Ti-containing phosphate（ Ti-P-O ） catalysts with different molar ratios of P to Ti （0--2. 0 ） were synthesized and characterized by XRD, N2-adsorption/desorption, IR and temperature-programmed desorption （TPD） m...Ti-containing phosphate（ Ti-P-O ） catalysts with different molar ratios of P to Ti （0--2. 0 ） were synthesized and characterized by XRD, N2-adsorption/desorption, IR and temperature-programmed desorption （TPD） methods. The catalytic properties of Ti-P-O samples in the vapor-phase O-methylation of catechol with methanol were also studied. The catechol conversion increases with the increase of the molar ratio of P to Ti in a range of 0-0. 33, while a further increase in the P content leads to a decrease of the catalytic activity. Meanwhile, the selectivities of the catalysts to the main product（guaiacol） increase gradually with the increase of the molar ratio of P to Ti. The presence of relatively strong Lewis acidic and/or basic sites in the P-free catalyst should be responsible for the formation of C-alkylation products. The weak acid-base characteristics of the catalysts are favourable for the mono-O-methylation of catechol. In comparison with the Lewis acidic sites, the Bronsted acidic sites on the catalysts are more active for the title reaction.展开更多
Racemic O-methyl O-pheayl thiophosphoric acid 1 has been successfully resolved through its quinine and brucine salts in methanol solution by fractional crystallization. The absolute configurations of the optically act...Racemic O-methyl O-pheayl thiophosphoric acid 1 has been successfully resolved through its quinine and brucine salts in methanol solution by fractional crystallization. The absolute configurations of the optically active 1 have been established as (+)-R-1 and (-)-S-1 by chemical correlation.展开更多
The functional impact of modifications of cellular RNAs,including m RNAs,mi RNAs and lnc RNAs,is a field of intense study.The role of such modifications in cancer has started to be elucidated.Diverse and sometimes opp...The functional impact of modifications of cellular RNAs,including m RNAs,mi RNAs and lnc RNAs,is a field of intense study.The role of such modifications in cancer has started to be elucidated.Diverse and sometimes opposite effects of RNA modifications have been reported.Some RNA modifications promote,while ot-hers decrease the growth and invasiveness of cancer.The present manuscript reviews the current knowledge on the potential impacts of N6-Methyladenosine,Pse-udouridine,Inosine,2’O-methylation or methylcytidine in cancer’s RNA.It also highlights the remaining qu-estions and provides hints on research avenues and potential therapeutic applications,whereby modulating dynamic RNA modifications may be a new method to treat cancer.展开更多
Caprolactam is treated with dimethyl sulfate in benzene medium under conditions of various molar ratios to yield two different methylatcd products. The homogeneous reaction of caprolactam with dimethyl sulfate without...Caprolactam is treated with dimethyl sulfate in benzene medium under conditions of various molar ratios to yield two different methylatcd products. The homogeneous reaction of caprolactam with dimethyl sulfate without any medium can only givc one methylated derivative. In a similar condition to that mentioned above, the reaction of caprolactam with diethylsulfate forms also one product, O-ethyl caprolactim. In this articlc NMR spectrum is applied to further identify the molecular structures of two methylated derivatives held by predecessors, and, applied the chemical shift reagent to induce the NMR and combined the field scanning and decoupling method to confirm the classification of signals, as a consequence the preferred conformation of caprolactam and its alkyl derivatives are proposed.展开更多
基金Supported by the Development Project of Science and Technology of Jilin Province(Nos. 20050309-1 and 20040563), the Spe-cialized Research Fund for the Doctoral Program of Higher Education(No.20040183003), CNPC(No.JTGS 20040010), and the Na-tional Natural Science Foundation of China(No.20403006)
文摘Ti-containing phosphate（ Ti-P-O ） catalysts with different molar ratios of P to Ti （0--2. 0 ） were synthesized and characterized by XRD, N2-adsorption/desorption, IR and temperature-programmed desorption （TPD） methods. The catalytic properties of Ti-P-O samples in the vapor-phase O-methylation of catechol with methanol were also studied. The catechol conversion increases with the increase of the molar ratio of P to Ti in a range of 0-0. 33, while a further increase in the P content leads to a decrease of the catalytic activity. Meanwhile, the selectivities of the catalysts to the main product（guaiacol） increase gradually with the increase of the molar ratio of P to Ti. The presence of relatively strong Lewis acidic and/or basic sites in the P-free catalyst should be responsible for the formation of C-alkylation products. The weak acid-base characteristics of the catalysts are favourable for the mono-O-methylation of catechol. In comparison with the Lewis acidic sites, the Bronsted acidic sites on the catalysts are more active for the title reaction.
基金This project was supported by National Natural Science Foundation of China
文摘Racemic O-methyl O-pheayl thiophosphoric acid 1 has been successfully resolved through its quinine and brucine salts in methanol solution by fractional crystallization. The absolute configurations of the optically active 1 have been established as (+)-R-1 and (-)-S-1 by chemical correlation.
基金Supported by University of Zurich:"URPP:Translational Cancer research"the"MERIT"project supported by the FP7 European Union’s ResearchInnovation Funding program
文摘The functional impact of modifications of cellular RNAs,including m RNAs,mi RNAs and lnc RNAs,is a field of intense study.The role of such modifications in cancer has started to be elucidated.Diverse and sometimes opposite effects of RNA modifications have been reported.Some RNA modifications promote,while ot-hers decrease the growth and invasiveness of cancer.The present manuscript reviews the current knowledge on the potential impacts of N6-Methyladenosine,Pse-udouridine,Inosine,2’O-methylation or methylcytidine in cancer’s RNA.It also highlights the remaining qu-estions and provides hints on research avenues and potential therapeutic applications,whereby modulating dynamic RNA modifications may be a new method to treat cancer.
文摘Caprolactam is treated with dimethyl sulfate in benzene medium under conditions of various molar ratios to yield two different methylatcd products. The homogeneous reaction of caprolactam with dimethyl sulfate without any medium can only givc one methylated derivative. In a similar condition to that mentioned above, the reaction of caprolactam with diethylsulfate forms also one product, O-ethyl caprolactim. In this articlc NMR spectrum is applied to further identify the molecular structures of two methylated derivatives held by predecessors, and, applied the chemical shift reagent to induce the NMR and combined the field scanning and decoupling method to confirm the classification of signals, as a consequence the preferred conformation of caprolactam and its alkyl derivatives are proposed.
