory response,but also protecting the skin barrier.The study aimed to explore the potential of fermented oats(FO)as an innovative ingredient in skin care products,focusing on its capacity to alleviate inflammation and repair the skin barrier.Methods:The present study aimed to characterize the active composition and skin care effects of FO,which underwent enzymatic hydrolysis followed by fermentation with Saccharomyces cerevisiae.To evaluate the antiinflammatory properties of FO,we performed experiments to inhibit TNF-α/TNFR1 binding,nitric oxide(NO)release in RAW264.7 macrophage cells and neutrophil aggregation in zebrafish embryos.Additionally,the study evaluated the secretion of inflammatory factors,skin barrier function and moisturizing effects using a UVBirradiated skin model as a surrogate for photodamaged skin.Results:This study reveals that the fermentation process involving Saccharomyces cerevisiae significantly enhances amino acids and their derivatives in FO.Specifically,β-glucan,total protein,and flavonoids in FO increased by 14.78%,39.13%,and 600%,respectively.FO achieved a 79.87%inhibition rate of TNF-α/TNFR1 binding.It also reduced lipopolysaccharide(LPS)-induced NO release in RAW264.7 cells and inhibited neutrophil recruitment in zebrafish embryos.In a capsaicin(CAP)-stimulated skin model,3.5%FO suppressed TRPV1 expression.In a UVB-irradiated 3D skin model,FO decreased the secretion of pro-inflammatory cytokines(IL-1α,IL-6,COX2,NF-κB)and significantly upregulated loricrin(128.57%),filaggrin(336.36%),transglutaminase 1(70.97%),and caspase-14(217.65%).Additionally,FO enhanced moisturizing efficacy by increasing skin moisture content and AQP3 levels.Conclusion:As a novel fermentation ingredient,FO inhibits the expression of inflammatory factors,improves skin tissue morphology,and enhances hydration,achieving multi-faceted soothing and repairing effects.These findings suggest that Saccharomyces cerevisiae-fermented oat extracts hold promise as an innovative ingredient with anti-inflammatory and skin-protective benefits.
文摘Background:Testicular sperm aspiration(TESA)is a minimally invasive testicular sperm retrieval technique that has been utilized in the treatment of male factor infertility.We sought to evaluate sperm retrieval outcomes of primary and redo TESA in men with severe oligoasthenoteratozoospermia(OAT)and obstructive azoospermia(OA).Methods:This is a retrospective analysis of consecutive TESAs(primary and redo)for men with severe OAT and OA performed between January 2011 and August 2022 at a high-volume infertility center.We compared TESA outcomes in men with severe OAT to those with OA and compared outcomes of men who underwent primary and redo TESA on the same testicular unit.Results:439 TESAs(366 primary and 73 redo)in men with severe OAT(n=133)and OA(n=306)were included.Men with OA had significantly higher sperm retrieval rate(SRR)and motile SRR compared to men with severe OAT(99%vs.95%and 98%vs.83%,respectively,p<0.05).The requirement for multiple biopsies and the total number of aspirates were significantly lower in men with OA compared to those with severe OAT(15%vs.32%and 1.2±0.5 vs.1.4±0.7,respectively,p<0.05).In both groups,SRR,motile SRR,the requirement for multiple biopsies,and the total number of aspirates were not significantly different in primary compared to redo cases.Conclusion:Our data demonstrate that TESA retrieval rates are significantly higher in men with OA compared to those with severe OAT.The data also demonstrate that a redo TESA in these men is as effective as a primary TESA,suggesting that areas of active spermatogenesis are preserved 6 months after TESA.
基金funded by the Latvian State Institute of Wood Chemistry Bioeconomic Research Grant No.09-24 titled“Selective Valorization of Lignocellulosic Biomass(SeVaLi)”.
文摘Oat husks,a byproduct of oat milling operations with limited economic value,present a promising feedstock for biorefinery processes due to their chemical composition.This study investigates the conversion of C5 carbohydrates in oat husks into furfural through hydrothermal pretreatment using various phosphate-based catalysts,including H_(3)PO_(4),NH_(4)H_(2)PO_(4),NaH_(2)PO_(4),KH_(2)PO_(4),K_(2)HPO_(4) and K_(3)PO_(4) as catalyst.The catalysts’effectiveness in promoting furfural production was evaluated under identical hydrothermal conditions(treatment time for 60 min at a constant temperature of 170℃ and a catalyst amount).Continuous water steam was used to strip furfural from the reaction zone and minimize its degradation.Results indicated that H_(3)PO_(4) was the most effective catalyst,achieving a furfural yield of 13.99 wt.%,which corresponds to approximately 57%of the theoretical yield.NH4H2PO4 also showed moderate effectiveness,while sodium and potassium phosphate salts were significantly less effective.A scanning electron microscope analysis shows that catalysts with lower pH may disrupt the oat husks external layer thus providing a higher C5 carbohydrates conversion rate into furfural.The chemical complexity of oat husk contributes to side reactions between its carbohydrates and lignin during the hydrothermal treatment.This results in an increase in acid-insoluble lignin and inorganic matter in the oat husk lignocellulosic residue,which can reduce the effectiveness of further cellulose saccharification by enzymatic hydrolysis.
基金funded by the Chinese Nutrition Society and PepsiCo Inc.
文摘Digestive health is important for overall well-being,but gut health problems are common in the Chinese population.The objective of this study was to investigate the effects of oatβ-glucan-based prebiotic blended formulas in humans on digestive health by assessing defecation frequency,defecation symptoms,stool quality,self-reported digestive feelings,defecation satisfaction,and gut bacteria.A parallel,randomized,double-blind,controlled trial was conducted in 168 eligible adults randomized to 3 groups for 14 days:Intervention groups A and B received 2 different doses of oatβ-glucan-based prebiotic blended formulas and a Control group received oatβ-glucan mixed with hydroxypropylmethyl-cellulose and microcrystalline cellulose.Participants completed a defecation diary and Bristol stool chart daily and digestive system questionnaires weekly.Fecal samples were collected on day 0 and day 14 to evaluate gut bacteria using 16S rDNA analysis.Both formulas improved defecation frequency,stool quality,defecation symptoms,defecation satisfaction,and on digestive health of human,compared with baseline(P<0.05).Both formulas led to increased quantities of Bifidobacterium and Akkermansia bacteria,compared to control,on day 14.This study therefore demonstrated the beneficial effects of oatβ-glucan-based prebiotic blended formulas on gut health in generally healthy Chinese adults.These formulas are a feasible nutritional strategy for digestive health.
基金the support from the research grants by National Natural Science Foundation of China(32202051)National Key R&D Program of China(2022YFF1100104)the Major Project of Inner Mongolia Science and Technology Department,China(2021ZD0002)。
文摘Whole-grain foods have attracted emerging attention due to their health benefits.Whole grains are rich in bound polyphenols(BPs)linked with dietary fibers,which is largely underestimated compared with free polyphenols.In this study,in vitro simulated gastrointestinal digestion and colonic fermentation models were used to study the release profile and metabolism of BPs of oat bran.Significantly higher level of BPs was released during in vitro colon fermentation(3.05 mg GAE/g)than in gastrointestinal digestion(0.54 mg GAE/g).Five polyphenols were detected via LC-MS and their possible conversion pathways were speculated.Released BPs exhibited chemical antioxidant capacity.16S rRNA sequencing further revealed that Clostridium butyricum,Enterococcus faecalis,Bacteroides acidifaciens were the key bacteria involved in the release of BPs,and this was verified by whole-cell transformation.Our results helped to explain the possible mechanism of the health benefits of BPs in whole grains.
基金was given by a 2017 Research Grant of the Italian Society of Interventional Cardiology (SICI-GISE)
文摘BACKGROUND Antithrombotic strategies after percutaneous coronary interventions(PCI)in elderly patients on oral anticoagulant therapy(OAT)are debated due to the balance between ischemic and bleeding risks.Recent guidelines recommend early transitioning from triple antithrombotic therapy to dual antithrombotic therapy,but there are limited data on elderly patients.METHODS We performed a post-hoc age-specific analysis of the PERSEO Registry population aimed to compare clinical features,therapeutic strategies,and outcomes of individuals aged≥80 years and<80 years who were on OAT and underwent PCI with stent.The primary endpoint was net adverse clinical events at 1-year follow-up.Secondary endpoints included major adverse cardiac and cerebral events(MACCE),major bleeding[Bleeding Academic Research Consortium(BARC)type 3–5],and clinically relevant bleeding(BARC type 2-5).RESULTS Among the 1234 patients enrolled,31%of patients were aged≥80 years(84±3 years,76% males).Compared to younger patients,elderly patients had higher rates of comorbidities such as hypertension,anaemia or chronic kidney disease,and atrial fibrillation was the leading indication for OAT.Elderly patients were more often discharged on dual antithrombotic therapy(23%)compared to younger patients(13%)(P<0.0001).They experienced higher net adverse clinical events(38%vs.21%,P<0.001),MACCE(24%vs.12%,P<0.001),as well as higher bleeding rates.Specifically,rates of major bleeding(9%vs.6%,P=0.026),and clinically relevant bleeding(21%vs.12%,P<0.001)were significantly higher in elderly patients.CONCLUSIONS Elderly patients on OAT undergoing PCI are a particular frail population with higher risk of MACCE and bleeding compared to younger patients despite a less aggressive antithrombotic therapy.
文摘Thediagnosis of Dry EyeDisease(DED),however,usually depends on clinical information and complex,high-dimensional datasets.To improve the performance of classification models,this paper proposes a Computer Aided Design(CAD)system that presents a new method for DED classification called(IAOO-PSO),which is a powerful Feature Selection technique(FS)that integrates with Opposition-Based Learning(OBL)and Particle Swarm Optimization(PSO).We improve the speed of convergence with the PSO algorithmand the exploration with the IAOO algorithm.The IAOO is demonstrated to possess superior global optimization capabilities,as validated on the IEEE Congress on Evolutionary Computation 2022(CEC’22)benchmark suite and compared with seven Metaheuristic(MH)algorithms.Additionally,an IAOO-PSO model based on Support Vector Machines(SVMs)classifier is proposed for FS and classification,where the IAOO-PSO is used to identify the most relevant features.This model was applied to the DED dataset comprising 20,000 cases and 26 features,achieving a high classification accuracy of 99.8%,which significantly outperforms other optimization algorithms.The experimental results demonstrate the reliability,success,and efficiency of the IAOO-PSO technique for both FS and classification in the detection of DED.
