We herein present the design and synthesis of a structurally unique oxa-spirocyclic diphosphine ligand,termed as O-SDP.The diphosphine ligand O-SDP derived from oxa-spirocyclic diphenols(O-SPINOL)has a relatively larg...We herein present the design and synthesis of a structurally unique oxa-spirocyclic diphosphine ligand,termed as O-SDP.The diphosphine ligand O-SDP derived from oxa-spirocyclic diphenols(O-SPINOL)has a relatively larger bite angle compared with that of SDP,and O-SDP has been successfully applied in the ruthenium-catalyzed asymmetric hydrogenation ofα,β-unsaturated carboxylic acids under mild reaction conditions.High yields and enantioselectivities were generally achieved for a wide range of substrates(up to 99%yield and>99%ee),and many of the resulting products are key intermediates of important drugs such as Sacubitril,Artemisinin,and Paroxetine.展开更多
基金the Free Exploration Fund from the Shenzhen Science and Technology Innovation Committee(JCYJ20170817105056467)the Youth Fund from National Natural Science Foundation of China(No.21901107)+3 种基金X.Zhang is indebted to Southern University of Science and Technology(start-up fund),Shenzhen Science and Technology Innovation Committee(nos.KQTD20150717103157174 and JSGG20170821140353405)Guangdong Provincial Key Laboratory of Catalysis(No.2020B121201002)National Natural Science Foundation of China(No.21991113)SZDRC Discipline Construction Program for financial support.
文摘We herein present the design and synthesis of a structurally unique oxa-spirocyclic diphosphine ligand,termed as O-SDP.The diphosphine ligand O-SDP derived from oxa-spirocyclic diphenols(O-SPINOL)has a relatively larger bite angle compared with that of SDP,and O-SDP has been successfully applied in the ruthenium-catalyzed asymmetric hydrogenation ofα,β-unsaturated carboxylic acids under mild reaction conditions.High yields and enantioselectivities were generally achieved for a wide range of substrates(up to 99%yield and>99%ee),and many of the resulting products are key intermediates of important drugs such as Sacubitril,Artemisinin,and Paroxetine.
